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45 条记录 (耗时 0.022 秒)

    Drill depth measuring devices and methods
    1.
    发明授权
    Drill depth measuring devices and methods 有权

    公开(公告)号：US10188406B2

    公开(公告)日：2019-01-29

    申请号：US15514400

    申请日：2015-09-25

    申请人： David G. Matsuura ,  Robert I. Gelb ,  Philip J. Simpson

    发明人： David G. Matsuura ,  Robert I. Gelb ,  Philip J. Simpson

    IPC分类号： A61B17/17 ,  A61B17/00 ,  A61B90/00

    摘要： Described herein include embodiments of devices, systems and methods for measuring drill depth, such as drill depths in bone material. For example, embodiments of drill depth measuring systems and associated methods are described. Some drill depth measuring systems can utilize at least resistance, capacitance, optical and/or acoustic sensing features for assisting the drill depth measuring system with determining drill depths and types of tissue being drilled into. Various other related features, devices and methods are also described.

    System and method for restoration of nutrient flow to nucleus pulposa
    2.
    发明授权
    System and method for restoration of nutrient flow to nucleus pulposa 有权
    恢复营养液流向髓核的系统和方法

    公开(公告)号：US08740979B2

    公开(公告)日：2014-06-03

    申请号：US11916641

    申请日：2006-06-07

    申请人： David G. Matsuura ,  Walter Dean Gillespie ,  Philip J. Simpson

    发明人： David G. Matsuura ,  Walter Dean Gillespie ,  Philip J. Simpson

    IPC分类号： A61F2/44

    CPC分类号： A61B17/00 ,  A61B17/7061 ,  A61F2002/444

    摘要： Disclosed are methods and devices for restoring or establishing nutrient flow to the nucleus pulposa. An implant comprises a nutrient flow path for extending between a source of nutrients and the nucleus pulposa. The implant is positioned within the patient such that a first end is in nutrient flow communication with a subject nucleus pulposa, and the source end is positioned in nutrient flow communication with a source of nutrients.

    摘要翻译： 公开了用于恢复或建立到髓核髓浆的营养物流的方法和装置。 植入物包括用于在营养源和髓核之间延伸的营养物流路径。 植入物定位在患者体内，使得第一端与受试者核髓浆进行营养物流连通，并且源端位于与营养源的营养流动连通中。

    Medical male luer connector with increased closing volume
    6.
    发明授权
    Medical male luer connector with increased closing volume 有权
    医用男性鲁尔连接器，增加闭合量

    公开(公告)号：US08066692B2

    公开(公告)日：2011-11-29

    申请号：US12789255

    申请日：2010-05-27

    申请人： Philip J Simpson ,  Walter D Gillespie ,  David G Matsuura

    发明人： Philip J Simpson ,  Walter D Gillespie ,  David G Matsuura

    IPC分类号： A61M25/16

    CPC分类号： A61M5/31 ,  A61M5/14 ,  A61M5/16881 ,  A61M5/3134 ,  A61M5/34 ,  A61M39/10 ,  A61M39/22 ,  A61M39/26 ,  A61M2005/3103 ,  A61M2005/3128 ,  A61M2039/1033 ,  A61M2039/1066 ,  A61M2205/19

    摘要： Disclosed herein is a valve assembly comprising a male luer end portion and a female luer end portion and a passage for the transfer of fluids extending between the male and female luer end portions, valve means movable between a first position, in which the passage is closed, and a second position, in which the passage is open, biasing means for biasing the valve means toward the first position, and actuating means extending into the male luer end portion and coupled to the valve means to actuate the valve means when a female luer end portion of a medical accessory is engaged with the male luer end portion.

    摘要翻译： 本文公开了一种阀组件，其包括阳鲁尔端部和阴鲁尔端部，以及用于传送在阳和鲁尔端部之间延伸的流体的通道，阀装置可在通道关闭的第一位置之间移动 ，以及第二位置，其中通道打开，用于将阀装置偏压朝向第一位置的偏压装置，以及致动装置，其延伸到阳鲁尔端部并联接到阀装置，以在阴路厄 医用附件的端部与阳鲁尔端部接合。

    Chlorination of sugars
    7.
    发明授权
    Chlorination of sugars 失效
    糖的氯化

    公开(公告)号：US5136031A

    公开(公告)日：1992-08-04

    申请号：US474314

    申请日：1990-07-09

    申请人： Riaz A. Khan ,  George H. Sankey ,  Philip J. Simpson ,  Nicholas M. Vernon

    发明人： Riaz A. Khan ,  George H. Sankey ,  Philip J. Simpson ,  Nicholas M. Vernon

    IPC分类号： C07H5/02 ,  C07H13/04 ,  C07H13/08

    CPC分类号： C07H5/02 ,  C07H13/04 ,  C07H13/08

    摘要： A process for the chlorination of sucrose or a derivative thereof, comprises reaction of the sucrose or derivative thereof with thionyl chloride and a nitrogen base at a ratio of about 1 molar equivalent (ME) of thionyl chloride and about 1 ME of base for every ME of free hydroxyl, in a non-reactive moderately polar solvent. The process is particularly suitable for the preparation of sucralose.

    摘要翻译： 蔗糖或其衍生物的氯化方法包括将蔗糖或其衍生物与亚硫酰氯和氮碱按每摩尔约1摩尔当量（ME）亚硫酰氯和约1ME碱的比例反应 的游离羟基，在非反应性中等极性溶剂中。 该方法特别适用于制备三氯蔗糖。

    Sucrose alkyl 4,6-orthoacylates
    8.
    发明授权
    Sucrose alkyl 4,6-orthoacylates 失效
    蔗糖烷基4,6-正酰基

    公开(公告)号：US4889928A

    公开(公告)日：1989-12-26

    申请号：US322695

    申请日：1989-03-13

    申请人： Philip J. Simpson

    发明人： Philip J. Simpson

    IPC分类号： C07H1/00 ,  C07H5/02 ,  C07H9/04 ,  C07H13/04 ,  C07H13/06 ,  C07H13/08

    CPC分类号： C07H13/04 ,  C07H13/08

    摘要： Sucrose 6-acylates, key intermediates in the preparation of sucralose, can be prepared by subjecting a sucrose alkyl 4,6-orthoacylate to mild aqueous acidic hydrolysis to provide a mixture of sucrose 4- and 6-acylates and then treating the mixture with a base to convert the 4- acylate to the 6-acylate.The novel sucrose alkyl 4,6-orthoacylates are prepared by reacting sucrose in solution or suspension in an inert organic solvent with a trialkyl orthoacrylate in the presence of an acid catalyst.

    摘要翻译： 蔗糖6-酰化物是制备三氯蔗糖的关键中间体，可以通过将4,6-正丙酸蔗糖烷基酯进行温和的酸性水解酸化来提供蔗糖4-和6-酰化物的混合物，然后用 将4-酰化物转化为6-酰化物。 通过蔗糖在惰性有机溶剂中的溶液或悬浮液与正丙酰三烷基酯在酸催化剂存在下反应来制备新的蔗糖烷基4,6-正己酸酯。

    Insertion handle for surgical implants
    10.
    发明授权
    Insertion handle for surgical implants 有权
    插入手柄用于外科植入物

    公开(公告)号：US08998924B2

    公开(公告)日：2015-04-07

    申请号：US13264498

    申请日：2010-04-15

    申请人： Philip J. Simpson ,  George A. Mansfield ,  Damien J. Shulock ,  David G. Matsuura ,  Walter Dean Gillespie ,  John E. Ashley

    发明人： Philip J. Simpson ,  George A. Mansfield ,  Damien J. Shulock ,  David G. Matsuura ,  Walter Dean Gillespie ,  John E. Ashley

    IPC分类号： A61B17/58 ,  A61B17/60 ,  A61F2/00 ,  A61F2/46 ,  A61F2/30

    CPC分类号： A61F2/4611 ,  A61F2002/30133 ,  A61F2002/30538 ,  A61F2002/4628 ,  A61F2230/0015 ,  A61F2250/0006

    摘要： An insertion handle for medical implants includes a handle with an elongate shaft extending therefrom and connection means for the implant disposed at the end of the shaft opposite the handle. The connection means includes a pivotable attachment for the implant that is controlled remotely from the handle. Both angle of the implant with respect to the handle and shaft as well as the attachment may be separately controlled and adjusted. Remote angular adjustment facilitates insertion of implants in to small surgical sites because the orientation of the implant may be repeatedly, remotely adjusted as the implant is inserted. Connectors may also be provided at the engagement surface between the handle and implant in order to provide communication with the implant or surgical site. The connectors also may serve as torque bearing members to avoid the need for separate torque bearing means such as keyways and the like.

    摘要翻译： 用于医疗植入物的插入手柄包括具有从其延伸的细长轴的手柄和用于植入物的连接装置，其设置在与手柄相对的轴的端部处。 连接装置包括用于植入物的可枢转附件，其从手柄远程地控制。 植入物相对于手柄和轴的角度以及附件可以单独控制和调整。 远程角度调节有利于将植入物插入小手术部位，因为植入物的插入方向可以重复地进行远程调整。 也可以在手柄和植入物之间的接合表面处设置连接器，以便提供与植入物或手术部位的连通。 连接器还可以用作扭矩轴承构件，以避免需要单独的扭矩承载装置，例如键槽等。