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1.发明授权Corneal vitrification, methods and devices to produce corneal vitrification and methods of use thereof 有权角膜玻璃化，产生角膜玻璃化的方法和装置及其使用方法公开(公告)号：US09545339B2
公开(公告)日：2017-01-17
申请号：US14512952
申请日：2014-10-13
CPC分类号： A61F9/008 , A61F2/142 , A61F9/0079 , A61F9/00814 , A61F2009/00872 , A61N7/00 , A61N2007/0004
摘要： The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased eletastic modulus; methods for producing and using the new composition of matter for modifying cortical structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photovitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters. A reverse template can be added to corneal vitrification systems to increase vitrification and modifications of structure and properties.
摘要翻译： 本发明包括：一种新的物质组合物（包括在原位眼中的天然存在的体内角膜以及在天然存在的角膜基质组织内形成的至少一个玻璃化非天然存在的角膜基质组织体积的复合物），其中 玻璃化组织在结构和性质上从其天然存在的状态改变成非天然存在的玻璃样状态，其中包括但不限于增加的电化学模量; 用于生产和使用新的组合物用于改变皮层结构和性质的方法，包括但不限于角膜光学像差; 伤口闭合粘连和移植附着力; 以及用于产生包含至少一个具有可控处理参数的光子源的新组合物的光生产系统。 可以向角膜玻璃化系统添加反向模板，以增加玻璃化和结构和性质的修改。
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2.发明授权Corneal vitrification, methods and devices to produce corneal vitrification and methods of use thereof 有权角膜玻璃化，产生角膜玻璃化的方法和装置及其使用方法公开(公告)号：US09532904B2
公开(公告)日：2017-01-03
申请号：US14674890
申请日：2015-03-31
CPC分类号： A61F9/008 , A61F2/142 , A61F9/0079 , A61F9/00814 , A61F2009/00872 , A61N7/00 , A61N2007/0004
摘要： The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased elastic modulus; methods for producing and using the new composition of matter for modifying corneal structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photovitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters. A reverse template can be added to corneal vitrification systems to increase vitrification and modifications of structure and properties.
摘要翻译： 本发明包括：一种新的物质组合物（包括在原位眼中的天然存在的体内角膜以及在天然存在的角膜基质组织内形成的至少一个玻璃化非天然存在的角膜基质组织体积的复合物），其中 玻璃化组织的结构和性质从其天然存在的状态改变成非天然存在的玻璃状状态，其中包括但不限于增加的弹性模量; 用于生产和使用用于修饰角膜结构和性质的新组合物的方法，包括但不限于角膜光学像差; 伤口闭合粘连和移植附着力; 以及用于产生包含至少一个具有可控处理参数的光子源的新组合物的光生产系统。 可以向角膜玻璃化系统添加反向模板，以增加玻璃化和结构和性质的修改。
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3.发明授权Corneal vitrification, methods and devices to produce corneal vitrification and methods of use thereof 有权角膜玻璃化，产生角膜玻璃化的方法和装置及其使用方法公开(公告)号：US09526656B2
公开(公告)日：2016-12-27
申请号：US14674992
申请日：2015-03-31
CPC分类号： A61F9/008 , A61F2/142 , A61F9/0079 , A61F9/00814 , A61F2009/00872 , A61N7/00 , A61N2007/0004
摘要： The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased elastic modulus; methods for producing and using the new composition of matter for modifying corneal structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photo vitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters. A reverse template can be added to corneal vitrification systems to increase vitrification and modifications of structure and properties.
摘要翻译： 本发明包括：一种新的物质组合物（包括在原位眼中的天然存在的体内角膜以及在天然存在的角膜基质组织内形成的至少一个玻璃化非天然存在的角膜基质组织体积的复合物），其中 玻璃化组织的结构和性质从其天然存在的状态改变成非天然存在的玻璃状状态，其中包括但不限于增加的弹性模量; 用于生产和使用用于修饰角膜结构和性质的新组合物的方法，包括但不限于角膜光学像差; 伤口闭合粘连和移植附着力; 以及用于产生包含至少一个具有可控处理参数的光子源的新组合物的照相玻璃化系统。 可以向角膜玻璃化系统添加反向模板，以增加玻璃化和结构和性质的修改。
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4.发明申请CORNEAL VITRIFICATION, METHODS AND DEVICES TO PRODUCE CORNEAL VITRIFICATION AND METHODS OF USE THEREOF 有权角膜修复，生产角膜修复的方法和装置及其使用方法公开(公告)号：US20150133901A1
公开(公告)日：2015-05-14
申请号：US14512952
申请日：2014-10-13
CPC分类号： A61F9/008 , A61F2/142 , A61F9/0079 , A61F9/00814 , A61F2009/00872 , A61N7/00 , A61N2007/0004
摘要： The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased eletastic modulus; methods for producing and using the new composition of matter for modifying cortical structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photovitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters. A reverse template can be added to corneal vitrification systems to increase vitrification and modifications of structure and properties.
摘要翻译： 本发明包括：一种新的物质组合物（包括在原位眼中的天然存在的体内角膜以及在天然存在的角膜基质组织内形成的至少一个玻璃化非天然存在的角膜基质组织体积的复合物），其中 玻璃化组织在结构和性质上从其天然存在的状态改变成非天然存在的玻璃样状态，其中包括但不限于增加的电化学模量; 用于生产和使用新的组合物用于改变皮层结构和性质的方法，包括但不限于角膜光学像差; 伤口闭合粘连和移植附着力; 以及用于产生包含至少一个具有可控处理参数的光子源的新组合物的光生产系统。 可以向角膜玻璃化系统添加反向模板，以增加玻璃化和结构和性质的修改。
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5.发明申请公开(公告)号：US20140276678A1
公开(公告)日：2014-09-18
申请号：US14215772
申请日：2014-03-17
IPC分类号： A61F9/008
CPC分类号： A61F9/009 , A61F2009/00872
摘要： In some embodiments, the instant invention provides for a system for shaping a human cornea of an eye that includes at least the following components: a sapphire applanation window/suction ring (SAWSR) system, where the SAWSR system includes a sapphire applanation window/suction ring (SAWSR), a conical holder, an illuminator, and a temperature control, where the SAWSR system is configured to: (i) be positioned on the eye, (ii) applanate the human cornea of the eye, (iii) generate and position a centration aid, and (iv) maintain temperature control; an optical delivery system, where the optical delivery system includes: (i) a laser, (ii) a fiber delivery holder, and (iii) a laser control subsystem, where the laser control subsystem is configured to display a user interface to: 1) control a power and a temporal waveform of each of the beamlets of light, and 2) irradiate the human cornea of the eye.
摘要翻译： 在一些实施例中，本发明提供了一种用于整形眼睛的人类角膜的系统，该系统至少包括以下部件：蓝宝石压平窗/吸力环（SAWSR）系统，其中SAWSR系统包括蓝宝石压平窗/抽吸 （SAWSR），锥形保持器，照明器和温度控制器，其中SAWSR系统被配置为：（i）定位在眼睛上，（ii）压制眼睛的人类角膜，（iii）产生和 定位助剂，（iv）保持温度控制; 光学传送系统，其中所述光学传送系统包括：（i）激光器，（ii）光纤传送保持器，以及（iii）激光控制子系统，其中所述激光控制子系统被配置为显示用户界面以：1 ）控制每个子束光的功率和时间波形，以及2）照射眼睛的人角膜。
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6.发明申请METHODS AND COMPOSITIONS FOR OPTIMIZING THE OUTCOMES OF REFRACTIVE LASER SURGERY OF THE CORNEA 审中-公开优化CORNEA激光激光手术成果的方法和组合公开(公告)号：US20070167935A1
公开(公告)日：2007-07-19
申请号：US11624945
申请日：2007-01-19
申请人： OLIVIA SERDAREVIC
发明人： OLIVIA SERDAREVIC
IPC分类号： A61B18/18
CPC分类号： A61F9/008 , A61F9/00802 , A61F2009/00872
摘要： Disclosed herein are methods and compositions for use in surgical procedures for refractive ablation of the cornea to achieve vision correction with a minimum of undesirable side effects and for a broad range of optical conditions such myopia, hyperopia, presbyopia and astigmatism. Specifically disclosed are compositions, and methods involving their use, wherein the compositions act as agents for the reversible removal of corneal epithelial layers to provide access for UV radiation in manipulation of the refractive properties of the cornea. The methods and compositions of the present invention are capable of achieving desirable results in corrective surgery not possible with current methods for exposing the corneal stroma to far-UV laser radiation.
摘要翻译： 本文公开了用于角膜的折射消融的外科手术中的方法和组合物，以实现具有最少不期望的副作用的视力矫正以及宽范围的光学条件，例如近视，远视，老花眼和散光。 具体公开的是涉及它们使用的组合物和方法，其中所述组合物作为用于可逆去除角膜上皮层的试剂，以在操纵角膜的折射性质时提供紫外线辐射的通路。 本发明的方法和组合物能够在用于将角膜基质暴露于远紫外线激光辐射的现有方法中获得对矫正手术不可取的期望结果。
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7.发明申请公开(公告)号：US20190060056A1
公开(公告)日：2019-02-28
申请号：US15693208
申请日：2017-08-31
IPC分类号： A61F2/16
摘要： Devices and methods for novel retinal irradiance distribution modification (IDM) to improve, stabilize or restore vision are described herein. Also encompassed herein are devices and methods to reduce vision loss from diseases, injuries and disorders that involve damaged and/or dysfunctional and/or sensorily deprived retinal cells. Conditions that may be treated using devices and methods described herein include macular degeneration, diabetic retinopathy and glaucoma. Therapy provided by retinal IDM devices and methods described herein may also be used in combination with other therapies including, but not limited to, pharmacological, retinal laser, gene and stem cell therapies.
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8.发明申请CORNEAL VITRIFICATION, METHODS AND DEVICES TO PRODUCE CORNEAL VITRIFICATION AND METHODS OF USE THEREOF 有权角膜修复，生产角膜修复的方法和装置及其使用方法公开(公告)号：US20150230985A1
公开(公告)日：2015-08-20
申请号：US14674992
申请日：2015-03-31
CPC分类号： A61F9/008 , A61F2/142 , A61F9/0079 , A61F9/00814 , A61F2009/00872 , A61N7/00 , A61N2007/0004
摘要： The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased elastic modulus; methods for producing and using the new composition of matter for modifying corneal structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photo vitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters. A reverse template can be added to corneal vitrification systems to increase vitrification and modifications of structure and properties.
摘要翻译： 本发明包括：一种新的物质组合物（包括在原位眼中的天然存在的体内角膜以及在天然存在的角膜基质组织内形成的至少一个玻璃化非天然存在的角膜基质组织体积的复合物），其中 玻璃化组织的结构和性质从其天然存在的状态改变成非天然存在的玻璃状状态，其中包括但不限于增加的弹性模量; 用于生产和使用用于修饰角膜结构和性质的新组合物的方法，包括但不限于角膜光学像差; 伤口闭合粘连和移植附着力; 以及用于产生包含至少一个具有可控处理参数的光子源的新组合物的照相玻璃化系统。 可以向角膜玻璃化系统添加反向模板，以增加玻璃化和结构和性质的修改。
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9.发明申请CORNEAL VITRIFICATION, METHODS AND DEVICES TO PRODUCE CORNEAL VITRIFICATION AND METHODS OF USE THEREOF 有权角膜修复，生产角膜修复的方法和装置及其使用方法公开(公告)号：US20150230979A1
公开(公告)日：2015-08-20
申请号：US14674890
申请日：2015-03-31
CPC分类号： A61F9/008 , A61F2/142 , A61F9/0079 , A61F9/00814 , A61F2009/00872 , A61N7/00 , A61N2007/0004
摘要： The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased elastic modulus; methods for producing and using the new composition of matter for modifying corneal structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photovitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters. A reverse template can be added to corneal vitrification systems to increase vitrification and modifications of structure and properties.
摘要翻译： 本发明包括：一种新的物质组合物（包括在原位眼中的天然存在的体内角膜以及在天然存在的角膜基质组织内形成的至少一个玻璃化非天然存在的角膜基质组织体积的复合物），其中 玻璃化组织的结构和性质从其天然存在的状态改变成非天然存在的玻璃状状态，其中包括但不限于增加的弹性模量; 用于生产和使用用于修饰角膜结构和性质的新组合物的方法，包括但不限于角膜光学像差; 伤口闭合粘连和移植附着力; 以及用于产生包含至少一个具有可控处理参数的光子源的新组合物的光生产系统。 可以向角膜玻璃化系统添加反向模板，以增加玻璃化和结构和性质的修改。
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