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    Device for enhancing broad band fluorescence with low loss and biological or chemical optic sensor using the same
    1.
    发明授权
    Device for enhancing broad band fluorescence with low loss and biological or chemical optic sensor using the same 有权
    用于增加具有低损耗的宽带荧光和使用其的生物或化学光学传感器的装置

    公开(公告)号：US07718422B2

    公开(公告)日：2010-05-18

    申请号：US10450100

    申请日：2001-12-12

    Applicant: Patrick Chaton ,  Françoise Vinet ,  Pierre Barritault ,  Stéphane Getin

    Inventor： Patrick Chaton ,  Françoise Vinet ,  Pierre Barritault ,  Stéphane Getin

    IPC: G01N33/551

    CPC classification number: G01N21/6428 ,  G01N21/6458 ,  Y10S435/808

    Abstract: The invention concerns a device for enhancing fluorescence comprising a support (10) carrying fluorescence enhancement means (11), the fluorescence enhancement means offering a reception surface for chemical or biological elements intended to be read by detection of a fluorescence signal emitted by a fluorophore, associated with the chemical or biological elements, under the effect of an excitation light beam. The fluorescence enhancement means (11) is made up of a thin, transparent, dielectric layer or a stack of thin, transparent, dielectric layers (12 to 16) ensuring a mirror function for the fluorescence signal and excitation light beam, the material of the thin layer or of each thin layer of the stack being chosen from among the following materials: TiO2, Ta2O5, HfO2, ZrO2, MgO, SiO2, Si3N4, MgF2 and YF3. The fluorescence enhancement device may be used for a biological or chemical optic sensor.

    Abstract translation: 本发明涉及一种用于增强荧光的装置，其包括载有荧光增强装置（11）的载体（10），所述荧光增强装置提供用于通过检测由荧光团发射的荧光信号而被读取的化学或生物元件的接收表面， 在激发光束的作用下与化学或生物元素相关联。 荧光增强装置（11）由薄的，透明的介电层或薄的，透明的电介质层（12至16）组成，确保了荧光信号和激发光束的反射镜功能， 薄层或每层薄层选自以下材料：TiO 2，Ta 2 O 5，HfO 2，ZrO 2，MgO，SiO 2，Si 3 N 4，MgF 2和YF 3。 荧光增强装置可用于生物或化学光学传感器。

    Molecular Spacer Arm, Process for the Production Thereof and Uses on an Analytical Chip Comprising Molecules or Biomolecules
    7.
    发明申请
    Molecular Spacer Arm, Process for the Production Thereof and Uses on an Analytical Chip Comprising Molecules or Biomolecules 审中-公开
    分子间隔臂，其制备方法和用于分子或生物分子的分析芯片

    公开(公告)号：US20080044838A2

    公开(公告)日：2008-02-21

    申请号：US10590137

    申请日：2006-08-22

    Applicant: Ve´ronique PERETTI ,  Françoise VINET ,  David BONNAFFE

    Inventor： Ve´ronique PERETTI ,  Françoise VINET ,  David BONNAFFE

    IPC: G01N33/53 ,  C08B37/00 ,  C07K14/775 ,  C07K14/47

    CPC classification number: C07H3/02 ,  G01N33/54353 ,  Y02P20/55

    Abstract: The present invention relates to a molecular spacer arm, to a process for attachment of a molecular unit to a solid support, and also to the use of this spacer arm on analytical chips comprising molecules or biomolecules. The spacer arm has the formula (I): in which X0, X4═C, O, S, Se, N, P, As; X1-3═C, O, N, S, Se, P, As, or C1-6 aryl or heteroaryl; Z1-2═C—R, Si—R, N, P and As, where R═C1-6 alkyl; R1-3═H, or C1-6 alkyl, aryl or heteroaryl; [Gp]=protective group for >N; n, m and p=integers ≧1; [Sup]=H or a silanized solid support; and [mo]=H or a molecular unit intended to be covalently attached to said silanized solid support by means of said spacer arm.

    Abstract translation: 本发明涉及一种分子间隔臂，一种将分子单元连接到固体支持物的方法，以及该分隔器臂在包含分子或生物分子的分析芯片上的用途。 间隔臂具有式（I）：其中X 0，X 4 -C，O，S，Se，N，P，As; C 1-3，C 1 -C 6烷基，杂芳基，杂芳基，杂芳基，杂芳基或杂芳基; Z-1-2C-R，Si-R，N，P和As，其中R-C 1-6烷基; R 1-3，或C 1-6烷基，芳基或杂芳基; [Gp] => N的保护基; n，m和p =整数> = 1; [Sup] = H或硅烷化固体载体; 和[mo] = H或旨在通过所述间隔臂共价连接到所述硅烷化固体支持物上的分子单元。

    Method for functionalising fluid lines contained in a micromechanical device, micromechanical device including functionalised lines, and method for manufacturing same
    8.
    发明授权
    Method for functionalising fluid lines contained in a micromechanical device, micromechanical device including functionalised lines, and method for manufacturing same 有权
    包含在微机械装置中的流体线的功能化方法，包括功能化线的微机械装置及其制造方法

    公开(公告)号：US08968673B2

    公开(公告)日：2015-03-03

    申请号：US13805491

    申请日：2011-06-29

    Applicant: Vincent Agache ,  Antoine Hoang ,  Françoise Vinet

    Inventor： Vincent Agache ,  Antoine Hoang ,  Françoise Vinet

    IPC: G01N33/00 ,  G03F7/24 ,  B81C1/00 ,  F04B19/00

    CPC classification number: G03F7/24 ,  B81B2201/0214 ,  B81B2201/058 ,  B81B2201/06 ,  B81C1/00206 ,  B81C2201/0154 ,  F04B19/006

    Abstract: The present invention relates to a method for functionalizing fluid lines (1b) in a micromechanical device, the walls of which include an opaque layer. For this purpose, the invention provides a method for functionalizing a micromechanical device provided with a fluid line including a peripheral wall (5) having a surface (2) outside the line and an inner surface (3) defining a space (1b) in which a fluid can circulate, the peripheral wall at least partially including a silicon layer (5a). The method includes the following steps: a) providing a device, the peripheral wall (5) of which at least partially includes a silicon layer (5a) having, at least locally, a thickness (e) of more than 100 nm and less than 200 nm, advantageously of 160 to 180 nm; c) silanizing at least the inner surface of the fluid line; d) the localized, selective photo-deprotection on at least the inner surface of the silanized device by exposing the peripheral wall (5) at the point at which said wall has a thickness (e) of more than 100 nm and less than 200 nm, advantageously of 160 to 180 nm.

    Abstract translation: 本发明涉及一种在微机械装置中功能化流体管线（1b）的方法，该方法的壁包括不透明层。 为此，本发明提供了一种功能化微机械装置的方法，该微机械装置具有流体管线，该流体管线包括在管线外部具有表面（2）的周壁（5）和限定空间（1b）的内表面（3） 流体可以循环，周壁至少部分地包括硅层（5a）。 该方法包括以下步骤：a）提供一种器件，其外围壁（5）至少部分地包括硅层（5a），该硅层至少局部地具有大于100nm的厚度（e）并且小于 200nm，有利地为160〜180nm; c）至少使流体管线的内表面硅烷化; d）通过在所述壁的厚度（e）大于100nm且小于200nm的点处暴露外围壁（5），至少在硅烷化装置的内表面上进行局部选择性光 - 去保护 ，有利地为160至180nm。

    USE OF POLYMER REAGENTS TO MODULATE AND CONTROL ELECTROKINETIC FLOWS IN A MICRO- OR NANOFLUIDIC DEVICE
    10.
    发明申请
    USE OF POLYMER REAGENTS TO MODULATE AND CONTROL ELECTROKINETIC FLOWS IN A MICRO- OR NANOFLUIDIC DEVICE 审中-公开
    聚合物试剂在微波或纳米级器件中调节和控制电动力流动的应用

    公开(公告)号：US20090200165A1

    公开(公告)日：2009-08-13

    申请号：US11994267

    申请日：2006-06-28

    Applicant: Jan Sudor ,  Françoise Vinet ,  Anne-Marie Gue ,  Daniel Esteve

    Inventor： Jan Sudor ,  Françoise Vinet ,  Anne-Marie Gue ,  Daniel Esteve

    IPC: B01D57/02

    CPC classification number: C03C17/3405 ,  C03C17/004 ,  C03C2218/11 ,  C03C2218/31 ,  G01N27/44752

    Abstract: The invention concerns the field of microfluidics and in particular that of electrophoresis on a micro- or nanofluidic device. More particularly, the invention concerns the use of a reactive polymer coating adapted to be submitted to a phase separation under the influence of an external stimulation of chemical or physical type, to modulate the electrokinetic flows (electroosmotic or electrophoretic flows during electrophoresis for example) in a micro- or nanofluidic device. The invention also concerns a method for varying the electrokinetic flows in such a device using said coating, as well as the micro- or nanofluidic devices comprising at least one channel or one capillary tube whereof the inner surface is covered at least partly with such a coating.

    Abstract translation: 本发明涉及微流体领域，特别涉及微流体或纳流体装置上的电泳领域。 更具体地说，本发明涉及适用于在化学或物理类型的外部刺激的影响下进行相分离的反应性聚合物涂层的用途，以调节动电流（例如电泳期间的电渗或电泳流） 微流体或纳流体装置。 本发明还涉及一种用于使用所述涂层改变这种装置中的电动动力流动的方法，以及包括至少一个通道或一个毛细管的微流体或纳流体装置，其中内表面至少部分地被这样的涂层 。

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