Corneal vitrification, methods and devices to produce corneal vitrification and methods of use thereof
    1.
    发明授权
    Corneal vitrification, methods and devices to produce corneal vitrification and methods of use thereof 有权
    角膜玻璃化,产生角膜玻璃化的方法和装置及其使用方法

    公开(公告)号:US09545339B2

    公开(公告)日:2017-01-17

    申请号:US14512952

    申请日:2014-10-13

    IPC分类号: A61F9/008 A61F9/007 A61N7/00

    摘要: The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased eletastic modulus; methods for producing and using the new composition of matter for modifying cortical structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photovitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters. A reverse template can be added to corneal vitrification systems to increase vitrification and modifications of structure and properties.

    摘要翻译: 本发明包括:一种新的物质组合物(包括在原位眼中的天然存在的体内角膜以及在天然存在的角膜基质组织内形成的至少一个玻璃化非天然存在的角膜基质组织体积的复合物),其中 玻璃化组织在结构和性质上从其天然存在的状态改变成非天然存在的玻璃样状态,其中包括但不限于增加的电化学模量; 用于生产和使用新的组合物用于改变皮层结构和性质的方法,包括但不限于角膜光学像差; 伤口闭合粘连和移植附着力; 以及用于产生包含至少一个具有可控处理参数的光子源的新组合物的光生产系统。 可以向角膜玻璃化系统添加反向模板,以增加玻璃化和结构和性质的修改。

    Corneal vitrification, methods and devices to produce corneal vitrification and methods of use thereof
    2.
    发明授权
    Corneal vitrification, methods and devices to produce corneal vitrification and methods of use thereof 有权
    角膜玻璃化,产生角膜玻璃化的方法和装置及其使用方法

    公开(公告)号:US09532904B2

    公开(公告)日:2017-01-03

    申请号:US14674890

    申请日:2015-03-31

    摘要: The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased elastic modulus; methods for producing and using the new composition of matter for modifying corneal structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photovitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters. A reverse template can be added to corneal vitrification systems to increase vitrification and modifications of structure and properties.

    摘要翻译: 本发明包括:一种新的物质组合物(包括在原位眼中的天然存在的体内角膜以及在天然存在的角膜基质组织内形成的至少一个玻璃化非天然存在的角膜基质组织体积的复合物),其中 玻璃化组织的结构和性质从其天然存在的状态改变成非天然存在的玻璃状状态,其中包括但不限于增加的弹性模量; 用于生产和使用用于修饰角膜结构和性质的新组合物的方法,包括但不限于角膜光学像差; 伤口闭合粘连和移植附着力; 以及用于产生包含至少一个具有可控处理参数的光子源的新组合物的光生产系统。 可以向角膜玻璃化系统添加反向模板,以增加玻璃化和结构和性质的修改。

    Corneal vitrification, methods and devices to produce corneal vitrification and methods of use thereof
    3.
    发明授权
    Corneal vitrification, methods and devices to produce corneal vitrification and methods of use thereof 有权
    角膜玻璃化,产生角膜玻璃化的方法和装置及其使用方法

    公开(公告)号:US09526656B2

    公开(公告)日:2016-12-27

    申请号:US14674992

    申请日:2015-03-31

    IPC分类号: A61B18/18 A61F9/008 A61F9/007

    摘要: The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased elastic modulus; methods for producing and using the new composition of matter for modifying corneal structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photo vitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters. A reverse template can be added to corneal vitrification systems to increase vitrification and modifications of structure and properties.

    摘要翻译: 本发明包括:一种新的物质组合物(包括在原位眼中的天然存在的体内角膜以及在天然存在的角膜基质组织内形成的至少一个玻璃化非天然存在的角膜基质组织体积的复合物),其中 玻璃化组织的结构和性质从其天然存在的状态改变成非天然存在的玻璃状状态,其中包括但不限于增加的弹性模量; 用于生产和使用用于修饰角膜结构和性质的新组合物的方法,包括但不限于角膜光学像差; 伤口闭合粘连和移植附着力; 以及用于产生包含至少一个具有可控处理参数的光子源的新组合物的照相玻璃化系统。 可以向角膜玻璃化系统添加反向模板,以增加玻璃化和结构和性质的修改。

    SYSTEMS AND DEVICES FOR SHAPING HUMAN CORNEA AND METHODS OF USE THEREOF
    4.
    发明申请
    SYSTEMS AND DEVICES FOR SHAPING HUMAN CORNEA AND METHODS OF USE THEREOF 审中-公开
    用于形成人造脊椎的系统和装置及其使用方法

    公开(公告)号:US20140276678A1

    公开(公告)日:2014-09-18

    申请号:US14215772

    申请日:2014-03-17

    IPC分类号: A61F9/008

    CPC分类号: A61F9/009 A61F2009/00872

    摘要: In some embodiments, the instant invention provides for a system for shaping a human cornea of an eye that includes at least the following components: a sapphire applanation window/suction ring (SAWSR) system, where the SAWSR system includes a sapphire applanation window/suction ring (SAWSR), a conical holder, an illuminator, and a temperature control, where the SAWSR system is configured to: (i) be positioned on the eye, (ii) applanate the human cornea of the eye, (iii) generate and position a centration aid, and (iv) maintain temperature control; an optical delivery system, where the optical delivery system includes: (i) a laser, (ii) a fiber delivery holder, and (iii) a laser control subsystem, where the laser control subsystem is configured to display a user interface to: 1) control a power and a temporal waveform of each of the beamlets of light, and 2) irradiate the human cornea of the eye.

    摘要翻译: 在一些实施例中,本发明提供了一种用于整形眼睛的人类角膜的系统,该系统至少包括以下部件:蓝宝石压平窗/吸力环(SAWSR)系统,其中SAWSR系统包括蓝宝石压平窗/抽吸 (SAWSR),锥形保持器,照明器和温度控制器,其中SAWSR系统被配置为:(i)定位在眼睛上,(ii)压制眼睛的人类角膜,(iii)产生和 定位助剂,(iv)保持温度控制; 光学传送系统,其中所述光学传送系统包括:(i)激光器,(ii)光纤传送保持器,以及(iii)激光控制子系统,其中所述激光控制子系统被配置为显示用户界面以:1 )控制每个子束光的功率和时间波形,以及2)照射眼睛的人角膜。

    CORNEAL VITRIFICATION, METHODS AND DEVICES TO PRODUCE CORNEAL VITRIFICATION AND METHODS OF USE THEREOF
    5.
    发明申请
    CORNEAL VITRIFICATION, METHODS AND DEVICES TO PRODUCE CORNEAL VITRIFICATION AND METHODS OF USE THEREOF 有权
    角膜修复,生产角膜修复的方法和装置及其使用方法

    公开(公告)号:US20150133901A1

    公开(公告)日:2015-05-14

    申请号:US14512952

    申请日:2014-10-13

    IPC分类号: A61F9/008 A61F9/007

    摘要: The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased eletastic modulus; methods for producing and using the new composition of matter for modifying cortical structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photovitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters. A reverse template can be added to corneal vitrification systems to increase vitrification and modifications of structure and properties.

    摘要翻译: 本发明包括:一种新的物质组合物(包括在原位眼中的天然存在的体内角膜以及在天然存在的角膜基质组织内形成的至少一个玻璃化非天然存在的角膜基质组织体积的复合物),其中 玻璃化组织在结构和性质上从其天然存在的状态改变成非天然存在的玻璃样状态,其中包括但不限于增加的电化学模量; 用于生产和使用新的组合物用于改变皮层结构和性质的方法,包括但不限于角膜光学像差; 伤口闭合粘连和移植附着力; 以及用于产生包含至少一个具有可控处理参数的光子源的新组合物的光生产系统。 可以向角膜玻璃化系统添加反向模板,以增加玻璃化和结构和性质的修改。

    CORNEAL VITRIFICATION, METHODS AND DEVICES TO PRODUCE CORNEAL VITRIFICATION AND METHODS OF USE THEREOF
    7.
    发明申请
    CORNEAL VITRIFICATION, METHODS AND DEVICES TO PRODUCE CORNEAL VITRIFICATION AND METHODS OF USE THEREOF 有权
    角膜修复,生产角膜修复的方法和装置及其使用方法

    公开(公告)号:US20150230985A1

    公开(公告)日:2015-08-20

    申请号:US14674992

    申请日:2015-03-31

    IPC分类号: A61F9/008 A61F9/007

    摘要: The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased elastic modulus; methods for producing and using the new composition of matter for modifying corneal structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photo vitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters. A reverse template can be added to corneal vitrification systems to increase vitrification and modifications of structure and properties.

    摘要翻译: 本发明包括:一种新的物质组合物(包括在原位眼中的天然存在的体内角膜以及在天然存在的角膜基质组织内形成的至少一个玻璃化非天然存在的角膜基质组织体积的复合物),其中 玻璃化组织的结构和性质从其天然存在的状态改变成非天然存在的玻璃状状态,其中包括但不限于增加的弹性模量; 用于生产和使用用于修饰角膜结构和性质的新组合物的方法,包括但不限于角膜光学像差; 伤口闭合粘连和移植附着力; 以及用于产生包含至少一个具有可控处理参数的光子源的新组合物的照相玻璃化系统。 可以向角膜玻璃化系统添加反向模板,以增加玻璃化和结构和性质的修改。

    CORNEAL VITRIFICATION, METHODS AND DEVICES TO PRODUCE CORNEAL VITRIFICATION AND METHODS OF USE THEREOF
    8.
    发明申请
    CORNEAL VITRIFICATION, METHODS AND DEVICES TO PRODUCE CORNEAL VITRIFICATION AND METHODS OF USE THEREOF 有权
    角膜修复,生产角膜修复的方法和装置及其使用方法

    公开(公告)号:US20150230979A1

    公开(公告)日:2015-08-20

    申请号:US14674890

    申请日:2015-03-31

    IPC分类号: A61F9/008 A61N7/00 A61F9/007

    摘要: The invention includes: a new composition of matter (a composite comprising a naturally occurring in vivo cornea in an in situ eye together with at least one volume of vitrified non-naturally occurring corneal stromal tissue formed within the naturally occurring corneal stromal tissue) wherein the vitrified tissue is modified in structure and properties from its naturally occurring condition into a non-naturally occurring glass-like condition with modifications including but not limited to increased elastic modulus; methods for producing and using the new composition of matter for modifying corneal structure and properties, including but not limited to corneal optical aberrations; wound closure adhesion and transplant adhesion; and a photovitrification system for producing the new composition of matter comprising at least one photon source with controllable treatment parameters. A reverse template can be added to corneal vitrification systems to increase vitrification and modifications of structure and properties.

    摘要翻译: 本发明包括:一种新的物质组合物(包括在原位眼中的天然存在的体内角膜以及在天然存在的角膜基质组织内形成的至少一个玻璃化非天然存在的角膜基质组织体积的复合物),其中 玻璃化组织的结构和性质从其天然存在的状态改变成非天然存在的玻璃状状态,其中包括但不限于增加的弹性模量; 用于生产和使用用于修饰角膜结构和性质的新组合物的方法,包括但不限于角膜光学像差; 伤口闭合粘连和移植附着力; 以及用于产生包含至少一个具有可控处理参数的光子源的新组合物的光生产系统。 可以向角膜玻璃化系统添加反向模板,以增加玻璃化和结构和性质的修改。