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公开(公告)号:US07371381B2
公开(公告)日:2008-05-13
申请号:US11009443
申请日:2004-12-10
申请人: Wade Aaron , Richard J. Austin , Cynthia L. Hart , Timothy C. Hoey , Paul D. Kassner , Derek E. Piper , Anthony J. Slavin
发明人: Wade Aaron , Richard J. Austin , Cynthia L. Hart , Timothy C. Hoey , Paul D. Kassner , Derek E. Piper , Anthony J. Slavin
IPC分类号: C07K16/28 , A61K39/395
CPC分类号: C07K16/26 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/92
摘要: The present invention provides antibodies that immunospecifically bind to a galanin peptide and compositions comprising said antibodies. The present invention also provides methods for preventing, treating, managing, and/or ameliorating hyperproliferative disorders or a symptom thereof comprising administering to a subject in need thereof one or more antibodies that immunospecifically bind to a galanin peptide. The invention also encompasses methods and compositions for diagnosing, monitoring, and prognosing hyperproliferative disorders. The present invention further relates to articles of manufacture and kits comprising antibodies that immunospecifically bind to a galanin peptide.
摘要翻译: 本发明提供免疫特异性结合甘丙肽肽的抗体和包含所述抗体的组合物。 本发明还提供了预防,治疗,治疗和/或改善过度增殖性疾病或其症状的方法,其包括向有需要的受试者施用一种或多种免疫特异性结合甘丙肽肽的抗体。 本发明还包括用于诊断,监测和预测过度增殖性疾病的方法和组合物。 本发明进一步涉及制品和包含免疫特异性结合甘丙肽的抗体的试剂盒。
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公开(公告)号:US20130337250A1
公开(公告)日:2013-12-19
申请号:US13906097
申请日:2013-05-30
IPC分类号: C09J7/04
CPC分类号: C09J7/29 , B32B5/022 , B32B5/024 , B32B17/04 , B32B27/08 , B32B27/12 , B32B27/283 , B32B27/285 , B32B27/286 , B32B27/288 , B32B27/306 , B32B27/322 , B32B2262/101 , B32B2270/00 , B32B2307/746 , C03C25/1095 , C03C25/305 , C03C25/40 , C03C25/50 , C09J2400/263 , C09J2427/006 , C09J2483/00 , D06M15/256 , D06M15/353 , D06M15/643 , D06M23/16 , D06N3/047 , D06N3/128 , D06N3/183 , Y10T428/2848 , Y10T442/2098
摘要: An improved perfluoropolymer composite that uses a blend of a perfluoropolymer (such as PTFE) and a silicone polymer. By coating a substrate, such as glass fiber fabric, with a blend of a perfluoropolymer and a silicone polymer, an adhesive layer can be bonded either directly to the surface of the perfluoropolymer composite or to a perfluoropolymer composite that has been primed without the need to have otherwise treated the perfluoropolymer surface, such as either by etching or by the deposition of an intermediate coating containing colloidal silica or other similar agents, to make the surface bondable.
摘要翻译: 改进的全氟聚合物复合材料,其使用全氟聚合物(例如PTFE)和硅氧烷聚合物的共混物。 通过用全氟聚合物和硅氧烷聚合物的共混物涂覆诸如玻璃纤维织物的基底,粘合剂层可以直接结合到全氟聚合物复合材料的表面上,或者直接结合到已经被引发的全氟聚合物复合材料上,而不需要 否则通过蚀刻或通过沉积含有胶体二氧化硅或其它类似试剂的中间涂层来处理全氟聚合物表面,以使表面可结合。
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公开(公告)号:US09434137B2
公开(公告)日:2016-09-06
申请号:US12885178
申请日:2010-09-17
申请人: Cheryl A. Prudhomme , James Holtzinger , Gene H. Goldstein , Michael J. Tzivanis , William E. Noonan , Richard J. Austin
发明人: Cheryl A. Prudhomme , James Holtzinger , Gene H. Goldstein , Michael J. Tzivanis , William E. Noonan , Richard J. Austin
CPC分类号: B32B25/20 , B32B27/12 , B32B37/12 , B32B2037/243 , B32B2038/0076 , B32B2305/30 , B32B2307/306 , B32B2307/554 , B32B2309/12 , B32B2310/0806 , B32B2310/0887 , B32B2319/00 , C09J7/29 , C09J2203/31 , C09J2483/006 , Y10T428/2848 , Y10T428/31663 , Y10T442/2631
摘要: A thermal spray masking tape includes a substrate having a first major surface and a second major surface. The thermal spray masking tape further includes a surface layer overlying the first major surface of the substrate. The surface layer is formed from an elastomer including a liquid silicone rubber.
摘要翻译: 热喷涂掩模胶带包括具有第一主表面和第二主表面的基材。 热喷涂掩模胶带还包括覆盖在基材的第一主表面上的表面层。 表面层由包括液体硅橡胶的弹性体形成。
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公开(公告)号:US20090048259A1
公开(公告)日:2009-02-19
申请号:US12214901
申请日:2008-06-23
IPC分类号: A61K31/502 , C07D237/30 , A61P35/00
CPC分类号: C07D409/14 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14
摘要: The present invention relates generally to compounds represented in Formula I, pharmaceutical compositions comprising them and methods of treating of diseases or disorders such as cancer.
摘要翻译: 本发明一般涉及式I表示的化合物,包含它们的药物组合物和治疗诸如癌症的疾病或病症的方法。
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公开(公告)号:US20100035501A1
公开(公告)日:2010-02-11
申请号:US12536964
申请日:2009-08-06
申请人: Cheryl A. Prudhomme , James Holtzinger , Gene H. Goldstein , Michael J. Tzivanis , William E. Noonan , Richard J. Austin
发明人: Cheryl A. Prudhomme , James Holtzinger , Gene H. Goldstein , Michael J. Tzivanis , William E. Noonan , Richard J. Austin
CPC分类号: B32B27/12 , B32B5/022 , B32B5/024 , B32B15/04 , B32B25/20 , B32B27/20 , B32B27/283 , B32B27/308 , B32B27/34 , B32B27/40 , B32B37/12 , B32B2255/00 , B32B2262/101 , B32B2262/105 , B32B2262/106 , B32B2264/102 , B32B2264/105 , B32B2264/107 , B32B2307/306 , B32B2307/3065 , B32B2307/4026 , B32B2307/54 , B32B2307/554 , B32B2307/702 , B32B2307/718 , B32B2307/748 , B32B2319/00 , B32B2405/00 , C09J7/29 , C09J2201/622 , C09J2203/31 , C09J2400/263 , C09J2483/006 , Y10T156/10 , Y10T428/31663 , Y10T428/31826 , Y10T442/679
摘要: A thermal spray masking tape includes a substrate having a first major surface and a second major surface and a surface layer overlying the first major surface of the substrate. The surface layer is formed from an elastomer having an ultimate tensile strength greater than about 600 lbs/square inch.
摘要翻译: 热喷涂掩模带包括具有第一主表面和第二主表面的基底,以及覆盖在基底的第一主表面上的表面层。 表面层由极限抗拉强度大于约600磅/平方英寸的弹性体形成。
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公开(公告)号:US08153633B2
公开(公告)日:2012-04-10
申请号:US12214901
申请日:2008-06-23
IPC分类号: A61K31/50 , A61K31/501 , C07D237/30
CPC分类号: C07D409/14 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/14
摘要: The present invention relates generally to compounds represented in Formula I, pharmaceutical compositions comprising them and methods of treating of diseases or disorders such as cancer.
摘要翻译: 本发明一般涉及式I表示的化合物,包含它们的药物组合物和治疗诸如癌症的疾病或病症的方法。
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公开(公告)号:US20110070795A1
公开(公告)日:2011-03-24
申请号:US12885178
申请日:2010-09-17
申请人: Cheryl A. Prudhomme , James Holtzinger , Gene H. Goldstein , Michael J. Tzivanis , William E. Noonan , Richard J. Austin
发明人: Cheryl A. Prudhomme , James Holtzinger , Gene H. Goldstein , Michael J. Tzivanis , William E. Noonan , Richard J. Austin
CPC分类号: B32B25/20 , B32B27/12 , B32B37/12 , B32B2037/243 , B32B2038/0076 , B32B2305/30 , B32B2307/306 , B32B2307/554 , B32B2309/12 , B32B2310/0806 , B32B2310/0887 , B32B2319/00 , C09J7/29 , C09J2203/31 , C09J2483/006 , Y10T428/2848 , Y10T428/31663 , Y10T442/2631
摘要: A thermal spray masking tape includes a substrate having a first major surface and a second major surface. The thermal spray masking tape further includes a surface layer overlying the first major surface of the substrate. The surface layer is formed from an elastomer including a liquid silicone rubber.
摘要翻译: 热喷涂掩模胶带包括具有第一主表面和第二主表面的基材。 热喷涂掩模胶带还包括覆盖在基材的第一主表面上的表面层。 表面层由包括液体硅橡胶的弹性体形成。
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