公开(公告)号：US06509457B1

公开(公告)日：2003-01-21

申请号：US09234245

申请日：1999-01-20

申请人： Raphael Rubin ,  Manorama Tewari

发明人： Raphael Rubin ,  Manorama Tewari

IPC分类号： C07H2104

CPC分类号： C07K14/47

摘要： AAC-11 polypeptide and DNA (RNA) encoding AAC-11 polypeptide and methods for producing such polypeptide by recombinant techniques. Also, methods of using the AAC-11 polynucleotides and/or polypeptides to inhibit apoptosis in cells. Further, methods of using agonists or antagonists to AAC-11 polypeptides to inhibit or induce apoptosis in cells.

摘要翻译： AAC-11多肽和编码AAC-11多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。 此外，使用AAC-11多核苷酸和/或多肽抑制细胞凋亡的方法。 此外，使用激动剂或拮抗剂对AAC-11多肽抑制或诱导细胞凋亡的方法。

公开(公告)号：US06331526B1

公开(公告)日：2001-12-18

申请号：US09389855

申请日：1999-09-02

申请人： Renato Baserga ,  Christian Sell ,  Raphael Rubin

发明人： Renato Baserga ,  Christian Sell ,  Raphael Rubin

IPC分类号： A61K4800

CPC分类号： C12N15/1138 ,  C07H21/00 ,  C12N2310/315

摘要： A method of inhibiting the proliferation and causing the differentiation of undifferentiated cells comprising contacting the undifferentiated cells with an effective amount of an antisense oligonucleotide having a sequence which is complementary to a region of the IGF-1 receptor RNA. The sequence of the antisense oligonucleotide is selected from an oligodeoxynucleotide sequence complementary to codons −29 to −24 of the signal sequence of the IGF-1 receptor and an oligoribonucleotide sequence complementary to codons 1 to 309 of the sequence of the IGF-1 receptor. The oligoribonucleotide sequence may be provided by an expression vector.

摘要翻译： 一种抑制增殖并引起未分化细胞分化的方法，包括使未分化细胞与有效量的具有与IGF-1受体RNA区域互补的序列的反义寡核苷酸接触。 反义寡核苷酸的序列选自与IGF-1受体的信号序列的密码子-29至-24互补的寡脱氧核苷酸序列和与IGF-1受体的序列的密码子1至309互补的寡核糖核苷酸序列。 寡核糖核苷酸序列可以由表达载体提供。

公开(公告)号：US20050063373A1

公开(公告)日：2005-03-24

申请号：US10897582

申请日：2004-07-23

申请人： Andre DeHon ,  Raphael Rubin

发明人： Andre DeHon ,  Raphael Rubin

IPC分类号： G06F15/80 ,  H03K19/177 ,  H04L12/28

CPC分类号： H03K19/17736 ,  G06F15/8023 ,  H03K19/1778 ,  H03K19/17796

摘要： A network for interconnecting processing element nodes which supports rich interconnection while having a number of switching elements which is linear in the number of processing elements interconnected. Processing elements connect to the lowest level of the tree and the higher levels of the tree make connections between the processing elements. The processing elements may be laid out in a two dimensional grid and one or more horizontal and vertical trees may be used to connect between the processing elements with corner switches used to connect between the horizontal and vertical trees. The levels of the tree can be accommodated in multiple layers of metalization such that the entire layout requires a two-dimensional area which is linear in the number of processing elements supported.

摘要翻译： 用于互连处理元件节点的网络，其支持丰富的互连，同时具有在互连的处理元件的数量中是线性的多个开关元件。 处理元件连接到树的最低级，树的较高级别使处理元件之间建立连接。 处理元件可以布置在二维网格中，并且一个或多个水平和垂直树可以用于在处理元件之间连接用于在水平和垂直树之间连接的角开关。 树的级别可以容纳在多层金属化中，使得整个布局需要在所支持的处理元件的数量上是线性的二维区域。

公开(公告)号：US06340674B1

公开(公告)日：2002-01-22

申请号：US09668822

申请日：2000-09-22

申请人： Renato Baserga ,  Christian Sell ,  Raphael Rubin

发明人： Renato Baserga ,  Christian Sell ,  Raphael Rubin

IPC分类号： A61K4800

CPC分类号： C12N15/1138 ,  C07H21/00 ,  C12N2310/315

摘要： A method of inhibiting the proliferation and causing the differentiation of undifferentiated cells comprising contacting the undifferentiated cells with an effective amount of an antisense oligonucleotide having a sequence which is complementary to a region of the IGF-1 receptor RNA. The sequence of the antisense oligonucleotide is selected from an oligodeoxynucleotide sequence complementary to codons −29 to −24 of the signal sequence of the IGF-1 receptor and an oligoribodeoxynucleotide sequence complementary to codons 1 to 309 of the sequence of the IGF-1 receptor. The oligoribonucleotide sequence may be provided by an expression vector.

摘要翻译： 一种抑制增殖并引起未分化细胞分化的方法，包括使未分化细胞与有效量的具有与IGF-1受体RNA区域互补的序列的反义寡核苷酸接触。 反义寡核苷酸的序列选自与IGF-1受体的信号序列的-29至-24的密码子互补的寡脱氧核苷酸序列和与IGF-1受体序列的密码子1至309互补的寡脱氧核糖核苷酸序列。 寡核糖核苷酸序列可以由表达载体提供。

公开(公告)号：US5643788A

公开(公告)日：1997-07-01

申请号：US479173

申请日：1995-06-06

申请人： Renato Baserga ,  Christian Sell ,  Raphael Rubin

发明人： Renato Baserga ,  Christian Sell ,  Raphael Rubin

IPC分类号： C12N15/09 ,  A61K31/70 ,  A61K48/00 ,  A61P35/00 ,  C07H21/00 ,  C12N5/10 ,  C12N15/113 ,  C12Q1/68

CPC分类号： C12N15/1138 ,  C07H21/00 ,  C12N2310/315

摘要： A method of inhibiting the proliferation and causing the differentiation of undifferentiated cells comprising contacting the undifferentiated cells with an effective amount of an antisense oligonucleotide having a sequence which is complementary to a region of the IGF-1 receptor RNA. The sequence of the antisense oligonucleotide is selected from an oligodeoxynucleotide sequence complementary to codons -29 to -24 of the signal sequence of the IGF-1 receptor and an oligoribonucleotide sequence complementary to codons 1 to 309 of the sequence of the IGF-1 receptor. The oligoribonucleotide sequence may be provided by an expression vector.

摘要翻译： 一种抑制增殖并引起未分化细胞分化的方法，包括使未分化细胞与有效量的具有与IGF-1受体RNA区域互补的序列的反义寡核苷酸接触。 反义寡核苷酸的序列选自与IGF-1受体的信号序列的密码子-29至-24互补的寡脱氧核苷酸序列和与IGF-1受体的序列的密码子1至309互补的寡核糖核苷酸序列。 寡核糖核苷酸序列可以由表达载体提供。

公开(公告)号：US07285487B2

公开(公告)日：2007-10-23

申请号：US10897582

申请日：2004-07-23

申请人： André DeHon ,  Raphael Rubin

发明人： André DeHon ,  Raphael Rubin

IPC分类号： H01L21/4763

CPC分类号： H03K19/17736 ,  G06F15/8023 ,  H03K19/1778 ,  H03K19/17796

摘要： A network for interconnecting processing element nodes which supports rich interconnection while having a number of switching elements which is linear in the number of processing elements interconnected. Processing elements connect to the lowest level of the tree and the higher levels of the tree make connections between the processing elements. The processing elements may be laid out in a two dimensional grid and one or more horizontal and vertical trees may be used to connect between the processing elements with corner switches used to connect between the horizontal and vertical trees. The levels of the tree can be accommodated in multiple layers of metalization such that the entire layout requires a two-dimensional area which is linear in the number of processing elements supported.

摘要翻译： 用于互连处理元件节点的网络，其支持丰富的互连，同时具有在互连的处理元件的数量中是线性的多个开关元件。 处理元件连接到树的最低级，树的较高级别使处理元件之间建立连接。 处理元件可以布置在二维网格中，并且一个或多个水平和垂直树可以用于在处理元件之间连接用于在水平和垂直树之间连接的角开关。 树的级别可以容纳在多层金属化中，使得整个布局需要在所支持的处理元件的数量上是线性的二维区域。

公开(公告)号：US06274562B1

公开(公告)日：2001-08-14

申请号：US08880313

申请日：1997-06-20

申请人： Renato Baserga ,  Christian Sell ,  Raphael Rubin

发明人： Renato Baserga ,  Christian Sell ,  Raphael Rubin

IPC分类号： A61K4800

CPC分类号： C12N15/1138 ,  C07H21/00 ,  C12N2310/315

摘要： A method of inhibiting the proliferation and causing the differentiation of undifferentiated cells comprising contacting the undifferentiated cells with an effective amount of an antisense oligonucleotide having a sequence which is complementary to a region of the IGF-1 receptor RNA. The sequence of the antisense oligonucleotide is selected from an oligodeoxynucleotide sequence complementary to codons −29 to −24 of the signal sequence of the IGF-1 receptor and an oligoribodeoxynucleotide sequence complementary to codons 1 to 309 of the sequence of the IGF-1 receptor. The oligoribodeoxynucleotide sequence may be provided by an expression vector.

摘要翻译： 一种抑制增殖并引起未分化细胞分化的方法，包括使未分化细胞与有效量的具有与IGF-1受体RNA区域互补的序列的反义寡核苷酸接触。 反义寡核苷酸的序列选自与IGF-1受体的信号序列的-29至-24的密码子互补的寡脱氧核苷酸序列和与IGF-1受体序列的密码子1至309互补的寡脱氧核糖核苷酸序列。 寡聚脱氧核苷酸序列可以由表达载体提供。