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1.发明授权公开(公告)号：US07915580B2
公开(公告)日：2011-03-29
申请号：US12252013
申请日：2008-10-15
申请人： Maurizio A. Splendore , Eloy R. Wouters , Michael W. Senko , Paul R. Atherton , Jean Jacques Dunyach , Christopher Mullen
发明人： Maurizio A. Splendore , Eloy R. Wouters , Michael W. Senko , Paul R. Atherton , Jean Jacques Dunyach , Christopher Mullen
IPC分类号： H01J49/06
CPC分类号： H01J49/0404 , H01J49/066
摘要： A device for improved transportation and focusing of ions in a low vacuum or atmospheric-pressure region of a mass spectrometer is constructed from one or more electro-dynamic or electrostatic focusing lenses that is/are coupled to the first electrode of a stacked ring ion guide (SRIG) to which oscillatory (e.g., radio-frequency) voltages are applied. Such configurations as disclosed herein, minimizes deleterious field effects and/or repositioning problems of desired ion transfer instruments that utilize such stacked ring ion guides by generally configuring the outlet end of the ion transfer device to a desired position within the electro-dynamic or electro-static focusing lens(es).
摘要翻译： 用于改善离子在质谱仪的低真空或大气压力区域中的运输和聚焦的装置由一个或多个电动或静电聚焦透镜构成，所述电动或静电聚焦透镜被耦合到堆叠环离子导向件的第一电极 （SRIG），施加振荡（例如，射频）电压。 通过将离子转移装置的出口端大致配置到电动态或电动式离子转移装置中的期望位置，使这种堆叠的环形离子引导件的所需离子传递装置的有害场效应和/或重新定位问题最小化， 静态聚焦透镜。
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2.发明申请公开(公告)号：US20100090104A1
公开(公告)日：2010-04-15
申请号：US12252013
申请日：2008-10-15
申请人： Maurizio A. Splendore , Eloy R. Wouters , Michael W. Senko , Paul R. Atherton , Jean Jacques Dunyach , Christopher Mullen
发明人： Maurizio A. Splendore , Eloy R. Wouters , Michael W. Senko , Paul R. Atherton , Jean Jacques Dunyach , Christopher Mullen
IPC分类号： B01D59/46
CPC分类号： H01J49/0404 , H01J49/066
摘要： A device for improved transportation and focusing of ions in a low vacuum or atmospheric-pressure region of a mass spectrometer is constructed from one or more electro-dynamic or electrostatic focusing lenses that is/are coupled to the first electrode of a stacked ring ion guide (SRIG) to which oscillatory (e.g., radio-frequency) voltages are applied. Such configurations as disclosed herein, minimizes deleterious field effects and/or repositioning problems of desired ion transfer instruments that utilize such stacked ring ion guides by generally configuring the outlet end of the ion transfer device to a desired position within the electro-dynamic or electro-static focusing lens(es).
摘要翻译： 用于改善离子在质谱仪的低真空或大气压力区域中的运输和聚焦的装置由一个或多个电动或静电聚焦透镜构成，所述电动或静电聚焦透镜被耦合到堆叠环离子导向件的第一电极 （SRIG），施加振荡（例如，射频）电压。 通过将离子转移装置的出口端大致配置到电动态或电动式离子转移装置中的期望位置，使这种堆叠的环形离子引导件的所需离子传递装置的有害场效应和/或重新定位问题最小化， 静态聚焦透镜。
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公开(公告)号：US07470899B2
公开(公告)日：2008-12-30
申请号：US11641451
申请日：2006-12-18
IPC分类号： H01J49/26
CPC分类号： H01J49/0404
摘要： An ion source includes an ion transfer tube having two segments for transporting a sample fluid containing ions between a first chamber and a second chamber maintained at a reduced pressure relative to the first chamber. A first segment may include a plurality of channels and heat conductive walls forming the plurality of channels. The plurality of channels and walls forming the channels promote efficient convective heat transfer to the sample fluid, thereby enabling operation at relatively high sample fluid flow rates, resulting in an increase in the number of ions that may be delivered to a mass analyzer. A second segment forms a single common channel that receives a plurality of sample streams and enables them to combine into a single ion stream that may be introduced as a single gas stream expansion into the second chamber.
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公开(公告)号：US20080142698A1
公开(公告)日：2008-06-19
申请号：US11641451
申请日：2006-12-18
IPC分类号： H01J49/26
CPC分类号： H01J49/0404
摘要： An ion source includes an ion transfer tube having two segments for transporting a sample fluid containing ions between a first chamber and a second chamber maintained at a reduced pressure relative to the first chamber. A first segment may include a plurality of channels and heat conductive walls forming the plurality of channels. The plurality of channels and walls forming the channels promote efficient convective heat transfer to the sample fluid, thereby enabling operation at relatively high sample fluid flow rates, resulting in an increase in the number of ions that may be delivered to a mass analyzer. A second segment forms a single common channel that receives a plurality of sample streams and enables them to combine into a single ion stream that may be introduced as a single gas stream expansion into the second chamber.
摘要翻译： 离子源包括离子传递管，其具有两个段，用于在第一腔室和第二腔室之间输送含有离子的样品流体，所述第一腔室和第二腔室相对于第一腔室保持减压。 第一段可以包括形成多个通道的多个通道和导热壁。 形成通道的多个通道和壁促进对样品流体的有效的对流热传递，从而使得能够以相对高的样品流体流速进行操作，导致可以递送到质量分析器的离子数量的增加。 第二段形成单个公共通道，其接收多个样品流并且使得它们能够组合成单个离子流，所述单个离子流可以作为单个气体流膨胀引入第二室。
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5.发明授权Method and apparatus for an ion transfer tube and mass spectrometer system using same 有权用于离子转移管和使用其的质谱仪系统的方法和装置公开(公告)号：US08242440B2
公开(公告)日：2012-08-14
申请号：US12434540
申请日：2009-05-01
IPC分类号： H01J49/04
CPC分类号： H01J49/0404
摘要： A method for analyzing a sample comprising the steps of: generating ions from the sample within an ionization chamber at substantially atmospheric pressure; entraining the ions in a background gas; transferring the background gas and entrained ions to an evacuated chamber of a mass spectrometer system using a single-piece capillary having an inlet end and an outlet end, wherein a portion of the capillary adjacent to the outlet end comprises an inner diameter that is greater than an inner diameter of an adjoining portion of the capillary; and analyzing the ions using a mass analyzer of the mass spectrometer system.
摘要翻译： 一种用于分析样品的方法，包括以下步骤：在基本上大气压下在离子化室内从样品产生离子; 在背景气体中夹带离子; 将背景气体和夹带的离子转移到使用具有入口端和出口端的单件式毛细管的质谱仪系统的真空室中，其中与出口端相邻的毛细管的一部分包括大于 毛细管的邻接部分的内径; 并使用质谱仪系统的质量分析仪分析离子。
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6.发明申请Method and Apparatus for an Ion Transfer Tube and Mass Spectrometer System Using Same 有权用于离子转移管和使用其的质谱仪系统的方法和装置公开(公告)号：US20100276584A1
公开(公告)日：2010-11-04
申请号：US12434540
申请日：2009-05-01
IPC分类号： B01D59/44
CPC分类号： H01J49/0404
摘要： A method for analyzing a sample comprising the steps of: generating ions from the sample within an ionization chamber at substantially atmospheric pressure; entraining the ions in a background gas; transferring the background gas and entrained ions to an evacuated chamber of a mass spectrometer system using an ion transfer tube having an inlet end and an outlet end, wherein a portion of the ion transfer tube adjacent to the outlet end comprises an inner diameter that is greater than an inner diameter of an adjoining portion of the ion transfer tube; and analyzing the ions using a mass analyzer of the mass spectrometer system.
摘要翻译： 一种用于分析样品的方法，包括以下步骤：在基本上大气压下在离子化室内从样品产生离子; 在背景气体中夹带离子; 使用具有入口端和出口端的离子传递管将背景气体和夹带的离子转移到质谱仪系统的抽真空室中，其中与出口端相邻的离子传输管的一部分包括更大的内径 比离子传输管的邻接部分的内径大; 并使用质谱仪系统的质量分析仪分析离子。
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公开(公告)号：US07781728B2
公开(公告)日：2010-08-24
申请号：US12125013
申请日：2008-05-21
申请人： Michael W. Senko , Viatcheslav V. Kovtoun , Paul R. Atherton , Jean Jacques Dunyach , Eloy R. Wouters , Maurizio Splendore , William Siebert
发明人： Michael W. Senko , Viatcheslav V. Kovtoun , Paul R. Atherton , Jean Jacques Dunyach , Eloy R. Wouters , Maurizio Splendore , William Siebert
CPC分类号： H01J49/065 , H01J3/14 , H01J49/066
摘要： A device for transporting and focusing ions in a low vacuum or atmospheric-pressure region of a mass spectrometer is constructed from a plurality of longitudinally spaced apart electrodes to which oscillatory (e.g., radio-frequency) voltages are applied. In order to create a tapered field that focuses ions to a narrow beam near the device exit, the inter-electrode spacing or the oscillatory voltage amplitude is increased in the direction of ion travel.
摘要翻译： 用于在质谱仪的低真空或大气压区域中输送和聚焦离子的装置由多个纵向间隔开的电极构成，施加振荡（例如，射频）电压。 为了创建将离子聚焦到设备出口附近的窄波束的锥形场，电离间隔或振荡电压振幅在离子行进方向上增加。
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公开(公告)号：US20090045062A1
公开(公告)日：2009-02-19
申请号：US12125013
申请日：2008-05-21
申请人： Michael W. Senko , Viatcheslav V. Kovtoun , Paul R. Atherton , Jean Jacques Dunyach , Eloy R. Wouters , Maurizio Splendore , William Siebert
发明人： Michael W. Senko , Viatcheslav V. Kovtoun , Paul R. Atherton , Jean Jacques Dunyach , Eloy R. Wouters , Maurizio Splendore , William Siebert
CPC分类号： H01J49/065 , H01J3/14 , H01J49/066
摘要： A device for transporting and focusing ions in a low vacuum or atmospheric-pressure region of a mass spectrometer is constructed from a plurality of longitudinally spaced apart electrodes to which oscillatory (e.g., radio-frequency) voltages are applied. In order to create a tapered field that focuses ions to a narrow beam near the device exit, the inter-electrode spacing or the oscillatory voltage amplitude is increased in the direction of ion travel.
摘要翻译： 用于在质谱仪的低真空或大气压区域中输送和聚焦离子的装置由多个纵向间隔开的电极构成，施加振荡（例如，射频）电压。 为了创建将离子聚焦到设备出口附近的窄波束的锥形场，电离间隔或振荡电压振幅在离子行进方向上增加。
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公开(公告)号：US07391019B2
公开(公告)日：2008-06-24
申请号：US11491439
申请日：2006-07-21
CPC分类号： H01J49/167 , H01J49/044
摘要： An on-axis ion source has an ionization chamber and an adjacent low-pressure region. The on-axis ion source also includes a capillary tube having an axial bore for supporting fluid communication between the ionization chamber and the adjacent low-pressure region, the axial bore of the capillary tube being substantially concentrically aligned with the orifice of a skimmer located downstream in the ion path from the capillary tube. A blocking element is provided in an aligned facing arrangement with the axial bore of the capillary tube and on an opposite side of the orifice relative to the capillary tube. The blocking element receives droplets or particles flowing through the axial bore of the capillary tube and passing through the orifice of the skimmer. The combination of an on-axis arrangement and the use of a blocking element results in improved signal-to-noise level due to enhanced ion transmission and reduction of noise arising from passage of undesolvated droplets and particles to the mass analyzer.
摘要翻译： 轴上离子源具有电离室和相邻的低压区域。 轴上离子源还包括毛细管，其具有用于支撑电离室和相邻低压区域之间的流体连通的轴向孔，毛细管的轴向孔基本上与位于下游的撇渣器的孔同心对准 在从毛细管的离子路径中。 阻挡元件设置成与毛细管的轴向孔对准并且在孔的相对侧相对于毛细管的对齐布置。 阻塞元件接收流经毛细管的轴向孔并通过撇渣器的孔的液滴或颗粒。 轴上布置和使用阻塞元件的组合导致改善的信噪比水平，这是由于增强的离子传播和减少由未被干燥的液滴和颗粒通过质量分析器而产生的噪声。
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公开(公告)号：US20080073555A1
公开(公告)日：2008-03-27
申请号：US11491439
申请日：2006-07-21
IPC分类号： H01J27/00
CPC分类号： H01J49/167 , H01J49/044
摘要： An on-axis ion source has an ionization chamber and an adjacent low-pressure region. The on-axis ion source also includes a capillary tube having an axial bore for supporting fluid communication between the ionization chamber and the adjacent low-pressure region, the axial bore of the capillary tube being substantially concentrically aligned with the orifice of a skimmer located downstream in the ion path from the capillary tube. A blocking element is provided in an aligned facing arrangement with the axial bore of the capillary tube and on an opposite side of the orifice relative to the capillary tube. The blocking element receives droplets or particles flowing through the axial bore of the capillary tube and passing through the orifice of the skimmer. The combination of an on-axis arrangement and the use of a blocking element results in improved signal-to-noise level due to enhanced ion transmission and reduction of noise arising from passage of undesolvated droplets and particles to the mass analyzer.
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