公开(公告)号：US10335444B2

公开(公告)日：2019-07-02

申请号：US15100055

申请日：2015-06-10

Applicant: Pawan Kumar Goel

Inventor： Dalip Uppal ,  Ashok Sharma ,  Kiran Tewari

IPC: A61K36/74 ,  A23F5/02 ,  A23L33/105

Abstract: An extract from green coffee beans is disclosed which contains polyphenols and bioactive compounds e.g. Chlorogenic acids in a significantly higher concentration (70-80%) than in extracts of prior art methods (40-50%). The extract has greater ability to quench oxidative stress and destroy free radicals and offers health benefits due to its anti-obesity, anti-diabetic, antihypertensive, anti-tumor and anti-acid properties. The higher concentration of bioactive compounds has been achieved by use of polar solvents having polarity less than that of alcohols used for extraction. The use of such solvents of lower polarity such as n-Butyl alcohol, ethyl acetate or acetone results in extraction of enriched Chlorogenic acid fractions into the extract, leaving polar impurities behind in aqueous medium. The extract obtained has significantly higher content of polyphenols and chlorogenic acids ranging from 70-80% and a distinctive HPLC profile.

公开(公告)号：US20170252391A1

公开(公告)日：2017-09-07

申请号：US15524757

申请日：2015-02-11

Applicant: PAWAN KUMAR GOEL

Inventor： Ashok SHARMA ,  Kiran TEWARI

IPC: A61K36/48 ,  A61K9/48 ,  A61K31/7048 ,  A61K9/00

CPC classification number: A61K36/48 ,  A61K9/0053 ,  A61K9/48 ,  A61K31/7048

Abstract: Discloses is a single herb extract for the treatment of PCOS (Poly Cystic Ovarian Syndrome) when given in oral dosage form as capsules of 500 mg, twice a day for period of time ranging from 30-90 days, The extract is obtained from fenugreek seeds using a specific method of extraction and comprises five furostanolicsaponins present in synergistic ratios as in Table 1 and having analytical profile as in FIG. 1.

公开(公告)号：US20210093686A1

公开(公告)日：2021-04-01

申请号：US17007180

申请日：2020-08-31

Applicant: PAWAN KUMAR GOEL

Inventor： Ashok SHARMA ,  Kiran TEWARI

IPC: A61K36/48 ,  A61K9/00 ,  A61K9/48 ,  A61K31/7048

Abstract: Discloses is a single herb extract for the treatment of PCOS (Poly Cystic Ovarian Syndrome) when given in oral dosage form as capsules of 500 mg, twice a day for period of time ranging from 30-90 days. The extract is obtained from fenugreek seeds using a specific method of extraction and comprises five furostanolicsaponins present in synergistic ratios as in Table 1 and having analytical profile as in FIG. 1.

公开(公告)号：US08217165B2

公开(公告)日：2012-07-10

申请号：US12665279

申请日：2008-09-03

Applicant: Pawan Kumar Goel

Inventor： Pawan Kumar Goel

IPC: C07H1/06 ,  C07H1/08

CPC classification number: C07J71/0031 ,  A61K36/48

Abstract: A novel, commercially viable process for the extraction of high purity (>70%), bioactive furostanolic saponins including protodioscin (>30%), from the seeds of fenugreek (Trigonella foenumgraecum) comprising essentially the steps of powdering of the natural material followed by a first extraction, an ion-exchange chromatographic purification and a second extraction using a novel composite solvent and drying of the product under defined conditions, the entire process being carried out at essentially neutral pH and low temperatures of less than 80° C.

Abstract translation: 一种用于从葫芦巴（Trigonella foenumgraecum）的种子中提取高纯度（> 70％），包括原花青素（> 30％）的生物活性呋喃糖醇皂苷的新颖的商业上可行的方法，其基本上包括以下步骤：粉碎天然材料， 第一次萃取，离子交换色谱纯化和使用新型复合溶剂的第二次萃取，并在规定的条件下干燥产物，整个过程在基本上中性的pH值和低于80℃的低温下进行。

公开(公告)号：US20120071427A1

公开(公告)日：2012-03-22

申请号：US13322460

申请日：2010-05-28

Applicant: Pawan Kumar Goel

Inventor： Pawan Kumar Goel

IPC: A61K31/7048 ,  A61P3/10

CPC classification number: A61K36/48

Abstract: The present invention discloses a novel anti-diabetic composition extracted from fenugreek seeds. The same comprises a furostanolic-saponin-rich fraction (>70%) with approximately 30% protodioscin as one of the bioactive components. Pre-clinical studies in rats indicated significant glucose lowering effect of the fraction (31.5%) as compared to control after two weeks of oral treatment. Clinical studies in human volunteers indicated suitability of a dosage form of 500 mg given once or twice daily as anti-diabetic agent either alone or in combination with standard, synthetic anti-diabetic drugs such as metformin and glipizide in controlling plasma glucose levels.

Abstract translation: 本发明公开了从葫芦巴种子提取的新型抗糖尿病组合物。 其中含有富含富鲁丝酵素 - 富含皂苷的级分（> 70％），其中约30％原生质蛋白作为生物活性成分之一。 大鼠的临床前研究表明，两周口服治疗后，与对照组相比，该组分（31.5％）具有显着的葡萄糖降低作用。 人类志愿者的临床研究表明500mg给药剂量的适用性，每日给予一次或两次，作为抗糖尿病药，单独使用或与标准的合成抗糖尿病药物如二甲双胍和格列吡嗪组合以控制血浆葡萄糖水平。

公开(公告)号：US20170007658A1

公开(公告)日：2017-01-12

申请号：US15100055

申请日：2015-06-10

Applicant: Pawan Kumar Goel

Inventor： Dalip Uppal ,  Ashok Sharma ,  Kiran Tewari

IPC: A61K36/74 ,  A23L33/105 ,  A23F5/02

CPC classification number: A61K36/74 ,  A23F5/02 ,  A23L33/105 ,  A23V2002/00 ,  A61K2236/00 ,  A61K2236/15 ,  A61K2236/33

Abstract: An extract from green coffee beans is disclosed which contains polyphenols and bioactive compounds e.g. Chlorogenic acids in a significantly higher concentration (70-80%) than in extracts of prior art methods (40-50%). The extract has greater ability to quench oxidative stress and destroy free radicals and offers health benefits due to its anti-obesity, anti-diabetic, antihypertensive, anti-tumor and anti-acid properties. The higher concentration of bioactive compounds has been achieved by use of polar solvents having polarity less than that of alcohols used for extraction. The use of such solvents of lower polarity such as n-Butyl alcohol, ethyl acetate or acetone results in extraction of enriched Chlorogenic acid fractions into the extract, leaving polar impurities behind in aqueous medium. The extract obtained has significantly higher content of polyphenols and chlorogenic acids ranging from 70-80% and a distinctive HPLC profile.

Abstract translation: 公开了一种来自生咖啡豆的提取物，其中含有多酚和生物活性化合物， 绿原酸浓度显着高于现有技术提取物（40-50％）浓度（70-80％）。 提取物具有较强的抗氧化应激能力和破坏自由基的功能，并且由于其抗肥胖，抗糖尿病，抗高血压，抗肿瘤和抗酸性质而具有健康益处。 通过使用极性小于用于萃取的醇的极性溶剂的极性溶剂，已经实现了更高浓度的生物活性化合物。 使用较低极性的溶剂如正丁醇，乙酸乙酯或丙酮导致将富集的绿原酸馏分萃取到萃取物中，在水介质中留下极性杂质。 所提取的提取物具有显着更高的多酚和绿原酸含量，范围为70-80％和独特的HPLC谱。

公开(公告)号：US11844821B2

公开(公告)日：2023-12-19

申请号：US17007180

申请日：2020-08-31

Applicant: Pawan Kumar Goel

Inventor： Ashok Sharma ,  Kiran Tewari

IPC: A61K36/48 ,  A61K9/00 ,  A61K9/48 ,  A61K31/7048

CPC classification number: A61K36/48 ,  A61K9/0053 ,  A61K9/48 ,  A61K31/7048

Abstract: Discloses is a single herb extract for the treatment of PCOS (Poly Cystic Ovarian Syndrome) when given in oral dosage form as capsules of 500 mg, twice a day for period of time ranging from 30-90 days. The extract is obtained from fenugreek seeds using a specific method of extraction and comprises five furostanolicsaponins present in synergistic ratios as in Table 1 and having analytical profile as in FIG. 1.

公开(公告)号：US20100160616A1

公开(公告)日：2010-06-24

申请号：US12665279

申请日：2008-09-03

Applicant: Pawan Kumar Goel

Inventor： Pawan Kumar Goel

IPC: C07H1/08 ,  C07H15/24

CPC classification number: C07J71/0031 ,  A61K36/48

Abstract: A novel, commercially viable process for the extraction of high purity (>70%), bioactive furostanolic saponins including protodioscin (>30%), from the seeds of fenugreek (Trigonella foenumgraecum) comprising essentially the steps of powdering of the natural material followed by a first extraction, an ion-exchange chromatographic purification and a second extraction using a novel composite solvent and drying of the product under defined conditions, the entire process being carried out at essentially neutral pH and low temperatures of less than 80° C.

Abstract translation: 一种用于从葫芦巴（Trigonella foenumgraecum）的种子中提取高纯度（> 70％），包括原花青素（> 30％）的生物活性呋喃糖醇皂苷的新颖的商业上可行的方法，其基本上包括以下步骤：粉碎天然材料， 第一次萃取，离子交换色谱纯化和使用新型复合溶剂的第二次萃取，并在规定的条件下干燥产物，整个过程在基本上中性的pH值和低于80℃的低温下进行。

公开(公告)号：US10730869B2

公开(公告)日：2020-08-04

申请号：US16406422

申请日：2019-05-08

Applicant: Pawan Kumar Goel

Inventor： Kiran Tewari ,  Ashok Sharma

IPC: C07D459/00 ,  A61K36/24 ,  B01D11/02

Abstract: Present invention discloses a novel, commercially viable process for extraction of Alpha yohimbine from the bark, stem and leaves of Rauwolfia species. The extract is obtained by a precipitation method involving alternate steps of acidification and alkalization along with use of specific organic solvents. The extract gives higher yield of 7-8 fold as compared to other processes and without use of any column chromatography at all. Yield of alpha yohimbine from roots and leaves of Rauwolfia canescens by process of present invention was 0.017% and 0.4% respectively, indicating that leaves are a much better source. The HPLC analysis of the compound obtained indicated a purity of >90%.

公开(公告)号：US20190330203A1

公开(公告)日：2019-10-31

申请号：US16406422

申请日：2019-05-08

Applicant: Pawan Kumar GOEL

Inventor： Kiran TEWARI ,  Ashok SHARMA

IPC: C07D459/00 ,  B01D11/02

Abstract: Present invention discloses a novel, commercially viable process for extraction of Alpha yohimbine from the bark, stem and leaves of Rauwolfia species. The extract is obtained by a precipitation method involving alternate steps of acidification and alkalization along with use of specific organic solvents. The extract gives higher yield of 7-8 fold as compared to other processes and without use of any column chromatography at all. Yield of alpha yohimbine from roots and leaves of Rauwolfia canescens by process of present invention was 0.017% and 0.4% respectively, indicating that leaves are a much better source. The HPLC analysis of the compound obtained indicated a purity of >90%.