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公开(公告)号：US08309327B2
公开(公告)日：2012-11-13
申请号：US13222066
申请日：2011-08-31
IPC分类号： A61K39/02 , A61K39/102
CPC分类号： A61K39/092 , A61K39/385 , A61K2039/6068 , C07K1/16 , C07K14/3156
摘要： The present invention relates to a method for purifying bacterial cytolysins such as pneumococcal pneumolysin. A single chromatography step produces excellent purification of the cytolysin by binding soluble aggregated cytolysin to a hydrophobic interaction chromatography material in the presence of detergent and high salt.
摘要翻译： 本发明涉及一种纯化细菌细胞溶质蛋白如肺炎球菌肺炎杆菌素的方法。 单一色谱步骤通过在洗涤剂和高盐存在下将可溶性聚集的细胞溶解素结合到疏水相互作用层析材料上，产生细胞溶素的极好的纯化。
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公开(公告)号：US20080025993A1
公开(公告)日：2008-01-31
申请号：US10525889
申请日：2003-08-28
申请人： Ralph Biemans , Philippe Denoel , Christiane Feron , Carine Goraj , Jan Poolman , Vincent Weynants
发明人： Ralph Biemans , Philippe Denoel , Christiane Feron , Carine Goraj , Jan Poolman , Vincent Weynants
CPC分类号： A61K39/095 , A61K39/102 , A61K39/1045 , A61K2039/55505 , A61K2039/55516 , A61K2039/55572 , A61K2039/55577 , C07K14/22
摘要： The present invention provides an isolated refolded NspA protein, and a method of preparing it.
摘要翻译： 本发明提供了分离的重折叠NspA蛋白质及其制备方法。
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公开(公告)号：US20060141563A1
公开(公告)日：2006-06-29
申请号：US10526062
申请日：2003-08-28
申请人： Ralph Biemans , Philippe Denoel , Christiane Feron , Karine Larine Goraj , Jeroen Kortekaas , Jan Poolman , Johannes Tommassen , Vincent Weynants
发明人： Ralph Biemans , Philippe Denoel , Christiane Feron , Karine Larine Goraj , Jeroen Kortekaas , Jan Poolman , Johannes Tommassen , Vincent Weynants
CPC分类号： A61K39/102 , A61K39/095 , A61K39/1045 , A61K2039/505 , A61K2039/55505 , A61K2039/55516 , A61K2039/55572 , A61K2039/55577 , C07K14/22
摘要： An FrpB protein having one or more deletions of non-conserved amino acids compared to a corresponding wild-type FrpB protein, and a method of refolding an FrpB protein.
摘要翻译： 与相应的野生型FrpB蛋白相比，具有一个或多个非保守氨基酸缺失的FrpB蛋白，以及重新折叠FrpB蛋白的方法。
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公开(公告)号：US08815254B2
公开(公告)日：2014-08-26
申请号：US13628632
申请日：2012-09-27
CPC分类号： A61K39/092 , A61K39/385 , A61K2039/6068 , C07K1/16 , C07K14/3156
摘要： The present invention relates to a method of detoxifying bacterial cytolysins such as pneumococcal pneumolysin, utilizing chemical cross-linking compounds.
摘要翻译： 本发明涉及利用化学交联化合物对细菌细胞溶素如肺炎球菌肺炎解毒素进行解毒的方法。
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公开(公告)号：US20140010843A1
公开(公告)日：2014-01-09
申请号：US13628632
申请日：2012-09-27
CPC分类号： A61K39/092 , A61K39/385 , A61K2039/6068 , C07K1/16 , C07K14/3156
摘要： The present invention relates to a method of detoxifying bacterial cytolysins such as pneumococcal pneumolysin, utilizing chemical cross-linking compounds.
摘要翻译： 本发明涉及利用化学交联化合物对细菌细胞溶素如肺炎球菌肺炎解毒素进行解毒的方法。
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6.发明申请公开(公告)号：US20060240045A1
公开(公告)日：2006-10-26
申请号：US10523117
申请日：2003-07-31
申请人： Francois-Xavier Berthet , Ralph Biemans , Philippe Denoel , Christiane Feron , Carine Goraj , Jan Poolman , Vincent Weynants
发明人： Francois-Xavier Berthet , Ralph Biemans , Philippe Denoel , Christiane Feron , Carine Goraj , Jan Poolman , Vincent Weynants
IPC分类号： A61K39/095
CPC分类号： A61K39/095 , A61K39/102 , A61K39/1045 , A61K2039/521 , A61K2039/55505 , A61K2039/55516 , A61K2039/55572 , A61K2039/55577 , A61K2039/70 , C07K14/22 , Y02A50/396
摘要： The present invention relates to immunogenic compositions and vaccines for the treatment and prevention of Neisserial disease. Immunogenic compositions of the invention contain combinations of antigens selected from at least two different classes of antigens including adhesins, autotransporter proteins, toxins, iron acquisitions proteins and membrane-associated protein (preferably integral outer membrane protein)s. Such combinations of antigens are able to target the immune response against different aspects of the neisserial life cycle, resulting in a more effective immune response.
摘要翻译： 本发明涉及用于治疗和预防奈瑟氏球菌病的免疫原性组合物和疫苗。 本发明的免疫原性组合物含有选自至少两种不同类型的抗原的抗原的组合，包括粘附素，自身转运蛋白，毒素，铁获得蛋白和膜相关蛋白（优选整体外膜蛋白）。 抗原的这种组合能够针对奈桑氏生命周期的不同方面靶向免疫应答，导致更有效的免疫应答。
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公开(公告)号：US20120064120A1
公开(公告)日：2012-03-15
申请号：US13299041
申请日：2011-11-17
申请人： Francois-Xavier Jacques Berthet , Ralph Biemans , Philippe Denoel , Christiane Feron , Carine Goraj , Jan Poolman , Vincent Weynants
发明人： Francois-Xavier Jacques Berthet , Ralph Biemans , Philippe Denoel , Christiane Feron , Carine Goraj , Jan Poolman , Vincent Weynants
IPC分类号： A61K39/095 , A61P37/04
CPC分类号： A61K39/095 , A61K39/102 , A61K39/1045 , A61K2039/521 , A61K2039/55505 , A61K2039/55516 , A61K2039/55572 , A61K2039/55577 , A61K2039/70 , C07K14/22 , Y02A50/396
摘要： The present invention relates to immunogenic compositions and vaccines for the treatment and prevention of Neisserial disease. Immunogenic compositions of the invention contain combinations of antigens selected from at least two different classes of antigens including adhesins, autotransporter proteins, toxins, iron acquisitions proteins and membrane-associated protein (preferably integral outer membrane protein)s. Such combinations of antigens are able to target the immune response against different aspects of the neisserial life cycle, resulting in a more effective immune response.
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公开(公告)号：US20120064119A1
公开(公告)日：2012-03-15
申请号：US13299007
申请日：2011-11-17
申请人： Francois-Xavier Jacques Berthet , Ralph Biemans , Philippe Denoel , Christiane Feron , Carine Goraj , Jan Poolman , Vincent Weynants
发明人： Francois-Xavier Jacques Berthet , Ralph Biemans , Philippe Denoel , Christiane Feron , Carine Goraj , Jan Poolman , Vincent Weynants
IPC分类号： A61K39/095 , A61P37/04
CPC分类号： A61K39/095 , A61K39/102 , A61K39/1045 , A61K2039/521 , A61K2039/55505 , A61K2039/55516 , A61K2039/55572 , A61K2039/55577 , A61K2039/70 , C07K14/22 , Y02A50/396
摘要： The present invention relates to immunogenic compositions and vaccines for the treatment and prevention of Neisserial disease. Immunogenic compositions of the invention contain combinations of antigens selected from at least two different classes of antigens including adhesins, autotransporter proteins, toxins, iron acquisitions proteins and membrane-associated protein (preferably integral outer membrane protein)s. Such combinations of antigens are able to target the immune response against different aspects of the neisserial life cycle, resulting in a more effective immune response.
摘要翻译： 本发明涉及用于治疗和预防奈瑟氏球菌病的免疫原性组合物和疫苗。 本发明的免疫原性组合物含有选自至少两种不同类型的抗原的抗原的组合，包括粘附素，自身转运蛋白，毒素，铁获得蛋白和膜相关蛋白（优选整体外膜蛋白）。 抗原的这种组合能够针对奈桑氏生命周期的不同方面靶向免疫应答，导致更有效的免疫应答。
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公开(公告)号：US20060057160A1
公开(公告)日：2006-03-16
申请号：US10523055
申请日：2003-07-31
申请人： Ralph Biemans , Philippe Denoel , Christiane Feron , Carine Goraj , Michael Jennings , Jan Poolman , Vincent Weynants
发明人： Ralph Biemans , Philippe Denoel , Christiane Feron , Carine Goraj , Michael Jennings , Jan Poolman , Vincent Weynants
CPC分类号： A61K39/095 , A61K39/102 , A61K39/1045 , A61K2039/521 , A61K2039/55505 , A61K2039/55516 , A61K2039/55572 , A61K2039/55577 , A61K2039/70 , C07K14/22 , Y02A50/396
摘要： The present invention relates to the field of neisserial vaccine compositions, their manufacture, and the use of such compositions in medicine. More particularly it relates to processes of making novel engineered meningococcal strains which are less phase variable in terms of their LOS immunotype, and from which novel LOS subunit or meningococcal outer-membrane vesicle (or bleb) vaccines can be derived.
摘要翻译： 本发明涉及奈瑟氏球菌疫苗组合物的领域，它们的制造以及这些组合物在医药中的应用。 更具体地说，涉及制备新的工程化脑膜炎球菌菌株的方法，根据它们的LOS免疫型，它们的相位变化较小，并且可从中产生新的LOS亚单位或脑膜炎球菌外膜囊泡（或气泡）疫苗。
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公开(公告)号：US08084235B2
公开(公告)日：2011-12-27
申请号：US10549064
申请日：2004-03-11
IPC分类号： C12P21/04 , A61K39/02 , A61K39/102
CPC分类号： A61K39/092 , A61K39/385 , A61K2039/6068 , C07K1/16 , C07K14/3156
摘要： The present invention relates to a method for purifying bacterial cytolysins such as pneumococcal pneumolysin. A single chromatography step produces excellent purification of the cytolysin by binding soluble aggregated cytolysin to a hydrophobic interaction chromatography material in the presence of detergent and high salt.
摘要翻译： 本发明涉及一种纯化细菌细胞溶质蛋白如肺炎球菌肺炎杆菌素的方法。 单一色谱步骤通过在洗涤剂和高盐存在下将可溶性聚集的细胞溶解素结合到疏水相互作用层析材料上，产生细胞溶素的极好的纯化。
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