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    CONTROL OF ATP RELEASE BY RED BLOOD CELLS AND THERAPEUTIC APPLICATIONS THEREOF
    2.
    发明申请
    CONTROL OF ATP RELEASE BY RED BLOOD CELLS AND THERAPEUTIC APPLICATIONS THEREOF 有权
    通过红血细胞控制ATP释放及其治疗应用

    公开(公告)号：US20070249668A1

    公开(公告)日：2007-10-25

    申请号：US11695102

    申请日：2007-04-02

    Applicant: Randy Sprague ,  Madelyn Stumpf

    Inventor： Randy Sprague ,  Madelyn Stumpf

    IPC: A61K31/4709 ,  A61K31/557

    CPC classification number: A61K31/4709 ,  A61K31/557 ,  A61K45/06 ,  A61K2300/00

    Abstract: The invention is based upon the discovery that red blood cells contain phosphodiesterase 3B (PDE3B), and that inhibition of that phosphodiesterase allows for an enhanced accumulation of cAMP and subsequent release of ATP. It was further discovered that RBCs treated with insulin accumulate significantly less cAMP and release significantly less ATP than normal RBCs. Likewise, RBCs of patients suffering from type 2 diabetes (hyperinsulinemia) accumulate significantly less cAMP and release significantly less ATP than normal RBCs. It was further discovered that prostaglandin analogues synergistically work with phosphodiesterase 3B inhibitors to improve or increase cAMP accumulation and ATP release by RBCs. Thus the invention is directed to compositions and methods for improving ATP release by RBCs, via administering PDE3B inhibitor or a combination of PDE3B inhibitor and prostaglandin analogue.

    Abstract translation: 本发明基于红细胞含有磷酸二酯酶3B（PDE3B）的发现，并且该磷酸二酯酶的抑制允许cAMP的增加的积累和随后的ATP释放。 进一步发现用胰岛素治疗的RBCs比正常的红细胞积累明显较少的cAMP并释放显着更少的ATP。 同样，患有2型糖尿病（高胰岛素血症）的患者的RBC积累了显着较少的cAMP，并且比正常的RBC显着减少ATP。 进一步发现前列腺素类似物与磷酸二酯酶3B抑制剂协同作用以改善或增加RBCs的cAMP积聚和ATP释放。 因此，本发明涉及通过施用PDE3B抑制剂或PDE3B抑制剂和前列腺素类似物的组合来改善RBCs ATP释放的组合物和方法。

    Apparatus and Method for Interpolating the Intensities of Scanned Pixels from Source Pixels
    4.
    发明申请
    Apparatus and Method for Interpolating the Intensities of Scanned Pixels from Source Pixels 审中-公开
    用于从源像素中插入扫描像素的强度的装置和方法

    公开(公告)号：US20090213040A1

    公开(公告)日：2009-08-27

    申请号：US12435568

    申请日：2009-05-05

    Applicant: Margaret Brown ,  Mark Freeman ,  John R. Lewis ,  Jim Bovee ,  Randy Sprague

    Inventor： Margaret Brown ,  Mark Freeman ,  John R. Lewis ,  Jim Bovee ,  Randy Sprague

    IPC: G09G3/00

    CPC classification number: G02B26/0816 ,  G09G3/02 ,  H04N3/08

    Abstract: A scan assembly of an image generator sweeps an image beam in a first dimension at a first rate and bi-directionally in a second dimension at a slower rate. Sweeping the beam bi-directionally in the vertical dimension (generally the dimension of the lower sweep rate) can reduce the scanning power by eliminating the flyback period, and, where the scan assembly includes a mechanical reflector, can reduce the error in the beam position without a feedback loop by reducing the number of harmonics in the vertical sweep function. Furthermore, because the image beam is “on” longer due to the elimination of the flyback period, the scanned image is often brighter for a given beam intensity. The scan assembly may also sweep the image beam non-linearly in the vertical dimension, and this sweep may be bi-directional or uni-directional. Sweeping the beam non-linearly can also reduce the error in the beam position by reducing the number of harmonics in the vertical sweep function.

    Abstract translation: 图像发生器的扫描组件以第一速率在第一维度中扫描图像束，并且以较慢的速率在第二维度中双向地扫描。 在垂直方向双向扫描光束（通常为较低扫描速率的尺寸）可以通过消除反激周期来降低扫描功率，并且在扫描组件包括机械反射器的情况下，可以减少光束位置的误差 没有通过减少垂直扫描功能中的谐波数量的反馈回路。 此外，由于由于消除反激周期而使图像束“更长”，因此对于给定的光束强度，扫描图像通常更亮。 扫描组件也可以在垂直维度上非线性扫描图像束，并且该扫描可以是双向的或单向的。 非线性扫描光束也可以通过减少垂直扫描功能中的谐波次数来减小光束位置的误差。

    Apparatus and method for bi-directionally sweeping an image beam in the vertical dimension and related apparati and methods
    8.
    发明授权
    Apparatus and method for bi-directionally sweeping an image beam in the vertical dimension and related apparati and methods 有权
    在垂直方向双向扫描图像束的装置和方法及相关设备和方法

    公开(公告)号：US07580007B2

    公开(公告)日：2009-08-25

    申请号：US10441916

    申请日：2003-05-19

    Applicant: Margaret Brown ,  Mark Freeman ,  John R. Lewis ,  Jim Bovee ,  Randy Sprague

    Inventor： Margaret Brown ,  Mark Freeman ,  John R. Lewis ,  Jim Bovee ,  Randy Sprague

    IPC: G09G1/08

    CPC classification number: G02B26/0816 ,  G09G3/02 ,  H04N3/08

    Abstract: A scan assembly of an image generator sweeps an image beam in a first dimension at a first rate and bi-directionally in a second dimension at a slower rate. Sweeping the beam bi-directionally in the vertical dimension (generally the dimension of the lower sweep rate) can reduce the scanning power by eliminating the flyback period, and, where the scan assembly includes a mechanical reflector, can reduce the error in the beam position without a feedback loop by reducing the number of harmonics in the vertical sweep function. Furthermore, because the image beam is “on” longer due to the elimination of the flyback period, the scanned image is often brighter for a given beam intensity. The scan assembly may also sweep the image beam non-linearly in the vertical dimension, and this sweep may be bi-directional or uni-directional. Sweeping the beam non-linearly can also reduce the error in the beam position by reducing the number of harmonics in the vertical sweep function.

    Abstract translation: 图像发生器的扫描组件以第一速率在第一维度中扫描图像束，并且以较慢的速率在第二维度中双向地扫描。 在垂直方向双向扫描光束（通常为较低扫描速率的尺寸）可以通过消除反激周期来降低扫描功率，并且在扫描组件包括机械反射器的情况下，可以减少光束位置的误差 没有通过减少垂直扫描功能中的谐波数量的反馈回路。 此外，由于由于消除反激周期而使图像束“更长”，因此对于给定的光束强度，扫描图像通常更亮。 扫描组件也可以在垂直维度上非线性扫描图像束，并且该扫描可以是双向的或单向的。 非线性扫描光束也可以通过减少垂直扫描功能中的谐波次数来减小光束位置的误差。

    Method for improving the performance of micromachined devices
    9.
    发明授权
    Method for improving the performance of micromachined devices 失效
    提高微加工设备性能的方法

    公开(公告)号：US06636819B1

    公开(公告)日：2003-10-21

    申请号：US09680375

    申请日：2000-10-05

    Applicant: Eric Abbott ,  Randy Sprague ,  James Michael McLaughlin

    Inventor： Eric Abbott ,  Randy Sprague ,  James Michael McLaughlin

    IPC: G01C1900

    CPC classification number: G01P15/097 ,  G01C19/56

    Abstract: A method for improving the performance of a micromachined device, preferably an angular rate microsensor, is provided. The method includes collecting data on rate bias over a selected operating phase demodulation angles for at least one tine of a microsensor and determining optimum settings for phase demodulation angles at which the rate bias hysteresis over temperature is at a minimum by applying dynamic programming.

    Abstract translation: 提供了一种用于改善微加工装置，优选角速率微传感器的性能的方法。 该方法包括针对微传感器的至少一个尖峰在所选择的操作相位解调角度收集关于速率偏差的数据，并且通过应用动态规划来确定温度上的速率偏差滞后最小的相位解调角度的最佳设置。

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