公开(公告)号：US08135236B2

公开(公告)日：2012-03-13

申请号：US13075609

申请日：2011-03-30

申请人： Rainer Dorrer

发明人： Rainer Dorrer

IPC分类号： G06K9/36

CPC分类号： G02B21/367 ,  G06K9/00134

摘要： A method of re-locating an object in a sample is provided for a previously-scanned slide having determined objects each with corresponding stored coordinates and a stored image, the objects being mapped relative to each other. The slide is positioned on a microscope stage, stored images of the objects are visually displayed, and a target object is selected. The slide is moved to an estimated coordinate position, corresponding to the coordinates of the target object, and a field-of-view image of the sample is captured for comparison to the stored image of the target. If the target is in the image, an offset between actual coordinates of the located target and the stored coordinates of the corresponding object is determined. The slide is then moved, via the stage, from the estimated coordinate position, according to the offset, to center the target in the image. Associated systems and methods are also provided.

摘要翻译： 为先前扫描的幻灯片提供了重新定位样本中的对象的方法，该幻灯片具有确定的对象，每个对象具有对应的存储的坐标和存储的图像，该对象被相对于彼此映射。 幻灯片放置在显微镜平台上，可视地显示对象的存储图像，并选择目标对象。 将幻灯片移动到对应于目标对象的坐标的估计坐标位置，并且捕获样本的视野图像以与存储的目标图像进行比较。 如果目标在图像中，则确定所定位目标的实际坐标与相应对象的存储坐标之间的偏移。 然后，幻灯片通过舞台从估计的坐标位置根据偏移量移动，以使目标在图像中居中。 还提供了相关系统和方法。

公开(公告)号：US20090196526A1

公开(公告)日：2009-08-06

申请号：US12415015

申请日：2009-03-31

申请人： Joachim Helmut Schmid ,  Thomas Gahm ,  Kevin Russell Kooy ,  Rainer Dorrer ,  Bruno Krief ,  John Royal Cheeseman

发明人： Joachim Helmut Schmid ,  Thomas Gahm ,  Kevin Russell Kooy ,  Rainer Dorrer ,  Bruno Krief ,  John Royal Cheeseman

IPC分类号： G06K9/64 ,  G06K9/36

CPC分类号： G02B21/0016 ,  G01N15/042 ,  G01N15/05 ,  G01N2035/00039 ,  G02B21/26 ,  G02B21/367 ,  G06K9/00127 ,  G06T2200/32

摘要： A scanning device for biological slides is provided, which can be operated in an interactive routine mode as well as in an unsupervised high speed automatic mode. In the first case, typical components, which the pathologist is used to operating manually, such as the microscope, the stage and the focus, and which have to be motorized for the automatic unsupervised system mode, are configured to simulate manual use, operation, and response. A non-interlaced area scan camera supports the interactive selection and acquisition of individual images in the manual mode, as well as the continuous high-speed scan motion for the rare event detection and virtual slide scan applications of the system. Due to the particular requirements to accommodate both operational modes, methods are described for constructing the virtual slide out of image tiles with varying overlap areas in the x- and y-directions.

摘要翻译： 提供了用于生物幻灯片的扫描装置，其可以以交互式例程模式以及无监督的高速自动模式操作。 在第一种情况下，病理学家用于手动操作的典型组件（如显微镜，平台和焦点）以及必须为自动无人监控系统模式而进行电动操作，被配置为模拟手动使用，操作， 和回应。 非隔行扫描摄像机支持在手动模式下交互式选择和采集各图像，以及用于系统的罕见事件检测和虚拟幻灯片扫描应用的连续高速扫描运动。 由于适应两种操作模式的特殊要求，描述了用于构造在x和y方向上具有不同重叠区域的图像瓦片中的虚拟幻灯片的方法。

公开(公告)号：US20060133657A1

公开(公告)日：2006-06-22

申请号：US11204954

申请日：2005-08-16

申请人： Joachim Schmid ,  Thomas Gahm ,  Kevin Kooy ,  Rainer Dorrer ,  Bruno Krief ,  John Cheeseman

发明人： Joachim Schmid ,  Thomas Gahm ,  Kevin Kooy ,  Rainer Dorrer ,  Bruno Krief ,  John Cheeseman

IPC分类号： G06K9/00

CPC分类号： G02B21/0016 ,  G01N15/042 ,  G01N15/05 ,  G01N2035/00039 ,  G02B21/26 ,  G02B21/367 ,  G06K9/00127 ,  G06T2200/32

摘要： A scanning device for biological slides is provided, which can be operated in an interactive routine mode as well as in an unsupervised high speed automatic mode. In the first case, typical components, which the pathologist is used to operating manually, such as the microscope, the stage and the focus, and which have to be motorized for the automatic unsupervised system mode, are configured to simulate manual use, operation, and response. A non-interlaced area scan camera supports the interactive selection and acquisition of individual images in the manual mode, as well as the continuous high-speed scan motion for the rare event detection and virtual slide scan applications of the system. Due to the particular requirements to accommodate both operational modes, methods are described for constructing the virtual slide out of image tiles with varying overlap areas in the x- and y-directions.

摘要翻译： 提供了用于生物幻灯片的扫描装置，其可以以交互式例程模式以及无监督的高速自动模式操作。 在第一种情况下，病理学家用于手动操作的典型组件（如显微镜，平台和焦点）以及必须为自动无人监控系统模式而进行电动操作，被配置为模拟手动使用，操作， 和回应。 非隔行扫描摄像机支持在手动模式下交互式选择和采集各图像，以及用于系统的罕见事件检测和虚拟幻灯片扫描应用的连续高速扫描运动。 由于适应两种操作模式的特殊要求，描述了用于构造在x和y方向上具有不同重叠区域的图像瓦片中的虚拟幻灯片的方法。

公开(公告)号：US20090006969A1

公开(公告)日：2009-01-01

申请号：US12146047

申请日：2008-06-25

申请人： Thomas Gahm ,  Rainer Dorrer ,  Joachim Schmid ,  Ryan Williams

发明人： Thomas Gahm ,  Rainer Dorrer ,  Joachim Schmid ,  Ryan Williams

IPC分类号： G09G5/00 ,  G06F3/00

CPC分类号： H04N1/32112 ,  G02B21/367 ,  G06F16/54 ,  H04N1/0402 ,  H04N1/0408 ,  H04N2201/3247 ,  H04N2201/3253 ,  H04N2201/3277

摘要： A slide viewer capable of simultaneous display of more than one representation of an area of interest of a slide is provided. The slide viewer includes a database containing at least two data files representing different representations for a same area of interest on one or multiple correlated slides or at least two different digital presentations of the same representation. The representations are views of different illumination and/or of different contrast. Associated with the database are a processor and a display. The processor retrieves data files representing different representations of the same of area of interest and displays them on the display. A user is allowed to simultaneously view representations of the same area of interest, where the representations are of views different from each other by either illumination and/or contrast or by the digital information content presented, and/or by the information acquired from multiple correlated slides.

摘要翻译： 提供能够同时显示幻灯片感兴趣区域的多于一个表示的幻灯片查看器。 幻灯片查看器包括数据库，其包含至少两个数据文件，该数据文件表示在一个或多个相关幻灯片上的相同感兴趣区域的不同表示，或至少两个相同表示的不同数字呈现。 表示是不同照明和/或不同对比度的视图。 与数据库相关联的是处理器和显示器。 处理器检索表示感兴趣区域相同面积的不同表示的数据文件，并将其显示在显示器上。 允许用户同时查看相同感兴趣区域的表示，其中表示是通过照明和/或对比度或由呈现的数字信息内容彼此不同的视图，和/或通过从多个相关的获取的信息 幻灯片。