摘要:
An mGluR4 receptor positive allosteric modulator is useful, alone or in combination with a neuroleptic agent, for treating or preventing movement disorders such as Parkinson's disease, dyskinesia, tardive dyskinesia, drug-induced parkinsonism, postencephalitic parkinsonism, progressive supranuclear palsy, multiple system atrophy, corticobasal degeneration, parkinsonian-ALS dementia complex, basal ganglia calcification, akinesia, akinetic-rigid syndrome, bradykinesia, dystonia, medication-induced parkinsonian, Gilles de la Tourette syndrome, Huntington's disease, tremor, chorea, myoclonus, tick disorder, and dystonia.
摘要翻译:mGluR4受体阳性变构调节剂单独使用或与精神安定药联合用于治疗或预防运动障碍如帕金森病,运动障碍,迟发性运动障碍,药物诱导的帕金森综合征,后脑卒中帕金森综合征,进行性核上性麻痹,多系统萎缩, 皮质基底膜变性,帕金森病ALS痴呆复合体,基底神经节钙化,运动不良,运动障碍,运动障碍,运动迟缓,肌张力障碍,药物诱导的帕金森病,Gilles de la Tourette综合征,亨廷顿病,震颤,舞蹈病,肌阵挛,蜱疾病和肌张力障碍。
摘要:
An improved patient leg support and bedding support frame which serves to elevate the sheets and blankets to prevent their interfering with the patient's leg movements, a leg support member formed of resilient material insertable between a patient's legs to assure maintenance of desired spacing of the legs and pivotally attachable to the frame to enable the patient to turn his legs and body without additional assistance.
摘要:
Provided is a method of treating conditions and disorders for which full mGluR5 antagonists are potentially effective, such as, e.g., anxiety, epilepsy, schizophrenia and other psychotic disorders, Parkinson's disease, addictive disorders, and the like in a subject in need of such treatment, comprising administration to such subject of a therapeutically effective amount of a partial, non-competitive mGluR5 antagonist compound of the invention. Specific examples of partial MgluR5 antagonists provided include those compounds having the formula: wherein: Z is, independently N or —CH—, provided that one, and only one Z is N; R is halogen (e.g., Br, F and the like), alkyl (e.g., methyl), alkenyl (e.g., CH═CH2, aryl (e.g., phenyl), heterocyclic (e.g., thiophenyl).
摘要:
A muscarinic M1 receptor ectopic activator, such as a muscarinic M1 receptor allosteric potentiator or a muscarinic M1 receptor ectopic agonist is useful, alone or in combination with other antipsychotic agents, for treating or preventing psychosis, such as a schizophrenic disorder or psychosis in Alzheimer's disease or bipolar disorder, for enhancing cognition and for neuropathic pain.
摘要:
This application relates to methods of identifying pharmacoperone agents that can restore function to a misfolded protein, such as a misfolded protein that causes disease. Also disclosed are methods of using such pharmacoperone agents to treat a disease or disorder that results from the misfolded protein.
摘要:
An automatic sampler for gases and liquids. The sampler has a pump which pumps a sample of a gas or a liquid from a source into a sample cylinder and a control mechanism for the pump. The control mechanism has a pressure regulator, an adjustable pneumatic timer, and a three-way button valve. The pump itself has an inlet valve which permits gas or liquid to flow into a cylinder. A piston in the cylinder moves to an appropriate position so that a desired size sample is trapped in the cylinder. The sample is then expelled through an outlet valve to a container such as a sample cylinder. The piston of the pump cylinder has a stinger projecting from one of its ends so that as the piston begins to move, the stinger shuts off the chamber that holds the sample. The inlet valve of the pump has a spring loaded plunger mounted within a cavity within the valve such that the plunger occupies a large part of the space in the cavity.