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公开(公告)号：US06890351B2
公开(公告)日：2005-05-10
申请号：US09949043
申请日：2001-09-07
CPC分类号： A61L27/58 , A61F2/02 , A61F2/06 , A61F2002/30062 , A61F2002/3024 , A61F2002/30971 , A61F2210/0004 , A61F2230/0069 , A61F2240/001 , A61L27/24 , A61L27/34 , Y10S623/917 , C08L89/06
摘要： A bioremodelable prosthesis for treating a patient with a diseased or damaged organs comprising a first layer that contains acid-extracted fibrillar or non-fibrillar collagen, and a second layer derived from the tunica submucosa of the small intestine that provides structural stability, is pliable and is semi-permeable,pe1 59564443.npc wherein the prosthesis undergoes controlled biodegradation occurring with adequate living cell replacement such that the original prosthesis is replaced by the patient's living cells.
摘要翻译： 用于治疗患有或受损器官的患者的生物可修改假体，其包括含有酸提取的纤维状或非纤维状胶原的第一层，以及衍生自提供结构稳定性的小肠粘膜下层的第二层，是柔韧的，并且 是半渗透性的，其中假体经受受控的生物降解，其具有足够的活细胞置换，使得原始假体被患者的活细胞代替。
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公开(公告)号：US07060103B2
公开(公告)日：2006-06-13
申请号：US10376788
申请日：2003-02-28
IPC分类号： A61F2/02
CPC分类号： A61L2/0088 , A61F2/0063 , A61F2/0077 , A61F2/06 , A61F2/105 , A61F2/2412 , A61F2/2475 , A61F2/442 , A61F2002/30062 , A61F2002/30929 , A61F2210/0004 , A61F2310/00365 , A61L27/24 , A61L27/3604 , A61L27/3629 , A61L27/3641 , A61L27/3687 , A61L27/58 , Y10S623/915 , Y10S623/917
摘要： A prosthesis, which, when implanted into a mammalian patient, serves as a functioning replacement for a body part, or tissue structure, and will undergo controlled biodegradation occurring concomitantly with bioremodeling by the patients living cells. The prosthesis is treated so that it is rendered non-antigenic so as not to elicit a significant humoral immune response. The prosthesis, in its various embodiments, thus has dual properties. First, it functions as a substitute body part, and second, it functions as bioremodeling template for the ingrowth of host cells.
摘要翻译： 一种假体，当植入哺乳动物患者时，其用作身体部位或组织结构的功能替代物，并将经受受控制的生物降解，伴随着患者活细胞的生物模型发生。 治疗假体使其变得非抗原性，以便不引起显着的体液免疫应答。 因此，假体在其各种实施例中具有双重性质。 首先，它用作替代体部分，其次，它用作宿主细胞向内生长的生物模型。
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公开(公告)号：US06334872B1
公开(公告)日：2002-01-01
申请号：US08889079
申请日：1997-07-07
IPC分类号： A61F200
CPC分类号： A61L27/58 , A61F2/02 , A61F2/06 , A61F2002/30062 , A61F2002/3024 , A61F2002/30971 , A61F2210/0004 , A61F2230/0069 , A61F2240/001 , A61L27/24 , A61L27/34 , Y10S623/917 , C08L89/06
摘要： This invention is directed to a method of treating a patient with diseased or damaged organs comprising administering to said patient a bioremodelable collagen-containing material which promotes the production of structural collagen, vascularization and epithelialization by the ingrowth of patient cells, wherein the material undergoes controlled biodegradation occurring with adequate living cell replacement such that the original implanted graft is bioremodeled by the patient's living cells.
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公开(公告)号：US07909886B2
公开(公告)日：2011-03-22
申请号：US11277406
申请日：2006-03-24
CPC分类号： A61L2/0088 , A61F2/0063 , A61F2/0077 , A61F2/06 , A61F2/105 , A61F2/2412 , A61F2/2475 , A61F2/442 , A61F2002/30062 , A61F2002/30929 , A61F2210/0004 , A61F2310/00365 , A61L27/24 , A61L27/3604 , A61L27/3629 , A61L27/3641 , A61L27/3687 , A61L27/58 , Y10S623/915 , Y10S623/917
摘要： This invention is directed to prosthesis, which, when implanted into a mammalian patient, serves as a functioning replacement for a body part, or tissue structure, and will undergo controlled biodegradation occurring concomitantly with bioremodeling by the patient's living cells. The prosthesis is treated so that it is rendered non-antigenic so as not to elicit a significant humoral immune response. The prosthesis of this invention, in its various embodiments, thus has dual properties. First, it functions as a substitute body part, and second, it functions as bioremodeling template for the ingrowth of host cells.
摘要翻译： 本发明涉及假体，其在植入哺乳动物患者时用作身体部位或组织结构的功能性替代物，并将经受受控的生物降解，伴随患者活细胞的生物模型发生。 治疗假体使其变得非抗原性，以便不引起显着的体液免疫应答。 因此，在其各种实施方案中，本发明的假体具有双重性质。 首先，它用作替代体部分，其次，它用作宿主细胞向内生长的生物模型。
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公开(公告)号：US5733337A
公开(公告)日：1998-03-31
申请号：US417868
申请日：1995-04-07
IPC分类号： A61L27/00 , A61F2/00 , A61F2/02 , A61F2/04 , A61F2/06 , A61F2/08 , A61F2/10 , A61F2/24 , A61F2/28 , A61F2/44 , A61L2/18 , A61L27/24 , A61L27/36 , A61L27/58
CPC分类号： A61L27/3691 , A61L2/18 , A61L27/24 , A61L27/3604 , A61L27/3687 , A61L27/58 , A61F2/0077
摘要： This invention is directed to prosthesis, which, when implanted into a mammalian patient, serve as a functioning replacement for a body part, or tissue structure, and will undergo controlled biodegradation occurring concomitantly with bioremodeling by the patient's living cells. The prosthesis of this invention, in its various embodiments, thus has dual properties. First, it functions as a substitute body part, and second, it functions as bioremodeling template for the ingrowth of host cells.
摘要翻译： 本发明涉及假体，其在植入哺乳动物患者时用作身体部位或组织结构的功能性替代物，并且将经受受控的生物降解，伴随着患者活细胞的生物模型发生。 因此，在其各种实施方案中，本发明的假体具有双重性质。 首先，它用作替代体部分，其次，它用作宿主细胞向内生长的生物模型。
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公开(公告)号：US5378469A
公开(公告)日：1995-01-03
申请号：US772529
申请日：1991-10-07
IPC分类号： A61F2/06 , A61F2/00 , A61K38/17 , A61L27/00 , A61L27/24 , A61L27/36 , A61P43/00 , D01F4/00 , A61F2/28 , A61K9/14 , A61K37/12 , C07K15/20
CPC分类号： A61L27/507 , A61L27/24 , A61L27/3808 , A61L27/3813 , A61L27/60 , D01F4/00 , A61F2310/00365 , Y10S623/901
摘要： The present invention provides improved collagen threads and methods of making and using such threads, including the production of yarn, as well as braided, knitted, and woven articles of manufacture, comprising such threads.
摘要翻译： 本发明提供了改进的胶原线以及制造和使用这种丝线的方法，包括生产纱线，以及包括这种纱线的编织，针织和编织制品。
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公开(公告)号：US08064987B2
公开(公告)日：2011-11-22
申请号：US12446644
申请日：2007-10-15
申请人： Robert M. Carr, Jr.
发明人： Robert M. Carr, Jr.
CPC分类号： A61B5/6842 , A61B90/39 , A61B2090/3908 , A61B2090/3987
摘要： Tissue markers, systems for marking tissue, and methods of using tissue markers. A tissue marker may have a body with a first surface and a second surface, a plurality of coupling sites, and a plurality of elongate members. The tissue marker may include a remotely visible material. The tissue marker may have a delivery configuration that is different from a deployed configuration.
摘要翻译： 组织标记，用于标记组织的系统和使用组织标记的方法。 组织标记可以具有带有第一表面和第二表面的主体，多个联接位置和多个细长构件。 组织标记可以包括远程可见的材料。 组织标记可以具有不同于展开配置的传送配置。
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公开(公告)号：US20100030149A1
公开(公告)日：2010-02-04
申请号：US12446644
申请日：2007-10-15
申请人： Robert M. Carr, Jr.
发明人： Robert M. Carr, Jr.
IPC分类号： A61M5/00
CPC分类号： A61B5/6842 , A61B90/39 , A61B2090/3908 , A61B2090/3987
摘要： Tissue markers, systems for marking tissue, and methods of using tissue markers. A tissue marker may have a body with a first surface and a second surface, a plurality of coupling sites, and a plurality of elongate members. The tissue marker may include a remotely visible material. The tissue marker may have a delivery configuration that is different from a deployed configuration.
摘要翻译： 组织标记，用于标记组织的系统和使用组织标记的方法。 组织标记可以具有带有第一表面和第二表面的主体，多个联接位置和多个细长构件。 组织标记可以包括远程可见的材料。 组织标记可以具有不同于展开配置的传送配置。
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公开(公告)号：US06599690B1
公开(公告)日：2003-07-29
申请号：US09450577
申请日：1999-11-30
IPC分类号： A01N102
CPC分类号： A61L27/3687 , A61K35/12 , A61K38/39 , A61L27/24 , A61L27/3695 , A61L2430/40 , Y10S623/917 , Y10S623/92
摘要： The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as proteoglycans and glycosaminoglycans, normally found in native tissues. Treatment of the tissue with alkali, chelating agents, acids and salts removes non-collagenous components from the collagenous tissue matrix while controlling the amount of swelling and dissolution so that the resultant collagen matrix retains its structural organization, integrity and bioremodelable properties. The process circumvents the need to use detergents and enzymes which detrimentally affect the cell compatibility, strength and bioremodelability of the collagen matrix. The collagenous tissue matrix is used for implantation, repair, or use in a mammalian host.
摘要翻译： 本发明涉及已被处理以去除非胶原成分如胶原组织的细胞，细胞碎片和其它细胞外基质组分，例如通常存在于天然组织中的蛋白聚糖和糖胺聚糖。 用碱处理组织，螯合剂，酸和盐从胶原组织基质中去除非胶原组分，同时控制溶胀和溶解量，使得所得到的胶原基质保持其结构组织，完整性和生物可重构性质。 该方法避免了使用有害地影响胶原基质的细胞相容性，强度和生物可塑性的洗涤剂和酶的需要。 胶原组织基质用于哺乳动物宿主的植入，修复或使用。
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公开(公告)号：US08992562B2
公开(公告)日：2015-03-31
申请号：US12880839
申请日：2010-09-13
申请人： Alexander W. Tessmer , David G. Spilka , David W. Rauch , Andrzej J. Chanduszko , Robert M. Carr, Jr.
发明人： Alexander W. Tessmer , David G. Spilka , David W. Rauch , Andrzej J. Chanduszko , Robert M. Carr, Jr.
CPC分类号： A61F2/01 , A61F2002/011 , A61F2002/016 , A61F2230/005 , A61F2230/0067 , A61F2230/008
摘要： A filter delivery device for implanting a vessel filter within a blood vessel of a patient's body. The filter delivery device includes a mechanism for preventing hooks and/or legs on a vessel filter from entangling with each other while the vessel filter is loaded within the delivery device. In one variation, the filter delivery device includes a delivery catheter with grooves at the distal end lumen opening. When a vessel filter with radially expanding legs is compressed and inserted into the distal end of the delivery catheter, the hooks on the distal end of the legs are received and separated by the corresponding grooves on the delivery catheter. In another variation, a pusher rod, with a receptacle for receiving the hooks, is positioned within a delivery catheter to prevent the entanglement of the hooks and/or legs of a filter loaded within the delivery catheter.
摘要翻译： 一种用于将血管过滤器植入患者身体的血管内的过滤器输送装置。 过滤器输送装置包括用于防止容器过滤器上的钩和/或腿彼此缠结的机构，同时容器过滤器被装载在输送装置内。 在一个变型中，过滤器输送装置包括在远端腔开口处具有凹槽的输送导管。 当具有径向扩张的腿的血管过滤器被压缩并插入输送导管的远端时，腿的远端上的钩被输送导管上的相应凹槽容纳并分离。 在另一个实施例中，具有用于接收钩的容器的推杆位于输送导管内，以防止装载在输送导管内的过滤器的钩和/或腿的缠结。
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