公开(公告)号：US20220084805A1

公开(公告)日：2022-03-17

申请号：US17474979

申请日：2021-09-14

Applicant: Quadrocore Corp.

Inventor： Gholamreza Javahery ,  Ali Sepehri Fard

IPC: H01J49/04

Abstract: A surface interaction sample introduction (SISI) system for mass spectrometers is disclosed that improves sensitivity and reduces chemical background. SISI comprises of a settling chamber with an inlet orifice that ions created by an ionization source enter the MS impinging surface that is located in front of the inlet orifice, thereby the high-speed gas jet entering the settling chamber from the inlet orifice impinges on the impinging surface resealing ions and molecules into the settling chamber. The impinging surface can be one of the settling chamber surfaces or an extra surface placed inside the settling chamber. The impinging surface can be orthogonal or angled with respect to the gas jet. The impinging surface is heated to apply thermal energy to the jet to promote the liberation of ionized particles from attached impurities. The released ions and molecules leave the settling chamber from an outlet port towards a mass spectrometer inlet.

公开(公告)号：US20210391163A1

公开(公告)日：2021-12-16

申请号：US17341153

申请日：2021-06-07

Applicant: Quadrocore Corp.

Inventor： Gholamreza Javahery ,  Ali Sepehri Fard

IPC: H01J49/04 ,  H01J49/16

Abstract: A system for sampling and analysis of the chemical composition of any material from any surface is provided. The system comprises of a sniffing line to collect a specimen from a surface for evaluation and a thermal desorption system to thermally desorb an analyte from the sampled material, The system may further comprise of an ionization system to form an ionized analyte. A mass spectrometer is then used to analyze the chemical composition of the ionized analyte sample.

公开(公告)号：US20240162024A1

公开(公告)日：2024-05-16

申请号：US18550945

申请日：2022-03-14

Applicant: QuadroCore Corp.

Inventor： Gholamreza Javahery ,  Victor Titov ,  Dmitry Valyaev ,  Fadi Jozif

IPC: H01J49/06 ,  H01J49/10 ,  H01J49/14

CPC classification number: H01J49/063 ,  H01J49/102 ,  H01J49/145

Abstract: A combined ion discharge tube and an ion guide system is disclosed. The ion discharge tube comprises of a cathode tube and an anode surface. The discharge tube acts as the cathode, whereas the anode can be any number of different configurations. In one embodiment the discharge tube is set inside a quadrupole ion guide, with the walls of the ion guide being the anode. In other embodiments, the discharge tube is placed inside the rods of the quadrupole and the inner walls of the rods or a separate plate acting as the anode. In all configurations, the ions are formed by the discharge tube and are introduced into the RF confinement of an ion guide to increase ion transfer efficiency.

公开(公告)号：US20250014883A1

公开(公告)日：2025-01-09

申请号：US18896692

申请日：2024-09-25

Applicant: QUADROCORE CORP.

Inventor： Gholamreza Javahery ,  Ramin Sharifi ,  Victor Titov ,  Dmitry Valyaev ,  Fadi Jozif

IPC: H01J49/04

Abstract: A deposit-reducing ionization source for sample introduction to a mass spectrometer is provided. It comprises a heated vessel with a set of circulating hot gases to avoid any condensation to be formed within the volume of the vessel, keeping the vessel clean. The vessel has a tubular cross section with a conduit attached to its side wall. The vessel is placed in front of the orifice of a curtain cone. An exhaust port is on the opposite side of the conduit on the wall and close to the curtain cone. A nebulizer is placed inside the conduit. A nebulizing gas and an auxiliary gas are introduced in the conduit and a curtain gas is introduced in the curtain cone.

公开(公告)号：US11621153B2

公开(公告)日：2023-04-04

申请号：US17341153

申请日：2021-06-07

Applicant: Quadrocore Corp.

Inventor： Gholamreza Javahery ,  Ali Sepehri Fard

IPC: H01J49/04 ,  H01J49/16

Abstract: A system for sampling and analysis of the chemical composition of any material from any surface is provided. The system comprises of a sniffing line to collect a specimen from a surface for evaluation and a thermal desorption system to thermally desorb an analyte from the sampled material, The system may further comprise of an ionization system to form an ionized analyte. A mass spectrometer is then used to analyze the chemical composition of the ionized analyte sample.

公开(公告)号：US11594407B2

公开(公告)日：2023-02-28

申请号：US17474979

申请日：2021-09-14

Applicant: Quadrocore Corp.

Inventor： Gholamreza Javahery ,  Ali Sepehri Fard

IPC: H01J49/00 ,  H01J49/04

Abstract: A surface interaction sample introduction (SISI) system for mass spectrometers is disclosed that improves sensitivity and reduces chemical background. SISI comprises of a settling chamber with an inlet orifice that ions created by an ionization source enter the MS impinging surface that is located in front of the inlet orifice, thereby the high-speed gas jet entering the settling chamber from the inlet orifice impinges on the impinging surface resealing ions and molecules into the settling chamber. The impinging surface can be one of the settling chamber surfaces or an extra surface placed inside the settling chamber. The impinging surface can be orthogonal or angled with respect to the gas jet. The impinging surface is heated to apply thermal energy to the jet to promote the liberation of ionized particles from attached impurities. The released ions and molecules leave the settling chamber from an outlet port towards a mass spectrometer inlet.

公开(公告)号：US20240387160A1

公开(公告)日：2024-11-21

申请号：US18293245

申请日：2023-01-27

Applicant: KIMIA ANALYTICS INC. ,  QUADROCORE CORP.

Inventor： Gholamreza JAVAHERY ,  Sina ALAVI ,  Javad MOSTAGHIMI ,  Kaveh KAHEN

IPC: H01J49/00 ,  H01J49/06

Abstract: A collision cell is disclosed that comprises of a support and a target material. The parent ions entering the cell are accelerated and collide with the target material resulting in their fragmentation. The target material can be made from any suitable materials such as graphene, carbon, silicon, a combination of these materials, or alloys which have an atomic or molecular structure. The target material and the support are so selected to optimize the fragmentation process for a particular range of molecules and ions. The fragmented ions produced within the collision or fragmentation zone are focused and collected by a set of lenses positioned on the downstream side of the cell.

公开(公告)号：US20240258093A1

公开(公告)日：2024-08-01

申请号：US18578707

申请日：2022-07-11

Applicant: QuadroCore Corp.

Inventor： Gholamreza Javahery ,  Fadi Jozif ,  Babak Shahabi ,  Farshid Pashaee

IPC: H01J49/14 ,  G01N30/72 ,  H01J49/06

CPC classification number: H01J49/147 ,  G01N30/7206 ,  H01J49/063 ,  H01J49/067

Abstract: The present system is a filament and an ion guide configuration. The ion source and an ion guide are combined in one system to create a fast release of ions, with increased efficiency of ion transport. The present device is a high-efficiency ion source operating at very low up to a few Torr pressure. Ions generated from the source immediately introduced into or created in an ion guide. The ions are introduced in or around the zero field lines of the RF field. Therefore, they will be trapped under the influence of the RF field there and can be transported to the next region of the mass spectrometer device. One method of transferring ions is by using ion-guides. Multipole ion guides have efficiently transferred ions through a vacuum or partial vacuum into mass analyzers. In particular, multipole ion guides have been configured to transport ions from a higher pressure region of a mass spectrometer to the lower pressure and then vacuum where the analyzer is operational.

公开(公告)号：US20240128070A1

公开(公告)日：2024-04-18

申请号：US18380019

申请日：2023-10-13

Applicant: Kimia Analytics Inc. ,  Quadrocore Corp.

Inventor： Sina ALAVI ,  Gholamreza JAVAHERY ,  Dmitry VALYAEV ,  Victor TITOV

IPC: H01J49/00 ,  H01J49/02 ,  H01J49/06

CPC classification number: H01J49/0095 ,  H01J49/027 ,  H01J49/061

Abstract: The present invention is ion detection method for mass spectrometer. An electron multiplier is coupled with a conversion dynode for the detection of positive and negative ions. The aperture of the present system is ungrounded. As the ions (positive or negative) approach and go through the aperture, they induce an image current into the aperture plate which can be amplified and measured by a processing circuit. The magnitude of the image current is directly proportional to the number density, speed, charge, and polarity of ions flowing through the aperture. The measured image current is used as a means to switch between various detection modes. The measured current is calibrated and used as a reference to automatically switch between analog/counting modes, positive/negative ion detection, or various types of detectors implemented in the ion detection system.