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1.发明申请公开(公告)号：US20100047357A1
公开(公告)日：2010-02-25
申请号：US12525329
申请日：2008-02-03
Applicant: Ofer Toledano , Hanan Sertchook , Natalia Loboda , Haim Bar-Simantov , Leora Shapiro , Raed Abu-Reziq
Inventor： Ofer Toledano , Hanan Sertchook , Natalia Loboda , Haim Bar-Simantov , Leora Shapiro , Raed Abu-Reziq
IPC: A61K9/14 , A61K31/327 , A61K31/202 , A61K31/192 , A61K31/4436 , A61P17/00 , A61P17/06 , A61P17/10
CPC classification number: A61K9/0014 , A61K9/28 , A61K47/34
Abstract: The invention relates to a composition for topical application comprising as an active ingredient a peroxide and a retinoid wherein one of said peroxide and retinoid is in the form of first microparticles comprising a solid particulate matter of the active ingredient coated by a metal oxide layer and the other of said peroxide and retinoid is present in an uncoated free form or in a coated form of the active ingredient. The invention further relates to method for treating a surface condition in a subject using said composition, a method for preparing a composition exhibiting improved stability, and a kit comprising: (a) a first composition comprising a peroxide as a first active ingredient; and (b) a second composition comprising a retinoid as a second active ingredient; at least one of said first and said second active ingredient being coated by a metal oxide layer.
Abstract translation: 本发明涉及用于局部应用的组合物，其包含作为活性成分的过氧化物和类视色素，其中所述过氧化物和类视色素之一为第一微粒的形式，其包含由金属氧化物层包被的活性成分的固体颗粒物质， 所述过氧化物和类视色素中的另一种以未包衣的游离形式或活性成分的包衣形式存在。 本发明还涉及使用所述组合物治疗受试者的表面状况的方法，制备显示出改善的稳定性的组合物的方法，以及试剂盒，其包含：（a）第一组合物，其包含作为第一活性成分的过氧化物; 和（b）第二组合物，其包含类视黄醇作为第二活性成分; 所述第一和第二活性成分中的至少一个被金属氧化物层包覆。
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2.发明申请MICROCAPSULES COMPRISING ACTIVE INGREDIENTS AND A METAL OXIDE SHELL, A METHOD FOR THEIR PREPARATION AND USES THEREOF 审中-公开包含活性成分和金属氧化物壳的微球，其制备方法及其用途公开(公告)号：US20110177951A1
公开(公告)日：2011-07-21
申请号：US13056952
申请日：2009-08-02
Applicant: Ofer Toledano , Hanan Sertchook , Natalia Loboda , Raed Abu-Reziq
Inventor： Ofer Toledano , Hanan Sertchook , Natalia Loboda , Raed Abu-Reziq
IPC: A01N37/22 , A61K9/50 , A61K8/11 , A61K31/327 , A61K31/07 , A01N25/08 , A01P3/00 , A01P7/04 , A61P17/06 , A61P17/04 , A61P17/10 , A61P17/08 , A61P17/00 , A61P31/10 , A61P31/04 , A61P29/00 , A61Q19/00 , A01P13/00 , B82Y5/00
Abstract: The present invention provides a process for preparing microcapsules comprising a core material encapsulated by a metal oxide shell, microcapsules obtained therewith and uses thereof.
Abstract translation: 本发明提供一种制备微胶囊的方法，其包含由金属氧化物壳包封的芯材料，由其获得的微胶囊及其用途。
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3.发明申请METHOD FOR PREPARING PARTICLES COMPRISING METAL OXIDE COATING AND PARTICLES WITH METAL OXIDE COATING 审中-公开用于制备包含金属氧化物涂层和颗粒与金属氧化物涂层的颗粒的方法公开(公告)号：US20100016443A1
公开(公告)日：2010-01-21
申请号：US12525331
申请日：2008-02-03
Applicant: Ofer Toledano , Haim Bar-Simantov , Nissim Bilman , Leora Shapiro , Raed Abu-Reziq , Srikanth Sriadibhatla , William T. Sommer
Inventor： Ofer Toledano , Haim Bar-Simantov , Nissim Bilman , Leora Shapiro , Raed Abu-Reziq , Srikanth Sriadibhatla , William T. Sommer
IPC: A61K31/327 , B05D7/00 , B32B5/16 , A61K47/02 , A01N25/26 , A61K31/11 , A01N31/04 , A01N35/02 , A61K31/07 , A01P7/04 , A61P17/00 , A61P17/10 , A61P17/04 , A61P17/06
CPC classification number: A61K9/5073 , A01N25/26 , A01N53/00 , A61K8/11 , A61K8/25 , A61K8/38 , A61K8/671 , A61K9/501 , A61K9/5021 , A61K9/5026 , A61K2800/412 , A61Q19/00 , B01J13/02 , B01J13/22 , C09C3/063 , Y10T428/2991 , A01N2300/00
Abstract: The invention relates to a process for coating a solid, water-insoluble particulate matter, with a metal oxide comprising: (a) contacting the solid, water-insoluble particulate matter with an ionic additive and an aqueous medium to obtain a dispersion of said particulate matter having positive charges on its surface; (b) subjecting the particulate matter to a coating procedure comprising precipitating a metal oxide salt onto the surface of the particulate matter to form a metal oxide layer thereon to thereby obtain particulate matter coated by a metal oxide coating layer; (c) repeating step (b) at least 4 more times; and (d) aging said coating layer. The invention further relates to particles comprising a particulate matter coated by a metal oxide layer, to a use of the particles for topical administration, and to a method for preventing, reducing, or eliminating pests at a locus, using the particles.
Abstract translation: 本发明涉及一种用金属氧化物涂覆固体，不溶于水的颗粒物质的方法，包括：（a）使固体，水不溶性颗粒物质与离子添加剂和水性介质接触，以获得所述颗粒的分散体 表面上有正面指控的事情; （b）对颗粒状物质进行包括在金属氧化物表面上析出金属氧化物盐以形成金属氧化物层的涂覆方法，从而获得由金属氧化物涂层涂覆的颗粒状物质; （c）重复步骤（b）至少4次以上; 和（d）老化所述涂层。 本发明还涉及包含由金属氧化物层涂覆的颗粒物质，使用该颗粒用于局部给药的颗粒，以及使用该颗粒来防止，减少或消除某些场所的害虫的方法。
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公开(公告)号：US10525433B2
公开(公告)日：2020-01-07
申请号：US12518743
申请日：2007-12-12
Applicant: Ofer Toledano , Hanan Sertchook , Raed Abu-Reziq , Haim Bar-Simantov , Leora Shapiro
Inventor： Ofer Toledano , Hanan Sertchook , Raed Abu-Reziq , Haim Bar-Simantov , Leora Shapiro
Abstract: A process for preparing nanocapsules having a core-shell structure, comprising:(a) preparing an oil-in-water emulsion by emulsification of an oily phase that comprises a core material, in an aqueous phase, under high shear forces, wherein one or both of the oily phase, and the aqueous phase comprises a sol-gel precursor; (b) subjecting the emulsion obtained in (a) to a high pressure homogenization to obtain a nano-emulsion; and (c) applying conditions for hydrolyzing and polycondensing the sol-gel precursor to obtain nanocapsules having a metal oxide shell encapsulating the core material, said nanocapsules have a particle size distribution of: d10=10-80 nm, d50=30-200 nm, and d90=70-500 nm, in diameter. The invention also relate to nanocapsules having the above particle size distribution and to composition comprising the nanocapsules.
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5.发明申请公开(公告)号：US20120269874A1
公开(公告)日：2012-10-25
申请号：US13495701
申请日：2012-06-13
Applicant: Ofer TOLEDANO , Hanan SERTCHOOK , Natalia LOBODA , Haim BAR-SIMANTOV , Leora SHAPIRO , Raed ABU-REZIQ
Inventor： Ofer TOLEDANO , Hanan SERTCHOOK , Natalia LOBODA , Haim BAR-SIMANTOV , Leora SHAPIRO , Raed ABU-REZIQ
IPC: A61K9/14 , A61K31/192 , A61K31/4436 , A61K31/327 , A61P17/10 , A61P17/06 , A61Q19/08 , A61Q19/02 , A61P31/00 , A61P17/00 , A61K8/38 , A61K8/49 , A61K8/02 , B05D7/24 , A61K31/203
CPC classification number: A61K9/0014 , A61K9/28 , A61K47/34
Abstract: The invention relates to a composition for topical application comprising as an active ingredient a peroxide and a retinoid wherein one of said peroxide and retinoid is in the form of first microparticles comprising a solid particulate matter of the active ingredient coated by a metal oxide layer and the other of said peroxide and retinoid is present in an uncoated free form or in a coated form of the active ingredient. The invention further relates to method for treating a surface condition in a subject using said composition, a method for preparing a composition exhibiting improved stability, and a kit comprising: (a) a first composition comprising a peroxide as a first active ingredient; and (b) a second composition comprising a retinoid as a second active ingredient; at least one of said first and said second active ingredient being coated by a metal oxide layer.
Abstract translation: 本发明涉及用于局部应用的组合物，其包含作为活性成分的过氧化物和类视色素，其中所述过氧化物和类视色素之一为第一微粒的形式，其包含由金属氧化物层包被的活性成分的固体颗粒物质， 所述过氧化物和类视色素中的另一种以未包衣的游离形式或活性成分的包衣形式存在。 本发明还涉及使用所述组合物治疗受试者的表面状况的方法，制备显示出改善的稳定性的组合物的方法，以及试剂盒，其包含：（a）第一组合物，其包含作为第一活性成分的过氧化物; 和（b）第二组合物，其包含类视黄醇作为第二活性成分; 所述第一和第二活性成分中的至少一个被金属氧化物层包覆。
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Patent Agency Ranking
公开(公告)号：US10688462B2
公开(公告)日：2020-06-23
申请号：US13056952
申请日：2009-08-02
Applicant: Ofer Toledano , Hanan Sertchook , Natalia Loboda , Raed Abu-Reziq
Inventor： Ofer Toledano , Hanan Sertchook , Natalia Loboda , Raed Abu-Reziq
Abstract: The present invention provides a process for preparing microcapsules comprising a core material encapsulated by a metal oxide shell, microcapsules obtained therewith and uses thereof.
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7.发明授权公开(公告)号：US08617580B2
公开(公告)日：2013-12-31
申请号：US13495701
申请日：2012-06-13
Applicant: Ofer Toledano , Hanan Sertchook , Natalia Loboda , Haim Bar-Simantov , Leora Shapiro , Raed Abu-Reziq
Inventor： Ofer Toledano , Hanan Sertchook , Natalia Loboda , Haim Bar-Simantov , Leora Shapiro , Raed Abu-Reziq
CPC classification number: A61K9/0014 , A61K9/28 , A61K47/34
Abstract: The invention relates to a composition for topical application comprising as an active ingredient a peroxide and a retinoid wherein one of said peroxide and retinoid is in the form of first microparticles comprising a solid particulate matter of the active ingredient coated by a metal oxide layer and the other of said peroxide and retinoid is present in an uncoated free form or in a coated form of the active ingredient. The invention further relates to method for treating a surface condition in a subject using said composition, a method for preparing a composition exhibiting improved stability, and a kit comprising: (a) a first composition comprising a peroxide as a first active ingredient; and (b) a second composition comprising a retinoid as a second active ingredient; at least one of said first and said second active ingredient being coated by a metal oxide layer.
Abstract translation: 本发明涉及用于局部应用的组合物，其包含作为活性成分的过氧化物和类视色素，其中所述过氧化物和类视色素之一为第一微粒的形式，其包含由金属氧化物层包被的活性成分的固体颗粒物质， 所述过氧化物和类视色素中的另一种以未包衣的游离形式或活性成分的包衣形式存在。 本发明还涉及使用所述组合物治疗受试者的表面状况的方法，制备显示出改善的稳定性的组合物的方法，以及试剂盒，其包含：（a）第一组合物，其包含作为第一活性成分的过氧化物; 和（b）第二组合物，其包含类视黄醇作为第二活性成分; 所述第一和第二活性成分中的至少一个被金属氧化物层包覆。
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8.发明申请公开(公告)号：US20100203121A1
公开(公告)日：2010-08-12
申请号：US12518743
申请日：2007-12-12
Applicant: Ofer Toledano , Hanan Sertchook , Raed Abu-Reziq , Haim Bar-Simantov , Leora Shapiro
Inventor： Ofer Toledano , Hanan Sertchook , Raed Abu-Reziq , Haim Bar-Simantov , Leora Shapiro
CPC classification number: B01J13/14
Abstract: A process for preparing nanocapsules having a core-shell structure, comprising:(a) preparing an oil-in-water emulsion by emulsification of an oily phase that comprises a core material, in an aqueous phase, under high shear forces, wherein one or both of the oily phase, and the aqueous phase comprises a sol-gel precursor; (b) subjecting the emulsion obtained in (a) to a high pressure homogenization to obtain a nano-emulsion; and (c) applying conditions for hydrolyzing and polycondensing the sol-gel precursor to obtain nanocapsules having a metal oxide shell encapsulating the core material, said nanocapsules have a particle size distribution of: d10=10-80 nm, d50=30-200 nm, and d90=70-500 nm, in diameter. The invention also relate to nanocapsules having the above particle size distribution and to composition comprising the nanocapsules.
Abstract translation: 一种制备具有核 - 壳结构的纳米胶囊的方法，包括：（a）通过在高剪切力下在水相中乳化包含核心材料的油相的水包油乳液制备，其中一个或 油相和水相都包含溶胶 - 凝胶前体; （b）将（a）中得到的乳液进行高压均化，得到纳米乳液; 并且（c）施加水解和缩聚溶胶 - 凝胶前体的条件以获得具有包封核心材料的金属氧化物壳的纳米胶囊，所述纳米胶囊的粒度分布为：d10 = 10-80nm，d50 = 30-200nm ，d90 = 70-500nm。 本发明还涉及具有上述粒度分布的纳米胶囊和包含纳米胶囊的组合物。
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公开(公告)号：US09643168B2
公开(公告)日：2017-05-09
申请号：US12783916
申请日：2010-05-20
Applicant: David Avnir , Raed Abu-Reziq , Rachael Ben Knaz , Itzik Yosef , Guy Nesher , Gad Marom
Inventor： David Avnir , Raed Abu-Reziq , Rachael Ben Knaz , Itzik Yosef , Guy Nesher , Gad Marom
CPC classification number: B01J31/003 , B01J23/50 , B01J31/06 , B01J31/2269 , B01J31/2273 , B01J31/2278 , B01J31/2295 , B01J31/2404 , B01J31/2409 , B01J2231/645 , B01J2531/0252 , B01J2531/0263 , B01J2531/0266 , B01J2531/822 , B01J2531/824 , B01J2531/827 , C07C5/03 , C12N11/14 , C07C15/073
Abstract: The present invention provides a composite comprising at least one hydrophobic organic compound and a matrix of at least one metal; wherein said at least one hydrophobic compound is entrapped within said matrix, compositions comprising at least one composite and methods of its preparation.
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公开(公告)号：US09561485B2
公开(公告)日：2017-02-07
申请号：US13515166
申请日：2010-12-06
Applicant: Laibin Bruce Yan , Craig Arlen Martin , Raed Abu-Reziq
Inventor： Laibin Bruce Yan , Craig Arlen Martin , Raed Abu-Reziq
CPC classification number: B01J13/185 , A01N25/28 , B01J13/20 , A01N33/18 , A01N39/04 , A01N43/653 , A01N53/00 , A01N57/16
Abstract: The present invention relates to a microcapsule exhibiting desirable sustained-release properties, which microcapsule comprises a core material comprising an active ingredient encapsulated within a silica shell, characterized in that the outer surface of such silica shell has a layer of a metal selected from Group 2a, Group 8, Group 2b or Group 3a of the Periodic Table bound thereto. In other aspects this invention relates to a method of making such a microcapsule; a pesticidal composition comprising microcapsules comprising a pesticidal active ingredient and a suitable carrier; and to a method of controlling pests comprising applying an effective amount of such a pesticidal composition to a locus where pests are or are expected to be present.
Abstract translation: 本发明涉及显示出所需持续释放性质的微胶囊，该微胶囊包括包含在二氧化硅壳内的活性成分的芯材，其特征在于，所述二氧化硅壳的外表面具有选自组2a的金属层 ，第8组，第2b组或第3a组与周期表结合。 在其它方面，本发明涉及制备这种微胶囊的方法; 包含含有杀虫活性成分和合适载体的微胶囊的农药组合物; 以及一种防治害虫的方法，包括将有效量的这种杀虫组合物施用于预期存在或预期存在的场所。
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