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1.发明授权Corneal vitrification, methods and devices to produce corneal vitrification and methods of use thereof 有权角膜玻璃化，产生角膜玻璃化的方法和装置及其使用方法公开(公告)号：US09545339B2
公开(公告)日：2017-01-17
申请号：US14512952
申请日：2014-10-13
CPC分类号： A61F9/008 , A61F2/142 , A61F9/0079 , A61F9/00814 , A61F2009/00872 , A61N7/00 , A61N2007/0004
摘要： The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased eletastic modulus; methods for producing and using the new composition of matter for modifying cortical structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photovitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters. A reverse template can be added to corneal vitrification systems to increase vitrification and modifications of structure and properties.
摘要翻译： 本发明包括：一种新的物质组合物（包括在原位眼中的天然存在的体内角膜以及在天然存在的角膜基质组织内形成的至少一个玻璃化非天然存在的角膜基质组织体积的复合物），其中 玻璃化组织在结构和性质上从其天然存在的状态改变成非天然存在的玻璃样状态，其中包括但不限于增加的电化学模量; 用于生产和使用新的组合物用于改变皮层结构和性质的方法，包括但不限于角膜光学像差; 伤口闭合粘连和移植附着力; 以及用于产生包含至少一个具有可控处理参数的光子源的新组合物的光生产系统。 可以向角膜玻璃化系统添加反向模板，以增加玻璃化和结构和性质的修改。
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2.发明授权Corneal vitrification, methods and devices to produce corneal vitrification and methods of use thereof 有权角膜玻璃化，产生角膜玻璃化的方法和装置及其使用方法公开(公告)号：US09532904B2
公开(公告)日：2017-01-03
申请号：US14674890
申请日：2015-03-31
CPC分类号： A61F9/008 , A61F2/142 , A61F9/0079 , A61F9/00814 , A61F2009/00872 , A61N7/00 , A61N2007/0004
摘要： The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased elastic modulus; methods for producing and using the new composition of matter for modifying corneal structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photovitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters. A reverse template can be added to corneal vitrification systems to increase vitrification and modifications of structure and properties.
摘要翻译： 本发明包括：一种新的物质组合物（包括在原位眼中的天然存在的体内角膜以及在天然存在的角膜基质组织内形成的至少一个玻璃化非天然存在的角膜基质组织体积的复合物），其中 玻璃化组织的结构和性质从其天然存在的状态改变成非天然存在的玻璃状状态，其中包括但不限于增加的弹性模量; 用于生产和使用用于修饰角膜结构和性质的新组合物的方法，包括但不限于角膜光学像差; 伤口闭合粘连和移植附着力; 以及用于产生包含至少一个具有可控处理参数的光子源的新组合物的光生产系统。 可以向角膜玻璃化系统添加反向模板，以增加玻璃化和结构和性质的修改。
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3.发明授权Corneal vitrification, methods and devices to produce corneal vitrification and methods of use thereof 有权角膜玻璃化，产生角膜玻璃化的方法和装置及其使用方法公开(公告)号：US09526656B2
公开(公告)日：2016-12-27
申请号：US14674992
申请日：2015-03-31
CPC分类号： A61F9/008 , A61F2/142 , A61F9/0079 , A61F9/00814 , A61F2009/00872 , A61N7/00 , A61N2007/0004
摘要： The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased elastic modulus; methods for producing and using the new composition of matter for modifying corneal structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photo vitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters. A reverse template can be added to corneal vitrification systems to increase vitrification and modifications of structure and properties.
摘要翻译： 本发明包括：一种新的物质组合物（包括在原位眼中的天然存在的体内角膜以及在天然存在的角膜基质组织内形成的至少一个玻璃化非天然存在的角膜基质组织体积的复合物），其中 玻璃化组织的结构和性质从其天然存在的状态改变成非天然存在的玻璃状状态，其中包括但不限于增加的弹性模量; 用于生产和使用用于修饰角膜结构和性质的新组合物的方法，包括但不限于角膜光学像差; 伤口闭合粘连和移植附着力; 以及用于产生包含至少一个具有可控处理参数的光子源的新组合物的照相玻璃化系统。 可以向角膜玻璃化系统添加反向模板，以增加玻璃化和结构和性质的修改。
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4.发明申请公开(公告)号：US20140276678A1
公开(公告)日：2014-09-18
申请号：US14215772
申请日：2014-03-17
IPC分类号： A61F9/008
CPC分类号： A61F9/009 , A61F2009/00872
摘要： In some embodiments, the instant invention provides for a system for shaping a human cornea of an eye that includes at least the following components: a sapphire applanation window/suction ring (SAWSR) system, where the SAWSR system includes a sapphire applanation window/suction ring (SAWSR), a conical holder, an illuminator, and a temperature control, where the SAWSR system is configured to: (i) be positioned on the eye, (ii) applanate the human cornea of the eye, (iii) generate and position a centration aid, and (iv) maintain temperature control; an optical delivery system, where the optical delivery system includes: (i) a laser, (ii) a fiber delivery holder, and (iii) a laser control subsystem, where the laser control subsystem is configured to display a user interface to: 1) control a power and a temporal waveform of each of the beamlets of light, and 2) irradiate the human cornea of the eye.
摘要翻译： 在一些实施例中，本发明提供了一种用于整形眼睛的人类角膜的系统，该系统至少包括以下部件：蓝宝石压平窗/吸力环（SAWSR）系统，其中SAWSR系统包括蓝宝石压平窗/抽吸 （SAWSR），锥形保持器，照明器和温度控制器，其中SAWSR系统被配置为：（i）定位在眼睛上，（ii）压制眼睛的人类角膜，（iii）产生和 定位助剂，（iv）保持温度控制; 光学传送系统，其中所述光学传送系统包括：（i）激光器，（ii）光纤传送保持器，以及（iii）激光控制子系统，其中所述激光控制子系统被配置为显示用户界面以：1 ）控制每个子束光的功率和时间波形，以及2）照射眼睛的人角膜。
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5.发明申请CORNEAL VITRIFICATION, METHODS AND DEVICES TO PRODUCE CORNEAL VITRIFICATION AND METHODS OF USE THEREOF 有权角膜修复，生产角膜修复的方法和装置及其使用方法公开(公告)号：US20150133901A1
公开(公告)日：2015-05-14
申请号：US14512952
申请日：2014-10-13
CPC分类号： A61F9/008 , A61F2/142 , A61F9/0079 , A61F9/00814 , A61F2009/00872 , A61N7/00 , A61N2007/0004
摘要： The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased eletastic modulus; methods for producing and using the new composition of matter for modifying cortical structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photovitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters. A reverse template can be added to corneal vitrification systems to increase vitrification and modifications of structure and properties.
摘要翻译： 本发明包括：一种新的物质组合物（包括在原位眼中的天然存在的体内角膜以及在天然存在的角膜基质组织内形成的至少一个玻璃化非天然存在的角膜基质组织体积的复合物），其中 玻璃化组织在结构和性质上从其天然存在的状态改变成非天然存在的玻璃样状态，其中包括但不限于增加的电化学模量; 用于生产和使用新的组合物用于改变皮层结构和性质的方法，包括但不限于角膜光学像差; 伤口闭合粘连和移植附着力; 以及用于产生包含至少一个具有可控处理参数的光子源的新组合物的光生产系统。 可以向角膜玻璃化系统添加反向模板，以增加玻璃化和结构和性质的修改。
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6.发明申请公开(公告)号：US20190060056A1
公开(公告)日：2019-02-28
申请号：US15693208
申请日：2017-08-31
IPC分类号： A61F2/16
摘要： Devices and methods for novel retinal irradiance distribution modification (IDM) to improve, stabilize or restore vision are described herein. Also encompassed herein are devices and methods to reduce vision loss from diseases, injuries and disorders that involve damaged and/or dysfunctional and/or sensorily deprived retinal cells. Conditions that may be treated using devices and methods described herein include macular degeneration, diabetic retinopathy and glaucoma. Therapy provided by retinal IDM devices and methods described herein may also be used in combination with other therapies including, but not limited to, pharmacological, retinal laser, gene and stem cell therapies.
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7.发明申请CORNEAL VITRIFICATION, METHODS AND DEVICES TO PRODUCE CORNEAL VITRIFICATION AND METHODS OF USE THEREOF 有权角膜修复，生产角膜修复的方法和装置及其使用方法公开(公告)号：US20150230985A1
公开(公告)日：2015-08-20
申请号：US14674992
申请日：2015-03-31
CPC分类号： A61F9/008 , A61F2/142 , A61F9/0079 , A61F9/00814 , A61F2009/00872 , A61N7/00 , A61N2007/0004
摘要： The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased elastic modulus; methods for producing and using the new composition of matter for modifying corneal structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photo vitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters. A reverse template can be added to corneal vitrification systems to increase vitrification and modifications of structure and properties.
摘要翻译： 本发明包括：一种新的物质组合物（包括在原位眼中的天然存在的体内角膜以及在天然存在的角膜基质组织内形成的至少一个玻璃化非天然存在的角膜基质组织体积的复合物），其中 玻璃化组织的结构和性质从其天然存在的状态改变成非天然存在的玻璃状状态，其中包括但不限于增加的弹性模量; 用于生产和使用用于修饰角膜结构和性质的新组合物的方法，包括但不限于角膜光学像差; 伤口闭合粘连和移植附着力; 以及用于产生包含至少一个具有可控处理参数的光子源的新组合物的照相玻璃化系统。 可以向角膜玻璃化系统添加反向模板，以增加玻璃化和结构和性质的修改。
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8.发明申请CORNEAL VITRIFICATION, METHODS AND DEVICES TO PRODUCE CORNEAL VITRIFICATION AND METHODS OF USE THEREOF 有权角膜修复，生产角膜修复的方法和装置及其使用方法公开(公告)号：US20150230979A1
公开(公告)日：2015-08-20
申请号：US14674890
申请日：2015-03-31
CPC分类号： A61F9/008 , A61F2/142 , A61F9/0079 , A61F9/00814 , A61F2009/00872 , A61N7/00 , A61N2007/0004
摘要： The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased elastic modulus; methods for producing and using the new composition of matter for modifying corneal structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photovitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters. A reverse template can be added to corneal vitrification systems to increase vitrification and modifications of structure and properties.
摘要翻译： 本发明包括：一种新的物质组合物（包括在原位眼中的天然存在的体内角膜以及在天然存在的角膜基质组织内形成的至少一个玻璃化非天然存在的角膜基质组织体积的复合物），其中 玻璃化组织的结构和性质从其天然存在的状态改变成非天然存在的玻璃状状态，其中包括但不限于增加的弹性模量; 用于生产和使用用于修饰角膜结构和性质的新组合物的方法，包括但不限于角膜光学像差; 伤口闭合粘连和移植附着力; 以及用于产生包含至少一个具有可控处理参数的光子源的新组合物的光生产系统。 可以向角膜玻璃化系统添加反向模板，以增加玻璃化和结构和性质的修改。
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9.发明申请LASER DEVICES UTILIZING ALEXANDRITE LASER OPERATING AT OR NEAR ITS GAIN PEAK AS SHORTER-WAVELENGTH PUMPING SOURCES AND METHODS OF USE THEREOF 有权激光器件利用亚临界激光器在其波峰值波峰或其附近工作或其附近的波峰波长电流源及其使用方法公开(公告)号：US20140276686A1
公开(公告)日：2014-09-18
申请号：US14216387
申请日：2014-03-17
申请人： Chunbai Wu , Donald F. Heller
发明人： Chunbai Wu , Donald F. Heller
CPC分类号： A61B18/203 , A61B2018/00452 , A61B2018/2035 , A61B2018/2065 , H01S3/0007 , H01S3/005 , H01S3/025 , H01S3/0404 , H01S3/0405 , H01S3/042 , H01S3/061 , H01S3/094038 , H01S3/1616 , H01S3/1643
摘要： In some embodiments, the instant invention provides for a system that includes at least the following components: (i) an Alexandrite laser pumping subsystem; where the Alexandrite laser pumping subsystem is configured to: 1) produce wavelengths between 700 and 820 nm, and 2) produce a pump pulse having: i) a duration between 1 to 10 milliseconds, and ii) an energy measuring up to 100 Joules; where the Alexandrite laser pumping subsystem includes: 1) an optical fiber, and 2) a Lens system, (ii) a Thulium doped Yttrium Aluminum Garnet (Tm:YAG) laser subsystem; where the Tm:YAG laser subsystem includes: 1) a Tm:YAG gain medium, 2) a rod heat sink, and 3) at least one cooling device, (iii) a wavelength selecting device, where the wavelength selecting device is configured to deliver a wavelength between 1.75 microns to 2.1 microns; and where the system is configured to produce a high energy conversion efficiency.
摘要翻译： 在一些实施例中，本发明提供了至少包括以下部件的系统：（i）亚历山大号激光泵浦子系统; 其中Alexandrite激光泵浦子系统被配置为：1）产生700和820nm之间的波长，以及2）产生泵浦脉冲，其具有：i）1至10毫秒之间的持续时间，以及ii）测量高达100焦耳的能量; Alexandrite激光泵浦子系统包括：1）光纤，2）透镜系统，（ii）掺a钇铝石榴石（Tm：YAG）激光子系统; 其中Tm：YAG激光子系统包括：1）Tm：YAG增益介质，2）棒状散热器，以及3）至少一个冷却装置，（iii）波长选择装置，其中波长选择装置被配置为 传递1.75微米至2.1微米的波长; 并且其中系统被配置为产生高能量转换效率。
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10.发明授权Method and apparatus for pumping of transition metal ion containing solid state lasers using diode laser sources 失效使用二极管激光源泵浦含有固态激光器的过渡金属离子的方法和装置
公开(公告)号：US6009114A
公开(公告)日：1999-12-28
申请号：US592897
申请日：1996-01-29
IPC分类号： H01S3/094 , H01S3/0941 , H01S3/16 , H01S3/91
CPC分类号： H01S3/09415 , H01S3/16 , H01S3/09408 , H01S3/0941 , H01S3/162 , H01S3/1623 , H01S3/1625 , H01S3/1633 , H01S3/1636 , H01S3/1648
摘要： The present invention encompasses an apparatus for pumping a laser (vibronic or otherwise), which comprises: a transition-metal ion-containing solid state laser gain medium; a means for exciting said laser medium to emit coherent radiation said exciting means being a pumping source comprising at least one laser diode operating at a wavelength shorter than 800 nm; and an optical resonator means for generating and controlling said coherent radiation.The present invention also encompasses a method of pumping a laser (vibronic or otherwise) comprising the steps of: generating a laser diode pumping beam at a wavelength shorter than 800 nm; exciting a transition-metal ion-containing solid state laser gain medium by impinging said laser diode pumping beam on said transition-metal ion-containing solid state laser gain medium, so as to excite the laser medium; and an optical resonator to emit coherent radiation.
摘要翻译： 本发明包括用于泵浦激光（振动或其他）的装置，其包括：含过渡金属离子的固态激光增益介质; 用于激发所述激光介质发射相干辐射的装置，所述激励装置是泵浦源，其包括以短于800nm的波长工作的至少一个激光二极管; 以及用于产生和控制所述相干辐射的光学谐振器装置。 本发明还包括泵浦激光（振动或其他）的方法，包括以下步骤：产生波长短于800nm的激光二极管泵浦光束; 通过将所述激光二极管泵浦光束照射在所述含过渡金属离子的固态激光增益介质上来激发含过渡金属离子的固态激光增益介质，以激发激光介质; 以及发射相干辐射的光学谐振器。
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