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公开(公告)号：US07399472B2
公开(公告)日：2008-07-15
申请号：US10379164
申请日：2003-03-03
CPC分类号： A61K39/39 , A61K39/0011 , A61K2039/55505 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/55577 , A61K2039/55583 , A61K2039/6068 , Y02A50/386 , Y02A50/412
摘要： The present invention relates to adjuvant compositions which are suitable to be used in vaccines. In particular, the adjuvant compositions of the present invention comprises a saponin and an immunostimulatory oligonucleotide, optionally with a carrier. Also provided by the present invention are vaccines comprising the adjuvants of the present invention and an antigen. Further provided are methods of manufacture of the adjuvants and vaccines of the present invention and their use as medicaments. Methods of treating an individual susceptible to or suffering from a disease by the administration of the vaccines of the present invention are also provided.
摘要翻译： 本发明涉及适合用于疫苗的佐剂组合物。 特别地，本发明的佐剂组合物包含皂苷和免疫刺激性寡核苷酸，任选地含有载体。 本发明还提供了包含本发明佐剂和抗原的疫苗。 还提供了制备本发明的佐剂和疫苗的方法及其作为药物的用途。 还提供了通过施用本发明的疫苗来治疗易患或患有疾病的个体的方法。
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公开(公告)号：US20080095788A1
公开(公告)日：2008-04-24
申请号：US11934206
申请日：2007-12-20
CPC分类号： A61K39/39 , A61K39/0011 , A61K2039/55505 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/55577 , A61K2039/55583 , A61K2039/6068 , Y02A50/386 , Y02A50/412
摘要： The present invention relates to adjuvant compositions which are suitable to be used in vaccines. In particular, the adjuvant compositions of the present invention comprises a saponin and an immunostimulatory oligonucleotide, optionally with a carrier. Also provided by the present invention are vaccines comprising the adjuvants of the present invention and an antigen. Further provided are methods of manufacture of the adjuvants and vaccines of the present invention and their use as medicaments. Methods of treating an individual susceptible to or suffering from a disease by the administration of the vaccines of the present invention are also provided.
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公开(公告)号：US20090155309A1
公开(公告)日：2009-06-18
申请号：US12388156
申请日：2009-02-18
申请人： Martin Friede , Veronique Henderickx , Philippe Hermand , Moncef Mohamed Saloui , Sefan Gabriel Jozef Thoelen
发明人： Martin Friede , Veronique Henderickx , Philippe Hermand , Moncef Mohamed Saloui , Sefan Gabriel Jozef Thoelen
IPC分类号： A61K39/145
CPC分类号： A61K39/39 , A61K9/0043 , A61K39/12 , A61K39/145 , A61K47/26 , A61K47/34 , A61K2039/5252 , A61K2039/543 , A61K2039/55511 , A61K2039/55555 , A61K2039/55572 , A61K2039/55577 , A61K2039/58 , A61K2039/70 , C12N7/00 , C12N2760/16134 , C12N2760/16234
摘要： The invention relates to the use of a non-live influenza virus antigen preparation, particularly a split influenza virus preparation, in the manufacture of a vaccine formulation for a one-dose intranasal vaccination against influenza, wherein the one-dose vaccination meets international regulatory requirements for influenza vaccines. Further provided are methods for the production of the vaccine, and a pharmaceutical kit comprising an intranasal administration device and the one-dose vaccine.
摘要翻译： 本发明涉及非生活流感病毒抗原制剂，特别是分裂型流感病毒制备物在制造针对流感的一次鼻内接种的疫苗制剂中的用途，其中一次性疫苗接种符合国际法规要求 用于流感疫苗。 进一步提供了用于生产疫苗的方法和包含鼻内施用装置和单剂量疫苗的药物试剂盒。
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公开(公告)号：US20080311156A1
公开(公告)日：2008-12-18
申请号：US12171770
申请日：2008-07-11
CPC分类号： A61K39/39 , A61K39/0011 , A61K2039/55505 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/55577 , A61K2039/55583 , A61K2039/6068 , Y02A50/386 , Y02A50/412
摘要： The present invention relates to adjuvant compositions which are suitable to be used in vaccines. In particular, the adjuvant compositions of the present invention comprises a saponin and an immunostimulatory oligonucleotide, optionally with a carrier. Also provided by the present invention are vaccines comprising the adjuvants of the present invention and an antigen. Further provided are methods of manufacture of the adjuvants and vaccines of the present invention and their use as medicaments. Methods of treating an individual susceptible to or suffering from a disease by the administration of the vaccines of the present invention are also provided.
摘要翻译： 本发明涉及适合用于疫苗的佐剂组合物。 特别地，本发明的佐剂组合物包含皂苷和免疫刺激性寡核苷酸，任选地含有载体。 本发明还提供了包含本发明佐剂和抗原的疫苗。 还提供了制备本发明的佐剂和疫苗的方法及其作为药物的用途。 还提供了通过施用本发明的疫苗来治疗易患或患有疾病的个体的方法。
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公开(公告)号：US06558670B1
公开(公告)日：2003-05-06
申请号：US09301829
申请日：1999-04-29
申请人： Martin Friede , Philippe Hermand
发明人： Martin Friede , Philippe Hermand
IPC分类号： A61K3939
CPC分类号： A61K39/39 , A61K2039/55561 , A61K2039/55577 , Y02A50/386
摘要： The present invention relates to adjuvant compositions which are suitable to be used in vaccines. In particular, the adjuvant compositions of the present invention comprises a saponin and an immunostimulatory oligonucleotide, preferably the saponins used in said adjuvant combinations are haemolytic. Also provided by the present invention are vaccines comprising the adjuvants of the present invention and an antigen. Further provided are methods of manufacture of the adjuvants and vaccines of the present invention and their use as medicaments.
摘要翻译： 本发明涉及适合用于疫苗的佐剂组合物。 特别地，本发明的佐剂组合物包含皂角苷和免疫刺激性寡核苷酸，优选在所述佐剂组合中使用的皂苷溶液是溶血性的。 本发明还提供了包含本发明佐剂和抗原的疫苗。 还提供了制备本发明的佐剂和疫苗的方法及其作为药物的用途。
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公开(公告)号：US20080081050A1
公开(公告)日：2008-04-03
申请号：US11745006
申请日：2007-05-07
申请人： Philippe Hermand , Craig Laferriere , Yves Lobet , Jan Poolman
发明人： Philippe Hermand , Craig Laferriere , Yves Lobet , Jan Poolman
CPC分类号： A61K39/092 , A61K39/0208 , A61K39/095 , A61K39/102 , A61K39/13 , A61K39/292 , A61K2039/55 , A61K2039/55572 , A61K2039/6068 , Y02A50/396 , Y02A50/466
摘要： The present invention relates to a combination of 2 or more S pneumoniae proteins, their manufacture and use in medicine as a vaccine. Such combinations are particularly useful for the protection of infants and elderly against streptococcal infection.
摘要翻译： 本发明涉及2种或更多种肺炎衣原体蛋白的组合，其在药物中的制造和用途作为疫苗。 这种组合对于保护婴幼儿免受链球菌感染特别有用。
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公开(公告)号：US06544518B1
公开(公告)日：2003-04-08
申请号：US09690921
申请日：2000-10-18
IPC分类号： A61K3900
CPC分类号： A61K39/39 , A61K39/0011 , A61K2039/55505 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/55577 , A61K2039/55583 , A61K2039/6068 , Y02A50/386 , Y02A50/412
摘要： The present invention relates to adjuvant compositions which are suitable to be used in vaccines. In particular, the adjuvant compositions of the present invention comprises a saponin and an immunostimulatory oligonucleotide, optionally with a carrier. Also provided by the present invention are vaccines comprising the adjuvants of the present invention and an antigen. Further provided are methods of manufacture of the adjuvants and vaccines of the present invention and their use as medicaments. Methods of treating an individual susceptible to or suffering from a disease by the administration of the vaccines of the present invention are also provided.
摘要翻译： 本发明涉及适合用于疫苗的佐剂组合物。 特别地，本发明的佐剂组合物包含皂苷和免疫刺激性寡核苷酸，任选地含有载体。 本发明还提供了包含本发明佐剂和抗原的疫苗。 还提供了制备本发明的佐剂和疫苗的方法及其作为药物的用途。 还提供了通过施用本发明的疫苗来治疗易患或患有疾病的个体的方法。
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公开(公告)号：US20050201946A1
公开(公告)日：2005-09-15
申请号：US11119994
申请日：2005-05-02
IPC分类号： A61K47/08 , A61K9/00 , A61K39/145 , A61K39/39 , A61K47/10 , A61K47/14 , A61K47/28 , A61K47/36 , A61P31/16 , A61L9/04
CPC分类号： A61K39/39 , A61K9/0043 , A61K39/12 , A61K39/145 , A61K47/26 , A61K47/34 , A61K2039/5252 , A61K2039/543 , A61K2039/55511 , A61K2039/55555 , A61K2039/55572 , A61K2039/55577 , A61K2039/58 , A61K2039/70 , C12N7/00 , C12N2760/16134 , C12N2760/16234
摘要： Aminopiperidine derivatives and pharmaceutically acceptable derivatives thereof are disclosed. Such derivatives are useful in methods of treatment of bacterial infections in mammals, particularly in man.
摘要翻译： 公开了氨基哌啶衍生物及其药学上可接受的衍生物。 这样的衍生物可用于哺乳动物，特别是人的细菌感染的治疗方法。
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公开(公告)号：US20050004915A1
公开(公告)日：2005-01-06
申请号：US10442263
申请日：2003-05-21
CPC分类号： G06F16/335
摘要： A method generates names that are different from those comprised in a set of existing names. A set of patterns is provided and one of the patterns of the set is selected. The pattern is then actualized to provide a list of candidate names. The list of candidate names is then filtered against the set of existing names to provide names, which are different from those comprised in the set of existing names. The method makes it possible to generate domain names, uniform resource locators, trademarks or the like.
摘要翻译： 一种方法生成与现有名称集中包含的名称不同的名称。 提供了一组图案，并且选择了一组图案。 然后，该模式被实现以提供候选名称的列表。 然后将候选名称列表与现有名称集合进行过滤，以提供与现有名称集中包含的名称不同的名称。 该方法可以生成域名，统一资源定位器，商标等。
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