公开(公告)号：US20090006969A1

公开(公告)日：2009-01-01

申请号：US12146047

申请日：2008-06-25

申请人： Thomas Gahm ,  Rainer Dorrer ,  Joachim Schmid ,  Ryan Williams

发明人： Thomas Gahm ,  Rainer Dorrer ,  Joachim Schmid ,  Ryan Williams

IPC分类号： G09G5/00 ,  G06F3/00

CPC分类号： H04N1/32112 ,  G02B21/367 ,  G06F16/54 ,  H04N1/0402 ,  H04N1/0408 ,  H04N2201/3247 ,  H04N2201/3253 ,  H04N2201/3277

摘要： A slide viewer capable of simultaneous display of more than one representation of an area of interest of a slide is provided. The slide viewer includes a database containing at least two data files representing different representations for a same area of interest on one or multiple correlated slides or at least two different digital presentations of the same representation. The representations are views of different illumination and/or of different contrast. Associated with the database are a processor and a display. The processor retrieves data files representing different representations of the same of area of interest and displays them on the display. A user is allowed to simultaneously view representations of the same area of interest, where the representations are of views different from each other by either illumination and/or contrast or by the digital information content presented, and/or by the information acquired from multiple correlated slides.

摘要翻译： 提供能够同时显示幻灯片感兴趣区域的多于一个表示的幻灯片查看器。 幻灯片查看器包括数据库，其包含至少两个数据文件，该数据文件表示在一个或多个相关幻灯片上的相同感兴趣区域的不同表示，或至少两个相同表示的不同数字呈现。 表示是不同照明和/或不同对比度的视图。 与数据库相关联的是处理器和显示器。 处理器检索表示感兴趣区域相同面积的不同表示的数据文件，并将其显示在显示器上。 允许用户同时查看相同感兴趣区域的表示，其中表示是通过照明和/或对比度或由呈现的数字信息内容彼此不同的视图，和/或通过从多个相关的获取的信息 幻灯片。

公开(公告)号：US20060133657A1

公开(公告)日：2006-06-22

申请号：US11204954

申请日：2005-08-16

申请人： Joachim Schmid ,  Thomas Gahm ,  Kevin Kooy ,  Rainer Dorrer ,  Bruno Krief ,  John Cheeseman

发明人： Joachim Schmid ,  Thomas Gahm ,  Kevin Kooy ,  Rainer Dorrer ,  Bruno Krief ,  John Cheeseman

IPC分类号： G06K9/00

CPC分类号： G02B21/0016 ,  G01N15/042 ,  G01N15/05 ,  G01N2035/00039 ,  G02B21/26 ,  G02B21/367 ,  G06K9/00127 ,  G06T2200/32

摘要： A scanning device for biological slides is provided, which can be operated in an interactive routine mode as well as in an unsupervised high speed automatic mode. In the first case, typical components, which the pathologist is used to operating manually, such as the microscope, the stage and the focus, and which have to be motorized for the automatic unsupervised system mode, are configured to simulate manual use, operation, and response. A non-interlaced area scan camera supports the interactive selection and acquisition of individual images in the manual mode, as well as the continuous high-speed scan motion for the rare event detection and virtual slide scan applications of the system. Due to the particular requirements to accommodate both operational modes, methods are described for constructing the virtual slide out of image tiles with varying overlap areas in the x- and y-directions.

摘要翻译： 提供了用于生物幻灯片的扫描装置，其可以以交互式例程模式以及无监督的高速自动模式操作。 在第一种情况下，病理学家用于手动操作的典型组件（如显微镜，平台和焦点）以及必须为自动无人监控系统模式而进行电动操作，被配置为模拟手动使用，操作， 和回应。 非隔行扫描摄像机支持在手动模式下交互式选择和采集各图像，以及用于系统的罕见事件检测和虚拟幻灯片扫描应用的连续高速扫描运动。 由于适应两种操作模式的特殊要求，描述了用于构造在x和y方向上具有不同重叠区域的图像瓦片中的虚拟幻灯片的方法。

公开(公告)号：US20110312026A1

公开(公告)日：2011-12-22

申请号：US13139896

申请日：2009-12-15

申请人： Florian Kirchner ,  Klaus Mauch ,  Joachim Schmid

发明人： Florian Kirchner ,  Klaus Mauch ,  Joachim Schmid

IPC分类号： C12P25/00 ,  C12N15/31 ,  C12N1/21

CPC分类号： C12P25/00 ,  C07K14/32

摘要： The invention relates to processes and means for the biotechnologically fermentative production of riboflavin (hereinafter also referred to as vitamin B2) and means for the implementation of this process, in particular a modified microbial host cell with increased riboflavin yield. The invention thus provides new processes and means for the regulation of the expression of enzyme activities involved in the riboflavin production of the host cell.

摘要翻译： 本发明涉及生物技术发酵生产核黄素（以下也称为维生素B2）的方法和手段，以及用于实施该方法的方法，特别是具有增加的核黄素产量的改良的微生物宿主细胞。 因此，本发明提供了用于调节参与宿主细胞的核黄素生产的酶活性的表达的新方法和手段。

公开(公告)号：US08212535B2

公开(公告)日：2012-07-03

申请号：US11884741

申请日：2006-02-17

申请人： Ruthard Minkner ,  Joachim Schmid ,  Rolf Fluri

发明人： Ruthard Minkner ,  Joachim Schmid ,  Rolf Fluri

IPC分类号： G05F5/00 ,  G05F1/00 ,  H02J3/08

CPC分类号： G01R15/181

摘要： Disclosed is a toroidal core current transformer comprising a primary conductor which penetrates the toroidal core and a secondary winding that is wound around the toroidal core. A measuring shunt (RSh) or a load (Zb) is provided at the secondary end. In order to compensate the phase error (f) between the primary current (IP) and the secondary current (Is), a compensation circuit (K) whose capacity (C) is measured substantially according to equation (I) or (II) is provided at the secondary end. In equation (I) or (II), C represents the capacity of the compensation circuit, ω represents the radian frequency, φ represents the phase error between the primary current and the secondary current, Rsh represents the resistance of an optional measuring shunt, and Zb represents the impedance of an optional load. C =  tan ⁢ ⁢ ϕ  ω · R sh ( I ) C =  tan ⁢ ⁢ φ  ω ·  Z _  ( II )

摘要翻译： 公开了一种环形磁芯电流互感器，其包括穿过环形磁芯的主导体和缠绕在环形磁芯上的次级绕组。 次级端设有测量分路（RSh）或负载（Zb）。 为了补偿初级电流（IP）和次级电流（Is）之间的相位误差（f），基本上按照式（I）或（II）测量容量（C）的补偿电路（K）是 提供在次级端。 在等式（I）或（II）中，C表示补偿电路的容量，ω表示弧度频率， 表示初级电流和次级电流之间的相位误差，Rsh表示可选的测量分流器的电阻，Zb表示可选负载的阻抗。 C = tan tan＆phis; ω·R sh（I）C = tan tan＆phgr; ω

公开(公告)号：US20120163681A1

公开(公告)日：2012-06-28

申请号：US13306470

申请日：2011-11-29

申请人： Jesper Lohse ,  Hans Christian Pedersen ,  Joachim Schmid ,  Jeff Caron ,  Rohit Jain ,  Thomas Briscoe

发明人： Jesper Lohse ,  Hans Christian Pedersen ,  Joachim Schmid ,  Jeff Caron ,  Rohit Jain ,  Thomas Briscoe

IPC分类号： G06K9/00

CPC分类号： G01N21/6456 ,  G01N21/6428 ,  G01N2021/6439

摘要： Disclosed are methods and systems for analyzing images of specimens processed by a programmable quantitative assay or more specifically a robust programmable quantitative dot assay, PDQA, that enable specimens to be imaged and assessed across a wide variety of conditions and applications. Specific embodiments directed to immunohistochemical applications provide more quantitative methods of imaging and assessing biological samples including tissue samples.

摘要翻译： 公开了用于分析通过可编程定量测定法处理的样品图像的方法和系统，或者更具体地说是稳健的可编程定量点测定法（PDQA），其使样本能够在各种条件和应用中成像和评估。 针对免疫组织化学应用的具体实施方案提供了更多的成像和评估包括组织样本的生物样品的定量方法。

公开(公告)号：US07972520B2

公开(公告)日：2011-07-05

申请号：US12223540

申请日：2007-01-30

申请人： Joachim Schmid

发明人： Joachim Schmid

IPC分类号： B04B3/00 ,  B04B5/12

CPC分类号： B04B3/00 ,  B04B15/06 ,  B04B15/12

摘要： The present invention relates to a process for operating a centrifuge which has a drive shaft used for loading, a drum which is connected to the drive shaft and has a drum casing and a drum base, a filter with a working region situated within the filter, an annular space formed between the filter and the drum casing, at least one drum base opening which is formed in the drum base and opens out into the annular space, and at least one swirl nozzle which is arranged in such a manner that it injects a fluid through the at least one drum base opening into the annular space. The process according to the invention includes the steps of loading a product suspension into the working region through the drive shaft, centrifuging the product suspension and drying the product suspension, wherein the drum rotates continuously during drying, and a fluid is injected into the drum through the annular space by means of the at least one swirl nozzle, and the rotational speed of the drum during drying is selected such that a product cake formed in the drum does not collapse.

摘要翻译： 本发明涉及一种用于操作离心机的方法，该离心机具有用于装载的驱动轴，连接到驱动轴并具有鼓壳体和鼓座的滚筒，具有位于过滤器内的工作区域的过滤器， 形成在所述过滤器和所述鼓壳体之间的环形空间，形成在所述滚筒基部中并且向所述环形空间开口的至少一个鼓基部开口，以及至少一个旋转喷嘴，其以这样的方式被布置： 流体通过至少一个鼓座开口进入环形空间。 根据本发明的方法包括以下步骤：将产品悬浮液通过驱动轴装载到工作区域中，离心产品悬浮液并干燥产品悬浮液，其中滚筒在干燥期间连续旋转，并且将流体注入滚筒中 通过至少一个旋流喷嘴的环形空间和干燥期间的滚筒的旋转速度被选择为使得在滚筒中形成的产品饼不会塌陷。

公开(公告)号：US06805893B2

公开(公告)日：2004-10-19

申请号：US10459251

申请日：2003-06-11

申请人： Gonzalo Acuna ,  Markus Gautschi ,  Frank Kumli ,  Joachim Schmid ,  Janos Zsindely

发明人： Gonzalo Acuna ,  Markus Gautschi ,  Frank Kumli ,  Joachim Schmid ,  Janos Zsindely

IPC分类号： A23L122

CPC分类号： C07C323/12

摘要： New diastereoisomer-enriched 3-mercapto-alkanols are disclosed. The compounds, namely 3-mercapto-2-methyl-butan-1-ol and/or 3-mercapto-3-methyl-hexan-1-ol, and the stereoisomers of each, are used to flavor products, such as foods and/or beverages. Methods for the preparation of both diastereoisomers of 3-mercapto-2-methyl-butan-1-ol are also disclosed.

摘要翻译： 公开了新的非对映异构体富集的3-巯基 - 链烷醇。 化合物，即3-巯基-2-甲基 - 丁-1-醇和/或3-巯基-3-甲基 - 己-1-醇及其各自的立体异构体用于调味产品，如食品和 /或饮料。 还公开了制备3-巯基-2-甲基 - 丁-1-醇的两种非对映异构体的方法。

公开(公告)号：US06610346B1

公开(公告)日：2003-08-26

申请号：US09579633

申请日：2000-05-26

申请人： Gonzalo Acuña ,  Markus Gautschi ,  Frank Kumli ,  Joachim Schmid ,  Janos Zsindely

发明人： Gonzalo Acuña ,  Markus Gautschi ,  Frank Kumli ,  Joachim Schmid ,  Janos Zsindely

IPC分类号： A23L122

CPC分类号： C07C323/12

摘要： New 3-mercapto-alkanols are disclosed. The compounds, namely 3-mercapto-2-methyl-butan-1-ol and/or 3-mercapto-3-methyl-hexan-1-ol, and the stereoisomers of each, are used to flavor products, such as foods and/or beverages. Methods for the preparation of both diastereoisomers of 3-mercapto-2-methyl-butan-1-ol are also disclosed.

摘要翻译： 公开了新的3-巯基 - 链烷醇。 化合物，即3-巯基-2-甲基 - 丁-1-醇和/或3-巯基-3-甲基 - 己-1-醇及其各自的立体异构体用于调味产品，如食品和 /或饮料。 还公开了制备3-巯基-2-甲基 - 丁-1-醇的两种非对映异构体的方法。

公开(公告)号：US09970874B2

公开(公告)日：2018-05-15

申请号：US13306470

申请日：2011-11-29

申请人： Jesper Lohse ,  Hans Christian Pedersen ,  Joachim Schmid ,  Jeff Caron ,  Rohit Jain ,  Thomas Briscoe

发明人： Jesper Lohse ,  Hans Christian Pedersen ,  Joachim Schmid ,  Jeff Caron ,  Rohit Jain ,  Thomas Briscoe

IPC分类号： G06K9/00 ,  G01N21/64

CPC分类号： G01N21/6456 ,  G01N21/6428 ,  G01N2021/6439

摘要： Disclosed are methods and systems for analyzing images of specimens processed by a programmable quantitative assay or more specifically a robust programmable quantitative dot assay, PDQA, that enable specimens to be imaged and assessed across a wide variety of conditions and applications. Specific embodiments directed to immunohistochemical applications provide more quantitative methods of imaging and assessing biological samples including tissue samples.

公开(公告)号：US08759024B2

公开(公告)日：2014-06-24

申请号：US13139896

申请日：2009-12-15

申请人： Florian Kirchner ,  Klaus Mauch ,  Joachim Schmid

发明人： Florian Kirchner ,  Klaus Mauch ,  Joachim Schmid

IPC分类号： C12P25/00 ,  C12N9/00 ,  C12N1/20 ,  C12N15/00 ,  C07H21/04

CPC分类号： C12P25/00 ,  C07K14/32

摘要： The invention relates to processes and means for the biotechnologically fermentative production of riboflavin (hereinafter also referred to as vitamin B2) and means for the implementation of this process, in particular a modified microbial host cell with increased riboflavin yield. The invention thus provides new processes and means for the regulation of the expression of enzyme activities involved in the riboflavin production of the host cell.

摘要翻译： 本发明涉及生物技术发酵生产核黄素（以下也称为维生素B2）的方法和手段，以及用于实施该方法的方法，特别是具有增加的核黄素产量的改良的微生物宿主细胞。 因此，本发明提供了用于调节参与宿主细胞的核黄素生产的酶活性的表达的新方法和手段。