公开(公告)号：US20250066486A1

公开(公告)日：2025-02-27

申请号：US18825514

申请日：2024-09-05

Applicant: Orionis Biosciences Inc. ,  Orionis Biosciences BV

Inventor： Nikolai KLEY ,  Jan TAVERNIER ,  Lennart ZABEAU ,  Erik DEPLA

IPC: C07K16/28 ,  A61K38/17 ,  A61K38/21 ,  A61K39/395 ,  A61K39/40 ,  A61K39/42 ,  A61P25/00 ,  C07K14/47 ,  C07K16/00 ,  C07K16/18

Abstract: The present invention relates, in part, to agents that bind Clec9A and their use as diagnostic and therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the Clec9A binding agents and their use in the treatment of various diseases.

公开(公告)号：US12091463B2

公开(公告)日：2024-09-17

申请号：US16636250

申请日：2018-08-08

Applicant: Orionis Biosciences Inc. ,  Orionis Biosciences BV

Inventor： Nikolai Kley ,  Jan Tavernier ,  Lennart Zabeau ,  Erik Depla

IPC: C07K16/18 ,  A61K38/17 ,  A61K38/21 ,  A61K39/395 ,  A61K39/40 ,  A61K39/42 ,  A61P25/00 ,  C07K14/47 ,  C07K16/00 ,  C07K16/28

CPC classification number: C07K16/2851 ,  A61K38/17 ,  A61K38/212 ,  A61K38/215 ,  A61K39/395 ,  A61K39/40 ,  A61K39/42 ,  A61P25/00 ,  C07K14/4713 ,  C07K16/00 ,  C07K16/18 ,  C07K2319/00 ,  C07K16/00 ,  A61K38/212 ,  A61K38/215

Abstract: The present invention relates, in part, to agents that bind Clec9A and their use as diagnostic and therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the Clec9A binding agents and their use in the treatment of various diseases.

公开(公告)号：US20230293652A1

公开(公告)日：2023-09-21

申请号：US18014581

申请日：2021-07-07

Applicant: Orionis Biosciences, Inc. ,  VIB VZW ,  Universiteit Gent

Inventor： Nikolai KLEY ,  Jan TAVERNIER ,  Frank PEELMAN ,  Sarah GERLO ,  Bram VAN DEN EECKHOUT

IPC: A61K39/00 ,  C07K16/28 ,  C07K16/10 ,  A61K39/12 ,  A61K9/00 ,  A61P31/14

CPC classification number: A61K39/001119 ,  A61K9/0078 ,  A61K39/12 ,  A61P31/14 ,  C07K16/1063 ,  C07K16/2809 ,  C07K16/2815 ,  A61K2039/545 ,  A61K2039/55527

Abstract: The present invention relates, in part, to vaccine compositions, adjuvants, chimeric proteins, or chimeric protein complexes and their use as vaccines or therapeutic agents. The present invention further relates to methods of vaccination or treatment of various diseases.

公开(公告)号：US11498966B2

公开(公告)日：2022-11-15

申请号：US16636501

申请日：2018-08-08

Applicant: Orionis Biosciences Inc. ,  Orionis Biosciences BV

Inventor： Nikolai Kley ,  Jan Tavernier ,  Lennart Zabeau ,  Erik Depla

IPC: C07K16/28 ,  A61P35/00 ,  A61K39/00 ,  C07K14/56 ,  C07K14/565

Abstract: The present invention relates, in part, to agents that bind PD-1 or PD-L1 and their use as diagnostic and therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the PD-1 or PD-L1 binding agents and their use in the treatment of various diseases.

公开(公告)号：US20220249609A1

公开(公告)日：2022-08-11

申请号：US17620329

申请日：2020-06-18

Applicant: Orionis Biosciences, Inc. ,  Orionis Biosciences BV ,  VIB VZW ,  Universiteit Gent

Inventor： Nikolai KLEY ,  Jan TAVERNIER ,  Leander HUYGHE

IPC: A61K38/17 ,  A61K31/704 ,  A61K38/19 ,  A61K38/21 ,  A61K9/00 ,  A61K9/127 ,  A61P35/00

Abstract: The present invention relates, in part, to chimeric protein or chimeric protein complex comprising a CD13 targeting moiety and a signaling agent (e.g., without limitation TNF or IFN-γ) and methods of treatment using such compositions.

公开(公告)号：US20220119472A1

公开(公告)日：2022-04-21

申请号：US17292017

申请日：2019-11-07

Applicant: Orionis Biosciences, Inc. ,  Orionis Biosciences BV ,  VIB VZW ,  Universiteit Gent

Inventor： Nikolai KLEY ,  Jan TAVERNIER ,  Anje CAUWELS ,  Lennart ZABEAU ,  Erik DEPLA

IPC: C07K14/56 ,  C07K16/28 ,  A61P35/00 ,  C07K14/565

Abstract: The present invention relates, in part, to agents, chimeric proteins and chimeric protein complexes that bind a plasmacytoid dendritic cell (pDC), e.g. Clec4C and their use as diagnostic and therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the pDC, e.g. Clec4C, binding agents, chimeric proteins, or chimeric protein complexes and their use in the treatment of various diseases, including autoimmune diseases.

公开(公告)号：US20200308244A1

公开(公告)日：2020-10-01

申请号：US16832995

申请日：2020-03-27

Applicant: Orionis Biosciences, Inc.

Inventor： Nikolai KLEY ,  Erik DEPLA ,  Lennart ZABEAU ,  Jan TAVERNIER

IPC: C07K14/56 ,  C07K16/28

Abstract: The present invention relates, in part, to chimeric proteins or chimeric protein complexes, such as Fc-based chimeric protein complexes, comprising interferon alpha 1, or a variant thereof, and their use as therapeutic agents.

公开(公告)号：US20240400633A1

公开(公告)日：2024-12-05

申请号：US18696738

申请日：2022-09-30

Applicant: Orionis Biosciences, Inc. ,  Orionis Biosciences BV

Inventor： Nikolai KLEY ,  Erik DEPLA ,  Lennart ZABEAU

IPC: C07K14/57 ,  A61K38/00 ,  C07K14/525

Abstract: The present invention relates, in part, to Fc-based chimeric protein complexes that include one or more multimeric wild type or modified human IFNγ or human TNFα signaling agents or multimeric targeting moieties and their use as therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the Fc-based chimeric protein complexes that include one or more multimeric wild type or modified human IFNγ or human TNFα signaling agents or multimeric targeting moieties and their use in the treatment of various diseases.

公开(公告)号：US11896643B2

公开(公告)日：2024-02-13

申请号：US16967288

申请日：2019-02-05

Applicant: Orionis Biosciences, Inc. ,  VIB VZW ,  Universiteit Gent

Inventor： Nikolai Kley ,  Jan Tavernier ,  Anje Cauwels

IPC: A61K38/16 ,  A61K31/704 ,  C07K14/555

CPC classification number: A61K38/16 ,  A61K31/704 ,  C07K14/555 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/569

Abstract: The present invention relates, in part, to agents that bind fibroblast activation protein (FAP) and their use as diagnostic and therapeutic agents. The present invention further relates to pharmaceutical compositions comprising the FAP binding agents and their use in the treatment of various diseases.

公开(公告)号：US11566072B2

公开(公告)日：2023-01-31

申请号：US16634325

申请日：2018-08-08

Applicant: Orionis Biosciences Inc. ,  Orionis Biosciences BV

Inventor： Nikolai Kley ,  Jan Tavernier ,  Lennart Zabeau ,  Erik Depla

IPC: C07K16/28 ,  C07K14/56

Abstract: The present invention relates, in part, to agents that bind CD8 and their use as therapeutic and diagnostic agents. The present invention further relates to pharmaceutical compositions comprising the CD8 binding agents and their use in the treatment of various diseases, including, for example, cancers.