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1.发明申请公开(公告)号：US20140031390A1
公开(公告)日：2014-01-30
申请号：US14111459
申请日：2012-04-10
CPC分类号： A61K47/02 , A61K9/2009 , A61K31/47
摘要： The present invention provides a pitavastatin-containing preparation containing pitavastatin or a pharmacologically acceptable salt thereof and at least one kind of a basic additive selected from the group consisting of basic magnesium compounds and basic calcium compounds, and an aqueous solution or an aqueous dispersion of the pitavastatin-containing preparation having a pH of more than 8 and 10 or less; and a method for producing a pitavastatin-containing preparation, including blending at least one kind of a basic additive selected from the group consisting of basic magnesium compounds and basic calcium compounds with pitavastatin or a pharmacologically acceptable salt thereof, to make an aqueous solution or an aqueous dispersion of the pitavastatin-containing preparation have a pH of more than 8 and 10 or less.
摘要翻译： 本发明提供了含有匹伐他汀或其药理学上可接受的盐和选自碱性镁化合物和碱性钙化合物的碱性添加剂中的至少一种的含匹伐他汀的制剂，以及水溶液或水分散体 具有大于8和10或更小的pH的匹伐他汀制剂; 以及含有匹伐他汀的制剂的制造方法，包括将选自碱性镁化合物和碱性钙化合物的碱性添加剂中的至少一种与匹伐他汀或其药理学可接受的盐混合，制成水溶液或 含匹萨他汀的制剂的水性分散体的pH值大于8且为10以下。
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2.发明申请Aptamers to the human IL-12 cytokine family and their use as autoimmune disease therapeutics 审中-公开适用于人IL-12细胞因子家族及其作为自身免疫疾病治疗剂的用途公开(公告)号：US20070066550A1
公开(公告)日：2007-03-22
申请号：US11075649
申请日：2005-03-07
申请人： John Diener , Alicia Ferguson , Nobuko Hamaguchi , Sara Keene , H.A. Lagasse , Pooja Sawhney , Kristin Thompson
发明人： John Diener , Alicia Ferguson , Nobuko Hamaguchi , Sara Keene , H.A. Lagasse , Pooja Sawhney , Kristin Thompson
CPC分类号： C12N15/115 , C07H21/04 , C12N2310/16 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/3521
摘要： The present invention provides materials and methods to treat immune disease in which cytokines are involved in pathogenesis. The materials and methods of the present invention are useful in the treatment of autoimmune diseases. The materials and methods of the present invention are directed to nucleic acid ligands capable of binding to human IL-23 and/or human IL-12 cytokines and thus modulate their biological activity and are useful as therapeutic agents in immune, auto-immune and cancer therapeutics.
摘要翻译： 本发明提供了治疗免疫疾病的材料和方法，其中细胞因子涉及发病机理。 本发明的材料和方法可用于治疗自身免疫性疾病。 本发明的材料和方法涉及能够结合人IL-23和/或人IL-12细胞因子并因此调节其生物学活性的核酸配体，并且可用作免疫，自身免疫和癌症中的治疗剂 疗法。
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公开(公告)号：US07125660B2
公开(公告)日：2006-10-24
申请号：US10215982
申请日：2002-08-09
申请人： Martin Stanton , David Epstein , Nobuko Hamaguchi , Markus Kurz , Tony Keefe , Charles Wilson , Dilara Grate , Kristin A. Marshall , Thomas G. McCauley , Jeffrey C. Kurz
发明人： Martin Stanton , David Epstein , Nobuko Hamaguchi , Markus Kurz , Tony Keefe , Charles Wilson , Dilara Grate , Kristin A. Marshall , Thomas G. McCauley , Jeffrey C. Kurz
CPC分类号： B82Y30/00 , B01J2219/00385 , B01J2219/00479 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00653 , B01J2219/00662 , B01J2219/00691 , B01J2219/00722 , C07H21/02 , C07H21/04 , C12Q1/485 , C12Q1/6816 , C12Q1/6825 , C40B40/06 , C40B60/14 , C12Q2565/101 , C12Q2525/179 , C12Q2521/337 , C12Q2521/501
摘要： Methods for engineering a nucleic acid sensor molecule are provided. Biosensors comprise a plurality of nucleic acid sensor molecules labeled with a first signaling moiety and a second signaling moiety. The nucleic acid sensor molecules recognizes target molecules which do not naturally bind to DNA. Binding of a target molecule to the sensor molecules triggers a change in the proximity of the signaling moieties which leads to a change in the optical properties of the nucleic acid sensor molecules on the biosensor. Reagents and systems for performing the method are also provided. The method is useful in diagnostic applications and drug optimization.
摘要翻译： 提供了设计核酸传感器分子的方法。 生物传感器包含用第一信号传导部分和第二信号传导部分标记的多个核酸传感器分子。 核酸传感器分子识别不天然结合DNA的靶分子。 靶分子与传感器分子的结合触发信号部分的接近度的变化，导致生物传感器上的核酸传感器分子的光学性质的变化。 还提供了用于执行该方法的试剂和系统。 该方法可用于诊断应用和药物优化。
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4.发明申请公开(公告)号：US20060193821A1
公开(公告)日：2006-08-31
申请号：US11234676
申请日：2005-09-22
申请人： John Diener , David Epstein , Alicia Ferguson , Nobuko Hamaguchi , H.A. Lagasse , Shannon Pendergrast , Pooja Sawhney , Kristin Thompson
发明人： John Diener , David Epstein , Alicia Ferguson , Nobuko Hamaguchi , H.A. Lagasse , Shannon Pendergrast , Pooja Sawhney , Kristin Thompson
IPC分类号： A61K48/00 , C07K14/715 , C08G63/91
CPC分类号： C12N15/115 , C07H21/04 , C12N2310/16 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/331 , C12N2310/346 , C12N2310/351 , C12N2310/3521
摘要： The present invention provides materials and methods to treat immune disease in which cytokines are involved in pathogenesis. The materials and methods of the present invention are useful in the treatment of autoimmune diseases. The materials and methods of the present invention are directed to nucleic acid ligands capable of binding to human IL-23 and/or human IL-12 cytokines and thus modulate their biological activity and are useful as therapeutic agents in immune, auto-immune and cancer therapeutics.
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公开(公告)号：US09399064B2
公开(公告)日：2016-07-26
申请号：US14111459
申请日：2012-04-10
CPC分类号： A61K47/02 , A61K9/2009 , A61K31/47
摘要： The present invention provides: a pitavastatin-containing preparation containing pitavastatin or a pharmacologically acceptable salt thereof and at least one kind of a basic additive selected from the group consisting of basic magnesium compounds and basic calcium compounds, and an aqueous solution or an aqueous dispersion of the pitavastatin-containing preparation having a pH of more than 8 and 10 or less; and a method for producing a pitavastatin-containing preparation, including blending at least one kind of a basic additive selected from the group consisting of basic magnesium compounds and basic calcium compounds with pitavastatin or a pharmacologically acceptable salt thereof, to make an aqueous solution or an aqueous dispersion of the pitavastatin-containing preparation have a pH of more than 8 and 10 or less.
摘要翻译： 本发明提供：含有匹伐他汀或其药理学上可接受的盐和选自碱性镁化合物和碱性钙化合物的碱性添加剂中的至少一种碱性添加剂的含匹伐他汀的制剂，以及水溶液或水分散体 含有匹伐他汀的制剂具有大于8和10或更小的pH; 以及含有匹伐他汀的制剂的制造方法，包括将选自碱性镁化合物和碱性钙化合物的碱性添加剂中的至少一种与匹伐他汀或其药理学可接受的盐混合，制成水溶液或 含匹萨他汀的制剂的水性分散体的pH值大于8且为10以下。
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公开(公告)号：US09314454B2
公开(公告)日：2016-04-19
申请号：US12810779
申请日：2008-12-26
IPC分类号： A61K9/14 , A61K31/4422 , A61K9/00 , A61K9/20
CPC分类号： A61K31/4422 , A61K9/0056 , A61K9/2018 , A61K9/2054 , A61K9/2095
摘要： The invention provides an orally disintegrating tablet containing (a) one or more saccharides or sugar alcohols selected from the group consisting of mannitol, lactose, xylitol, sucrose, erythritol and glucose and (b) low substituted hydroxypropylcellulose and substantially free of a starch disintegrant, which tablet is produced by steps of granulating a composition containing the above-mentioned components (a) and (b) by an agitation granulation method, and compression-molding the obtained granulation product. The invention also provides a method of producing an orally disintegrating tablet substantially free of a starch disintegrant, including steps of granulating a composition containing the above-mentioned components by an agitation granulation method, and compression-molding the obtained granulation product.
摘要翻译： 本发明提供一种口服崩解片，其含有（a）一种或多种选自甘露醇，乳糖，木糖醇，蔗糖，赤藓醇和葡萄糖的糖或糖醇，和（b）低取代羟丙基纤维素，基本上不含淀粉崩解剂， 通过使用搅拌造粒法将含有上述成分（a）和（b）的组合物成粒的工序来制造该片剂，并对得到的造粒物进行压缩成型。 本发明还提供一种生产基本上不含淀粉崩解剂的口腔崩解片剂的方法，包括通过搅拌造粒法造粒含有上述组分的组合物，并将所得制粒产品压缩成型的步骤。
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公开(公告)号：US20100278930A1
公开(公告)日：2010-11-04
申请号：US12810779
申请日：2008-12-26
CPC分类号： A61K31/4422 , A61K9/0056 , A61K9/2018 , A61K9/2054 , A61K9/2095
摘要： The invention provides an orally disintegrating tablet containing (a) one or more saccharides or sugar alcohols selected from the group consisting of mannitol, lactose, xylitol, sucrose, erythritol and glucose and (b) low substituted hydroxypropylcellulose and substantially free of a starch disintegrant, which tablet is produced by steps of granulating a composition containing the above-mentioned components (a) and (b) by an agitation granulation method, and compression-molding the obtained granulation product. The invention also provides a method of producing an orally disintegrating tablet substantially free of a starch disintegrant, including steps of granulating a composition containing the above-mentioned components by an agitation granulation method, and compression-molding the obtained granulation product.
摘要翻译： 本发明提供一种口服崩解片，其含有（a）一种或多种选自甘露醇，乳糖，木糖醇，蔗糖，赤藓醇和葡萄糖的糖或糖醇，和（b）低取代羟丙基纤维素，基本上不含淀粉崩解剂， 通过使用搅拌造粒法将含有上述成分（a）和（b）的组合物成粒的工序来制造该片剂，并对得到的造粒物进行压缩成型。 本发明还提供一种生产基本上不含淀粉崩解剂的口腔崩解片剂的方法，包括通过搅拌造粒法造粒含有上述组分的组合物，并将所得制粒产品压缩成型的步骤。
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8.发明申请Aptamers to the human IL-12 cytokine family and their use as autoimmune disease therapeutics 审中-公开适用于人IL-12细胞因子家族及其作为自身免疫疾病治疗剂的用途公开(公告)号：US20090082555A1
公开(公告)日：2009-03-26
申请号：US12157383
申请日：2008-06-09
申请人： John L. Diener , Alicia Ferguson , Nobuko Hamaguchi , Sara Chesworth Keene , H.A. Daniel Lagasse , Pooja Sawhney , Kristin Thompson
发明人： John L. Diener , Alicia Ferguson , Nobuko Hamaguchi , Sara Chesworth Keene , H.A. Daniel Lagasse , Pooja Sawhney , Kristin Thompson
IPC分类号： C12N15/24
CPC分类号： C12N15/115 , C07H21/04 , C12N2310/16 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/3521
摘要： The present invention provides materials and methods to treat immune disease in which cytokines are involved in pathogenesis. The materials and methods of the present invention are useful in the treatment of autoimmune diseases. The materials and methods of the present invention are directed to nucleic acid ligands capable of binding to human IL-23 and/or human IL-12 cytokines and thus modulate their biological activity and are useful as therapeutic agents in immune, auto-immune and cancer therapeutics.
摘要翻译： 本发明提供了治疗免疫疾病的材料和方法，其中细胞因子涉及发病机理。 本发明的材料和方法可用于治疗自身免疫性疾病。 本发明的材料和方法涉及能够结合人IL-23和/或人IL-12细胞因子并因此调节其生物学活性的核酸配体，并且可用作免疫，自身免疫和癌症中的治疗剂 疗法。
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