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公开(公告)号：US07371381B2
公开(公告)日：2008-05-13
申请号：US11009443
申请日：2004-12-10
申请人： Wade Aaron , Richard J. Austin , Cynthia L. Hart , Timothy C. Hoey , Paul D. Kassner , Derek E. Piper , Anthony J. Slavin
发明人： Wade Aaron , Richard J. Austin , Cynthia L. Hart , Timothy C. Hoey , Paul D. Kassner , Derek E. Piper , Anthony J. Slavin
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/92
摘要： The present invention provides antibodies that immunospecifically bind to a galanin peptide and compositions comprising said antibodies. The present invention also provides methods for preventing, treating, managing, and/or ameliorating hyperproliferative disorders or a symptom thereof comprising administering to a subject in need thereof one or more antibodies that immunospecifically bind to a galanin peptide. The invention also encompasses methods and compositions for diagnosing, monitoring, and prognosing hyperproliferative disorders. The present invention further relates to articles of manufacture and kits comprising antibodies that immunospecifically bind to a galanin peptide.
摘要翻译： 本发明提供免疫特异性结合甘丙肽肽的抗体和包含所述抗体的组合物。 本发明还提供了预防，治疗，治疗和/或改善过度增殖性疾病或其症状的方法，其包括向有需要的受试者施用一种或多种免疫特异性结合甘丙肽肽的抗体。 本发明还包括用于诊断，监测和预测过度增殖性疾病的方法和组合物。 本发明进一步涉及制品和包含免疫特异性结合甘丙肽的抗体的试剂盒。
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公开(公告)号：US20130004501A1
公开(公告)日：2013-01-03
申请号：US13504449
申请日：2010-10-26
申请人： Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
发明人： Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
CPC分类号： C07K16/244 , A61K39/395 , A61K47/6845 , A61K2039/505 , C07K16/24 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/76 , C07K2317/92
摘要： Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.
摘要翻译： 提供了结合人IL-23蛋白的抗原结合蛋白。 还提供编码抗原结合蛋白，载体和编码相同的细胞以及用于诊断和治疗目的的IL-23抗原结合蛋白的使用的核酸。
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公开(公告)号：US07112606B2
公开(公告)日：2006-09-26
申请号：US10354923
申请日：2003-01-29
申请人： Xian Yun Jiao , Frank Kayser , David J. Kopecky , Sharon McKendry , Derek E. Piper , Andrew K. Shiau
发明人： Xian Yun Jiao , Frank Kayser , David J. Kopecky , Sharon McKendry , Derek E. Piper , Andrew K. Shiau
IPC分类号： A61K31/40 , C07D207/30
CPC分类号： C07D207/333 , C07D207/335
摘要： Heterocyclic arylsulfonamidobenzylic compounds are provided which are useful in treating lipid disorders, metabolic disorders and cell-proliferative diseases.
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公开(公告)号：US09487580B2
公开(公告)日：2016-11-08
申请号：US14228556
申请日：2014-03-28
申请人： Jennifer E. Towne , Janet D. Cheng , Jason C. O'neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
发明人： Jennifer E. Towne , Janet D. Cheng , Jason C. O'neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
IPC分类号： A61K39/395 , C07K16/24 , A61K39/00
CPC分类号： C07K16/244 , A61K39/395 , A61K47/6845 , A61K2039/505 , C07K16/24 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/76 , C07K2317/92
摘要： Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.
摘要翻译： 提供了结合人IL-23蛋白的抗原结合蛋白。 还提供编码抗原结合蛋白，载体和编码相同的细胞以及用于诊断和治疗目的的IL-23抗原结合蛋白的使用的核酸。
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公开(公告)号：US20140212428A1
公开(公告)日：2014-07-31
申请号：US14228556
申请日：2014-03-28
申请人： Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
发明人： Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
IPC分类号： C07K16/24
CPC分类号： C07K16/244 , A61K39/395 , A61K47/6845 , A61K2039/505 , C07K16/24 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/76 , C07K2317/92
摘要： Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.
摘要翻译： 提供了结合人IL-23蛋白的抗原结合蛋白。 还提供编码抗原结合蛋白，载体和编码相同的细胞以及用于诊断和治疗目的的IL-23抗原结合蛋白的使用的核酸。
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公开(公告)号：US07473703B2
公开(公告)日：2009-01-06
申请号：US11501594
申请日：2006-08-08
申请人： Xian Yun Jiao , Frank Kayser , David J. Kopecky , Sharon McKendry , Derek E. Piper , Andrew K. Shiau
发明人： Xian Yun Jiao , Frank Kayser , David J. Kopecky , Sharon McKendry , Derek E. Piper , Andrew K. Shiau
IPC分类号： A61K31/40 , C07D207/325
CPC分类号： C07D207/333 , C07D207/335
摘要： Heterocyclic arylsulfonamidobenzylic compounds are provided which are useful in treating lipid disorders, metabolic disorders and cell-proliferative diseases.
摘要翻译： 提供了可用于治疗脂质疾病，代谢紊乱和细胞增殖性疾病的杂环芳基磺酰氨基苄基化合物。
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公开(公告)号：US08722033B2
公开(公告)日：2014-05-13
申请号：US13504449
申请日：2010-10-26
申请人： Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
发明人： Jennifer E. Towne , Janet D. Cheng , Jason C. O'Neill , Yu Zhang , Yu Sun , Heather Cerne , Derek E. Piper , Randal R. Ketchem
IPC分类号： C07K16/24 , A61K39/395
CPC分类号： C07K16/244 , A61K39/395 , A61K47/6845 , A61K2039/505 , C07K16/24 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/76 , C07K2317/92
摘要： Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same as well as use of IL-23 antigen binding proteins for diagnostic and therapeutic purposes are also provided.
摘要翻译： 提供了结合人IL-23蛋白的抗原结合蛋白。 还提供编码抗原结合蛋白，载体和编码相同的细胞以及用于诊断和治疗目的的IL-23抗原结合蛋白的使用的核酸。
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公开(公告)号：US07326812B2
公开(公告)日：2008-02-05
申请号：US11333958
申请日：2006-01-17
IPC分类号： C07C311/15
CPC分类号： C07D207/33 , C07C311/21 , C07C317/32 , C07C2601/08 , C07C2601/16 , C07D207/333 , C07D207/335 , C07D213/30 , C07D213/42 , C07D231/12 , C07D233/61 , C07D233/64 , C07D235/12 , C07D235/14 , C07D239/26 , C07D257/04 , C07D277/24 , C07D277/28 , C07D333/34 , C07F7/081
摘要： Arylsulfonamidobenzyl alcohols, amines and sulfonamides are provided which are useful in treating lipid disorders, metabolic diseases and cell-proliferative diseases.
摘要翻译： 提供了芳基磺酰胺苄醇，胺和磺酰胺，其可用于治疗脂质疾病，代谢疾病和细胞增殖性疾病。
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公开(公告)号：US07071358B2
公开(公告)日：2006-07-04
申请号：US10354922
申请日：2003-01-29
IPC分类号： C07C311/37 , A61K31/18
CPC分类号： C07D207/33 , C07C311/21 , C07C317/32 , C07C2601/08 , C07C2601/16 , C07D207/333 , C07D207/335 , C07D213/30 , C07D213/42 , C07D231/12 , C07D233/61 , C07D233/64 , C07D235/12 , C07D235/14 , C07D239/26 , C07D257/04 , C07D277/24 , C07D277/28 , C07D333/34 , C07F7/081
摘要： Arylsulfonamidobenzyl alcohols, amines and sulfonamides are provided which are useful in treating lipid disorders, metabolic diseases and cell-proliferative diseases.
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