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    DNA VACCINE COMPOSITIONS AND METHODS OF USE
    1.
    发明申请
    DNA VACCINE COMPOSITIONS AND METHODS OF USE 有权
    DNA疫苗组合物及其使用方法

    公开(公告)号：US20090233857A1

    公开(公告)日：2009-09-17

    申请号：US12368151

    申请日：2009-02-09

    申请人： Opendra Narayan ,  Zhenqian Liu

    发明人： Opendra Narayan ,  Zhenqian Liu

    IPC分类号： A61K38/19 ,  C12N15/63 ,  A61K31/7088

    CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55522 ,  C12N2740/16034

    摘要： The present invention is directed to a DNA vaccine for immunization against HIV. The invention comprises a DNA molecule that has a sequence encoding a plurality of viral proteins capable of stimulating an immune response against HIV. The DNA molecule is rendered safe for used as a vaccine by the disruption of genes encoding reverse transcriptase, integrase, and Vif. The DNA molecule is further rendered safe by at least a partial deletion of the 3′ LTR.

    摘要翻译： 本发明涉及用于免疫HIV的DNA疫苗。 本发明包括具有编码能够刺激针对HIV的免疫应答的多种病毒蛋白的序列的DNA分子。 通过破坏编码逆转录酶，整合酶和Vif的基因，DNA分子被安全地用作疫苗。 通过至少部分删除3'LTR，进一步使DNA分子变得安全。

    DNA vaccine compositions and methods of use
    5.
    发明授权
    DNA vaccine compositions and methods of use 有权
    DNA疫苗组合物和使用方法

    公开(公告)号：US08003113B2

    公开(公告)日：2011-08-23

    申请号：US12368151

    申请日：2009-02-09

    申请人： Opendra Narayan ,  Zhenqian Liu

    发明人： Opendra Narayan ,  Zhenqian Liu

    IPC分类号： A61K39/21 ,  A61K39/12 ,  C07H21/04

    CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55522 ,  C12N2740/16034

    摘要： The present invention is directed to a DNA vaccine for immunization against HIV. The invention comprises a DNA molecule that has a sequence encoding a plurality of viral proteins capable of stimulating an immune response against HIV. The DNA molecule is rendered safe for used as a vaccine by the disruption of genes encoding reverse transcriptase, integrase, and Vif. The DNA molecule is further rendered safe by at least a partial deletion of the 3′ LTR.

    摘要翻译： 本发明涉及用于免疫HIV的DNA疫苗。 本发明包括具有编码能够刺激针对HIV的免疫应答的多种病毒蛋白的序列的DNA分子。 通过破坏编码逆转录酶，整合酶和Vif的基因，DNA分子被安全地用作疫苗。 通过至少部分删除3'LTR，进一步使DNA分子变得安全。

    Borna disease virus-specific DNA and proteins
    6.
    发明授权
    Borna disease virus-specific DNA and proteins 失效
    伯纳病病毒特异性DNA和蛋白质

    公开(公告)号：US6060236A

    公开(公告)日：2000-05-09

    申请号：US222227

    申请日：1998-12-29

    申请人： Janice E. Clements ,  Opendra Narayan ,  Susan Vandewoude ,  Juergen A. Richt

    发明人： Janice E. Clements ,  Opendra Narayan ,  Susan Vandewoude ,  Juergen A. Richt

    IPC分类号： C07K14/08 ,  C12N15/31 ,  C12Q1/70

    CPC分类号： C07K14/005 ,  C12N2720/10022 ,  C12N2760/00022 ,  Y10S530/826

    摘要： Borna disease virus (BDV) causes a rare neurological disease in horses and sheep. A subtractive cDNA expression library was constructed with poly A-selected RNA from a BDV infected MDCK cell line. A clone (B8) was isolated that specifically hybridizes to RNA isolated from BDV-infected brain tissue and BDV-infected cell lines. This clone hybridizes to four BDV-specific positive strand RNAs and one negative strand RNA in BDV-infected rat brain. Nucleotide sequence analysis of the clone suggests that it represents a full length mRNA which contains several open reading frames. The Borna Disease Virus DNA sequences as well as proteins encoded by the BDV DNA sequences are provided.

    摘要翻译： 博尔纳病毒（BDV）在马和绵羊中引起罕见的神经系统疾病。 用来自BDV感染的MDCK细胞系的聚A选择的RNA构建减数cDNA表达文库。 分离出与从BDV感染的脑组织和BDV感染的细胞系分离的RNA特异性杂交的克隆（B8）。 该克隆与BDV感染的大鼠脑中的四种BDV特异性正链RNA和一条负链RNA杂交。 该克隆的核苷酸序列分析表明它代表一个全长的mRNA，它包含几个开放阅读框。 提供博尔纳病病毒DNA序列以及由BDV DNA序列编码的蛋白质。

    DNA vaccine compositions and methods of use
    7.
    发明授权
    DNA vaccine compositions and methods of use 有权
    DNA疫苗组合物和使用方法

    公开(公告)号：US07488485B2

    公开(公告)日：2009-02-10

    申请号：US10941164

    申请日：2004-09-15

    申请人： Opendra Narayan ,  Zhenqian Liu

    发明人： Opendra Narayan ,  Zhenqian Liu

    IPC分类号： A61K39/21 ,  A01N43/04 ,  C07H21/04 ,  C12N15/00 ,  C12N15/63

    CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55522 ,  C12N2740/16034

    摘要： The present invention is directed to a DNA vaccine for immunization against HIV. The invention comprises a DNA molecule that has a sequence encoding a plurality of viral proteins capable of stimulating an immune response against HIV. The DNA molecule is rendered safe for use as a vaccine by the disruption of genes encoding reverse transcriptase, integrase, and Vif. The DNA molecule is further rendered safe by at least a partial deletion of the 3′ LTR.

    摘要翻译： 本发明涉及用于免疫HIV的DNA疫苗。 本发明包括具有编码能够刺激针对HIV的免疫应答的多种病毒蛋白的序列的DNA分子。 通过破坏编码逆转录酶，整合酶和Vif的基因，DNA分子被安全地用作疫苗。 通过至少部分删除3'LTR，进一步使DNA分子变得安全。

    HIV DNA vaccine
    9.
    发明申请
    HIV DNA vaccine 审中-公开
    HIV DNA疫苗

    公开(公告)号：US20070010471A1

    公开(公告)日：2007-01-11

    申请号：US11360957

    申请日：2006-02-23

    申请人： Opendra Narayan

    发明人： Opendra Narayan

    IPC分类号： A61K48/00 ,  A61K39/21

    CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/5254 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/55522 ,  A61K2039/57 ,  C12N7/00 ,  C12N2740/15022 ,  C12N2740/15034 ,  C12N2740/16034 ,  C12N2740/16062 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2740/16322

    摘要： A DNA vaccines or immunogenic composition for providing an immune response against HIV without exhibiting pathogenicity in the immunized individual because of the disruption of the ability of the DNA molecules to encode for viral proteins critical in producing pathogenicity. The DNA molecule is derived by passaging a SHIV in order to develop a SHIV that exhibits an increased replication efficiency and increased pathogenicity. Following passaging, the highly virulent SHIV virus is rendered safe by disrupting one or more genes, such as the rt, int, and vif genes, as well as the 3′ LTR.

    摘要翻译： DNA疫苗或免疫原性组合物，用于提供针对HIV的免疫应答，而不会在免疫个体中表现出致病性，因为DNA分子编码对产生致病性至关重要的病毒蛋白质的能力的破坏。 通过传代SHIV来产生DNA分子，以开发显示增加的复制效率和增加的致病性的SHIV。 传播后，通过破坏一个或多个基因，如rt，int和vif基因以及3'LTR，使高度毒力的SHIV病毒变得安全。

    Animal model for HIV-1 induced disease
    10.
    发明授权
    Animal model for HIV-1 induced disease 失效
    HIV-1诱发疾病的动物模型

    公开(公告)号：US5849994A

    公开(公告)日：1998-12-15

    申请号：US442010

    申请日：1995-05-16

    申请人： Opendra Narayan

    发明人： Opendra Narayan

    IPC分类号： A01K67/027 ,  C12N7/00 ,  C12N15/49 ,  C12N15/86 ,  C12N7/02 ,  C12N7/08

    CPC分类号： C12N7/00 ,  A01K67/027 ,  A01K2267/0337 ,  C12N2740/15011 ,  C12N2740/16011

    摘要： HIV-1 does not cause disease in any non-human species. Thus, there is no animal model system to evaluate the efficacy of strategies aimed at preventing or ameliorating disease caused by this virus. The instant invention provides an animal model for HIV-1 induced disease, virus for generating such model animals, and methods for generating pathogenic SHIV.

    摘要翻译： HIV-1在任何非人类物种中都不会引起疾病。 因此，没有动物模型系统来评估旨在预防或改善由该病毒引起的疾病的策略的功效。 本发明提供了用于HIV-1诱导的疾病的动物模型，用于产生这种模型动物的病毒以及产生致病性SHIV的方法。