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    Sulphonamide derivatives, their preparation and their therapeutic application
    4.
    发明授权
    Sulphonamide derivatives, their preparation and their therapeutic application 失效
    磺酰胺衍生物，其制备及其治疗应用

    公开(公告)号：US07396958B2

    公开(公告)日：2008-07-08

    申请号：US11670586

    申请日：2007-02-02

    申请人： Gilles Courtemanche ,  Pierre Despeyroux ,  Evelyne Fontaine ,  Pierrick Rochard ,  Claudine Serradeil-Le Gal

    发明人： Gilles Courtemanche ,  Pierre Despeyroux ,  Evelyne Fontaine ,  Pierrick Rochard ,  Claudine Serradeil-Le Gal

    IPC分类号： C07C303/00 ,  A01N41/06

    CPC分类号： C07D213/42 ,  C07C311/21 ,  C07C311/29 ,  C07C311/44 ,  C07D217/06 ,  C07D233/64 ,  C07D257/04 ,  C07D271/06 ,  C07D277/28 ,  C07D317/62 ,  C07D319/18 ,  C07D333/20

    摘要： Disclosed are compounds having the general formula (I) as defined herein, the preparation thereof, and the use thereof for the prophylaxis or treatment of any disease involving a dysfunction associated with the orexin 2 receptor such as obesity, appetite or taste disorders including cachexia, anorexia and bulimia, diabetes, metabolic syndromes, vomiting and nausea, depression and anxiety, addictions, mood and behaviour disorders, schizophrenia, sleep disorders, restless legs syndrome, memory learning disorders, sexual and psychosexual dysfunctions, pain, visceral or neuropathic pain, hyperalgesia, allodynia, digestive disorders, irritable bowel syndrome, neuronal degenerescence, ischaemic or haemorrhagic attacks, Cushing's disease, Guillain-Barré syndrome, myotonic dystrophy, urinary incontinence, hyperthyroidism, pituitary function disorders, hypertension or hypotension.

    摘要翻译： 公开了具有本文所定义的通式（I）的化合物，其制备方法及其用于预防或治疗涉及食欲肽2受体相关功能障碍的任何疾病，例如肥胖，食欲或味觉障碍，包括恶病质， 厌食和贪食症，糖尿病，代谢综合征，呕吐和恶心，抑郁和焦虑，瘾，情绪和行为障碍，精神分裂症，睡眠障碍，不宁腿综合征，记忆学习障碍，性和心理性功能障碍，疼痛，内脏或神经性疼痛，痛觉过敏 ，异常性疼痛，消化系统疾病，肠易激综合征，神经元脱色，缺血性或出血性发作，库欣氏病，吉兰巴利综合征，强直性营养不良，尿失禁，甲状腺机能亢进，垂体功能障碍，高血压或低血压。

    SULPHONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
    6.
    发明申请
    SULPHONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION 失效
    磺酰胺衍生物，其制备及其治疗应用

    公开(公告)号：US20070185136A1

    公开(公告)日：2007-08-09

    申请号：US11670586

    申请日：2007-02-02

    申请人： Gilles COURTEMANCHE ,  Pierre DESPEYROUX ,  Evelyne FONTAINE ,  Pierrick ROCHARD ,  Claudine SERRADEIL-LE GAL

    发明人： Gilles COURTEMANCHE ,  Pierre DESPEYROUX ,  Evelyne FONTAINE ,  Pierrick ROCHARD ,  Claudine SERRADEIL-LE GAL

    IPC分类号： A61K31/506 ,  A61K31/4709 ,  A61K31/4433 ,  A61K31/427 ,  A61K31/381

    CPC分类号： C07D213/42 ,  C07C311/21 ,  C07C311/29 ,  C07C311/44 ,  C07D217/06 ,  C07D233/64 ,  C07D257/04 ,  C07D271/06 ,  C07D277/28 ,  C07D317/62 ,  C07D319/18 ,  C07D333/20

    摘要： Disclosed are compounds having the general formula (I) as defined herein, the preparation thereof, and the use thereof for the prophylaxis or treatment of any disease involving a dysfunction associated with the orexin 2 receptor such as obesity, appetite or taste disorders including cachexia, anorexia and bulimia, diabetes, metabolic syndromes, vomiting and nausea, depression and anxiety, addictions, mood and behaviour disorders, schizophrenia, sleep disorders, restless legs syndrome, memory learning disorders, sexual and psychosexual dysfunctions, pain, visceral or neuropathic pain, hyperalgesia, allodynia, digestive disorders, irritable bowel syndrome, neuronal degenerescence, ischaemic or haemorrhagic attacks, Cushing's disease, Guillain-Barré syndrome, myotonic dystrophy, urinary incontinence, hyperthyroidism, pituitary function disorders, hypertension or hypotension.

    摘要翻译： 公开了具有本文所定义的通式（I）的化合物，其制备方法及其用于预防或治疗涉及食欲肽2受体相关功能障碍的任何疾病，例如肥胖，食欲或味觉障碍，包括恶病质， 厌食和贪食症，糖尿病，代谢综合征，呕吐和恶心，抑郁和焦虑，瘾，情绪和行为障碍，精神分裂症，睡眠障碍，不宁腿综合征，记忆学习障碍，性和心理性功能障碍，疼痛，内脏或神经性疼痛，痛觉过敏 ，异常性疼痛，消化系统疾病，肠易激综合征，神经元脱色，缺血性或出血性发作，库欣氏病，吉兰巴利综合征，强直性营养不良，尿失禁，甲状腺功能亢进，垂体功能障碍，高血压或低血压。