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公开(公告)号：US08975438B2
公开(公告)日：2015-03-10
申请号：US13541795
申请日：2012-07-05
申请人： Beat Birrer , Leo Clarke , Walter Deichtmann , John Hayes , Julius Jeisy , Christian Lautz , Rainer E. Martin , Michael Meade , Joaquim Pintao , Michelangelo Scalone , Juergen Schaefer , Dennis Smith , Andreas Staempfli , Joachim Veits , Christian Walch , Andrew Walsh , Andreas Zogg
发明人： Beat Birrer , Leo Clarke , Walter Deichtmann , John Hayes , Julius Jeisy , Christian Lautz , Rainer E. Martin , Michael Meade , Joaquim Pintao , Michelangelo Scalone , Juergen Schaefer , Dennis Smith , Andreas Staempfli , Joachim Veits , Christian Walch , Andrew Walsh , Andreas Zogg
IPC分类号： C07C259/04 , C07C319/20 , C07C51/06 , C07C51/08 , C07C319/06 , C07C327/30 , C07C51/02
CPC分类号： C07C319/20 , C07C51/02 , C07C51/06 , C07C51/08 , C07C319/06 , C07C327/30 , C07C2601/14 , C07C323/40 , C07C61/08
摘要： A process for the preparation of a compound of formula (I): which is useful as an intermediate in the preparation of pharmaceutically active compounds.
摘要翻译： 制备式（I）化合物的方法：其可用作药物活性化合物的制备中的中间体。
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2.发明授权4-phenoxy-nicotinamide or 4-phenoxy-pyrimidine-5-carboxamide compounds 失效4-苯氧基 - 烟酰胺或4-苯氧基 - 嘧啶-5-甲酰胺化合物公开(公告)号：US08420647B2
公开(公告)日：2013-04-16
申请号：US13005566
申请日：2011-01-13
申请人： Caterina Bissantz , Henrietta Dehmlow , Shawn David Erickson , Kyungjin Kim , Rainer E. Martin , Ulrike Obst Sander , Sherrie Lynn Pietranico-Cole , Hans Richter , Christoph Ulmer
发明人： Caterina Bissantz , Henrietta Dehmlow , Shawn David Erickson , Kyungjin Kim , Rainer E. Martin , Ulrike Obst Sander , Sherrie Lynn Pietranico-Cole , Hans Richter , Christoph Ulmer
IPC分类号： A61K31/498
CPC分类号： C07D417/14 , C07D213/82 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D417/12
摘要： This invention relates to novel phenyl amide or pyridyl amide derivatives of the formula wherein A1, A2, B1, B2 and R1 to R11 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.
摘要翻译： 本发明涉及下式的新型苯基酰胺或吡啶基酰胺衍生物，其中A1，A2，B1，B2和R1至R11如说明书和权利要求书中所定义，以及其药学上可接受的盐。 这些化合物是GPBAR1激动剂，可用作治疗II型糖尿病等疾病的药物。
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公开(公告)号：US08008503B2
公开(公告)日：2011-08-30
申请号：US12862823
申请日：2010-08-25
申请人： Gregory Martin Benson , Konrad Bleicher , Uwe Grether , Rainer E Martin , Jean-Marc Plancher , Hans Richter , Sven Taylor , Minmin Yang
发明人： Gregory Martin Benson , Konrad Bleicher , Uwe Grether , Rainer E Martin , Jean-Marc Plancher , Hans Richter , Sven Taylor , Minmin Yang
IPC分类号： A61K31/4184 , C07D235/06
CPC分类号： C07D235/06 , C07D405/12 , C07D409/12
摘要： The invention is concerned with novel substituted benzimidazole derivatives of formula (I) wherein R1 to R10 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds can be used as medicaments.
摘要翻译： 本发明涉及式（I）的新型取代的苯并咪唑衍生物，其中R 1至R 10如说明书和权利要求书中所定义，以及其生理学上可接受的盐和酯。 这些化合物可以用作药物。
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4.发明申请4-PHENOXY-NICOTINAMIDE OR 4-PHENOXY-PYRIMIDINE-5-CARBOXAMIDE COMPOUNDS 失效4-苯氧基-N-或4-苯氧基 - 吡咯烷-5-羧酰胺化合物公开(公告)号：US20110178089A1
公开(公告)日：2011-07-21
申请号：US13005566
申请日：2011-01-13
申请人： Caterina Bissantz , Henrietta Dehmlow , Shawn David Erickson , Kyungjin Kim , Rainer E. Martin , Ulrike Obst Sander , Sherrie Lynn Pietranico-Cole , Hans Richter , Christoph Ulmer
发明人： Caterina Bissantz , Henrietta Dehmlow , Shawn David Erickson , Kyungjin Kim , Rainer E. Martin , Ulrike Obst Sander , Sherrie Lynn Pietranico-Cole , Hans Richter , Christoph Ulmer
IPC分类号： C07D401/06 , C07D213/82 , C07D401/12 , C07D401/14 , C07D417/14 , C07D403/06 , A61K31/4709 , A61K31/498 , A61K31/44 , A61K31/4545 , A61K31/444 , A61K31/506 , A61P3/10 , A61P3/04 , A61P3/00 , A61P3/06 , A61P29/00
CPC分类号： C07D417/14 , C07D213/82 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D417/12
摘要： This invention relates to novel phenyl amide or pyridyl amide derivatives of the formula wherein A1, A2, B1, B2 and R1 to R11 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.
摘要翻译： 本发明涉及下式的新型苯基酰胺或吡啶基酰胺衍生物，其中A1，A2，B1，B2和R1至R11如说明书和权利要求书中所定义，以及其药学上可接受的盐。 这些化合物是GPBAR1激动剂，可用作治疗II型糖尿病等疾病的药物。
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公开(公告)号：US20100331371A1
公开(公告)日：2010-12-30
申请号：US12862823
申请日：2010-08-25
申请人： Gregory Martin Benson , Konrad Bleicher , Uwe Grether , Rainer E. Martin , Jean-Marc Plancher , Hans Richter , Sven Taylor , Minmin Yang
发明人： Gregory Martin Benson , Konrad Bleicher , Uwe Grether , Rainer E. Martin , Jean-Marc Plancher , Hans Richter , Sven Taylor , Minmin Yang
IPC分类号： A61K31/4439 , C07D235/04 , A61K31/4184 , C07D401/02 , A61P3/10 , A61P3/06
CPC分类号： C07D235/06 , C07D405/12 , C07D409/12
摘要： The invention is concerned with novel substituted benzimidazole derivatives of formula (I) wherein R1 to R10 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds can be used as medicaments.
摘要翻译： 本发明涉及式（I）的新型取代的苯并咪唑衍生物，其中R 1至R 10如说明书和权利要求书中所定义，以及其生理学上可接受的盐和酯。 这些化合物可以用作药物。
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6.发明申请PHENYL, PYRIDINE, QUINOLINE, ISOQUINOLINE, NAPHTHYRIDINE AND PYRAZINE DERIVATIVES 失效苯胺，吡啶，喹啉，异喹啉，萘啶和吡啶衍生物公开(公告)号：US20100222350A1
公开(公告)日：2010-09-02
申请号：US12776748
申请日：2010-05-10
IPC分类号： A61K31/5377 , C07D211/58 , A61K31/4468 , A61P3/10 , A61K31/4535 , C07D409/12 , C07D413/12 , A61K31/454 , C07D401/12 , A61K31/4709 , C07D471/04 , A61K31/4375 , A61K31/4725 , A61K31/497 , C07D405/14 , C07D413/14
CPC分类号： C07D211/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D471/04
摘要： This invention is concerned with compounds of the formula and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are associated with the modulation of SST receptors subtype 5.
摘要翻译： 本发明涉及下式的化合物及其药学上可接受的盐。 本发明还涉及含有这些化合物的药物组合物，其制备方法及其用于治疗和/或预防与调节SST受体亚型5相关的疾病的用途。
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公开(公告)号：US20090163552A1
公开(公告)日：2009-06-25
申请号：US12331461
申请日：2008-12-10
申请人： Gregory Martin Benson , Konrad Bleicher , Uwe Grether , Bernd Kuhn , Rainer E. Martin , Jean-Marc Plancher , Hans Richter , Sven Taylor , Minmin Yang
发明人： Gregory Martin Benson , Konrad Bleicher , Uwe Grether , Bernd Kuhn , Rainer E. Martin , Jean-Marc Plancher , Hans Richter , Sven Taylor , Minmin Yang
IPC分类号： A61K31/4184 , C07D401/12 , C07D401/14 , A61P9/00 , A61P25/28 , A61P35/00 , C07D235/16 , A61K31/4439
CPC分类号： C07D401/04 , C07D235/12 , C07D401/12 , C07D401/14
摘要： This invention relates to novel carboxyl- or hydroxyl-substituted benzimidazole derivatives of formula (I) wherein R1 to R6 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to FXR and can be used as medicaments.
摘要翻译： 本发明涉及式（I）的新型羧基或羟基取代的苯并咪唑衍生物，其中R 1至R 6如说明书和权利要求书中所定义，以及其生理上可接受的盐和酯。 这些化合物与FXR结合，可用作药物。
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8.发明授权3-amino-indazole or 3-amino-4,5,6,7-tetrahydro-indazole derivatives 失效3-氨基 - 吲唑或3-氨基-4,5,6,7-四氢 - 吲唑衍生物公开(公告)号：US08153663B2
公开(公告)日：2012-04-10
申请号：US12563189
申请日：2009-09-21
申请人： Gregory Martin Benson , Konrad Bleicher , Song Feng , Uwe Grether , Bernd Kuhn , Rainer E. Martin , Jean-Marc Plancher , Hans Richter , Markus Rudolph , Sven Taylor
发明人： Gregory Martin Benson , Konrad Bleicher , Song Feng , Uwe Grether , Bernd Kuhn , Rainer E. Martin , Jean-Marc Plancher , Hans Richter , Markus Rudolph , Sven Taylor
IPC分类号： A61K31/44 , A61K31/415 , C07D401/02 , C07D231/56
CPC分类号： C07D231/56 , C07D401/12 , C07D407/12
摘要： This invention relates to novel indazole derivatives of formula I: wherein R1 to R7 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are FXR modulators and can be used as medicaments.
摘要翻译： 本发明涉及式I的新型吲唑衍生物：其中R 1至R 7如说明书和权利要求书中所定义，以及其生理上可接受的盐。 这些化合物是FXR调节剂，可用作药物。
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9.发明申请Phenyl, Pyridine, Quinoline, Isoquinoline, Naphthyridine and Pyrazine Derivatives 失效苯基，吡啶，喹啉，异喹啉，萘啶和吡嗪衍生物公开(公告)号：US20080045544A1
公开(公告)日：2008-02-21
申请号：US11834184
申请日：2007-08-06
IPC分类号： A61K31/4465 , A61K31/4375 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61P3/10 , C07D211/58 , C07D401/02 , C07D487/04
CPC分类号： C07D211/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D471/04
摘要： This invention is concerned with compounds of the formula and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are associated with the modulation of SST receptors subtype 5.
摘要翻译： 本发明涉及下式的化合物及其药学上可接受的盐。 本发明还涉及含有这些化合物的药物组合物，其制备方法及其用于治疗和/或预防与调节SST受体亚型5相关的疾病的用途。
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公开(公告)号：US08765730B2
公开(公告)日：2014-07-01
申请号：US13180574
申请日：2011-07-12
申请人： Caterina Bissantz , Henrietta Dehmlow , Shawn David Erickson , Kyungjin Kim , Rainer E. Martin , Patrizio Mattei , Ulrike Obst Sander , Sherrie Lynn Pietranico-Cole , Hans Richter , Christoph Ullmer
发明人： Caterina Bissantz , Henrietta Dehmlow , Shawn David Erickson , Kyungjin Kim , Rainer E. Martin , Patrizio Mattei , Ulrike Obst Sander , Sherrie Lynn Pietranico-Cole , Hans Richter , Christoph Ullmer
IPC分类号： A61K31/4409 , C07D401/10
CPC分类号： C07C251/48 , C07C2601/02 , C07C2601/14 , C07D213/53 , C07D213/55 , C07D213/64 , C07D213/89 , C07D215/12 , C07D239/26 , C07D241/12 , C07D401/10 , C07D413/10 , C07D417/10
摘要： This invention relates to novel 1-hydroxyimino-3-phenyl-propanes of the formula wherein R1 to R10 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and may be used as medicaments for the treatment of diseases such as type II diabetes.
摘要翻译： 本发明涉及下式的新颖的1-肟基-3-苯基 - 丙烷，其中R 1至R 10如说明书和权利要求书中所定义，以及其药学上可接受的盐。 这些化合物是GPBAR1激动剂，可用作治疗II型糖尿病等疾病的药物。
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