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27 条记录 (耗时 0.016 秒)

    Process for preparing ultrathin polymethylmethacrylate polymer films
    2.
    发明授权
    Process for preparing ultrathin polymethylmethacrylate polymer films 失效
    制备超薄聚甲基丙烯酸甲酯聚合物膜的方法

    公开(公告)号：US4765939A

    公开(公告)日：1988-08-23

    申请号：US917806

    申请日：1986-10-10

    申请人： Rachel S. Kohn

    发明人： Rachel S. Kohn

    IPC分类号： B29C41/12 ,  C08J5/18 ,  B29C39/02 ,  C08F120/18

    CPC分类号： C08J5/18 ,  B29C41/12 ,  B29K2033/04 ,  B29K2995/0088 ,  C08J2333/12

    摘要： A process to prepare pinhole-free, ultrathin, polymethylmethacrylate films having thicknesses of about 400 angstroms or less. The films are prepared by dissolving a polymethylmethacrylate polymer in a mixture of solvents to form a casting solution and then casting the solution upon water to form a free-standing film. The films find particular utility in separatory applications.

    摘要翻译： 制备厚度为约400埃或更小的无针孔，超薄，聚甲基丙烯酸甲酯薄膜的方法。 通过将聚甲基丙烯酸甲酯聚合物溶解在溶剂的混合物中以形成浇铸溶液然后将溶液浇注在水上以形成独立的膜来制备膜。 这些电影在分离应用中特别有用。

    Thixotropic aqueous solutions containing a divinylsulfone-crosslinked polygalactomannan gum
    3.
    发明授权
    Thixotropic aqueous solutions containing a divinylsulfone-crosslinked polygalactomannan gum 失效
    含有二乙烯基砜交联的聚半乳甘露聚糖胶的触变性水溶液

    公开(公告)号：US4752339A

    公开(公告)日：1988-06-21

    申请号：US547145

    申请日：1983-10-31

    申请人： Rachel S. Kohn

    发明人： Rachel S. Kohn

    IPC分类号： C08B37/00 ,  C09K8/08 ,  E21B21/00 ,  C08L5/00

    CPC分类号： C08B37/0087 ,  C09K8/08 ,  E21B21/003

    摘要： This invention provides a process for preparing a viscoelastic aqueous solution which contains divinylsulfone-crosslinked polygalactomannan gum that is formed in situ.An invention thixotropic aqueous medium is characterized by excellent heat/shear stability and high tolerance to the presence of inorganic salts.A unique property of an invention thixotropic aqueous medium is a time-dependent gradual restoration of high viscosity after cessation of high shear deformation.

    摘要翻译： 本发明提供一种制备粘弹性水溶液的方法，该方法含有原位形成的二乙烯基砜交联的聚半乳甘露聚糖胶。 本发明的触变性水性介质的特征在于优异的热/剪切稳定性和对无机盐的存在的高耐受性。 触发性水性介质的独特性质是停止高剪切变形后的高粘度的时间依赖性逐渐​​恢复。

    Benzoquinone ether adduct of polygalactomannan gum
    4.
    发明授权
    Benzoquinone ether adduct of polygalactomannan gum 失效
    聚半乳甘露聚糖胶的苯醌加成物

    公开(公告)号：US4452639A

    公开(公告)日：1984-06-05

    申请号：US441715

    申请日：1982-11-15

    申请人： Rachel S. Kohn

    发明人： Rachel S. Kohn

    IPC分类号： C08B37/14 ,  C08K5/08 ,  C08L5/00 ,  C08G59/40

    CPC分类号： C08K5/08 ,  C08L5/00

    摘要： This invention provides a viscoelastic aqueous solution which contains a novel benzoquinone ether adduct of polygalactomannan gum as a thickening agent.An invention thixotropic aqueous medium is characterized by excellent heat stability and high tolerance to the presence of inorganic salts.A unique property of an invention thixotropic aqueous medium is a time-dependent gradual restoration of high viscosity after cessation of high shear deformation.

    摘要翻译： 本发明提供一种粘弹性水溶液，其含有聚半乳甘露聚糖胶作为增稠剂的新型苯醌加成物。 本发明的触变性水性介质的特征在于优异的热稳定性和对无机盐的存在的高耐受性。 触发性水性介质的独特性质是停止高剪切变形后的高粘度的时间依赖性逐渐​​恢复。

    Biodegradable polymer encapsulated pharmaceutical compositions and method for preparing the same
    5.
    发明授权
    Biodegradable polymer encapsulated pharmaceutical compositions and method for preparing the same 失效
    可生物降解聚合物包封的药物组合物及其制备方法

    公开(公告)号：US06455526B1

    公开(公告)日：2002-09-24

    申请号：US09454555

    申请日：1999-12-07

    申请人： Rachel S. Kohn ,  Stephen J. Hanley ,  Stephen J. Comiskey

    发明人： Rachel S. Kohn ,  Stephen J. Hanley ,  Stephen J. Comiskey

    IPC分类号： A61K31495

    CPC分类号： A61K31/50 ,  A61K9/1647 ,  A61K9/1694 ,  A61K31/495

    摘要： A new class of biodegradable pharmaceutical compositions useful as sustained release medicamentous compositions, including methods of making and methods of using these compositions, are described and claimed. The method of making these compositions include the steps of: a) dry mixing of a pharmaceutically active molecule with a biodegradable polymer; b) melt extruding the mixture to form a solid solution of the active molecule in the polymer; and c) pulverizing the solid solution to form microparticles such that they can be formed into injectable formulations. Preferred embodiments include pharmaceutical compositions of polylactide-co-glycolide and (+)-&agr;-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol (active ingredient) and a method for its formation. These compositions release the active ingredient at a steady rate over a period of days to weeks. The active ingredient antagonizes the effects of serotonin at the 5HT2A receptor and are useful in treating various conditions such as, for example, psychoses including schizophrenia, obsessive compulsive disorder, sleep disorder, depression, anorexia, anxiety, drug addiction and bipolar disorders.

    摘要翻译： 描述和要求保护的一类新的可生物降解的药物组合物，其用作缓释药物组合物，包括制备方法和使用这些组合物的方法。 制备这些组合物的方法包括以下步骤：a）将药物活性分子与可生物降解的聚合物干混; b）熔融挤出混合物以形成聚合物中活性分子的固溶体; 和c）粉碎固溶体以形成微粒，使得它们可以形成可注射制剂。 优选的实施方案包括聚丙交酯 - 共 - 乙交酯和（+） - α-（2,3-二甲氧基苯基）-1- [2-（4-氟苯基）乙基] -4-哌啶甲醇（活性成分）的药物组合物和 其形成。 这些组合物在几天到数周的时间内以稳定的速率释放活性成分。 活性成分拮抗5-羟色胺在5HT2A受体上的作用，可用于治疗各种病症，例如精神病，包括精神分裂症，强迫症，睡眠障碍，抑郁症，厌食症，焦虑症，药物成瘾和双相性精神障碍。

    Gas separation membranes comprising miscible blends of polyimide polymers
    6.
    发明授权
    Gas separation membranes comprising miscible blends of polyimide polymers 失效
    气体分离膜包括聚酰亚胺聚合物的混溶混合物

    公开(公告)号：US5055116A

    公开(公告)日：1991-10-08

    申请号：US505099

    申请日：1990-04-03

    申请人： Rachel S. Kohn ,  Maria R. Coleman ,  Tai-Shung Chung

    发明人： Rachel S. Kohn ,  Maria R. Coleman ,  Tai-Shung Chung

    IPC分类号： B01D53/22 ,  B01D71/64 ,  C08G73/10 ,  C08L79/08

    CPC分类号： C08G73/1039 ,  B01D71/64 ,  C08L79/08

    摘要： The present invention provides for gas separation membranes which are engineered to have specific gas transport properties based on the blending of certain polymers. In preferred embodiments, the blended polymers are polyimides which have different molecular structures and different gas transport properties. Despite these differences, however, the polymers are completely miscible and can be effectively utilized to prepare gas separation membranes having specifically tailored properties.

    摘要翻译： 本发明提供了气体分离膜，其被工程化以具有基于某些聚合物的共混的特定的气体输送性质。 在优选实施方案中，共混聚合物是具有不同分子结构和不同气体输送性质的聚酰亚胺。 然而，尽管存在这些差异，聚合物是完全可混溶的，并且可以有效地用于制备具有特别定制性质的气体分离膜。