公开(公告)号：US07371381B2

公开(公告)日：2008-05-13

申请号：US11009443

申请日：2004-12-10

申请人： Wade Aaron ,  Richard J. Austin ,  Cynthia L. Hart ,  Timothy C. Hoey ,  Paul D. Kassner ,  Derek E. Piper ,  Anthony J. Slavin

发明人： Wade Aaron ,  Richard J. Austin ,  Cynthia L. Hart ,  Timothy C. Hoey ,  Paul D. Kassner ,  Derek E. Piper ,  Anthony J. Slavin

IPC分类号： C07K16/28 ,  A61K39/395

CPC分类号： C07K16/26 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/92

摘要： The present invention provides antibodies that immunospecifically bind to a galanin peptide and compositions comprising said antibodies. The present invention also provides methods for preventing, treating, managing, and/or ameliorating hyperproliferative disorders or a symptom thereof comprising administering to a subject in need thereof one or more antibodies that immunospecifically bind to a galanin peptide. The invention also encompasses methods and compositions for diagnosing, monitoring, and prognosing hyperproliferative disorders. The present invention further relates to articles of manufacture and kits comprising antibodies that immunospecifically bind to a galanin peptide.

摘要翻译： 本发明提供免疫特异性结合甘丙肽肽的抗体和包含所述抗体的组合物。 本发明还提供了预防，治疗，治疗和/或改善过度增殖性疾病或其症状的方法，其包括向有需要的受试者施用一种或多种免疫特异性结合甘丙肽肽的抗体。 本发明还包括用于诊断，监测和预测过度增殖性疾病的方法和组合物。 本发明进一步涉及制品和包含免疫特异性结合甘丙肽的抗体的试剂盒。

公开(公告)号：US06686154B2

公开(公告)日：2004-02-03

申请号：US09874547

申请日：2001-06-04

申请人： Steffen Nock ,  Paul D. Kassner

发明人： Steffen Nock ,  Paul D. Kassner

IPC分类号： C12Q168

CPC分类号： C40B40/02 ,  C12N15/1037

摘要： This invention provides methods for screening populations of phage-displayed polypeptides that are particularly well-suited for high-throughput screening. The methods do not require the clearing of cells from a culture used to obtain the population of phage or other replicable genetic packages. Accordingly, the invention provides methods for forming complexes between a replicable genetic package displaying a polypeptide fusion and a target molecule in an uncleared cell culture containing replicable genetic package. Compositions made up of an uncleared cell culture containing replicable genetic packages displaying a polypeptide fusion and a target molecule are provided in the invention as well.

摘要翻译： 本发明提供筛选特别适合于高通量筛选的噬菌体展示多肽群体的方法。 该方法不需要从用于获得噬菌体群体或其他可复制遗传包的培养物中清除细胞。 因此，本发明提供了在含有可复制遗传包装的未清除细胞培养物中形成显示多肽融合物的可复制遗传包装与靶分子之间的复合物的方法。 在本发明中还提供了由含有显示多肽融合物和靶分子的可复制遗传包装的未清除细胞培养物组成的组合物。