公开(公告)号：US06211231B1

公开(公告)日：2001-04-03

申请号：US09570995

申请日：2000-05-15

Applicant: Rajiv Mathur

Inventor： Rajiv Mathur

IPC: A61K3134

CPC classification number: A61K31/34

Abstract: The invention features a method of stabilizing free 1-ascorbic acid from oxidation by dispersing the free 1-ascorbic acid in a mixed glycol carrier and a solution containing the ascorbic acid in the mixed glycol solution. The mixed glycol carrier contains a mixture of at least propylene glycol and butylene glycol, but may contain other glycols such as polyethylene glycol, and stabilizing and solubility assisting agents as well.

Abstract translation: 本发明的特征在于通过将游离的1-抗坏血酸分散在混合的二醇载体和含有抗坏血酸的溶液在混合的二醇溶液中而使游离的1-抗坏血酸免于氧化的方法。 混合乙二醇载体含有至少丙二醇和丁二醇的混合物，但也可以含有其它二醇，如聚乙二醇，以及稳定和助溶剂。

公开(公告)号：US5219538A

公开(公告)日：1993-06-15

申请号：US662850

申请日：1991-03-01

Applicant: Sheryl L. Henderson ,  Donald F. H. Wallach ,  Rajiv Mathur

Inventor： Sheryl L. Henderson ,  Donald F. H. Wallach ,  Rajiv Mathur

IPC: A61K8/14 ,  A61K8/70 ,  A61K9/00 ,  A61K9/127 ,  A61K49/22 ,  A61Q19/00 ,  B01J13/02 ,  B01J13/20 ,  C08K9/04 ,  C08L101/00 ,  C11D17/00

CPC classification number: A61K9/0026 ,  A61K49/227 ,  A61K8/14 ,  A61K8/22 ,  A61K8/70 ,  A61K9/1272 ,  A61K9/1277 ,  A61K9/1278 ,  A61Q19/00 ,  B01J13/203 ,  C11D17/0021 ,  C11D17/0026 ,  Y10S436/829 ,  Y10S514/832 ,  Y10T428/2984

Abstract: The present invention relates to the production of lipid vesicles having a moderately volatile material such as a perfluorocarbon or a silicone oil encapsulated therein. In another aspect, lipid vesicles having a gas-filled center or core are made. The lipid vesicles having gas-filled central core are made by dehydrating vesicles having the moderately volatile liquid encapsulated in the central core. This drives off the water first, allowing the moderately volatile liquid to stabilize the vesicle structure as it dries, finally forming a central void which can refract light. The preferred vesicles of the invention are paucilamellar vesicles.

Abstract translation: 本发明涉及具有中等挥发性物质如全氟化碳或其中包封的硅油的脂质囊泡的生产。 在另一方面，制备具有充气中心或芯的脂质囊泡。 具有气体填充的中心芯的脂质囊泡通过将包含在中心核心中的中等挥发性液体的脱水囊泡制成。 这首先驱除水分，允许中等挥发性液体在干燥时稳定囊泡结构，最终形成可折射光的中心空隙。 本发明的优选囊泡是小泡囊泡。

公开(公告)号：US5164191A

公开(公告)日：1992-11-17

申请号：US654327

申请日：1991-02-12

Applicant: S. Esmail Tabibi ,  An-Cheng Chang ,  Rajiv Mathur ,  Donald F. H. Wallach

Inventor： S. Esmail Tabibi ,  An-Cheng Chang ,  Rajiv Mathur ,  Donald F. H. Wallach

IPC: A61K9/127

CPC classification number: A61K9/1272 ,  Y10T428/2984

Abstract: The present invention features a method of making lipid vesicles and the lipid vesicles themselves made from monomeric and dimeric alkyds. These alkyds are esters made as a condensation product of a first reactant having at least one free hydroxyl group and a C.sub.12 -C.sub.20 fatty acids chain and a second reactant which is an aromatic acid chloride or anhydride. Preferred first reactants are esters of polyols and C.sub.12 -C.sub.20 fatty acids, ethers of polyols and C.sub.12 -C.sub.20 fatty acids, and C.sub.12 -C.sub.20 fatty alcohols.

Abstract translation: 本发明的特征在于制备脂质囊泡的方法，脂质囊泡本身由单体和二聚醇酸树脂制成。 这些醇酸树脂是作为具有至少一个游离羟基的第一反应物和C 12 -C 20脂肪酸链和作为芳族酰氯或酸酐的第二反应物的缩合产物的酯。 优选的第一反应物是多元醇和C 12 -C 20脂肪酸的酯，多元醇和C 12 -C 20脂肪酸的醚和C 12 -C 20脂肪醇。

公开(公告)号：US07621740B2

公开(公告)日：2009-11-24

申请号：US11682602

申请日：2007-03-06

Applicant: Robert Mills ,  Rajiv Mathur ,  Nadya Lawrence

Inventor： Robert Mills ,  Rajiv Mathur ,  Nadya Lawrence

IPC: A61K36/00

CPC classification number: A61Q19/00 ,  A61K8/14 ,  A61K8/97 ,  A61K9/0014 ,  A61K9/127 ,  A61K36/29 ,  A61Q19/007

Abstract: A skin treatment composition comprising a Mahonia aquifolium extract in a liposome delivery system is described. The Mahonia aquifolium extract is present in the skin treatment composition in a range of from 5% to 20% by weight of the total composition. The skin treatment composition is particularly effective in the treatment of psoriasis, eczema and other dry skin conditions. A process for obtaining an extract of Mahonia aquifolium is also disclosed.

Abstract translation: 描述了在脂质体递送系统中包含马鞭草提取物的皮肤处理组合物。 马鞭草提取物以总组合物的5重量％至20重量％的范围存在于皮肤处理组合物中。 皮肤治疗组合物在治疗牛皮癣，湿疹和其它干性皮肤病症中特别有效。 还公开了一种获得大洋沼泽提取物的方法。

公开(公告)号：US6087393A

公开(公告)日：2000-07-11

申请号：US329608

申请日：1999-06-10

Applicant: Rajiv Mathur

Inventor： Rajiv Mathur

IPC: A61K31/34

CPC classification number: A61K31/34

Abstract: The invention features a method of stabilizing free 1-ascorbic acid from oxidation by dispersing the free 1-ascorbic acid in a mixed glycol carrier and a solution containing the ascorbic acid in the mixed glycol solution. The mixed glycol carrier contains a mixture of at least propylene glycol and butylene glycol, but may contain other glycols such as polyethylene glycol , and stabilizing and solubility assisting agents as well.

Abstract translation: 本发明的特征在于通过将游离的1-抗坏血酸分散在混合的二醇载体和含有抗坏血酸的溶液在混合的二醇溶液中而使游离的1-抗坏血酸免于氧化的方法。 混合乙二醇载体含有至少丙二醇和丁二醇的混合物，但也可以含有其它二醇，如聚乙二醇，以及稳定和助溶剂。

公开(公告)号：US5643600A

公开(公告)日：1997-07-01

申请号：US583667

申请日：1996-01-05

Applicant: Rajiv Mathur

Inventor： Rajiv Mathur

IPC: A61K8/14 ,  A61K8/92 ,  A61K9/127 ,  A61Q5/12 ,  A61Q19/00 ,  A61Q19/08 ,  A61K7/00

CPC classification number: A61K8/922 ,  A61K8/14 ,  A61K9/1272 ,  A61Q19/00 ,  A61Q19/08 ,  A61Q5/12 ,  Y10T428/2984

Abstract: Disclosed are oil-filled paucilamellar lipid vesicles containing at least one non-phospholipid amphiphile as the primary lipid of the vesicle bilayers and avocado oil unsaponifiables. The vesicles are particularly useful for delivering dermatological, cosmetic and pharmaceutical formulations. A method of manufacture for these vesicles is also disclosed.

Abstract translation: 公开了含有至少一种非磷脂两亲物作为囊泡双层的主要脂质和鳄梨油不皂化物的油充满的小囊脂质囊泡。 囊泡对于递送皮肤病学，化妆品和药物制剂是特别有用的。 还公开了这些囊泡的制造方法。

公开(公告)号：US5256422A

公开(公告)日：1993-10-26

申请号：US909112

申请日：1992-07-08

Applicant: Elizabeth C. Albert ,  Donald F. H. Wallach ,  Rajiv Mathur

Inventor： Elizabeth C. Albert ,  Donald F. H. Wallach ,  Rajiv Mathur

IPC: A23D7/005 ,  A61K8/14 ,  A61K9/113 ,  A61K9/127 ,  A61Q19/00

CPC classification number: A61K8/064 ,  A23D7/0056 ,  A61K8/14 ,  A61K9/113 ,  A61K9/1272 ,  A61Q19/00 ,  Y10S514/937 ,  Y10S514/938 ,  Y10S514/941 ,  Y10S514/943 ,  Y10T428/2984

Abstract: The present invention features water-in-oil emulsions having intact lipid vesicles dispersed in the water or aqueous phase. Methods of making the emulsions are also disclosed. The preferred vesicles for use in the emulsions are paucilamellar lipid vesicles, most preferably those having nonionic amphiphiles as their major structural component. The water-in-oil emulsions are useful in cosmetics, pharmaceuticals, and foods such as margarine.

Abstract translation: 本发明的特征在于具有分散在水或水相中的完整脂质囊泡的油包水乳液。 还公开了制备乳液的方法。 用于乳液的优选囊泡是微囊脂质囊泡，最优选的是具有非离子两亲物作为其主要结构组分的囊泡。 油包水乳液可用于化妆品，药​​物和人造黄油等食品。

公开(公告)号：US20150220927A1

公开(公告)日：2015-08-06

申请号：US14129543

申请日：2013-09-25

Applicant: Ned M. SMITH ,  Thomas J. SAWICKI ,  Rajiv MATHUR ,  Tolga ACAR ,  Yuriy BULYGIN ,  Thomas G. WILLIS ,  Intel Corporation

Inventor： Ned M. Smith ,  Thomas J. Sawicki ,  Rajiv Mathur ,  Tolga Acar ,  Yuriy Bulygin ,  Thomas G. Willis

IPC: G06Q20/40 ,  H04L29/08

CPC classification number: G06Q20/4016 ,  G06Q30/06 ,  G06Q40/08 ,  H04L67/10

Abstract: Techniques and mechanisms to provide indemnification for a transaction involving communications between networked devices. In an embodiment, attestation logic of a first device sends to a second device attestation information to indicate a trustworthiness level of first device. Based on the attestation information, indemnification logic of the second device determines an indemnification value representing a cost of an indemnification for a first transaction. Indemnification logic of the first device receives the indemnification value and determines, based on the indemnification value, whether a participation in the transaction is to take place.

Abstract translation: 为涉及网络设备之间通信的交易提供赔偿的技术和机制。 在一个实施例中，第一设备的认证逻辑发送到第二设备认证信息以指示第一设备的可信赖级别。 基于认证信息，第二设备的赔偿逻辑确定代表第一交易的赔偿成本的赔偿价值。 第一设备的赔偿逻辑接收赔偿价值，并根据赔偿价值确定是否要进行交易。

公开(公告)号：US5439967A

公开(公告)日：1995-08-08

申请号：US148952

申请日：1993-11-08

Applicant: Rajiv Mathur

Inventor： Rajiv Mathur

IPC: A61K8/14 ,  A61K8/92 ,  A61K9/127 ,  A61K47/06 ,  A61K47/14 ,  A61Q5/12 ,  A61Q19/00 ,  A61Q19/08 ,  B01J13/02

CPC classification number: A61Q19/00 ,  A61K8/14 ,  A61K8/922 ,  A61K9/1272 ,  A61Q19/08 ,  A61Q5/12 ,  Y10T428/2984

Abstract: Disclosed are lipid vesicles containing a blend of amphiphiles, including propylene glycol stearate, in the lipid bilayers. The vesicles may have either an aqueous or oil-filled central cavity and are particularly useful for delivering dermatological, cosmetic and pharmaceutical formulations. A method of manufacture for these vesicles is also disclosed.

Abstract translation: 公开了在脂质双层中含有两亲物（包括丙二醇硬脂酸酯）的混合物的脂质囊泡。 囊泡可以具有水或油填充的中心腔，并且特别可用于递送皮肤病学，化妆品和药物制剂。 还公开了这些囊泡的制造方法。

公开(公告)号：US5260065A

公开(公告)日：1993-11-09

申请号：US761253

申请日：1991-09-17

Applicant: Rajiv Mathur ,  Donald F. H. Wallach

Inventor： Rajiv Mathur ,  Donald F. H. Wallach

IPC: A61K8/14 ,  A61K8/92 ,  A61K9/127 ,  A61K47/06 ,  A61Q5/12 ,  A61Q19/00 ,  A61Q19/08 ,  B01J13/02

CPC classification number: A61Q19/00 ,  A61K8/14 ,  A61K8/922 ,  A61K9/1272 ,  A61Q19/08 ,  A61Q5/12 ,  Y10T428/2984

Abstract: A new class of lipid vesicles having a blend of two lipids, a primary lipid and a secondary lipid, has been developed. The primary lipid, which forms the greatest proportion of lipid by weight, will not form vesicles nor preferably, even a lamellar phase, without addition of the secondary lipid. Preferably primary lipids are C.sub.12 -C.sub.18 fatty alcohols, C.sub.12 -C.sub.18 glycol monoesters, and C.sub.12 -C.sub.18 glyceryl mono- and diesters.

Abstract translation: 已经开发了一类具有两种脂质，一种主要脂质和二级脂质的混合物的脂质囊泡。 形成脂质重量比例最大的主要脂质不会形成囊泡，也不会优选甚至层状相，而不添加次级脂质。 初级脂质优选为C12-C18脂肪醇，C12-C18二醇单酯和C12-C18甘油单酯和二酯。