公开(公告)号：US20070117773A1

公开(公告)日：2007-05-24

申请号：US11604630

申请日：2006-11-27

申请人： Makoto Koizumi ,  Osamu Ando

发明人： Makoto Koizumi ,  Osamu Ando

IPC分类号： A61K48/00 ,  C07H21/04

CPC分类号： C12N15/1137 ,  A61K31/7125 ,  C07H21/00 ,  C12N2310/11 ,  C12N2310/3231 ,  C12Y207/07049

摘要： A telomerase-inhibiting ENA oligonucleotide compound represented by a formula: E1-B1-B2-B3-B4-E2 (I), wherein E1 represents a group represented by the formula R1-; E2 represents a group represented by the formula -B7-R2; B4, B5, and B8 are identical or different, and each represents Tp; B1, B2, B3, and B12 are identical or different, and each represents Gp; B16 represents Cp; and B6, B10, B14, and B18 are identical or different, and each represents Ap, or a pharmacologically acceptable salt thereof for treating diseases in which telomerase is involved, such as cancer.

摘要翻译： 1.一种由式E1-B1-B2-B3-B4-E2（Ⅰ）表示的端粒酶抑制型ENA寡核苷酸化合物，其中，E1表示式R1-表示的基团。 E2表示由式-B7-R2表示的基团; B4，B5和B8是相同或不同的，并且各自表示T

P; B1，B2，B3和B12相同或不同，并且各自表示G < B16表示C p 和B6，B10，B14和B18相同或不同，并且各自表示用于治疗涉及端粒酶的疾病例如癌症的Aβ或其药理学上可接受的盐。

公开(公告)号：USRE43858E1

公开(公告)日：2012-12-11

申请号：US13224745

申请日：2006-09-13

申请人： Tomio Kimura ,  Nobuyuki Ohkawa ,  Takayoshi Nagasaki ,  Atsuhiro Sugidachi ,  Osamu Ando

发明人： Tomio Kimura ,  Nobuyuki Ohkawa ,  Takayoshi Nagasaki ,  Atsuhiro Sugidachi ,  Osamu Ando

IPC分类号： A61K31/335 ,  C07D317/72

摘要： A compound of formula (I) Wherein X, Y, ring A, ring B, l, m, R1, R2, R4 and R5 are as defined herein, to supress intracellular signal transduction or cell activation induced by endotoxin and to suppress cell responses due to the intracellular signal transduction and cell activation such as an excess generation of inflammatory mediators such as TNF-α, pharmacologically acceptable salts therefor, a preparation method therefor, and a medicament containing the aforementioned substituted cycloalkene derivative as an active ingredient which is superior in prophylaxis and/or treatment of diseases such as sepsis (septic shock, disseminated intravascular coagulation, multiple organ failure and the like), that are associated with intracellular signal transduction or cell activation induced by endotoxin and to cell responses to the intracellular signal transduction and cell activation.

摘要翻译： 式（I）化合物其中X，Y，环A，环B，l，m，R 1，R 2，R 4和R 5如本文所定义，以抑制由内毒素诱导的细胞内信号转导或细胞活化并抑制细胞反应 由于细胞内信号转导和细胞活化，例如过量产生炎症介质如TNF-α，其药理学上可接受的盐，其制备方法，以及含有上述取代的环烯烃衍生物作为活性成分的药物，其优于 与细胞内信号转导或由内毒素诱导的细胞活化以及对细胞内信号转导和细胞的细胞反应相关的诸如败血症（败血症休克，弥散性血管内凝血，多器官功能衰竭等）的疾病的预防和/或治疗 激活。

公开(公告)号：US5290649A

公开(公告)日：1994-03-01

申请号：US246916

申请日：1988-09-16

申请人： Tetsumi Suzuki ,  Hitoshi Ono ,  Osamu Ando

发明人： Tetsumi Suzuki ,  Hitoshi Ono ,  Osamu Ando

IPC分类号： C09B26/02 ,  G03G5/06

CPC分类号： C09B26/02 ,  G03G5/0668

摘要： An electrophotographic photoreceptor is formed by a photosensitive layer containing a naphtylhydrazone compound of the formula: ##STR1## wherein X and Y are independently a hydrogen atom, lower alkyl group, lower alkoxy group, phenoxy group or arylalkoxy group; R.sup.1 is a naphtyl group; R.sup.2 is a hydrogen atom, lower alkyl group, allyl group, substituted or unsubstituted phenyl group, or aralkyl group; and l and m are 1 or 2. The photoreceptor thus formed is not only highly sensitive but resistant to ozone deterioration, which markedly improves the durability thereof.

摘要翻译： 电子照相感光体由含有下式的化合物（*化学结构*）的感光层形成，其中X和Y独立地为氢原子，低级烷基，低级烷氧基，苯氧基或芳基烷氧基; R1是萘基; R2是氢原子，低级烷基，烯丙基，取代或未取代的苯基或芳烷基; l和m为1或2.由此形成的感光体不仅高度敏感，而且耐臭氧劣化，这显着提高了其耐久性。

公开(公告)号：US5166030A

公开(公告)日：1992-11-24

申请号：US757211

申请日：1991-09-10

申请人： Hitoshi Ono ,  Osamu Ando ,  Masako Takeuchi

发明人： Hitoshi Ono ,  Osamu Ando ,  Masako Takeuchi

IPC分类号： G03G9/097

CPC分类号： G03G9/09758 ,  G03G9/0975

摘要： An electrostatic image-developing toner comprising at least a resin and a colorant, which contains at least one member selected from the group consisting of compounds of the following formulas (I) and (II): ##STR1## wherein each of R.sup.1, R.sup.2, Ar.sup.1 and Ar.sup.2 is a substituted or unsubstituted alkyl group, or a substituted or unsubstituted aralkyl group, and A is (B) (SO.sub.3.sup..crclbar.).sub.2 or MX.sub.6.sup.2.crclbar., wherein B is ##STR2## (wherein each of R.sup.3 and R.sup.4 is a hydrogen atom, an alkyl group, a hydroxyl group or an amino group), M is a titanium atom, a zirconium atom or a silicon atom, and X is a fluorine atom, a chlorine atom or a bromine atom.

公开(公告)号：US20090246672A1

公开(公告)日：2009-10-01

申请号：US12108790

申请日：2008-04-24

申请人： Tomoko Ishikawa ,  Yuqing Xu ,  Katsuo Koizumi ,  Noriaki Takahashi ,  Osamu Ando

发明人： Tomoko Ishikawa ,  Yuqing Xu ,  Katsuo Koizumi ,  Noriaki Takahashi ,  Osamu Ando

IPC分类号： G03G9/09 ,  G03G9/08 ,  G03G9/087 ,  G03G9/00

CPC分类号： G03G9/091 ,  G03G9/08 ,  G03G9/0808 ,  G03G9/08782 ,  G03G9/08795 ,  G03G9/08797

摘要： A toner for the development of an electrostatic image is provided wherein at least one layer of a particulate resin is coated onto a substantial portion of the surface of an agglomerate of particles made from at least primary polymer particles and primary colorant particles, wherein at least one of the primary polymer particles and the particulate resin contains a wax, and the particulate resin of the outermost layer is substantially free of wax and a process for producing the toner.

摘要翻译： 提供了用于显影静电图像的调色剂，其中至少一层颗粒树脂涂覆在由至少一次聚合物颗粒和初级着色剂颗粒制成的颗粒团聚体的大部分表面的表面上，其中至少一个 的初级聚合物颗粒和颗粒状树脂含有蜡，最外层的颗粒状树脂基本上不含蜡和调色剂的制造方法。

公开(公告)号：US20070221448A1

公开(公告)日：2007-09-27

申请号：US11804513

申请日：2007-05-18

申请人： Masashi Kudo ,  Kenichi Fujimoto ,  Atsushi Koga ,  Yoshifumi Kojima ,  Osamu Ando ,  Yoshiki Nakagawa

发明人： Masashi Kudo ,  Kenichi Fujimoto ,  Atsushi Koga ,  Yoshifumi Kojima ,  Osamu Ando ,  Yoshiki Nakagawa

IPC分类号： C09K3/10 ,  F01M11/00

CPC分类号： F16J15/102 ,  C08F220/18 ,  C08G77/12 ,  C08L33/14 ,  C08L57/04 ,  C08L83/04 ,  C09J133/08 ,  C09K3/10 ,  C09K2200/0208 ,  C09K2200/0625 ,  F01M2011/0091 ,  F16J15/14 ,  C08L2666/04 ,  C08F2220/285 ,  C08F236/02

摘要： A sealing material, which comprises a curing product of a composition comprising (A) an acrylic polymer having at least one alkenyl group capable of undergoing hydrosilylation reaction, (B) a hydrosilyl group-containing compound and (C) a hydrosilylation catalyst as essential components, is suitable for use as cam cover seals and oil pan seals for automobile engines, fuel cell cooling medium seals, automobile wire harnesses seals, HDD cover gasket or vibration-insulating HDD cover gasket seals, etc.

公开(公告)号：US5422483A

公开(公告)日：1995-06-06

申请号：US88453

申请日：1993-07-07

申请人： Osamu Ando ,  Atsuhiro Iida ,  Kan Nakamura ,  Yasuo Tsukuda

发明人： Osamu Ando ,  Atsuhiro Iida ,  Kan Nakamura ,  Yasuo Tsukuda

IPC分类号： G01N21/35

CPC分类号： G01N21/359 ,  G01N21/3563 ,  G01N2201/065

摘要： A near infrared analyzer has, arranged on a base, a halogen tungsten lamp as light source, an optical stop for light from the source, an optical system for converging a flux of light for measuring and directing it to a measuring section and a system including an integrating sphere at which a sample is set. A spectrometer part has its entrance slit placed on the bottom surface of the integrating sphere, and includes a diffraction grating for diffraction and dispersion of incident light flux from the entrance slit, an arrayed detector and a reflective mirror for reflecting the diffracted light from the diffraction grating so as to be dispersed and focused on the surface of the detector. Signals from the detector can be sequentially retrieved for electronically scanning wavelengths without mechanically oscillating or rotating the grating. This makes it possible to maintain high accuracy in wavelengths over a long period of time. As the speed of measurement is increased, measurements can be repeated and obtained data integrated for reducing noise and improving accuracy of measurement.

摘要翻译： 一种近红外线分析器，其设置在卤素钨灯作为光源的基座上，用于来自光源的光的停止点，用于会聚用于测量的光束并将其引导到测量部分的光学系统，以及包括 设置样品的积分球。 光谱仪部分的入射狭缝位于积分球的底面，并包括衍射光栅，用于从入射狭缝衍射和分散入射光束，阵列检测器和反射镜，用于反射来自衍射的衍射光 光栅以分散和聚焦在检测器的表面上。 可以顺序地检索来自检测器的信号用于电子扫描波长，而无需机械振荡或旋转光栅。 这使得可以在长时间内保持高精度的波长。 随着测量速度的提高，可以重复测量并获得集成的数据，以减少噪音和提高测量精度。

公开(公告)号：US5311292A

公开(公告)日：1994-05-10

申请号：US915599

申请日：1992-07-21

申请人： Tatsumi Sato ,  Osamu Ando

发明人： Tatsumi Sato ,  Osamu Ando

IPC分类号： G01M11/00 ,  G01J3/08 ,  G01J3/50 ,  G01N21/25 ,  G01N21/27 ,  G01N21/31 ,  G01N21/59 ,  G01J3/46

CPC分类号： G01N21/25 ,  G01J3/0251 ,  G01J3/08 ,  G01J3/50 ,  G01N2021/3166 ,  G01N2201/065

摘要： An apparatus for measuring color transmissivities of a color separation prism P includes (where the color separation prism P receives a measurement light S on an incident path and emits three color lights Sr, Sg and Sb on three exit paths of different directions): a photomultiplier 21 and an integrating sphere I for measuring an intensity of light entering the integrating sphere I on an entrance path, where the entrance path is set detached from an extension of the incident path; a first movable mirror 9 located in one of four paths including an extension of the incident path and the three exit paths for reflecting the light on each path to the second movable mirror 10; and a second movable mirror 10 placed on the entrance path of the integrating sphere I (with the photomultiplier 21) and oriented in one of four directions for reflecting the light from the first movable mirror 9 to the integrating sphere I. Because the 100%-transmission light and the three color lights transmitted through the color separation prism P undergo the same optical history, absolute transmissivities of the color lights can be measured, and the two-beam method can be used since the integrating sphere I is fixed.

摘要翻译： 用于测量分色棱镜P的颜色透射率的装置包括（其中分色棱镜P接收入射路径上的测量光S并在不同方向的三个出口处发射三色光Sr，Sg和Sb）：光电倍增管 21和用于测量在入射路径上进入积分球I的光的强度的积分球I，其中入射路径与入射路径的延伸部分离开; 第一可移动镜9，其位于包括入射路径的延伸部的四个路径中的一个中，以及用于将每条路径上的光反射到第二可移动镜10的三个出射路径; 以及放置在积分球I（与光电倍增管21）的入射路径上的第二可移动镜10，并且在四个方向中的一个方向上定向，以将来自第一可移动镜9的光反射到积分球I.由于100％ - 透射光和通过分色棱镜P透射的三色光经历相同的光学历史，可以测量彩色光的绝对透射率，并且可以使用双积分方法，因为积分球I是固定的。

公开(公告)号：US5223913A

公开(公告)日：1993-06-29

申请号：US858631

申请日：1992-03-27

申请人： Osamu Ando ,  Toshiaki Fukuma

发明人： Osamu Ando ,  Toshiaki Fukuma

IPC分类号： G01J3/00 ,  G01J3/02 ,  G01J3/06 ,  G01J3/10 ,  G01J3/12 ,  G01J3/18

CPC分类号： G01J3/10 ,  G01J3/02 ,  G01J3/0235 ,  G01J3/027 ,  G01J3/06 ,  G01J2003/063 ,  G01J2003/064 ,  G01J2003/1213 ,  G01J3/18

摘要： A spectrophotometer including: a) a light source switching mechanism for switching a plurality of light sources by swinging a light source mirror; b) a filter selecting mechanism; c) a diffraction grating rotating mechanism; and d) a controller for determining the operation origins of the three driving mechanisms using a rough origin sensor provided for the diffraction grating rotating mechanism and a photometer. The operation of the controller is to: i) determine an origin of the movement of the filter by making an end of the filter frame to touch a stopper; ii) determine a rough origin of the diffraction grating using the rough origin sensor; and iii) determine an origin of the movement of the light source mirror and a precise origin of the movement of the diffraction grating by detecting the position at which the photometer detects the maximum intensity of light.

公开(公告)号：US5162868A

公开(公告)日：1992-11-10

申请号：US589555

申请日：1990-09-28

申请人： Osamu Ando

发明人： Osamu Ando

IPC分类号： G01J3/02 ,  G01J3/28

CPC分类号： G01J3/28 ,  G01J3/0291

摘要： A spectrophotometer includes a frame made of Glass Fiber Reinforced Unsaturated Polyester, a light source portion, a monochromator portion and a detector. The frame is fabricated with features such as bosses, holes, grooves, steps and detents, so that the frame makes it easy to install necessary parts at the precise position.

摘要翻译： 分光光度计包括由玻璃纤维增​​强不饱和聚酯制成的框架，光源部分，单色器部分和检测器。 框架由诸如凸台，孔，凹槽，台阶和棘爪的特征制成，使得框架使得容易在精确位置安装必要的部件。