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1.发明授权公开(公告)号：US08232095B2
公开(公告)日：2012-07-31
申请号：US11719749
申请日：2005-11-18
申请人： Chih-Ming Ho , Pak Kin Wong , Ren Sun , Fuqu Yu
发明人： Chih-Ming Ho , Pak Kin Wong , Ren Sun , Fuqu Yu
CPC分类号： C12Q1/02 , C12M41/48 , C12Q3/00 , G01N35/0092 , G01N2035/0094 , Y02A90/26
摘要： The invention provides systems and methods for manipulating, e.g., optimizing and controlling, biological systems, e.g., for eliciting a more desired biological response of biological sample, such as a tissue, organ, and/or a cell. In one aspect, systems and methods of the invention operate by efficiently searching through a large parametric space of stimuli and system parameters to manipulate, control, and optimize the response of biological samples sustained in the system, e.g., a bioreactor. In alternative aspects, systems include a device for sustaining cells or tissue samples, one or more actuators for stimulating the samples via biochemical, electromagnetic, thermal, mechanical, and/or optical stimulation, one or more sensors for measuring a biological response signal of the samples resulting from the stimulation of the sample. In one aspect, the systems and methods of the invention use at least one optimization algorithm to modify the actuator's control inputs for stimulation, responsive to the sensor's output of response signals. The compositions and methods of the invention can be used, e.g., to for systems optimization of any biological manufacturing or experimental system, e.g., bioreactors for proteins, e.g., therapeutic proteins, polypeptides or peptides for vaccines, and the like, small molecules (e.g., antibiotics), polysaccharides, lipids, and the like. Another use of the apparatus and methods includes combination drug therapy, e.g. optimal drug cocktail, directed cell proliferations and differentiations, e.g. in tissue engineering, e.g. neural progenitor cells differentiation, and discovery of key parameters in complex biological systems.
摘要翻译： 本发明提供了用于操纵，例如优化和控制生物系统的系统和方法，例如用于引发生物样品例如组织，器官和/或细胞的更期望的生物反应。 在一个方面，本发明的系统和方法通过有效地搜索刺激和系统参数的大参数空间来操作，控制和优化在系统例如生物反应器中维持的生物样品的响应。 在替代方面，系统包括用于维持细胞或组织样本的装置，用于通过生物化学，电磁，热，机械和/或光刺激刺激样品的一个或多个致动器，用于测量生物反应信号的一个或多个传感器 样品刺激产生的样品。 在一个方面，本发明的系统和方法使用至少一种优化算法，以响应于传感器的响应信号的输出来修改致动器的用于刺激的控制输入。 本发明的组合物和方法可用于例如任何生物制备或实验系统的系统优化，例如用于蛋白质的生物反应器，例如用于疫苗的治疗性蛋白质，多肽或肽等，小分子（例如， ，抗生素），多糖，脂质等。 该装置和方法的另一用途包括组合药物治疗，例如， 最佳药物混合物，定向细胞增殖和分化，例如。 在组织工程中。 神经祖细胞分化，以及复杂生物系统中关键参数的发现。
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公开(公告)号：US09112090B2
公开(公告)日：2015-08-18
申请号：US13476717
申请日：2012-05-21
IPC分类号： H01L31/0232 , H01L31/18 , H01L31/103 , H01L27/146 , H01L21/768
CPC分类号： H01L31/103 , H01L21/76814 , H01L21/76825 , H01L27/14621 , H01L27/14627 , H01L27/14636 , H01L27/1464 , H01L27/14643 , H01L27/14645 , H01L27/14698 , H01L31/1804 , Y02E10/547 , Y02P70/521
摘要： A method of an embodiment comprises forming a dielectric layer on a first side of an image sensor substrate, and exposing the dielectric layer to ultraviolet (UV) radiation. The image sensor substrate comprises a photo diode. A structure of an embodiment comprises a substrate and a charge-less dielectric. The substrate comprises a photo diode. The charge-less dielectric layer is on a first side of the substrate, and a total charge of the charge-less dielectric results in an average voltage drop of less than 0.2 V across the charge-less dielectric layer.
摘要翻译： 实施例的方法包括在图像传感器基板的第一侧上形成电介质层，并将介电层暴露于紫外线（UV）辐射。 图像传感器基板包括光电二极管。 实施例的结构包括基板和无电荷电介质。 衬底包括光电二极管。 无电荷介电层位于衬底的第一侧上，无电荷电介质的总电荷导致无电荷介电层的平均电压降低于0.2V。
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3.发明申请公开(公告)号：US20140007905A1
公开(公告)日：2014-01-09
申请号：US13544637
申请日：2012-07-09
IPC分类号： B08B3/00
CPC分类号： H01L21/67051 , H01L21/67046 , H01L21/68728
摘要： A wafer cleaning system includes a platform, a plurality of wafer holding units over the platform, a front-end rinse nozzle, and a back-end purge unit. The plurality of wafer holding units is set to define a reference plane of wafer holding. The front-end rinse nozzle is above the reference plane and configured to dispense a first rinse fluid toward the reference plane. The back-end purge unit is below the reference plane and configured to dispense an electrolytic gas
摘要翻译： 晶片清洁系统包括平台，平台上的多个晶片保持单元，前端冲洗喷嘴和后端清洗单元。 多个晶片保持单元被设置为限定晶片保持的参考平面。 前端冲洗喷嘴位于参考平面之上，并被配置成朝向参考平面分配第一冲洗流体。 后端清洗单元低于参考平面，并配置为分配电解气体
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公开(公告)号：US20130193541A1
公开(公告)日：2013-08-01
申请号：US13476717
申请日：2012-05-21
IPC分类号： H01L31/0232 , H01L31/18
CPC分类号： H01L31/103 , H01L21/76814 , H01L21/76825 , H01L27/14621 , H01L27/14627 , H01L27/14636 , H01L27/1464 , H01L27/14643 , H01L27/14645 , H01L27/14698 , H01L31/1804 , Y02E10/547 , Y02P70/521
摘要： A method of an embodiment comprises forming a dielectric layer on a first side of an image sensor substrate, and exposing the dielectric layer to ultraviolet (UV) radiation. The image sensor substrate comprises a photo diode. A structure of an embodiment comprises a substrate and a charge-less dielectric. The substrate comprises a photo diode. The charge-less dielectric layer is on a first side of the substrate, and a total charge of the charge-less dielectric results in an average voltage drop of less than 0.2 V across the charge-less dielectric layer.
摘要翻译： 实施例的方法包括在图像传感器基板的第一侧上形成电介质层，并将介电层暴露于紫外线（UV）辐射。 图像传感器基板包括光电二极管。 实施例的结构包括基板和无电荷电介质。 衬底包括光电二极管。 无电荷介电层位于衬底的第一侧上，无电荷电介质的总电荷导致无电荷介电层的平均电压降低于0.2V。
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公开(公告)号：US20120256324A1
公开(公告)日：2012-10-11
申请号：US13528130
申请日：2012-06-20
IPC分类号： H01L23/485 , H01L21/768
CPC分类号： H01L23/53238 , H01L21/76807 , H01L21/76832 , H01L21/76834 , H01L23/5329 , H01L23/53295 , H01L2924/0002 , H01L2924/00
摘要： A method of forming an interconnect structure includes providing a dielectric layer; forming a metal line in the dielectric layer; and forming a composite etch stop layer (ESL), which includes forming a lower ESL over the metal line and the dielectric layer; and forming an upper ESL over the lower ESL. The upper ESL and the lower ESL have different compositions. The step of forming the lower ESL and the step of forming the upper ESL are in-situ performed.
摘要翻译： 形成互连结构的方法包括：提供介电层; 在介电层中形成金属线; 以及形成复合蚀刻停止层（ESL），其包括在所述金属线和所述介电层上形成较低的ESL; 并在较低的ESL上形成较高的ESL。 上ESL和下ESL具有不同的组成。 形成较低ESL的步骤和形成上部ESL的步骤被原位执行。
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6.发明申请公开(公告)号：US20090075360A1
公开(公告)日：2009-03-19
申请号：US11719749
申请日：2005-11-18
申请人： Chih-Ming Ho , Pak Kin Wong , Ren Sun , Fuqu Yu
发明人： Chih-Ming Ho , Pak Kin Wong , Ren Sun , Fuqu Yu
CPC分类号： C12Q1/02 , C12M41/48 , C12Q3/00 , G01N35/0092 , G01N2035/0094 , Y02A90/26
摘要： The invention provides systems and methods for manipulating, e.g., optimizing and controlling, biological systems, e.g., for eliciting a more desired biological response of biological sample, such as a tissue, organ, and/or a cell. In one aspect, systems and methods of the invention operate by efficiently searching through a large parametric space of stimuli and system parameters to manipulate, control, and optimize the response of biological samples sustained in the system, e.g., a bioreactor. In alternative aspects, systems include a device for sustaining cells or tissue samples, one or more actuators for stimulating the samples via biochemical, electromagnetic, thermal, mechanical, and/or optical stimulation, one or more sensors for measuring a biological response signal of the samples resulting from the stimulation of the sample. In one aspect, the systems and methods of the invention use at least one optimization algorithm to modify the actuator's control inputs for stimulation, responsive to the sensor's output of response signals. The compositions and methods of the invention can be used, e.g., to for systems optimization of any biological manufacturing or experimental system, e.g., bioreactors for proteins, e.g., therapeutic proteins, polypeptides or peptides for vaccines, and the like, small molecules (e.g., antibiotics), polysaccharides, lipids, and the like. Another use of the apparatus and methods includes combination drug therapy, e.g. optimal drug cocktail, directed cell proliferations and differentiations, e.g. in tissue engineering, e.g. neural progenitor cells differentiation, and discovery of key parameters in complex biological systems.
摘要翻译： 本发明提供了用于操纵，例如优化和控制生物系统的系统和方法，例如用于引发生物样品例如组织，器官和/或细胞的更期望的生物反应。 在一个方面，本发明的系统和方法通过有效地搜索刺激和系统参数的大参数空间来操作，控制和优化在系统例如生物反应器中维持的生物样品的响应。 在替代方面，系统包括用于维持细胞或组织样本的装置，用于通过生物化学，电磁，热，机械和/或光刺激刺激样品的一个或多个致动器，用于测量生物反应信号的一个或多个传感器 样品刺激产生的样品。 在一个方面，本发明的系统和方法使用至少一种优化算法，以响应于传感器的响应信号的输出来修改致动器的用于刺激的控制输入。 本发明的组合物和方法可用于例如任何生物制备或实验系统的系统优化，例如用于蛋白质的生物反应器，例如用于疫苗的治疗性蛋白质，多肽或肽等，小分子（例如， ，抗生素），多糖，脂质等。 该装置和方法的另一用途包括组合药物治疗，例如， 最佳药物混合物，定向细胞增殖和分化，例如。 在组织工程中。 神经祖细胞分化，以及复杂生物系统中关键参数的发现。
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7.发明授权Grids in backside illumination image sensor chips and methods for forming the same 有权背面照明图像传感器芯片中的栅格及其形成方法公开(公告)号：US09041140B2
公开(公告)日：2015-05-26
申请号：US13420847
申请日：2012-03-15
申请人： Shiu-Ko JangJian , Min Hao Hong , Ting-Chun Wang , Chung-Ren Sun
发明人： Shiu-Ko JangJian , Min Hao Hong , Ting-Chun Wang , Chung-Ren Sun
IPC分类号： H01L31/18 , H01L27/146
CPC分类号： H01L27/14685 , H01L27/14621 , H01L27/14625 , H01L27/14627 , H01L27/14629 , H01L27/1464 , H01L27/14683
摘要： A device includes a semiconductor substrate having a front side and a backside, a photo-sensitive device disposed on the front side of the semiconductor substrate, and a first and a second grid line parallel to each other. The first and the second grid lines are on the backside of, and overlying, the semiconductor substrate. The device further includes an adhesion layer, a metal oxide layer over the adhesion layer, and a high-refractive index layer over the metal layer. The adhesion layer, the metal oxide layer, and the high-refractive index layer are substantially conformal, and extend on top surfaces and sidewalls of the first and the second grid lines.
摘要翻译： 一种器件包括具有正面和背面的半导体衬底，设置在半导体衬底的前侧的光敏器件以及彼此平行的第一和第二栅极线。 第一和第二栅格线位于半导体衬底的背面并覆盖其上。 该装置还包括粘合层，粘合层上的金属氧化物层和金属层上的高折射率层。 粘合层，金属氧化物层和高折射率层基本上是共形的，并且在第一和第二栅格线的顶表面和侧壁上延伸。
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8.发明申请公开(公告)号：US20130130360A1
公开(公告)日：2013-05-23
申请号：US13562216
申请日：2012-07-30
申请人： Chih-Ming HO , Pak Kin WONG , Ren SUN , Fuqu YU
发明人： Chih-Ming HO , Pak Kin WONG , Ren SUN , Fuqu YU
IPC分类号： C12Q1/02
CPC分类号： C12Q1/02 , C12M41/48 , C12Q3/00 , G01N35/0092 , G01N2035/0094 , Y02A90/26
摘要： The invention provides systems and methods for manipulating biological systems, for example to elicit a more desired biological response from a biological sample, such as a tissue, organ, and/or a cell. In one aspect, the invention operates by efficiently searching through a large parametric space of stimuli and system parameters to manipulate, control, and optimize the response of biological samples sustained in the system In one aspect, the systems and methods of the invention use at least one optimization algorithm to modify the actuator's control inputs for stimulation, responsive to the sensor's output of response signals. The invention can be used, e.g., to optimize any biological system, e.g., bioreactors for proteins, and the like, small molecules, polysaccharides, lipids, and the like. Another use of the apparatus and methods includes is for the discovery of key parameters in complex biological systems.
摘要翻译： 本发明提供了用于操纵生物系统的系统和方法，例如从生物样品（例如组织，器官和/或细胞）引出更希望的生物反应。 一方面，本发明通过有效搜索刺激的大参数空间和系统参数来操作，控制和优化系统中持续的生物样品的响应。一方面，本发明的系统和方法至少使用 一种优化算法，用于根据传感器的响应信号输出来修改执行器的控制输入以进行刺激。 本发明可用于例如优化任何生物系统，例如用于蛋白质的生物反应器等，小分子，多糖，脂质等。 该装置和方法的另一用途包括在复杂生物系统中发现关键参数。
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公开(公告)号：US20100252930A1
公开(公告)日：2010-10-07
申请号：US12708160
申请日：2010-02-18
IPC分类号： H01L23/48 , H01L21/768
CPC分类号： H01L23/53238 , H01L21/76807 , H01L21/76832 , H01L21/76834 , H01L23/5329 , H01L23/53295 , H01L2924/0002 , H01L2924/00
摘要： A method of forming an interconnect structure includes providing a dielectric layer; forming a metal line in the dielectric layer; and forming a composite etch stop layer (ESL), which includes forming a lower ESL over the metal line and the dielectric layer; and forming an upper ESL over the lower ESL. The upper ESL and the lower ESL have different compositions. The step of forming the lower ESL and the step of forming the upper ESL are in-situ performed.
摘要翻译： 形成互连结构的方法包括：提供介电层; 在介电层中形成金属线; 以及形成复合蚀刻停止层（ESL），其包括在所述金属线和所述介电层上形成较低的ESL; 并在较低的ESL上形成较高的ESL。 上ESL和下ESL具有不同的组成。 形成较低ESL的步骤和形成上部ESL的步骤被原位执行。
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10.发明授权公开(公告)号：US08765459B2
公开(公告)日：2014-07-01
申请号：US13562216
申请日：2012-07-30
申请人： Chih-Ming Ho , Pak Kin Wong , Ren Sun , Fuqu Yu
发明人： Chih-Ming Ho , Pak Kin Wong , Ren Sun , Fuqu Yu
CPC分类号： C12Q1/02 , C12M41/48 , C12Q3/00 , G01N35/0092 , G01N2035/0094 , Y02A90/26
摘要： The invention provides systems and methods for manipulating biological systems, for example to elicit a more desired biological response from a biological sample, such as a tissue, organ, and/or a cell. In one aspect, the invention operates by efficiently searching through a large parametric space of stimuli and system parameters to manipulate, control, and optimize the response of biological samples sustained in the system. In one aspect, the systems and methods of the invention use at least one optimization algorithm to modify the actuator's control inputs for stimulation, responsive to the sensor's output of response signals. The invention can be used, e.g., to optimize any biological system, e.g., bioreactors for proteins, and the like, small molecules, polysaccharides, lipids, and the like. Another use of the apparatus and methods includes is for the discovery of key parameters in complex biological systems.
摘要翻译： 本发明提供了用于操纵生物系统的系统和方法，例如从生物样品（例如组织，器官和/或细胞）引出更希望的生物反应。 在一个方面，本发明通过有效搜索刺激的大参数空间和系统参数来操作，控制和优化系统中持续的生物样品的响应。 在一个方面，本发明的系统和方法使用至少一种优化算法，以响应于传感器的响应信号的输出来修改致动器的用于刺激的控制输入。 本发明可用于例如优化任何生物系统，例如用于蛋白质的生物反应器等，小分子，多糖，脂质等。 该装置和方法的另一用途包括在复杂生物系统中发现关键参数。
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