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公开(公告)号：US09050286B2
公开(公告)日：2015-06-09
申请号：US12673375
申请日：2008-08-08
申请人： Regent Laporte , Pierre J-M Riviere
发明人： Regent Laporte , Pierre J-M Riviere
摘要： The present invention relates to the use of novel compounds for the manufacture of a medicament for treatment of inter alia conditions associated with critical care as well as to a method for treatment of said conditions, wherein said compounds are administered. The compounds utilized are represented by the general formula (I), as further defined in the specification.
摘要翻译： 本发明涉及新化合物在制备用于治疗特别是与重症监护有关的病症的药物中的用途，以及治疗所述病症的方法，其中施用所述化合物。 所使用的化合物由通式（I）表示，如说明书中进一步定义的。
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公开(公告)号：US20110237494A1
公开(公告)日：2011-09-29
申请号：US12673375
申请日：2008-08-08
申请人： Regent Laporte , Pierre J-M Riviere
发明人： Regent Laporte , Pierre J-M Riviere
摘要： The present invention relates to the use of novel compounds for the manufacture of a medicament for treatment of inter alia conditions associated with critical care as well as to a method for treatment of said conditions, wherein said compounds are administered. The compounds utilised are represented by the general formula (I), as further defined in the specification.
摘要翻译： 本发明涉及新化合物在制备用于治疗特别是与重症监护有关的病症的药物中的用途，以及治疗所述病症的方法，其中施用所述化合物。 所使用的化合物由通式（I）表示，如说明书中进一步定义的。
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公开(公告)号：US08222202B2
公开(公告)日：2012-07-17
申请号：US12223673
申请日：2007-02-12
摘要： The present invention relates to the use of novel compounds for the manufacture of a medicament for treatment of, inter alia, conditions associated with critical care sepsis, septic shock, hepatorenal syndrome type I, hypertension induced by endstage venal disease, severe burns, thermal injury as well as to a method for treatment of the conditions by administering the compounds. The compounds used are represented by the general formula (1), as further defined in the specification.
摘要翻译： 本发明涉及新化合物用于制造药物的用途，所述药物尤其用于治疗与重症监护脓毒症，脓毒性休克，I型肝肾综合征，终末期病变引起的高血压，严重烧伤，热损伤 以及通过施用化合物治疗病症的方法。 所使用的化合物由通式（I）表示，如说明书中进一步定义的。
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4.发明申请公开(公告)号：US20100105777A1
公开(公告)日：2010-04-29
申请号：US12390969
申请日：2009-02-23
申请人： Chia-Ping CHANG , Jacek STALEWSKI , Pierre J-M. RIVIERE , Kazimierz A. WISNIEWSKI , Claudio D. SCHTEINGART
发明人： Chia-Ping CHANG , Jacek STALEWSKI , Pierre J-M. RIVIERE , Kazimierz A. WISNIEWSKI , Claudio D. SCHTEINGART
CPC分类号： C07C229/12 , C07C229/34 , C07C271/54
摘要： The present invention relates to novel compounds, pharmaceutical compositions comprising the same, use of said compounds for the manufacture of a medicament for treatment of pain and disorders related thereto as well as a method for treatment of pain and disorders related thereto, wherein said compounds are administered. The compounds are represented by the general formula (I), as further defined in the specification.
摘要翻译： 本发明涉及新化合物，包含其的药物组合物，所述化合物在制备用于治疗与其相关的疼痛和病症的药物中的用途以及治疗与之有关的疼痛和病症的方法，其中所述化合物为 管理。 化合物由通式（I）表示，如说明书中进一步定义的。
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公开(公告)号：US20080108562A1
公开(公告)日：2008-05-08
申请号：US10587184
申请日：2005-01-13
CPC分类号： A61K38/29
摘要： Symptoms associated with the growth of bone-metastasized cancer or bone-originated cancer, such as bone loss, bone fracturing, and pain, can be ameliorated by administering a effective amount of a PTH receptor agonist, which can be PTH, a PTH fragment, or an analog thereof or parathyroid hormone-related protein, a fragment or an analog thereof.
摘要翻译： 通过施用有效量的PTH受体激动剂可以改善与骨转移的癌症或骨源性癌症（例如骨丢失，骨折和疼痛）的生长相关的症状，其可以是PTH，PTH片段， 或其类似物或甲状旁腺激素相关蛋白，其片段或类似物。
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公开(公告)号：US07157241B2
公开(公告)日：2007-01-02
申请号：US10982512
申请日：2004-11-05
CPC分类号： C12N9/48 , C12N2799/026
摘要： Novel proteins or polypeptides having significant sequence homology to DPPIV, nucleic acids coding therefor, cells which have been modified with such nucleic acid so as to express these proteins, antibodies to these proteins, screening methods for the discovery of new therapeutic agents which are inhibitors of the activity of these proteins or of related proteins, and therapeutic agents discovered by such screening methods, as well as new therapeutic treatments, are all provided.
摘要翻译： 与DPPIV具有显着序列同源性的新型蛋白质或多肽，其编码的核酸，已经用此类核酸修饰以表达这些蛋白质的细胞，对这些蛋白质的抗体，用于发现作为这些蛋白质的抑制剂的新治疗剂的筛选方法 这些蛋白质或相关蛋白质的活性以及通过这种筛选方法发现的治疗剂以及新的治疗方法都被提供。
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公开(公告)号：US06844180B2
公开(公告)日：2005-01-18
申请号：US09976674
申请日：2001-10-12
IPC分类号： G01N33/50 , A61K45/00 , A61P3/14 , A61P7/02 , A61P9/10 , A61P9/12 , A61P17/06 , A61P21/04 , A61P25/08 , A61P25/14 , A61P31/12 , A61P35/02 , A61P43/00 , C07K16/40 , C12N1/21 , C12N5/10 , C12N9/48 , C12N9/64 , C12N15/09 , C12Q1/37 , G01N33/15 , G01N33/53 , G01N33/566 , C12N9/62 , C07H21/04 , C12N1/20 , C12N5/00 , C12N15/00
CPC分类号： C12N9/48 , C12N2799/026
摘要： Novel proteins or polypeptides having significant sequence homology to DPPIV, nucleic acids coding therefor, cells which have been modified with such nucleic acid so as to express these proteins, antibodies to these proteins, screening methods for the discovery of new therapeutic agents which are inhibitors of the activity of these proteins or of related proteins, and therapeutic agents discovered by such screening methods, as well as new therapeutic treatments, are all provided.
摘要翻译： 与DPPIV具有显着序列同源性的新型蛋白质或多肽，其编码的核酸，已经用此类核酸修饰以表达这些蛋白质的细胞，对这些蛋白质的抗体，用于发现作为这些蛋白质的抑制剂的新治疗剂的筛选方法 这些蛋白质或相关蛋白质的活性以及通过这种筛选方法发现的治疗剂以及新的治疗方法都被提供。
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8.发明授权Use of fedotozine in the treatment of functional states of intestinal obstructions 失效使用fedotozine治疗肠梗阻功能状态
公开(公告)号：US5362756A
公开(公告)日：1994-11-08
申请号：US937127
申请日：1992-08-31
IPC分类号： C07C217/48 , A61K31/135
CPC分类号： C07C217/48
摘要： A process for inhibiting functional ileus in a patient, which consists of administering a therapeutically effective dose of (+)-1-1[(3,4,5-trimethoxy)benzyloxymethyl]-1-phenyl-N,N dimethylpropylamine or the addition salt thereof with (-)-tartaric acid is disclosed.
摘要翻译： 一种用于抑制患者功能性肠梗阻的方法，其包括施用治疗有效剂量的（+） - 1-1 [（3,4,5-三甲氧基）苄氧基甲基] -1-苯基-N，N二甲基丙胺或加成 公开了其与（ - ） - 酒石酸的盐。
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