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公开(公告)号：US08658430B2
公开(公告)日：2014-02-25
申请号：US13554655
申请日：2012-07-20
申请人： Benjamin J. Miller , Qun Zhong , Darren Roy Link
发明人： Benjamin J. Miller , Qun Zhong , Darren Roy Link
IPC分类号： G01N1/10
CPC分类号： C12Q1/6806 , B01F3/0807 , B01F13/0062 , B01F15/00357 , B01L3/502761 , B01L7/525 , B01L2200/025 , B01L2200/0647 , B01L2200/141 , B01L2200/143 , B01L2200/148 , B01L2300/0867 , B01L2300/14 , B01L2400/0487 , B05B1/02 , B05B1/08 , B05B1/26 , B05B7/0012 , Y10T436/2575
摘要： The invention generally relates to methods and systems for manipulating droplet size. In certain aspects, the invention provides methods for manipulating droplet size that include forming droplets of aqueous fluid surrounded by an immiscible carrier fluid, and manipulating droplet size during the forming step by adjusting pressure exerted on the aqueous fluid or the carrier fluid.
摘要翻译： 本发明一般涉及用于操纵液滴尺寸的方法和系统。 在某些方面，本发明提供了用于操纵液滴尺寸的方法，其包括形成由不混溶的载体流体包围的水性流体的液滴，并且在成形步骤期间通过调节施加在含水流体或载体流体上的压力来操纵液滴尺寸。
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公开(公告)号：US20130099018A1
公开(公告)日：2013-04-25
申请号：US13554655
申请日：2012-07-20
申请人： Benjamin J. Miller , Qun Zhong , Darren Roy Link
发明人： Benjamin J. Miller , Qun Zhong , Darren Roy Link
IPC分类号： B05B1/08
CPC分类号： C12Q1/6806 , B01F3/0807 , B01F13/0062 , B01F15/00357 , B01L3/502761 , B01L7/525 , B01L2200/025 , B01L2200/0647 , B01L2200/141 , B01L2200/143 , B01L2200/148 , B01L2300/0867 , B01L2300/14 , B01L2400/0487 , B05B1/02 , B05B1/08 , B05B1/26 , B05B7/0012 , Y10T436/2575
摘要： The invention generally relates to methods and systems for manipulating droplet size. In certain aspects, the invention provides methods for manipulating droplet size that include forming droplets of aqueous fluid surrounded by an immiscible carrier fluid, and manipulating droplet size during the forming step by adjusting pressure exerted on the aqueous fluid or the carrier fluid.
摘要翻译： 本发明一般涉及用于操纵液滴尺寸的方法和系统。 在某些方面，本发明提供了用于操纵液滴尺寸的方法，其包括形成由不混溶的载体流体包围的水性流体的液滴，并且在成形步骤期间通过调节施加在含水流体或载体流体上的压力来操纵液滴尺寸。
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公开(公告)号：US08535889B2
公开(公告)日：2013-09-17
申请号：US13026107
申请日：2011-02-11
CPC分类号： C12Q1/6816 , C12Q1/6827 , C12Q1/686 , C12Q1/6883 , C12Q1/6886 , C12Q2600/172 , C12Q2563/159 , C12Q2565/629 , C12Q2537/143 , C12Q2531/113 , C12Q2535/131
摘要： The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.
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公开(公告)号：US20110250597A1
公开(公告)日：2011-10-13
申请号：US13026120
申请日：2011-02-11
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , C12Q1/6827 , C12Q1/686 , C12Q1/6883 , C12Q1/6886 , C12Q2600/172 , C12Q2563/159 , C12Q2565/629 , C12Q2537/143 , C12Q2531/113 , C12Q2535/131
摘要： The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.
摘要翻译： 本发明一般涉及基于液滴的数字PCR和使用其进行目标核酸分析的方法。 在某些实施方案中，本发明的方法包括形成含有平均单个靶核酸的样品液滴，扩增液滴中的靶，不包含来自靶标的扩增子的液滴和来自靶标变体的扩增子，并分析靶扩增子 。
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公开(公告)号：US20110244455A1
公开(公告)日：2011-10-06
申请号：US13026107
申请日：2011-02-11
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , C12Q1/6827 , C12Q1/686 , C12Q1/6883 , C12Q1/6886 , C12Q2600/172 , C12Q2563/159 , C12Q2565/629 , C12Q2537/143 , C12Q2531/113 , C12Q2535/131
摘要： The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.
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公开(公告)号：US09441266B2
公开(公告)日：2016-09-13
申请号：US13773868
申请日：2013-02-22
CPC分类号： C12Q1/6816 , C12Q1/6827 , C12Q1/686 , C12Q1/6883 , C12Q1/6886 , C12Q2600/172 , C12Q2563/159 , C12Q2565/629 , C12Q2537/143 , C12Q2531/113 , C12Q2535/131
摘要： The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.
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公开(公告)号：US09074242B2
公开(公告)日：2015-07-07
申请号：US13026120
申请日：2011-02-11
CPC分类号： C12Q1/6816 , C12Q1/6827 , C12Q1/686 , C12Q1/6883 , C12Q1/6886 , C12Q2600/172 , C12Q2563/159 , C12Q2565/629 , C12Q2537/143 , C12Q2531/113 , C12Q2535/131
摘要： The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.
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公开(公告)号：US20130196324A1
公开(公告)日：2013-08-01
申请号：US13773868
申请日：2013-02-22
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6816 , C12Q1/6827 , C12Q1/686 , C12Q1/6883 , C12Q1/6886 , C12Q2600/172 , C12Q2563/159 , C12Q2565/629 , C12Q2537/143 , C12Q2531/113 , C12Q2535/131
摘要： The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.
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公开(公告)号：US20130295567A1
公开(公告)日：2013-11-07
申请号：US13866126
申请日：2013-04-19
申请人： Darren Roy Link , Qun Zhong , Andrew Watson
发明人： Darren Roy Link , Qun Zhong , Andrew Watson
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , C12Q1/686 , C12Q2563/159 , C12Q2565/629
摘要： The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.
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公开(公告)号：US09364803B2
公开(公告)日：2016-06-14
申请号：US13371222
申请日：2012-02-10
CPC分类号： B01F13/0076 , B01F3/0803 , B01F3/0865 , B01F5/0085 , B01F5/0471 , B01F5/0473 , B01F13/0062 , B01F13/0071 , B01F2215/0037 , B01L3/502784 , B01L7/525 , B01L2200/0652 , B01L2200/0673 , B01L2300/0867 , B01L2400/0415 , B01L2400/0487
摘要： The invention generally relates to methods for forming mixed droplets. In certain embodiments, methods of the invention involve forming a droplet, and contacting the droplet with a fluid stream, wherein a portion of the fluid stream integrates with the droplet to form a mixed droplet.
摘要翻译： 本发明一般涉及用于形成混合液滴的方法。 在某些实施方案中，本发明的方法包括形成液滴并使液滴与流体流接触，其中流体流的一部分与液滴形成混合液滴。
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