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    FVIII-independent FIX-mutant proteins for hemophilia a treatment
    1.
    发明授权
    FVIII-independent FIX-mutant proteins for hemophilia a treatment 有权
    FVIII独立的FIX突变蛋白用于血友病治疗

    公开(公告)号：US08513386B2

    公开(公告)日：2013-08-20

    申请号：US13096894

    申请日：2011-04-28

    申请人： Michael Dockal ,  Rudolf Hartmann ,  Friedrich Scheiflinger

    发明人： Michael Dockal ,  Rudolf Hartmann ,  Friedrich Scheiflinger

    IPC分类号： A61K35/14 ,  A61K38/36 ,  C07K14/745

    CPC分类号： C12N9/644 ,  A61K38/00 ,  C12Y304/21022

    摘要： The present invention relates to recombinant blood coagulation factor IX (rFIX) mutants having factor VIII (FVIII) independent factor X (FX) activation potential. Five full length FIX proteins with combinations of mutations of amino acids important for functional activity of FIX and FIX wild type were cloned and expressed in HEK 293 cells. The proteins were tested by an activated partial thromboplastin time (aPTT) assay in FVIII-depleted plasma as well as in FVIII-inhibited patient plasma. In FVIII-depleted plasma functional activity of the FIX mutants was calculated as increased FVIII equivalent activity. The mutant proteins had increased FVIII equivalent activity. In FVIII-inhibited patient plasma the FEIBA equivalent activity was calculated for analysis of FVIII independent FX activation potential. The proteins had also increased FEIBA equivalent activity. Furthermore, the pre-activated FIX proteins had an increased activity in FIX-depleted plasma containing FVIII inhibitors. Therefore these FIX mutants are alternatives as bypassing agents for treatment of FVIII inhibitor patients.

    摘要翻译： 本发明涉及具有因子VIII（FVIII）独立因子X（FX）活化电位的重组凝血因子IX（rFIX）突变体。 在HEK 293细胞中克隆并表达具有FIX和FIX野生型功能活性重要的氨基酸突变组合的五个全长FIX蛋白。 通过在FVIII消除的血浆以及FVIII抑制的患者血浆中的活化部分凝血活酶时间（aPTT）测定来测试蛋白质。 在FVIII消耗的血浆中，FIX突变体的功能活性被计算为增加的FVIII当量活性。 突变蛋白具有增加的FVIII当量活性。 在FVIII抑制的患者血浆中，计算FEIBA等效活性以分析FVIII独立的FX激活电位。 蛋白质也增加了FEIBA等效活性。 此外，预活化的FIX蛋白在含有FVIII抑制剂的FIX耗尽血浆中具有增加的活性。 因此，这些FIX突变体是用于治疗FVIII抑制剂患者的旁路药物的替代物。

    METHOD AND DEVICE FOR PROCESSING PLASTIC-CONTAINING WASTE
    3.
    发明申请
    METHOD AND DEVICE FOR PROCESSING PLASTIC-CONTAINING WASTE 审中-公开
    用于处理含塑料废物的方法和装置

    公开(公告)号：US20090321317A1

    公开(公告)日：2009-12-31

    申请号：US12438647

    申请日：2007-08-23

    申请人： Christian Widmer ,  Rudolf Hartmann ,  Gerold Weser

    发明人： Christian Widmer ,  Rudolf Hartmann ,  Gerold Weser

    IPC分类号： B01J19/00 ,  C10G11/00 ,  F28D21/00

    CPC分类号： C10G1/10 ,  Y02P30/20

    摘要： The invention relates to a method and device for processing plastic-containing and organic fluids based on crude oil, cooking oil, fats or the like, wherein the substance mixture is fed into a reactor, is then melted in the melting zone of the reactor and the interfering substances are discharged from the melt. The long-chained polymers still present in the melt are cracked in a crack zone of the reactor until they assume a gaseous state. Then the gas phase is discharged from the reactor an condensed in a cooler. Impurities are then removed from the volatile liquid present after cooling and the volatile liquid is stored.

    摘要翻译： 本发明涉及一种用于处理基于原油，食用油，脂肪等的含塑料和有机流体的方法和装置，其中将物质混合物进料到反应器中，然后在反应器的熔融区域中熔化， 干扰物质从熔体中排出。 仍然存在于熔体中的长链聚合物在反应器的裂纹区中破裂，直到它们呈现气态。 然后将气相从反应器中排出，在冷却器中冷凝。 然后在冷却后从存在的挥发性液体中除去杂质，并且储存挥发性液体。

    Sensor for detecting condensation and use in a sensor module
    4.
    发明授权
    Sensor for detecting condensation and use in a sensor module 有权
    用于检测冷凝和传感器模块中使用的传感器

    公开(公告)号：US06809530B2

    公开(公告)日：2004-10-26

    申请号：US10281360

    申请日：2002-10-28

    申请人： Hans-Michael Schmitt ,  Juergen Bach ,  Guenther Oennig ,  Thomas Polzer ,  Martin Blaufuss ,  Rudolf Hartmann

    发明人： Hans-Michael Schmitt ,  Juergen Bach ,  Guenther Oennig ,  Thomas Polzer ,  Martin Blaufuss ,  Rudolf Hartmann

    IPC分类号： G01R2726

    CPC分类号： B60H1/00785 ,  B60S1/0825 ,  B60S1/0866

    摘要： As is well known, the influencing variables most important for a sense of comfort are considered during regulation in controlled heating and air conditioning units. Incipient condensation on the windshield or other windows in particular is to be prevented thereby. Sensor modules, inter alia, are employed for this purpose, which have, for example, a capacitative thin-layer sensor. An additional thermopile is provided for determining the window temperature. The present idea eliminates the determination of the window temperature, for which purpose a sensor working capacitatively in the exemplary embodiment is brought directly to the window temperature and a direct thermal coupling of the sensor with the window occurs via a metal plate connected directly to the sensor and a thin adhesive film. The metal plate can thereby form one of the electrodes of the sensor itself or be connected to said electrode in a direct thermal manner. The use of the sensor in the sensor module is a further preferred embodiment.

    摘要翻译： 众所周知，在受控加热和空调装置的调节期间考虑了对舒适感最重要的影响因素。 尤其要防止挡风玻璃或其他窗户上的初期冷凝。 传感器模块尤其用于此目的，其具有例如电容性薄层传感器。 提供另外的热电堆用于确定窗口温度。 本想法消除了窗口温度的确定，为了这个目的，在示例性实施例中电容地工作的传感器直接进入窗口温度，并且传感器与窗口的直接热耦合通过直接连接到传感器的金属板 和薄的粘合剂膜。 因此，金属板可以形成传感器本身的电极之一或者以直接热方式连接到所述电极。 在传感器模块中使用传感器是另一优选实施例。

    Suspension means for mounting an instrument susceptible to shock
    5.
    发明授权
    Suspension means for mounting an instrument susceptible to shock 失效
    用于安装容易受到冲击的仪器的悬挂装置

    公开(公告)号：US4379542A

    公开(公告)日：1983-04-12

    申请号：US63774

    申请日：1979-08-06

    申请人： Ludwig Pietzsch ,  Rudolf Hartmann

    发明人： Ludwig Pietzsch ,  Rudolf Hartmann

    IPC分类号： B60P7/16 ,  F16F13/00 ,  F16M13/00

    CPC分类号： B60P7/16 ,  F16F13/002

    摘要： A suspension means for mounting an instrument or the like which is susceptible to shock on a movable carrier, in particular a vehicle, comprises a flexible sealing means adapted to absorb shocks in at least one direction and further comprises a blocking device for rigid coupling of said instrument with said carrier, the blocking device being actuable by a drive means which works in said one direction against the resiliency of the sealing means.

    摘要翻译： 用于将易受冲击的仪器等安装在可移动的载体，特别是车辆上的悬挂装置包括适于在至少一个方向上吸收冲击的柔性密封装置，并且还包括用于刚性联接所述 具有所述托架的装置，所述阻挡装置可通过驱动装置致动，所述驱动装置克服所述密封装置的弹性在所述一个方向上工作。

    Torsional spring
    7.
    发明授权
    Torsional spring 失效
    扭转春天

    公开(公告)号：US5020783A

    公开(公告)日：1991-06-04

    申请号：US459696

    申请日：1990-01-26

    申请人： Bernd Schroder ,  Rudolf Hartmann ,  Helmut Thate

    发明人： Bernd Schroder ,  Rudolf Hartmann ,  Helmut Thate

    IPC分类号： B62D55/108 ,  F16F1/14 ,  F16F1/366

    CPC分类号： F16F1/14 ,  B62D55/108 ,  F16F1/366 ,  B60G2200/132 ,  B60G2202/134 ,  B60G2204/122 ,  B60G2206/42 ,  B60G2206/427 ,  B60G2206/7101 ,  B60G2206/8103 ,  B60G2206/82013

    摘要： A torsional spring to be secured non-rotating to mutually rotating components at each end. At least two thin-walled piping sections are positioned loosely coaxial and secured together non-rotating at one end, accordingly functioning as a series of resilient sections. There are means of securing them non-rotating to the mutually rotating components at the other end. The spring especially constitutes a torsion bar for a connecting rod that pivots in a bearing mounted stationary in a vehicle and positions either a running wheel or a caterpillar cogwheel at the end remote from the bearing. The piping sections are integrated into each other such that one merges directly into the other at the end where they are secured together non-rotating in a turnback that represents a transition point. The piping sections are preferably made of fiber-reinforced plastic and may have several layers.

    摘要翻译： PCT No.PCT / DE89 / 00364 Sec。 371 1990年1月26日第 102（e）日期1990年1月26日PCT提交1989年6月2日PCT公布。 WO89 / 11993 PCT出版物 日期是1989年12月14日。一个扭转弹簧被固定在每个端部不旋转到相互旋转的部件。 至少两个薄壁管道段被松散地同轴并且固定在一端不旋转的一端，因此用作一系列的弹性部分。 在另一端有固定它们不旋转到相互旋转的部件的装置。 弹簧特别构成用于连接杆的扭杆，该连杆在固定在车辆中的轴承中枢转，并且在远离轴承的一端定位跑步轮或履带式齿轮。 管道部分彼此集成在一起，使得它们在末端被合并到另一个端部，在它们的端部处，它们被固定在一起，在转向中的转动中不旋转。 管道部分优选地由纤维增强塑料制成，并且可以具有几层。

    Variable electromechanical device
    8.
    发明授权
    Variable electromechanical device 失效
    可变机电装置

    公开(公告)号：US4296292A

    公开(公告)日：1981-10-20

    申请号：US94891

    申请日：1979-11-16

    申请人： Christian Schuberth ,  Rudolf Hartmann

    发明人： Christian Schuberth ,  Rudolf Hartmann

    IPC分类号： F16F9/14 ,  H01C10/14 ,  H01H3/60 ,  H01H3/62 ,  H01H3/08 ,  H01C10/00

    CPC分类号： F16F9/145 ,  H01C10/14 ,  H01H3/60 ,  H01H3/62

    摘要： A variable electromechanical device, such as a rotary potentiometer, incls a housing with a sleeve having a bore through which an actuation shaft extends. The shaft is provided with an annular groove. A portion of the sleeve is displaced by stamping so that it extends into the annular groove of the shaft to prevent axial movement of the latter. A projection formed on the shaft within the annular groove cooperates with the displaced portion of the sleeve for limiting the rotation of the shaft. A lubricating and braking liquid of high viscosity is filled in the groove, and one or more passages are formed on the projection so that the liquid can pass from one side of the projection to the other side thereof when the shaft is rotated.

    摘要翻译： 诸如旋转电位计的可变机电装置包括具有套筒的壳体，所述套筒具有致动轴延伸穿过的孔。 轴设有环形槽。 套筒的一部分通过冲压而移位，使其延伸到轴的环形槽中，以防止轴的轴向移动。 形成在该环内的轴上的突起与套筒的移位部分配合，以限制该轴的转动。 在该凹槽中填充有高粘度的润滑制动液，在突出部上形成有一个或多个通道，使得当轴旋转时，液体可以从突出部的一侧通过到另一侧。

    Reciprocating piston machine with a rotary hydraulic displacer between pistons and machine shaft
    9.
    发明授权
    Reciprocating piston machine with a rotary hydraulic displacer between pistons and machine shaft 失效
    活塞式离心机与活塞式离心机

    公开(公告)号：US3696614A

    公开(公告)日：1972-10-10

    申请号：US3696614D

    申请日：1971-05-12

    申请人： RUDOLF HARTMANN ,  HORST ZIMMERMANN

    发明人： HARTMANN RUDOLF ,  ZIMMERMANN HORST

    IPC分类号： F04B53/14 ,  F16H43/00 ,  H01H11/04 ,  F15B7/00 ,  F03C3/00 ,  F04B9/08 ,  F04B17/00 ,  F04B35/00

    CPC分类号： H01H11/043 ,  F04B53/142 ,  F16H43/00

    摘要： A reciprocating piston machine comprises a housing structure with hydraulic cylinders, piston means reciprocable in said respective cylinders, and a revolvable shaft. A hydraulic displacer mechanism has oil columns in the respective cylinders for linking the displacer mechanism with the pistons, the displacer mechanism comprises a stationary annular portion coaxial with the shaft and forming part of the housing structure. The annular portion has inwardly open chamber recesses distributed along its inner periphery and communicating with the oil columns. The hydraulic displacer mechanism has a rotor diametrically smaller than the interior of the annular housing portion and connected with the shaft in eccentric relation thereto, the rotor is consecutively engageable with the recesses to thereby vary the oil volume in the chambers. A circle of fixed internal gear teeth on the housing structure, meshes with a gearteeth circle on the eccentric rotor. The latter circle has a smaller diameter than the circle of the fixed gear teeth and is in rolling mesh engagement therewith, whereby during operation the rotor sequentially coacts the said respective recesses to form variable volume chambers together therewith.

    摘要翻译： 往复式活塞机包括具有液压缸的壳体结构，可在所述各个气缸中往复运动的活塞装置和可旋转轴。 液压置换机构在相应气缸中具有用于将置换器机构与活塞连接的油柱，所述置换机构包括与所述轴同轴并形成所述壳体结构的一部分的静止环形部分。 环形部分沿其内周分布有向内敞开的腔室凹部并与油柱连通。 液压置换机构具有直径小于环形壳体部分内部的转子，并与轴偏心地连接，该转子可与凹部连续地接合，从而改变腔室中的油量。 外壳结构上的一圈固定的内齿轮齿与偏心转子上的齿轮齿啮合。 后一个圆的直径小于固定齿轮齿的直径，并与其啮合，从而在操作过程中，转子顺序地与所述相应的凹槽共同构成可变体积的腔室。