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17 条记录 (耗时 0.018 秒)

    Cyclin-dependent kinase inhibitors as targets for opiod growth factor treatment
    4.
    发明申请
    Cyclin-dependent kinase inhibitors as targets for opiod growth factor treatment 有权
    细胞周期蛋白依赖性激酶抑制剂作为阿片类生长因子治疗的靶标

    公开(公告)号：US20080146512A1

    公开(公告)日：2008-06-19

    申请号：US11901770

    申请日：2007-09-19

    申请人： Ian S. Zagon ,  Patricia J. McLaughlin ,  Michael F. Verderame

    发明人： Ian S. Zagon ,  Patricia J. McLaughlin ,  Michael F. Verderame

    IPC分类号： A61K38/08 ,  C12Q1/48 ,  G01N33/48 ,  A61P17/02

    CPC分类号： G01N33/574 ,  A61K38/005 ,  A61K38/33 ,  G01N33/68 ,  G01N33/6842 ,  G01N2333/475 ,  G01N2333/91215 ,  G01N2800/52

    摘要： The present invention provides methods of cell cycle control by administering opioid growth factor (OGF), which activates opioid growth factor receptor (OGFr) signaling. Particularly, the present invention provides a method for monitoring OGF modulation or treatment of a cell proliferation or growth related condition in a subject by assessing the level of the cyclin dependent kinase inhibitor (CKI) relevant or corresponding to the condition. The present invention also provides a method for screening the eligibility of a subject for OGF modulation or treatment by assessing the level of OGF receptor (OGFr) and the relevant CKI. A method for enhancing the efficacy of OGF therapy by increasing the level of the relevant CKI and/or OGFr is also provided.

    摘要翻译： 本发明通过施用激活阿片样物质生长因子受体（OGFr）信号传导的阿片样生长因子（OGF）来提供细胞周期控制的方法。 特别地，本发明提供了通过评估与病症相关或相应的细胞周期蛋白依赖性激酶抑制剂（CKI）的水平来监测受试者的OGF调节或治疗细胞增殖或生长相关状态的方法。 本发明还提供了通过评估OGF受体（OGFr）水平和相关CKI来筛选受试者对OGF调节或治疗的资格的方法。 还提供了通过增加相关CKI和/或OGFr的水平来提高OGF治疗功效的方法。

    Growth regulation and related applications of opioid antagonists
    5.
    发明授权
    Growth regulation and related applications of opioid antagonists 失效
    阿片类拮抗剂的生长调节和相关应用

    公开(公告)号：US5426112A

    公开(公告)日：1995-06-20

    申请号：US21191

    申请日：1993-02-23

    申请人： Ian S. Zagon ,  Patricia J. McLaughlin

    发明人： Ian S. Zagon ,  Patricia J. McLaughlin

    IPC分类号： A01N43/90 ,  A61K31/485 ,  A61K31/41

    CPC分类号： A61K31/485 ,  A01N43/90 ,  Y10S514/812

    摘要： A method for regulating the growth processes in a myriad of cells, tissues, organ systems and unicellular and multicellular organisms including plants, animals and man by the administration of effective amounts of the opioid antagonists naloxone, naltrexone, their analogs, metabolites derivatives, and/or mixtures thereof. At the cellular level, the growth processes entail all mitetic events and related processes including cell proliferation, as well as cell migration and cell differentiation, and at the somatic or organismal level, anatomical, behavioral and neurological development, metamorphisis and maturation. Growth regulation can be effected in vivo and/or in vitro.

    摘要翻译： 通过施用有效量的阿片样物质拮抗剂纳洛酮，纳曲酮，其类似物，代谢物衍生物和/或其衍生物，调节无数细胞，组织，器官系统和单细胞和多细胞生物体中包括植物，动物和人的生长过程的方法， 或其混合物。 在细胞水平上，生长过程需要所有的细胞事件和相关过程，包括细胞增殖，以及细胞迁移和细胞分化，以及体细胞或生物体的水平，解剖学，行为和神经发育，变质和成熟。 生长调节可以在体内和/或体外进行。

    Growth regulation and related applications of opioid antagonists
    6.
    发明授权
    Growth regulation and related applications of opioid antagonists 失效
    阿片类拮抗剂的生长调节和相关应用

    公开(公告)号：US4689332A

    公开(公告)日：1987-08-25

    申请号：US598092

    申请日：1984-04-09

    申请人： Patricia J. McLaughlin ,  Ian S. Zagon

    发明人： Patricia J. McLaughlin ,  Ian S. Zagon

    IPC分类号： A01N43/90 ,  A61K31/485 ,  A61P3/00 ,  A61P5/00 ,  C07D489/08 ,  A61K31/41

    CPC分类号： A61K31/485 ,  A01N43/90 ,  Y10S514/812

    摘要： A method for regulating the growth processes in a myriad of cells, tissues, organ systems and unicellular and multicellular organisms including plants, animals and man by the administration of effective amounts of the opioid antagonists naloxone, naltrexone, their analogs metabolites derivatives, and/or mixtures thereof. At the cellular level, the growth processes entail all mitotic events and related processes including cell proliferation, as well as cell migration and cell differentiation, and at the somatic or organismal level, anatomical, behavioral and neurological development, metamorphisis and maturation. Growth regulation can be effected in vivo and/or in vitro.

    摘要翻译： 通过施用有效量的阿片样物质拮抗剂纳洛酮，纳曲酮，其类似物代谢物衍生物和/或其它类似物来调节无数细胞，组织，器官系统和单细胞和多细胞生物体（包括植物，动物和人）中的生长过程的方法 其混合物。 在细胞水平上，生长过程需要所有有丝分裂事件和相关过程，包括细胞增殖，以及细胞迁移和细胞分化，以及体细胞或生物体内的解剖，行为和神经发育，变质和成熟。 生长调节可以在体内和/或体外进行。

    Opioid growth factor receptors
    9.
    发明授权
    Opioid growth factor receptors 有权
    阿片样生长因子受体

    公开(公告)号：US07576180B2

    公开(公告)日：2009-08-18

    申请号：US11890621

    申请日：2007-08-07

    申请人： Ian S. Zagon ,  Patricia J. McLaughlin ,  Michael F. Verderame

    发明人： Ian S. Zagon ,  Patricia J. McLaughlin ,  Michael F. Verderame

    IPC分类号： C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  A01N37/18 ,  A61K38/00

    CPC分类号： C12N15/1138 ,  A61K38/00 ,  C07K14/71 ,  C07K16/28 ,  C12N2310/11 ,  C12N2310/315

    摘要： This invention relates to novel nucleic acid molecules coding for opioid growth factor receptors. In particular, the present invention provides isolated nucleic acid molecules coding for human and rat OGF receptors. Antisense molecules, expression vectors and host cells, isolated proteins encoded by such nucleic acid molecules, antibodies directed against such proteins, as well as pharmaceutical compositions derived therefrom are also included. The invention further provides methods of modulating cell growth by using the isolated nucleic acid molecules, the antisense molecules and the antibodies directed against the encoded proteins.

    摘要翻译： 本发明涉及编码阿片类生长因子受体的新型核酸分子。 特别地，本发明提供编码人和大鼠OGF受体的分离的核酸分子。 还包括反义分子，表达载体和宿主细胞，由这种核酸分子编码的分离的蛋白质，针对这种蛋白质的抗体，以及由其衍生的药物组合物。 本发明还提供了通过使用分离的核酸分子，反义分子和针对编码的蛋白质的抗体来调节细胞生长的方法。