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1.发明授权公开(公告)号：US07531622B2
公开(公告)日：2009-05-12
申请号：US10528320
申请日：2003-09-19
Applicant: Pascal Dumy , Marie-Christine Favrot , Didier Boturyn , Jean-Luc Coll
Inventor： Pascal Dumy , Marie-Christine Favrot , Didier Boturyn , Jean-Luc Coll
IPC: C07K7/50
Abstract: A method for preparing a grafted homodetic cyclopeptide forming a framework that defines a grafted upper face and grafted lower face, including synthesizing a linear peptide from modified or unmodified amino acids, some of which carry orthogonal protective groups; intramolecular cyclizing the resulting protected linear peptide; substituting some or all of orthogonal protective groups with a protected precursor; and grafting at least one molecule of interest onto one and/or the other face of the framework via an oxime bond.
Abstract translation: 制备接枝的均质环肽的方法，其形成界定接枝的上表面和接枝的下表面的骨架，包括从修饰或未修饰的氨基酸合成线性肽，其中一些具有正交的保护基团; 分子内环化所得保护的线性肽; 用保护的前体取代一些或全部正交保护基; 并通过肟键将至少一个感兴趣的分子接枝到骨架的一个和/或另一个面上。
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2.发明申请USE OF VCAM-1 LIGANDS FOR DETECTING AND/OR TREATING CARDIOVASCULAR DISEASES 审中-公开使用VCAM-1配体检测和/或治疗心血管疾病公开(公告)号：US20090208408A1
公开(公告)日：2009-08-20
申请号：US11576480
申请日：2005-09-30
Applicant: Didier Boturyn , Laurent Riou , Catherine Ghezzi , Daniel Fagret , Pascal Dumy
Inventor： Didier Boturyn , Laurent Riou , Catherine Ghezzi , Daniel Fagret , Pascal Dumy
Abstract: The invention concerns the use of VCAM-1 ligands in medical imagery, in particular for characterizing and/or therapeutic monitoring of cardiovascular diseases and more particularly for detecting vulnerable coronary atheroma. The invention also concerns the use of VCAM-1 ligands for making a medicine for treating a cardiovascular disease.
Abstract translation: 本发明涉及VCAM-1配体在医学图像中的应用，特别是用于表征和/或治疗心血管疾病的监测，更特别是用于检测易受伤害的冠状动脉粥样硬化。 本发明还涉及使用VCAM-1配体制备用于治疗心血管疾病的药物。
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3.发明申请公开(公告)号：US20060173160A1
公开(公告)日：2006-08-03
申请号：US10528320
申请日：2003-09-19
Applicant: Pascal Dumy , Marie-Christine Favrot , Didier Boturyn , Jean-Luc Coll
Inventor： Pascal Dumy , Marie-Christine Favrot , Didier Boturyn , Jean-Luc Coll
Abstract: A method for preparing a grafted homodetic cyclopeptide froming a framework that defines a grafted upper face and grafted lower face, including synthesizing a linear peptide from modified or unmodified amino acids, some of which carry orthogonal protective groups; intramolecular cyclizing the resulting protected linear peptide; substituting some or all of orthogonal protective groups with a protected precursor; and grafting at least one molecule of interest onto one and/or the other face of the framework via an oxime bond.
Abstract translation: 一种从界定接枝的上表面和接枝的下表面的骨架制备接枝的均质环肽的方法，包括从修饰或未修饰的氨基酸合成线性肽，其中一些具有正交保护基; 分子内环化所得保护的线性肽; 用保护的前体取代一些或全部正交保护基; 并通过肟键将至少一个感兴趣的分子接枝到骨架的一个和/或另一个面上。
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公开(公告)号：US20130251639A1
公开(公告)日：2013-09-26
申请号：US13698450
申请日：2011-05-17
Applicant: Pascale Delangle , Anaïs Pujol , Pascal Dumy , Olivier Renaudet , Michel Ferrand
Inventor： Pascale Delangle , Anaïs Pujol , Pascal Dumy , Olivier Renaudet , Michel Ferrand
CPC classification number: C07K9/006 , A61K49/0056 , C07K7/64
Abstract: The invention relates to novel cyclodecapeptide compounds having formula (I) for use as drugs and, more specifically, for use in the diagnosis, prevention and/or treatment of neurodegenerative diseases, such as Wilson's disease and Alzheimer's disease, and for use in the diagnosis, prevention and/or treatment of poisoning with metal ions, such as copper and mercury ions. The invention also relates to pharmaceutical compositions comprising at least one compound having formula (I) as an active principle.
Abstract translation: 本发明涉及具有式（I）的新型环十一肽化合物，其用作药物，更具体地涉及用于诊断，预防和/或治疗诸如威尔逊病和阿尔茨海默病的神经变性疾病和用于诊断 ，用铜和汞离子等金属离子预防和/或治疗中毒。 本发明还涉及包含至少一种具有式（I）的化合物作为活性成分的药物组合物。
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公开(公告)号：US20080292556A1
公开(公告)日：2008-11-27
申请号：US11996208
申请日：2006-07-18
Applicant: Isabelle Texier-Nogues , Jean-Luc Coll , Pascal Dumy , Didier Boturyn , Marie Favrot
Inventor： Isabelle Texier-Nogues , Jean-Luc Coll , Pascal Dumy , Didier Boturyn , Marie Favrot
IPC: A61K49/00
CPC classification number: A61K49/0056 , A61K47/62 , A61K49/0002 , A61K49/0032 , A61K49/0041 , A61K49/0052
Abstract: The invention concerns the field of molecular probe architecture for in vivo imaging. More particularly, the invention concerns molecular constructs providing an imaging function activable in intracellular environment, said constructs being further bound to a vector which enables certain cells to be targeted, and said cells to be internalized. The inventive fluorescence probes enable in particular images of certain targeted tissues to be formed, while maintaining a low background noise level and, preferably, while obtaining at the targeted tissue, an imaging signal increasing in time.
Abstract translation: 本发明涉及体内成像的分子探针结构领域。 更具体地，本发明涉及提供可在细胞内环境中活化的成像功能的分子构建体，所述构建体进一步与使得能够靶向某些细胞的载体结合，并且所述细胞被内化。 本发明的荧光探针能够特别地形成某些目标组织的图像，同时保持低的背景噪声水平，并且优选地，在靶组织获得时间上增加的成像信号。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20070298516A1
公开(公告)日：2007-12-27
申请号：US11572668
申请日：2005-07-11
Applicant: Antoine Hoang , Francoise Vinet , Eric Defrancq , Pascal Dumy
Inventor： Antoine Hoang , Francoise Vinet , Eric Defrancq , Pascal Dumy
IPC: G01N33/566 , C07C271/60 , C07D207/46 , C07F7/18
CPC classification number: C07C271/08 , C07D207/46 , C07F7/1804 , C07F9/2408 , Y02P20/55
Abstract: The invention relates to compounds comprising a photolabile protecting group and to the use thereof as coupling agents for the functionalisation of solid supports. The invention also relates to the solid supports functionalised by said compounds and to the use of same for the immobilisation of biological molecules of interest, such as nucleic acid molecules.
Abstract translation: 本发明涉及包含光不稳定保护基团的化合物及其作为用于固体支持物官能化的偶联剂的用途。 本发明还涉及由所述化合物官能化的固体支持物及其用于固定目标生物分子例如核酸分子的用途。
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公开(公告)号：US09856294B2
公开(公告)日：2018-01-02
申请号：US13698450
申请日：2011-05-17
Applicant: Pascale Delangle , Anaïs Pujol , Pascal Dumy , Olivier Renaudet , Michel Ferrand
Inventor： Pascale Delangle , Anaïs Pujol , Pascal Dumy , Olivier Renaudet , Michel Ferrand
CPC classification number: C07K9/006 , A61K49/0056 , C07K7/64
Abstract: The invention relates to novel cyclodecapeptide compounds having formula (I) for use as drugs and, more specifically, for use in the diagnosis, prevention and/or treatment of neurodegenerative diseases, such as Wilson's disease and Alzheimer's disease, and for use in the diagnosis, prevention and/or treatment of poisoning with metal ions, such as copper and mercury ions. The invention also relates to pharmaceutical compositions comprising at least one compound having formula (I) as an active principle.
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公开(公告)号：US09421281B2
公开(公告)日：2016-08-23
申请号：US11996208
申请日：2006-07-18
Applicant: Isabelle Texier-Nogues , Jean-Luc Coll , Pascal Dumy , Didier Boturyn , Marie Favrot
Inventor： Isabelle Texier-Nogues , Jean-Luc Coll , Pascal Dumy , Didier Boturyn , Marie Favrot
CPC classification number: A61K49/0056 , A61K47/62 , A61K49/0002 , A61K49/0032 , A61K49/0041 , A61K49/0052
Abstract: The invention concerns the field of molecular probe architecture for in vivo imaging. More particularly, the invention concerns molecular constructs providing an imaging function activable in intracellular environment. The inventive fluorescence probes enable in particular images of certain targeted tissues to be formed, while maintaining a low background noise level and, preferably, while obtaining at the targeted tissue, an imaging signal increasing in time.
Abstract translation: 本发明涉及体内成像的分子探针结构领域。 更具体地，本发明涉及提供可在细胞内环境中活化的成像功能的分子结构。 本发明的荧光探针能够特别地形成某些目标组织的图像，同时保持低的背景噪声水平，并且优选地，在靶组织获得时间上增加的成像信号。
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9.发明申请公开(公告)号：US20120034163A1
公开(公告)日：2012-02-09
申请号：US13143920
申请日：2010-01-05
Applicant: Daniel Fagret , Catherine Ghezzi , Pascal Dumy , Laurent Riou , Didier Boturyn
Inventor： Daniel Fagret , Catherine Ghezzi , Pascal Dumy , Laurent Riou , Didier Boturyn
CPC classification number: A61K51/088 , A61K38/00 , A61K38/08 , A61K38/177 , A61K49/00 , C07K14/70539 , C07K14/70542
Abstract: The present invention relates to a polypeptide comprising the sequence RILAR (SEQ ID NO: 3), the use thereof in imaging methods, in diagnostic or prognostic methods and for use as a medicament.
Abstract translation: 本发明涉及包含序列RILAR（SEQ ID NO：3）的多肽，其在成像方法中的用途，在诊断或预后方法中并用作药物。
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10.发明授权Coupling agents comprising a photolabile protecting group and uses thereof, such as for the functionalisation of solid supports 有权包含光不稳定保护基团的偶联剂及其用途，例如固体载体的功能化公开(公告)号：US07846875B2
公开(公告)日：2010-12-07
申请号：US11572668
申请日：2005-07-11
Applicant: Antoine Hoang , Françoise Vinet , Eric Defrancq , Pascal Dumy
Inventor： Antoine Hoang , Françoise Vinet , Eric Defrancq , Pascal Dumy
IPC: C04B50/18
CPC classification number: C07C271/08 , C07D207/46 , C07F7/1804 , C07F9/2408 , Y02P20/55
Abstract: The invention relates to compounds comprising a photolabile protecting group and to the use thereof as coupling agents for the functionalisation of solid supports. The invention also relates to the solid supports functionalised by said compounds and to the use of same for the immobilisation of biological molecules of interest, such as nucleic acid molecules.
Abstract translation: 本发明涉及包含光不稳定保护基团的化合物及其作为用于固体支持物官能化的偶联剂的用途。 本发明还涉及由所述化合物官能化的固体支持物及其用于固定目标生物分子例如核酸分子的用途。
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