Process for the manufacture of prosthetic elements and elements produced
thereby
    1.
    发明授权
    Process for the manufacture of prosthetic elements and elements produced thereby 失效
    用于制造由此制造的假体元件和元件的方法

    公开(公告)号:US5275717A

    公开(公告)日:1994-01-04

    申请号:US778061

    申请日:1992-01-30

    IPC分类号: A61C8/00 A61C13/00 C25D11/04

    摘要: Process for the manufacture of dental or maxillo-facial prostheses, particularly endo-osseous prostheses or pivots, in which a layer of pure aluminum is deposited on a conductive substrate, preferably a metal, which forms the core of the prosthesis. The aluminum layer is obtained by electrochemical deposition of pure aluminum with non-aqueous electrolyte base of the type which has an aluminumorganic complex bath. The layer is then oxidized by anodization such that an alumina layer which is sealed and electrically insulated, is obtained, separating the core and the biological tissues surrounding the prosthesis.

    摘要翻译: PCT No.PCT / FR90 / 00391 Sec。 371日期:1992年1月30日 102(e)日期1992年1月30日PCT提交1990年6月5日PCT公布。 WO90 / 14801 PCT出版物 日期1990年12月13日。用于制造牙科或上颌面部假体的方法,特别是内骨假体或枢轴,其中纯铝层沉积在导电基底上,优选金属形成核心 假体。 铝层通过电化学沉积纯铝与非水电解质碱获得,该非水电解质碱是具有铝有机络合物浴的类型。 然后通过阳极氧化使该层氧化,使得获得密封和电绝缘的氧化铝层,分离芯和假体周围的生物组织。

    Immunogenic compositions comprising a xenogenic prostate protein p501s
    3.
    发明申请
    Immunogenic compositions comprising a xenogenic prostate protein p501s 审中-公开
    包含异种前列腺蛋白p501s的免疫原性组合物

    公开(公告)号:US20060140965A1

    公开(公告)日:2006-06-29

    申请号:US10517552

    申请日:2003-06-06

    IPC分类号: A61K48/00 A61K39/00

    CPC分类号: A61K39/0011

    摘要: The present invention relates to pharmaceutical/immunogenic compositions and methods for inducing an immune response against tumour-related antigens. More specifically, the invention relates to non-human prostate-specific antigens, more precisely to the non-human prostate-specific P501S, which can be used as xenogeneic antigen in prostate cancer vaccine therapy and as diagnostic agents for prostate tumours in humans, to immunogenic compositions containing them, to methods of manufacture of such compositions and to their use in medicine. Methods for formulating vaccines for immunotherapeutically treating P501S-expressing prostate tumors, prostatic hyperplasia, and prostate intraepithelilial neoplasia (PIN) are also provided.

    摘要翻译: 本发明涉及用于诱导针对肿瘤相关抗原的免疫应答的药物/免疫原性组合物和方法。 更具体地,本发明涉及非人前列腺特异性抗原,更准确地涉及非人前列腺特异性P501S,其可以用作前列腺癌疫苗治疗中的异种抗原,并用作人类前列腺肿瘤的诊断剂, 含有它们的免疫原性组合物,这些组合物的制造方法及其在医学中的应用。 还提供了用于免疫治疗性治疗P501S表达前列腺肿瘤,前列腺增生和前列腺上皮内瘤变(PIN)的疫苗配制方法。