公开(公告)号：US20210188863A1

公开(公告)日：2021-06-24

申请号：US16755172

申请日：2018-10-08

申请人： David Annunziato CANDITO ,  Thomas, H. GRAHAM ,  John ACTON ,  Ryan Wing-Kun CHAU ,  Joanna L. CHEN ,  J. Michael ELLIS ,  Peter H. FULLER ,  Anmol GULATI ,  Hakan GUNAYDIN ,  Solomon KATTAR ,  Mitchell Henry KEYLOR ,  Blair T. LAPOINTE ,  Ping LIU ,  Weiguo LIU ,  Joey L. METHOT ,  Santhosh F. NEELAMKAVIL ,  Vladimir SIMOV ,  Ling TONG ,  Harold B. WOOD ,  Merck Sharp & Dohme Corp.

发明人： David Annunziato Candito ,  Thomas H. Graham ,  John Acton ,  Ryan Wing-Kun Chau ,  Joanna L. Chen ,  J. Michael Ellis ,  Peter H. Fuller ,  Anmol Gulati ,  Hakan Gunaydin ,  Solomon Kattar ,  Mitchell Henry Keylor ,  Blair T. Lapointe ,  Ping Liu ,  Weiguo Liu ,  Joey L. Methot ,  Santhosh F. Neelamkavil ,  Vladimir Simov ,  Ling Tong ,  Harold B. Wood

IPC分类号： C07D491/10 ,  C07D403/14 ,  C07D487/08 ,  C07D405/14 ,  C07D401/14 ,  C07D413/14 ,  C07D498/10 ,  C07D519/00 ,  C07D498/04 ,  C07D403/04

摘要： The present invention is directed to substituted certain reversed indazolyl-spiro[2.2]pentane-carbonitrile derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, X, Y, and Z are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.

公开(公告)号：US10930371B2

公开(公告)日：2021-02-23

申请号：US15644886

申请日：2017-07-10

申请人： Jang-Jih Lu ,  Chun-Hsien Chen ,  Hsin-Yao Wang ,  Tsui-Ping Liu

发明人： Jang-Jih Lu ,  Chun-Hsien Chen ,  Hsin-Yao Wang ,  Tsui-Ping Liu

IPC分类号： G16B40/00 ,  G06N7/00 ,  G16B40/10 ,  G06N20/00

摘要： A method of creating characteristic peak profiles of mass spectra and identification model for analyzing and identifying microorganisms are provided. MALDI-TOF MS data of microorganisms having the same feature are gathered. Discretization of the data is performed. Density-based clustering is used to find m/z values of spectral peaks with high probability of occurrence from the discretized data. A characteristic MS peak profile is created for every specific feature of microorganisms. Every such a characteristic profile forms a feature template. The mass spectrum of each known isolate is matched against all the feature templates and a number of matched vectors are obtained. The matched vectors are then concatenated into a single “integrated vector.” Then, a machine learning method and the integrated vectors generated from all known isolates are used to create a classification model for microorganism identification.

公开(公告)号：US10208060B2

公开(公告)日：2019-02-19

申请号：US15513854

申请日：2015-09-23

申请人： Jiaqiang Cai ,  Alejandro Crespo ,  John Debenham ,  Xiaoxing Du ,  Ping Liu ,  Rongqiang Liu ,  Christina B. Madsen-Duggan ,  Weiguo Quan ,  Christopher Sinz ,  Liping Wang

发明人： Jiaqiang Cai ,  Alejandro Crespo ,  John Debenham ,  Xiaoxing Du ,  Ping Liu ,  Rongqiang Liu ,  Christina B. Madsen-Duggan ,  Weiguo Quan ,  Christopher Sinz ,  Liping Wang

IPC分类号： C07D491/048 ,  C07D495/04 ,  A61P7/06

摘要： The present invention concerns compounds of formula I or a pharmaceutically acceptable salt thereof which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.

公开(公告)号：US10164231B2

公开(公告)日：2018-12-25

申请号：US13760043

申请日：2013-02-05

申请人： Wen Li ,  Ping Liu ,  Jocelyn Hicks-Garner

发明人： Wen Li ,  Ping Liu ,  Jocelyn Hicks-Garner

IPC分类号： H01M2/16 ,  H02J7/00 ,  H01M2/14 ,  H01M10/052 ,  H01M10/44

摘要： This invention, in some variations, provides a separator for a lithium-sulfur battery, comprising a porous substrate that is permeable to lithium ions; and a lithium-ion-conducting metal oxide layer on the substrate, wherein the metal oxide layer includes deposits of sulfur that are intentionally introduced prior to battery operation. The deposits of sulfur may be derived from treatment of the metal oxide layer with one or more sulfur-containing precursors (e.g., lithium polysulfides) prior to operation of the lithium-sulfur battery. Other variations provide a method of charging a lithium-sulfur battery that includes the disclosed separator, the charging being accomplished by continuously applying a substantially constant voltage to the lithium-sulfur battery until the battery charging current is at or below a selected current.

公开(公告)号：US10072990B1

公开(公告)日：2018-09-11

申请号：US15193040

申请日：2016-06-25

申请人： Chia-Ming Chang ,  John Wang ,  Geoffrey P McKnight ,  Ping Liu

发明人： Chia-Ming Chang ,  John Wang ,  Geoffrey P McKnight ,  Ping Liu

IPC分类号： G01K7/36 ,  G01R33/00 ,  G01K11/00 ,  G01K7/00 ,  G01K7/38

CPC分类号： G01K7/38 ,  G01K7/36 ,  G01R31/36 ,  G01R33/00 ,  G01R33/1223 ,  H01M10/486

摘要： A thermomagnetic sensor includes a thermomagnetic probe that includes a ferromagnetic material having a temperature-dependent magnetic permeability characterized by a maximum magnetic permeability value at a temperature below a Curie temperature of the ferromagnetic material. The thermomagnetic sensor further includes an alternating magnetic field source to produce an alternating magnetic field in a vicinity of the thermomagnetic probe to facilitate a measurement of the temperature-dependent magnetic permeability as function of temperature remotely using a thermomagnetic effect. A predetermined relationship between the temperature-dependent magnetic permeability and temperature in a range between the maximum magnetic permeability value and the Curie temperature provides a measurement of a temperature local to the thermomagnetic probe. A battery-temperature measurement system includes the thermomagnetic probe in a battery, a magnetic field coil to apply the alternating magnetic field, and a magnetic permeability measurement apparatus to measure the temperature-dependent magnetic permeability.

公开(公告)号：US09504868B2

公开(公告)日：2016-11-29

申请号：US13151261

申请日：2011-06-01

申请人： Ping Liu

发明人： Ping Liu

IPC分类号： A63B21/072 ,  A63B21/075

CPC分类号： A63B21/0726 ,  A63B21/00065 ,  A63B21/0728 ,  A63B21/075

摘要： A dumbbell apparatus which is adapted with a series of weight plates, the number of which can be safely and reliably adjusted with a single simple motion. The apparatus comprises a cradle for storing and deploying the apparatus, weight plates, and a handle apparatus which has two spline bolts which support the weight plates and are used to simultaneously be adjusted by means of an adjusting pin which moves the spline members together through a motion transmitting gear. The apparatus may be further enhance with permanent weights and gripping options.

摘要翻译： 一种哑铃装置，适用于一系列称重板，其数量可以通过单一简单的运动安全可靠地进行调整。 该装置包括用于储存和展开该装置的支架，配重板和具有两个花键螺栓的手柄装置，该花键螺栓支撑配重板并用于通过调节销同时调节，该调节销将花键构件一起通过一个 运动传动装置。 该装置可以进一步增强具有永久重量和夹持选项。

公开(公告)号：US09281526B1

公开(公告)日：2016-03-08

申请号：US12629066

申请日：2009-12-02

申请人： Ping Liu ,  John Wang ,  Souren Soukiazian

发明人： Ping Liu ,  John Wang ,  Souren Soukiazian

IPC分类号： H01M4/02 ,  H01M8/02

CPC分类号： H01M8/02 ,  H01M4/02 ,  H01M4/5825 ,  H01M4/587 ,  H01M10/0445 ,  H01M10/0525 ,  H01M10/058 ,  Y02T10/7011

摘要： This invention provides batteries with improved calendar and cycle lifetimes. A rechargeable battery comprises an additional electrode that includes active ions, such as lithium ions. Cell capacity of the battery can be increased by supplying these active ions to the anode or the cathode. In some variations, this invention provides a lithium-ion battery comprising an anode, a cathode, an electrolyte, and an additional lithium-containing electrode, wherein the additional lithium-containing electrode is capable of supplying lithium ions to the anode or the cathode in the presence of an electrical current.

摘要翻译： 本发明提供了具有改进的日历和周期寿命的电池。 可充电电池包括包括诸如锂离子的活性离子的附加电极。 通过将这些活性离子提供给阳极或阴极，可以提高电池的电池容量。 在一些变型中，本发明提供了一种锂离子电池，其包括阳极，阴极，电解质和附加的含锂电极，其中所述另外的含锂电极能够将锂离子供应到阳极或阴极 存在电流。

公开(公告)号：US20150274664A1

公开(公告)日：2015-10-01

申请号：US14431366

申请日：2013-09-25

申请人： John J. ACTON ,  Scott D. EDMONDSON ,  Ping LIU ,  Michael W. MILLER ,  Harold B. WOOD ,  Byron G. DUBOIS ,  William B. GEISS ,  MERCK SHARP & DOHME CORP.

发明人： John J. Acton ,  Scott D. Edmondson ,  Ping Liu ,  Michael W. Miller ,  Harold B. Wood ,  Byron G. DuBois ,  William B. Geiss

IPC分类号： C07D211/60 ,  C07D401/12 ,  C07D413/04 ,  C07D401/14 ,  C07D401/04

CPC分类号： C07D211/60 ,  A61K31/506 ,  C07D211/22 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D413/04 ,  C07D413/14

摘要： Substituted cyclopropyl piperidinyl compounds and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included.

摘要翻译： 公开了用于治疗或预防2型糖尿病和类似病症的取代的环丙基哌啶基化合物及其药学上可接受的盐。 该化合物可用作G蛋白偶联受体GPR-119的激动剂。 还包括药物组合物和治疗方法。

公开(公告)号：US09017899B2

公开(公告)日：2015-04-28

申请号：US13805329

申请日：2010-06-18

申请人： Yongming Zhang ,  Junke Tang ,  Ping Liu ,  Heng Zhang ,  Jun Wang

发明人： Yongming Zhang ,  Junke Tang ,  Ping Liu ,  Heng Zhang ,  Jun Wang

IPC分类号： H01M8/10 ,  B01D69/10 ,  B01D69/14 ,  C08J5/22 ,  D06M14/28 ,  B01D71/32 ,  C08K9/04

CPC分类号： H01M8/1041 ,  B01D69/10 ,  B01D69/141 ,  B01D71/32 ,  B01D2323/30 ,  B01D2325/42 ,  C08J5/2281 ,  C08J2327/18 ,  C08K9/04 ,  D06M14/28 ,  H01M8/1023 ,  H01M8/1039 ,  H01M8/106 ,  H01M8/1072 ,  Y02E60/521 ,  Y02P70/56

摘要： Provided is a composite which is comprised of one or more ion exchange resin(s) and fluorine containing polymer fiber, wherein the fiber and the film-forming resin form a triazine-ring crosslinked structure, so that the film prepared from the composite is of good airtightness and stability, as well as high ion exchange capacity and high conductivity. The preparation method of the composite, the product prepared from this composite and the use thereof are also provided.

摘要翻译： 提供了由一种或多种离子交换树脂和含氟聚合物纤维组成的复合材料，其中纤维和成膜树脂形成三嗪环交联结构，使得由复合材料制备的膜为 良好的气密性和稳定性，以及高离子交换能力和高导电性。 还提供了复合材料的制备方法，由该复合材料制备的产品及其用途。

公开(公告)号：US09006228B2

公开(公告)日：2015-04-14

申请号：US14126685

申请日：2012-06-11

申请人： Michael Miller ,  Andrew Stamford ,  Kallol Basu ,  Harold B. Wood ,  Duane DeMong ,  Wanying Sun ,  Joie Garfunkle ,  Christopher Moyes ,  Zhiyong Hu ,  Ping Liu ,  Scott D. Edmondson ,  Xing Dai ,  Byron Gabriel DuBois

发明人： Michael Miller ,  Andrew Stamford ,  Kallol Basu ,  Harold B. Wood ,  Duane DeMong ,  Wanying Sun ,  Joie Garfunkle ,  Christopher Moyes ,  Zhiyong Hu ,  Ping Liu ,  Scott D. Edmondson ,  Xing Dai ,  Byron Gabriel DuBois

IPC分类号： C07D417/14 ,  C07D211/24 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14 ,  C07D211/22

CPC分类号： C07D211/24 ,  C07D211/22 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14

摘要： Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included.

摘要翻译： 公开了取代的式I的环丙基化合物及其药学上可接受的盐可用于治疗或预防2型糖尿病和类似病症。 该化合物可用作G蛋白偶联受体GPR-119的激动剂。 还包括药物组合物和治疗方法。