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    Method of pre-treating sample for measuring saccharified amine and method of measuring saccharified amine
    2.
    再颁专利
    Method of pre-treating sample for measuring saccharified amine and method of measuring saccharified amine 有权

    公开(公告)号：USRE46073E1

    公开(公告)日：2016-07-19

    申请号：US14751351

    申请日：2015-06-26

    申请人： ARKRAY, Inc.

    发明人： Satoshi Yonehara ,  Tsuguki Komori

    IPC分类号： C12Q1/26 ,  C12N9/06 ,  C12N9/52 ,  C12Q1/37 ,  G01N33/00 ,  G01N33/72 ,  G01N33/92 ,  G01N33/68

    CPC分类号： C12Q1/26 ,  C12Q1/37 ,  G01N33/723 ,  G01N2333/906

    摘要： The present invention provides a method of pretreating a sample containing a glycated amine as an analyte, thereby enabling highly reliable measurement of a glycated amine. A glycated amino acid in the sample is degraded by causing a fructosyl amino acid oxidase (FAOD) to act thereon, and thereafter, a FAOD further is caused to act on the glycated amine as the analyte in the sample to cause a redox reaction. The amount of the glycated amine is determined by measuring the redox reaction. The substrate specificity of the FAOD caused to act on the glycated amino acid may be either the same as or different from that of the FAOD caused to act on the glycated amine. When using the same FAOD, a FAOD is caused to act on the glycated amino acid to degrade it, and thereafter, the sample is treated with a protease to inactivate the FAOD and also to degrade the glycated amine. Then, the same FAOD further is added so that the FAOD acts on the degradation product obtained to cause a redox reaction, and the redox reaction is measured.

    Method of pre-treating sample for measuring saccharified amine and method of measuring saccharified amine
    3.
    再颁专利
    Method of pre-treating sample for measuring saccharified amine and method of measuring saccharified amine 有权
    预处理用于测定糖化胺的样品的方法和测定糖化胺的方法

    公开(公告)号：USRE45074E1

    公开(公告)日：2014-08-12

    申请号：US13653024

    申请日：2012-10-16

    申请人： ARKRAY, Inc.

    发明人： Satoshi Yonehara ,  Tsuguki Komori

    IPC分类号： C12Q1/26 ,  C12Q1/37 ,  C12N9/06 ,  C12N9/52 ,  G01N33/92 ,  G01N33/00

    CPC分类号： C12Q1/26 ,  C12N9/52 ,  C12Q1/37 ,  G01N33/68 ,  G01N33/723 ,  G01N2333/906

    摘要： The present invention provides a method of pretreating a sample containing a glycated amine as an analyte, thereby enabling highly reliable measurement of a glycated amine. A glycated amino acid in the sample is degraded by causing a fructosyl amino acid oxidase (FAOD) to act thereon, and thereafter, a FAOD further is caused to act on the glycated amine as the analyte in the sample to cause a redox reaction. The amount of the glycated amine is determined by measuring the redox reaction. The substrate specificity of the FAOD caused to act on the glycated amino acid may be either the same as or different from that of the FAOD caused to act on the glycated amine. When using the same FAOD, a FAOD is caused to act on the glycated amino acid to degrade it, and thereafter, the sample is treated with a protease to inactivate the FAOD and also to degrade the glycated amine. Then, the same FAOD further is added so that the FAOD acts on the degradation product obtained to cause a redox reaction, and the redox reaction is measured.

    摘要翻译： 本发明提供一种预处理含有糖化胺作为分析物的样品的方法，由此能够高度可靠地测量糖化胺。 通过使果糖基氨基酸氧化酶（FAOD）在其上作用，使样品中的糖化氨基酸降解，此后，进一步使FAOD作为样品中的分析物作用于糖化胺以引起氧化还原反应。 通过测量氧化还原反应来测定糖化胺的量。 引起作用于糖化氨基酸的FAOD的底物特异性可以与引起作用于糖基化胺的FAOD的底物特异性相同或不同。 当使用相同的FAOD时，使FAOD作用于糖化氨基酸以使其降解，然后用蛋白酶处理样品以使FAOD失活并降解糖化胺。 然后，加入相同的FAOD，使得FAOD作用于所得到的降解产物以引起氧化还原反应，并测量氧化还原反应。

    Compositions and Methods For Detecting Histamine Related Disorders
    5.
    发明申请
    Compositions and Methods For Detecting Histamine Related Disorders 审中-公开
    用于检测组胺相关疾病的组合物和方法

    公开(公告)号：US20100297631A1

    公开(公告)日：2010-11-25

    申请号：US12671285

    申请日：2008-07-31

    申请人： Denis Vincent

    发明人： Denis Vincent

    IPC分类号： G01N33/53 ,  C12Q1/68

    CPC分类号： C12Q1/26 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/573 ,  G01N2333/906

    摘要： The present invention generally relates to methods and compositions (e.g., assay kit) for the diagnosis of histamine related disorders. The invention also relates to a novel molecular target of histamine related disorders and the uses thereof for detecting or diagnosing such diseases, as well as to develop adapted and efficient therapeutic treatment thereof. The invention may be used in any mammalian subject, particularly human subjects.

    摘要翻译： 本发明一般涉及用于诊断组胺相关疾病的方法和组合物（例如，测定试剂盒）。 本发明还涉及组胺相关病症的新型分子靶标及其用于检测或诊断这些疾病的用途，以及开发其适应和有效的治疗方法。 本发明可用于任何哺乳动物受试者，特别是人类受试者。

    POSTPRANDIAL HYPERGLYCEMIA MARKER, METHOD OF MEASURING THE SAME, AND USAGE THEREOF
    6.
    发明申请
    POSTPRANDIAL HYPERGLYCEMIA MARKER, METHOD OF MEASURING THE SAME, AND USAGE THEREOF 有权
    POSTPRANDIAL HYPERGLYCEMIA MARKER，其测量方法及其用途

    公开(公告)号：US20100190194A1

    公开(公告)日：2010-07-29

    申请号：US12376914

    申请日：2007-08-10

    申请人： Satoshi Yonehara ,  Toshihiro Imai

    发明人： Satoshi Yonehara ,  Toshihiro Imai

    IPC分类号： C12Q1/34 ,  C07K14/435 ,  G01N33/72 ,  C12Q1/00 ,  C12Q1/02

    CPC分类号： G01N33/723 ,  G01N27/447 ,  G01N2030/027 ,  G01N2333/906 ,  G01N2800/042

    摘要： A new method of diagnosing postprandial hyperglycemia by indirectly measuring a blood glucose level is provided. Postprandial hyperglycemia is detected by measuring a glycation degree of lysine in hemoglobin, in which a side chain amino group of lysine is glycated (GHbLys %). Measurement of GHbLys % can be performed by cleaving hemoglobin by protease, treating a glycated part of a lysine residue in the obtained cleavage product of hemoglobin with fructosyl amino acid oxidase, and measuring a redox reaction between the glycated part and fructosyl amino acid oxidase.

    摘要翻译： 提供了一种通过间接测量血糖水平来诊断餐后高血糖的新方法。 通过测定血红蛋白中的赖氨酸的糖基化程度，其中赖氨酸的侧链氨基被糖化（GHbLys％）来检测餐后高血糖。 GHbLys％的测定可以通过蛋白酶切割血红蛋白，用获得的果糖基氨基酸氧化酶处理得到的血红蛋白裂解产物的赖氨酸残基的糖基化部分，测定糖基化部分和果糖基氨基酸氧化酶之间的氧化还原反应。

    Method and antibodies for detecting nitrofuran
    7.
    发明授权
    Method and antibodies for detecting nitrofuran 有权
    用于检测硝基呋喃的方法和抗体

    公开(公告)号：US07632928B2

    公开(公告)日：2009-12-15

    申请号：US11583236

    申请日：2006-10-18

    申请人： Say-Jong Law ,  Stanley E. Charm ,  Steven J. Saul

    发明人： Say-Jong Law ,  Stanley E. Charm ,  Steven J. Saul

    IPC分类号： C07K1/13 ,  C07K1/04 ,  C07D263/02

    CPC分类号： C07K16/44 ,  G01N33/9446 ,  G01N2333/906

    摘要： An antibody and immunogen for generating an antibody to nitrofuran and/or nitrofuran metabolite such as tissue or protein bound nitrofuran metabolites. Nitrofurans and and/or nitrofuran metabolites in a biological sample can be detected by contacting the sample with the antibodies to form a complex that can be detected. The antibodies may also be incorporated into test kits for the detection of nitrofuran and/or nitrofuran metabolites.

    摘要翻译： 用于产生硝基呋喃和/或硝基呋喃代谢物的抗体和免疫原，例如组织或蛋白质结合的硝基呋喃代谢物。 可以通过使样品与抗体接触以形成可检测的复合物来检测生物样品中的硝基呋喃和/或硝基呋喃代谢物。 抗体也可以并入用于检测硝基呋喃和/或硝基呋喃代谢物的检测试剂盒中。

    Method of measuring glycated amine
    8.
    发明申请
    Method of measuring glycated amine 有权
    测定糖化胺的方法

    公开(公告)号：US20070134754A1

    公开(公告)日：2007-06-14

    申请号：US10575214

    申请日：2004-12-10

    申请人： Kaoru Hirai

    发明人： Kaoru Hirai

    IPC分类号： C12Q1/37

    CPC分类号： G01N33/723 ,  C12Q1/26 ,  G01N2333/906

    摘要： The present invention aims to enable highly reliable measurement of a glycated amine. A fructosyl amino acid oxidase (FAOD) is added to a sample to remove a non-analyte glycated amine that is present in the sample and different from an analyte glycated amine. Thereafter, a protease is added to the sample to degrade the analyte glycated amine, and the degradation product of the analyte glycated amine reacts with the FAOD that has already been added to the sample. By measuring this redox reaction, the amount of the analyte glycated amine can be measured.

    摘要翻译： 本发明的目的在于能够高度可靠地测量糖化胺。 向样品中加入果糖基氨基酸氧化酶（FAOD）以除去样品中存在的不同于分析物的糖化胺的非分析物糖化胺。 此后，向样品中加入蛋白酶以降解分析物糖化胺，分析物糖化胺的降解产物与已添加到样品中的FAOD反应。 通过测量该氧化还原反应，可以测量分析物糖化胺的量。

    Amino polyol amine oxidase polynucleotides and related polypeptides and methods of use
    10.
    发明申请
    Amino polyol amine oxidase polynucleotides and related polypeptides and methods of use 失效
    氨基多胺胺氧化酶多核苷酸及相关多肽及其使用方法

    公开(公告)号：US20030126636A1

    公开(公告)日：2003-07-03

    申请号：US09770564

    申请日：2001-01-26

    发明人： Jonathan P. Duvick ,  Jacob T. Gilliam ,  Joyce R. Maddox ,  Oswald R. Crasta ,  Otto Folkerts

    IPC分类号： A01H001/00 ,  C12N015/87 ,  C07H021/04 ,  C12N009/16 ,  C12N005/04 ,  C12P021/02

    CPC分类号： C12N9/0022 ,  A23K10/14 ,  A23K10/18 ,  A23K30/18 ,  C07K2319/00 ,  C12N9/16 ,  C12N15/8209 ,  C12N15/8242 ,  C12N15/8282 ,  G01N2333/906

    摘要： The present invention provides polynucleotides and related polypeptides of the enzyme APAO isolated from Exophiala spinifera. Additionally, the polynucleotide encoding for the APAO enzyme can be used to transform plant cells normally susceptible to Fusarium or other toxin-producing fungus infection. Plants can be regenerated from the transformed plant cells. Additionally, the present invention provides for expressing both APAO and a fumonisin esterase in a transgenic plant. In this way, a transgenic plant can be produced with the capability of degrading fumonisin, as well as with the capability of producing the degrading enzymes. In addition, the present invention provides methods for producing the APAO enzyme in both prokaryotic and non-plant eukaryotic systems. Methods for detoxification in grain, grain processing, silage, food crops and in animal feed and rumen microbes are also disclosed.

    摘要翻译： 本发明提供了从Exophiala spinifera分离的酶APAO的多核苷酸和相关多肽。 此外，编码APAO酶的多核苷酸可用于转化通常易受镰刀菌或其它产生毒素的真菌感染敏感的植物细胞。 植物可以从转化的植物细胞中再生。 另外，本发明提供在转基因植物中表达APAO和伏马菌素酯酶。 以这种方式，可以生产具有降解伏马菌素的能力以及产生降解酶的能力的转基因植物。 此外，本发明提供了在原核和非植物真核系统中生产APAO酶的方法。 还公开了谷物，谷物加工，青贮饲料，粮食作物，动物饲料和瘤胃微生物的解毒方法。