公开(公告)号：US20060029967A1

公开(公告)日：2006-02-09

申请号：US11234425

申请日：2005-09-23

申请人： Kirk Hogan ,  Rebecca Selzer

发明人： Kirk Hogan ,  Rebecca Selzer

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q1/26 ,  C12Q2600/156 ,  G01N33/6896 ,  G01N2333/906

摘要： A method for detection of susceptibility to nitrous oxide neurologic syndrome in a subject is disclosed. In one embodiment, the method comprises: (a) providing a sample from a subject, wherein said subject is a candidate for nitrous oxide anesthesia; and (b) detecting the presence or absence of folate, cobalamin, methionine and homocysteine pathway genetic polymorphisms in said sample, wherein the presence of a polymorphism indicates that the subject is susceptible to nitrous oxide neurologic syndrome.

公开(公告)号：US20050282211A1

公开(公告)日：2005-12-22

申请号：US11157629

申请日：2005-06-21

申请人： Emile Nuwaysir ,  Roland Green ,  Rebecca Selzer ,  Todd Richmond ,  Mark McCormick ,  Steven Smith

发明人： Emile Nuwaysir ,  Roland Green ,  Rebecca Selzer ,  Todd Richmond ,  Mark McCormick ,  Steven Smith

IPC分类号： C12P19/34 ,  C12Q1/68

CPC分类号： C12Q1/6837 ,  C12Q1/6806

摘要： The present invention provides methods for optimizing nucleic acid detection assays for use in basic research and clinical research. Specifically, the invention provides a method for empirically optimizing nucleic acid probes by testing them with samples containing genomic DNA with variations in copy number in different regions of the genome. The invention enables the optimization of probes for any hybridization based assay including microarrays, bead-based assays, genotyping assays and RNAi assays.

摘要翻译： 本发明提供用于优化用于基础研究和临床研究的核酸检测测定法的方法。 具体地，本发明提供了一种用于经验优化核酸探针的方法，通过用含有基因组不同区域中拷贝数变化的基因组DNA的样品进行测试。 本发明使得能够优化用于任何基于杂交的测定的探针，包括微阵列，基于珠的测定，基因分型测定和RNAi测定。