公开(公告)号：US07915580B2

公开(公告)日：2011-03-29

申请号：US12252013

申请日：2008-10-15

申请人： Maurizio A. Splendore ,  Eloy R. Wouters ,  Michael W. Senko ,  Paul R. Atherton ,  Jean Jacques Dunyach ,  Christopher Mullen

发明人： Maurizio A. Splendore ,  Eloy R. Wouters ,  Michael W. Senko ,  Paul R. Atherton ,  Jean Jacques Dunyach ,  Christopher Mullen

IPC分类号： H01J49/06

CPC分类号： H01J49/0404 ,  H01J49/066

摘要： A device for improved transportation and focusing of ions in a low vacuum or atmospheric-pressure region of a mass spectrometer is constructed from one or more electro-dynamic or electrostatic focusing lenses that is/are coupled to the first electrode of a stacked ring ion guide (SRIG) to which oscillatory (e.g., radio-frequency) voltages are applied. Such configurations as disclosed herein, minimizes deleterious field effects and/or repositioning problems of desired ion transfer instruments that utilize such stacked ring ion guides by generally configuring the outlet end of the ion transfer device to a desired position within the electro-dynamic or electro-static focusing lens(es).

摘要翻译： 用于改善离子在质谱仪的低真空或大气压力区域中的运输和聚焦的装置由一个或多个电动或静电聚焦透镜构成，所述电动或静电聚焦透镜被耦合到堆叠环离子导向件的第一电极 （SRIG），施加振荡（例如，射频）电压。 通过将离子转移装置的出口端大致配置到电动态或电动式离子转移装置中的期望位置，使这种堆叠的环形离子引导件的所需离子传递装置的有害场效应和/或重新定位问题最小化， 静态聚焦透镜。

公开(公告)号：US20100090104A1

公开(公告)日：2010-04-15

申请号：US12252013

申请日：2008-10-15

申请人： Maurizio A. Splendore ,  Eloy R. Wouters ,  Michael W. Senko ,  Paul R. Atherton ,  Jean Jacques Dunyach ,  Christopher Mullen

发明人： Maurizio A. Splendore ,  Eloy R. Wouters ,  Michael W. Senko ,  Paul R. Atherton ,  Jean Jacques Dunyach ,  Christopher Mullen

IPC分类号： B01D59/46

CPC分类号： H01J49/0404 ,  H01J49/066

摘要： A device for improved transportation and focusing of ions in a low vacuum or atmospheric-pressure region of a mass spectrometer is constructed from one or more electro-dynamic or electrostatic focusing lenses that is/are coupled to the first electrode of a stacked ring ion guide (SRIG) to which oscillatory (e.g., radio-frequency) voltages are applied. Such configurations as disclosed herein, minimizes deleterious field effects and/or repositioning problems of desired ion transfer instruments that utilize such stacked ring ion guides by generally configuring the outlet end of the ion transfer device to a desired position within the electro-dynamic or electro-static focusing lens(es).

摘要翻译： 用于改善离子在质谱仪的低真空或大气压力区域中的运输和聚焦的装置由一个或多个电动或静电聚焦透镜构成，所述电动或静电聚焦透镜被耦合到堆叠环离子导向件的第一电极 （SRIG），施加振荡（例如，射频）电压。 通过将离子转移装置的出口端大致配置到电动态或电动式离子转移装置中的期望位置，使这种堆叠的环形离子引导件的所需离子传递装置的有害场效应和/或重新定位问题最小化， 静态聚焦透镜。

公开(公告)号：US07781728B2

公开(公告)日：2010-08-24

申请号：US12125013

申请日：2008-05-21

申请人： Michael W. Senko ,  Viatcheslav V. Kovtoun ,  Paul R. Atherton ,  Jean Jacques Dunyach ,  Eloy R. Wouters ,  Maurizio Splendore ,  William Siebert

发明人： Michael W. Senko ,  Viatcheslav V. Kovtoun ,  Paul R. Atherton ,  Jean Jacques Dunyach ,  Eloy R. Wouters ,  Maurizio Splendore ,  William Siebert

IPC分类号： H01J3/14 ,  B01D59/44

CPC分类号： H01J49/065 ,  H01J3/14 ,  H01J49/066

摘要： A device for transporting and focusing ions in a low vacuum or atmospheric-pressure region of a mass spectrometer is constructed from a plurality of longitudinally spaced apart electrodes to which oscillatory (e.g., radio-frequency) voltages are applied. In order to create a tapered field that focuses ions to a narrow beam near the device exit, the inter-electrode spacing or the oscillatory voltage amplitude is increased in the direction of ion travel.

摘要翻译： 用于在质谱仪的低真空或大气压区域中输送和聚焦离子的装置由多个纵向间隔开的电极构成，施加振荡（例如，射频）电压。 为了创建将离子聚焦到设备出口附近的窄波束的锥形场，电离间隔或振荡电压振幅在离子行进方向上增加。

公开(公告)号：US20090045062A1

公开(公告)日：2009-02-19

申请号：US12125013

申请日：2008-05-21

申请人： Michael W. Senko ,  Viatcheslav V. Kovtoun ,  Paul R. Atherton ,  Jean Jacques Dunyach ,  Eloy R. Wouters ,  Maurizio Splendore ,  William Siebert

发明人： Michael W. Senko ,  Viatcheslav V. Kovtoun ,  Paul R. Atherton ,  Jean Jacques Dunyach ,  Eloy R. Wouters ,  Maurizio Splendore ,  William Siebert

IPC分类号： C25B15/00 ,  C25B9/06 ,  C25B11/02

CPC分类号： H01J49/065 ,  H01J3/14 ,  H01J49/066

摘要： A device for transporting and focusing ions in a low vacuum or atmospheric-pressure region of a mass spectrometer is constructed from a plurality of longitudinally spaced apart electrodes to which oscillatory (e.g., radio-frequency) voltages are applied. In order to create a tapered field that focuses ions to a narrow beam near the device exit, the inter-electrode spacing or the oscillatory voltage amplitude is increased in the direction of ion travel.

摘要翻译： 用于在质谱仪的低真空或大气压区域中输送和聚焦离子的装置由多个纵向间隔开的电极构成，施加振荡（例如，射频）电压。 为了创建将离子聚焦到设备出口附近的窄波束的锥形场，电离间隔或振荡电压振幅在离子行进方向上增加。

公开(公告)号：US08829463B2

公开(公告)日：2014-09-09

申请号：US13956907

申请日：2013-08-01

申请人： Michael W. Senko ,  Eloy R. Wouters

发明人： Michael W. Senko ,  Eloy R. Wouters

IPC分类号： G21K5/04

CPC分类号： H01J29/58 ,  H01J49/062

摘要： An ion transport apparatus for a mass- or ion-mobility-spectrometer comprises: (a) a plurality of strip electrodes in a series on a flat substrate; (b) an ion outlet aperture in the substrate disposed adjacent to a first one of the plurality of strip electrodes; (c) a cage electrode at least partially enclosing the plurality of strip electrodes and the ion outlet aperture; (d) a radio frequency (RF) voltage generator operable to supply an RF phase difference between each pair of adjacent electrodes; and (e) at least one DC voltage source operable to supply first and second DC voltages to the cage electrode and an extraction electrode and to supply respective DC bias voltages to each of the plurality of electrodes, wherein electrode strip widths of a series of the plurality of electrodes progressively increase away from the first one of the plurality of electrodes.

摘要翻译： 用于质量或离子迁移率光谱仪的离子迁移装置包括：（a）在平坦基底上串联的多个条状电极; （b）所述基板中的与所述多个条形电极中的第一条相邻设置的离子出口孔; （c）至少部分地包围所述多个条状电极和所述离子出口孔的笼状电极; （d）可操作以在每对相邻电极之间提供RF相位差的射频（RF）电压发生器; 和（e）至少一个DC电压源，其可操作以向所述笼电极和引出电极提供第一和第二DC电压，并向所述多个电极中的每一个提供相应的DC偏置电压，其中一系列的电极条宽度 多个电极从多个电极中的第一个逐渐增加。

公开(公告)号：US08193484B2

公开(公告)日：2012-06-05

申请号：US12849733

申请日：2010-08-03

申请人： Scott T. Quarmby ,  Michael W. Senko

发明人： Scott T. Quarmby ,  Michael W. Senko

IPC分类号： H01J49/00 ,  B01D59/44

CPC分类号： H01J49/025

摘要： A method and apparatus involve: performing a plurality of analytical scans during normal operation of a mass spectrometer having a detection section, wherein data is generated during the analytical scans in a manner that includes use of the detection section; and automatically evaluating the data from the analytical scans to monitor whether an actual gain of the detection section changes over time.

摘要翻译： 一种方法和装置包括：在具有检测部分的质谱仪的正常操作期间执行多个分析扫描，其中在分析扫描期间以包括检测部分的使用的方式产生数据; 并自动评估来自分析扫描的数据，以监测检测部分的实际增益随时间变化。

公开(公告)号：US20090014647A1

公开(公告)日：2009-01-15

申请号：US11777926

申请日：2007-07-13

申请人： Michael W. Senko

发明人： Michael W. Senko

IPC分类号： B01D59/44

CPC分类号： H01J49/004 ,  H01J49/38 ,  H01J49/422 ,  H01J49/427

摘要： The present invention pertains to a method and apparatus which increases the efficiency with which ions are transported from a first ion trap to a second ion trap, and subsequently trapped in the second ion trap. In one aspect the invention, increased efficiency takes the form or enabling ions of both high and low mass to charge ratios to be trapped in the second ion trap at substantially the same time, or at least within a relatively small window of time. This can be achieved by minimizing the undesirable time-of-flight separation by the high and low mass to charge ratio ions as they are transported from a first ion trap to the second ion trap. This minimization can be realized by adjusting the potential energy applied to ion transfer optics disposed between the two ion traps.

摘要翻译： 本发明涉及提高离子从第一离子阱传递到第二离子阱的效率的方法和装置，并随后被捕获在第二离子阱中。 在一个方面，本发明提供的效率使得高质量和低质量的电荷离子的形式或使得能够在基本上相同的时间或至少在相对较小的时间窗内被捕获在第二离子阱中。 这可以通过将高质量和低质量与电荷比的离子在从第一离子阱传输到第二离子阱时最小化不期望的飞行时间分离来实现。 这种最小化可以通过调节施加到设置在两个离子阱之间的离子传递光学器件的势能来实现。

公开(公告)号：US07425699B2

公开(公告)日：2008-09-16

申请号：US11832596

申请日：2007-08-01

申请人： Alexander Makarov ,  Mark E Hardman ,  Jae C. Schwartz ,  Michael W. Senko

发明人： Alexander Makarov ,  Mark E Hardman ,  Jae C. Schwartz ,  Michael W. Senko

IPC分类号： G01N27/62 ,  H01J49/00 ,  B01D59/44

CPC分类号： H01J49/4225 ,  G01N27/62 ,  H01J49/425

摘要： A mass spectrometer 10 comprises an ion source 12 which generates nebulized ions which enter an ion cooler 20 via an ion source block 16. Ions within a window of m/z of interest are extracted via a quadrupole mass filter 24 and passed to a linear trap 30. Ions are trapped in a potential well in the linear trap 30 and are bunched at the bottom of the potential well adjacent an exit segment 50. Ions are gated out of the linear trap 30 into an electrostatic ion trap 130 and are detected by a secondary electron multiplier 10. By bunching the ions in the linear trap 30 prior to ejection, and by focussing the ions in time of flight (TOF) upon the entrance of the electrostatic trap 130, the ions arrive at the electrostatic trap 130 as a convolution of short, energetic packets of similar m/z. Such packets are particularly suited to an electrostatic trap because the FWHM of each packet's TOF distribution is less than the period of oscillation of those ions in the electrostatic trap.

摘要翻译： 质谱仪10包括产生经由离子源块16进入离子冷却器20的雾化离子的离子源12。 通过四极质量过滤器24提取感兴趣的m / z窗口内的离子，并将其传递到线性阱30中。离子被捕获在线性阱30中的势阱中，并且在与潜在井相邻的势阱的底部聚集 离子区域从线性阱30门控进入静电离子阱130中，并由二次电子倍增器10检测。通过在排出之前聚集线性阱30中的离子，并且通过在 飞行（TOF）在静电捕获器130的入口处，离子以类似m / z的短能量分组的卷积到达静电捕获器130。 由于每个分组的TOF分布的FWHM小于静电阱中的那些离子的振荡周期，所以这样的分组特别适用于静电阱。

公开(公告)号：US20080067362A1

公开(公告)日：2008-03-20

申请号：US11429612

申请日：2006-05-05

申请人： Michael W. Senko

发明人： Michael W. Senko

IPC分类号： H01J49/42

CPC分类号： H01J49/009 ,  H01J49/4225 ,  H01J49/429

摘要： An electrode network for N parallel ion traps, wherein N is an integer larger than 1, includes at most 2N+2 electrodes, which form N trapping volumes each corresponding to a respective one of the N parallel ion traps. Also provided is a parallel mass spectrometer, comprising: a vacuum chamber and a network of at most 2N+2 electrodes disposed in the vacuum chamber and held in fixed positions with respect to each other, the network of electrodes forming N trapping volumes each corresponding one of N parallel ion traps. The network of electrodes may be arranged in first and second rows of electrodes. A plurality of detectors is positioned to receive ions ejected from the trapping volumes through spaces between adjacent electrodes in the first row of electrodes.

公开(公告)号：US07312441B2

公开(公告)日：2007-12-25

申请号：US11077105

申请日：2005-03-09

申请人： Adrian Land ,  Lee Earley ,  Mark Hardman ,  Rexford T. Heller ,  Michael W. Senko

发明人： Adrian Land ,  Lee Earley ,  Mark Hardman ,  Rexford T. Heller ,  Michael W. Senko

IPC分类号： B01D59/44

CPC分类号： H01J49/4265 ,  H01J49/40

摘要： A method of controlling the population of ions in a mass spectrometer in which a first sample of ions is provided in the mass spectrometer, a measure of abundance of a species of interest in the first sample of ions is determined, the measure of abundance comprising an intensity value, and a second sample of ions is introduced into the mass spectrometer. The second sample of ions is introduced in an amount determined at least in part on the measure of abundance of the species of interest in the first sample of ions.

摘要翻译： 一种控制质谱仪中离子质量的方法，其中在质谱仪中提供第一离子样品，确定第一离子样品中感兴趣的物种的丰度的量度，其含量为 强度值和第二离子样品引入质谱仪。 第二离子样品的引入量至少部分取决于第一离子样品中感兴趣物种丰度的量度。