利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

19 条记录 (耗时 0.03 秒)

    Sulphonamide derivatives, their preparation and their therapeutic application
    2.
    发明授权
    Sulphonamide derivatives, their preparation and their therapeutic application 失效
    磺酰胺衍生物，其制备及其治疗应用

    公开(公告)号：US07396958B2

    公开(公告)日：2008-07-08

    申请号：US11670586

    申请日：2007-02-02

    申请人： Gilles Courtemanche ,  Pierre Despeyroux ,  Evelyne Fontaine ,  Pierrick Rochard ,  Claudine Serradeil-Le Gal

    发明人： Gilles Courtemanche ,  Pierre Despeyroux ,  Evelyne Fontaine ,  Pierrick Rochard ,  Claudine Serradeil-Le Gal

    IPC分类号： C07C303/00 ,  A01N41/06

    CPC分类号： C07D213/42 ,  C07C311/21 ,  C07C311/29 ,  C07C311/44 ,  C07D217/06 ,  C07D233/64 ,  C07D257/04 ,  C07D271/06 ,  C07D277/28 ,  C07D317/62 ,  C07D319/18 ,  C07D333/20

    摘要： Disclosed are compounds having the general formula (I) as defined herein, the preparation thereof, and the use thereof for the prophylaxis or treatment of any disease involving a dysfunction associated with the orexin 2 receptor such as obesity, appetite or taste disorders including cachexia, anorexia and bulimia, diabetes, metabolic syndromes, vomiting and nausea, depression and anxiety, addictions, mood and behaviour disorders, schizophrenia, sleep disorders, restless legs syndrome, memory learning disorders, sexual and psychosexual dysfunctions, pain, visceral or neuropathic pain, hyperalgesia, allodynia, digestive disorders, irritable bowel syndrome, neuronal degenerescence, ischaemic or haemorrhagic attacks, Cushing's disease, Guillain-Barré syndrome, myotonic dystrophy, urinary incontinence, hyperthyroidism, pituitary function disorders, hypertension or hypotension.

    摘要翻译： 公开了具有本文所定义的通式（I）的化合物，其制备方法及其用于预防或治疗涉及食欲肽2受体相关功能障碍的任何疾病，例如肥胖，食欲或味觉障碍，包括恶病质， 厌食和贪食症，糖尿病，代谢综合征，呕吐和恶心，抑郁和焦虑，瘾，情绪和行为障碍，精神分裂症，睡眠障碍，不宁腿综合征，记忆学习障碍，性和心理性功能障碍，疼痛，内脏或神经性疼痛，痛觉过敏 ，异常性疼痛，消化系统疾病，肠易激综合征，神经元脱色，缺血性或出血性发作，库欣氏病，吉兰巴利综合征，强直性营养不良，尿失禁，甲状腺机能亢进，垂体功能障碍，高血压或低血压。

    Cyclohexyl(alkyl)propanolamines, preparation method and pharmaceutical compositions containing same
    4.
    发明授权
    Cyclohexyl(alkyl)propanolamines, preparation method and pharmaceutical compositions containing same 有权

    公开(公告)号：US07419974B2

    公开(公告)日：2008-09-02

    申请号：US11464537

    申请日：2006-08-15

    申请人： Philippe R. Bovy ,  Roberto Cecchi ,  Gilles Courtemanche ,  Tiziano Croci ,  Ambrogio Oliva ,  Nunzia Viviani

    发明人： Philippe R. Bovy ,  Roberto Cecchi ,  Gilles Courtemanche ,  Tiziano Croci ,  Ambrogio Oliva ,  Nunzia Viviani

    IPC分类号： A61K31/216 ,  A61K31/423 ,  A61K31/553 ,  A61K31/401

    CPC分类号： C07C311/21 ,  C07C229/46 ,  C07C311/08 ,  C07C317/22 ,  C07C2601/14

    摘要： The present invention relates to the compounds of formula (I): in which A is a group of formula (a) or (b) in which R represents a hydrogen or halogen atom, an —S(O)z(C1-C4)alkyl group, an —NHSO2(C1-C4)alkyl group, an —SO2NH(C1-C4)alkyl group, an —NHSO2phenyl-(C1-C4)alkyl group or an —NHSO2phenyl group, said phenyl possibly being substituted with a halogen atom, with a (C1-C4)alkyl group or with a (C1-C4)alkoxy group; R1 represents a hydrogen atom or a (C1-C4)alkyl group, a —CO(C1-C4)alkyl group, a phenyl-(C1-C4)alkyl group or a —COphenyl group, said phenyl also possibly being substituted with a halogen atom or with a (C1-C4)alkoxy group; R2 is a hydrogen atom or an —SO2(C1-C4)alkyl group, an —SO2phenyl-(C1-C4)alkyl group or an —SO2phenyl group; X completes a ring of 5 to 8 atoms, said ring being saturated or unsaturated, possibly being substituted with one or two (C1-C4)alkyl groups and bearing one or two carbonyl groups; n, m and z are, independently, 0, 1 or 2; R3 represents a hydrogen or halogen atom, a (C1-C6)alkyl group, a (C1-C4)alkoxy group, a —COO(C1-C4)alkyl group, a —CO(C1-C4)alkyl group, an —NHSO2(C1-C4)alkyl group, an —NHSO2phenyl-(C1-C4)alkyl groups, —NO2, —CN, —CONR4R5, —COOH, or a 4,5-dihydro-1,3-oxazol-2-yl or 4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl group; R4 and R5 represent, independently, a hydrogen atom, a phenyl, a (C1-C4)alkyl group or a phenyl-(C1-C4)alkyl group or R4 and R5 with the nitrogen atom to which they are attached, may form a ring of 5 to 7 atoms in total; and to the salts or solvates thereof, to the pharmaceutical compositions containing them, to a process for the preparation thereof and to intermediates in this process.

    Method for producing glass sheets using flotation
    5.
    发明授权
    Method for producing glass sheets using flotation 失效
    使用浮选制造玻璃板的方法

    公开(公告)号：US6089043A

    公开(公告)日：2000-07-18

    申请号：US952215

    申请日：1998-04-09

    申请人： Gilles Courtemanche ,  Michel Coquillon

    发明人： Gilles Courtemanche ,  Michel Coquillon

    IPC分类号： C03B18/06 ,  C03B13/00 ,  C03B18/00 ,  C03B18/02

    CPC分类号： C03B18/06

    摘要： The present invention relates to a process for the manufacture of glass sheets, according to which molten glass is poured into a liquid support which is denser than the glass to form a glass strip. The glass strip is drawn and is accompanied in its movement using a continuous and flexible guiding element made of a solid material capable of adhering to the molten glass, the elements being brought into contact with the side edges of the strip. The product (P) of the value (s) of the speed of the strip and of the value (t) of its final thickness is less than 2.5.times.10.sup.-4 m.sup.2 s.sup.-1. The process makes it possible to obtain thin glass sheets exhibiting a constant thickness and a satisfactory optical quality.

    摘要翻译： PCT No.PCT / FR97 / 00555 Sec。 371日期：1998年4月9日 102（e）1998年4月9日PCT 1997年3月27日PCT公布。 公开号WO97 / 37945 PCT 日期1997年10月16日本发明涉及一种玻璃板的制造方法，根据该方法，将熔融玻璃倒入比玻璃更密的液体载体中以形成玻璃带。 玻璃带被拉伸并伴随其运动，使用由能够粘附到熔融玻璃上的固体材料制成的连续且柔性的引导元件，元件与条的侧边缘接触。 带材的速度值和其最终厚度的值（t）的乘积（P）小于2.5×10 -4 m 2·s -1。 该方法可以获得具有恒定厚度和令人满意的光学质量的薄玻璃板。

    Cyclohexyl(alkyl)propanolamines, preparation method and pharmaceutical compositions containing same
    7.
    发明授权
    Cyclohexyl(alkyl)propanolamines, preparation method and pharmaceutical compositions containing same 有权

    公开(公告)号：US07622460B2

    公开(公告)日：2009-11-24

    申请号：US12144843

    申请日：2008-06-24

    申请人： Philippe R. Bovy ,  Roberto Cecchi ,  Gilles Courtemanche ,  Tiziano Croci ,  Ambrogio Oliva ,  Nunzia Viviani

    发明人： Philippe R. Bovy ,  Roberto Cecchi ,  Gilles Courtemanche ,  Tiziano Croci ,  Ambrogio Oliva ,  Nunzia Viviani

    IPC分类号： A61K31/553 ,  C07D263/54 ,  C07D267/02 ,  C07C311/01

    摘要： The present invention relates to the compounds of formula (I): in which A is a group of formula (a) or (b) in which R represents a hydrogen or halogen atom, an —S(O)z(C1-C4)alkyl group, an —NHSO2(C1-C4)alkyl group, an —SO2NH(C1-C4)alkyl group, an —NHSO2phenyl-(C1-C4)alkyl group or an —NHSO2phenyl group, said phenyl possibly being substituted with a halogen atom, with a (C1-C4)alkyl group or with a (C1-C4)alkoxy group; R1 represents a hydrogen atom or a (C1-C4)alkyl group, a —CO(C1-C4)alkyl group, a phenyl-(C1-C4)alkyl group or a —COphenyl group, said phenyl also possibly being substituted with a halogen atom or with a (C1-C4)alkoxy group; R2 is a hydrogen atom or an —SO2(C1-C4)alkyl group, an —SO2phenyl-(C1-C4)alkyl group or an —SO2phenyl group; X completes a ring of 5 to 8 atoms, said ring being saturated or unsaturated, possibly being substituted with one or two (C1-C4)alkyl groups and bearing one or two carbonyl groups; n, m and z are, independently, 0, 1 or 2; R3 represents a hydrogen or halogen atom, a (C1-C6)alkyl group, a (C1-C4)alkoxy group, a —COO(C1-C4)alkyl group, a —CO(C1-C4)alkyl group, an —NHSO2(C1-C4)alkyl group, an —NHSO2phenyl-(C1-C4)alkyl groups, —NO2, —CN, —CONR4R5, —COOH, or a 4,5-dihydro-1,3-oxazol-2-yl or 4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl group; R4 and R5 represent, independently, a hydrogen atom, a phenyl, a (C1-C4)alkyl group or a phenyl-(C1-C4)alkyl group or R4 and R5 with the nitrogen atom to which they are attached, may form a ring of 5 to 7 atoms in total; and to the salts or solvates thereof, to the pharmaceutical compositions containing them, to a process for the preparation thereof and to intermediates in this process.

    Compositions of silico-sodo-calcic glasses and their applications
    10.
    发明授权
    Compositions of silico-sodo-calcic glasses and their applications 失效
    硅藻石眼镜组合及其应用

    公开(公告)号：US5776844A

    公开(公告)日：1998-07-07

    申请号：US646337

    申请日：1996-12-13

    申请人： Stephanie Koch ,  Didier Jousse ,  Rene Gy ,  Gilles Courtemanche

    发明人： Stephanie Koch ,  Didier Jousse ,  Rene Gy ,  Gilles Courtemanche

    IPC分类号： C03B18/02 ,  C03C3/076 ,  C03C3/085 ,  C03C3/087 ,  C03C3/091 ,  C03C3/093 ,  C03C15/02 ,  C03C21/00 ,  C03C23/00

    CPC分类号： C03C23/007 ,  C03C15/02 ,  C03C21/00 ,  C03C3/076 ,  C03C3/087 ,  C03C3/091 ,  C03C3/093 ,  A47B2200/0094

    摘要： This invention concerns a thermally stable glass composition, which comprises the following constituents in the following proportions by weight: ______________________________________ SiO.sub.2 45 to 68% Al.sub.2 O.sub.3 0 to 20% ZrO.sub.2 0 to 20% B.sub.2 O.sub.3 0 to 10% Na.sub.2 O 2 to 12% K.sub.2 O 3.5 to 9% CaO 1 to 13% MgO 0 to 8% ______________________________________ the sum of the contents of the oxides SiO.sub.2, Al.sub.2 O.sub.3 and ZrO.sub.2 remaining equal to or less than 70%, the sum of the oxides Al.sub.2 O.sub.3 and ZrO.sub.2 being equal to or greater than 2%, the sum of the alkaline oxides Na.sub.2 O and K.sub.2 O being equal to or greater than 8%, said composition comprising, if desired, the oxides BaO and/or SrO in proportions such that: 11%.ltoreq.MgO+CaO+BaO+SrO

    摘要翻译： PCT No.PCT / FR95 / 01347 Sec。 371日期1996年12月13日第 102（e）日期1996年12月13日PCT提交1995年10月13日PCT公布。 公开号WO96 / 11887 日期1996年04月25日本发明涉及一种热稳定性玻璃组合物，其包含以下重量比的以下组分：SiO 2 45至68％Al 2 O 3 0至20％ZrO 2 0至20％-B 2 O 3 0至10％ - Na2O 2〜12％ - K2O 3.5〜9％ - CaO 1〜13％ - MgO 0〜8％ - 氧化物SiO 2，Al 2 O 3和ZrO 2的含量之和等于或小于70％ 氧化物Al 2 O 3和ZrO 2等于或大于2％，碱性氧化物Na 2 O和K 2 O的总和等于或大于8％，如果需要，所述组合物包含氧化物BaO和/或SrO，其比例使得 ：11％