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1.发明授权公开(公告)号：US08157717B2
公开(公告)日：2012-04-17
申请号：US12544101
申请日：2009-08-19
IPC分类号： A61N5/00
CPC分类号： A61N5/1015 , A61N2005/1018
摘要： A brachytherapy device may include an expandable outer cage, an expandable inner cage positioned within the outer cage and configured to receive radioactive material at its perimeter, and a movable actuator configured to cause the outer and inner cages to expand simultaneously in response to movement of the actuator between certain positions while maintaining a substantially constant separation distance between the outer and inner cages.
摘要翻译： 近距离放射治疗装置可以包括可扩张的外笼，位于外笼内并被配置为在其外周处接收放射性物质的可扩展的内笼，以及可移动的致动器，该致动器构造成使得外壳和内笼同时响应于 致动器在某些位置之间，同时保持外笼和内笼之间的基本恒定的间隔距离。
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公开(公告)号：US20100121130A1
公开(公告)日：2010-05-13
申请号：US12691508
申请日：2010-01-21
IPC分类号： A61M36/12
CPC分类号： A61N5/1027 , A61N5/1007 , A61N2005/1023 , A61N2005/1024 , B29C47/0009 , B29C47/021 , B29C47/028 , G21G4/08
摘要： A prescription method of treating tissue comprises the steps of accepting a prescription tissue treatment plan for the tissue to be treated, positioning seeds relative to each other per the prescription tissue treatment plan such that the positions of seeds relative to each other is only established by the prescription tissue treatment plan, and creating a treatment strand by heating and cooling a material to position the plurality of treatment seeds in the material. The prescription tissue treatment plan specifies a number and a spacing of the seeds to be provided in the treatment strand, the spacing of the treatment seeds being unrestricted by any use of spacers and independently set by and according to the prescription tissue treatment plan.
摘要翻译： 处理组织的处方方法包括以下步骤：接受处理组织的处方组织处理计划，根据处方组织处理计划相对于彼此定位种子，使得种子相对于彼此的位置仅由 处方组织处理计划，以及通过加热和冷却材料以将多种处理种子定位在材料中来形成治疗股。 处方组织处理计划规定了要在治疗链中提供的种子的数量和间距，处理种子的间距通过任何使用间隔物而不受限制，并且根据处方组织处理计划独立设定。
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3.发明授权公开(公告)号：US07540998B2
公开(公告)日：2009-06-02
申请号：US10987141
申请日：2004-11-12
CPC分类号： A61L2/206 , A61N5/1027 , A61N2005/1011
摘要： A process is provided for sterilizing brachytherapy devices with Ethylene Oxide gas and releasing the devices on a parametric release basis. Devices that can be sterilized with this process include interstitial radiation seed strand implants and the needles used for implantation. In order to be sterilized effectively by EtO gas, the devices are constructed such that surfaces not readily infused with EtO gas are made to be gas permeable, and will not retain the gas after the sterilization process. Performance qualification of the sterilization process is performed through physical and microbiological studies, and set of established physical process parameters. Maintaining the physical process parameters in subsequent sterilization cycles will consistently yield the desired sterility assurance level without having to test the devices for sterility.
摘要翻译： 提供了一种使用环氧乙烷气体灭菌近距离放射治疗装置并以参数释放为基础释放装置的方法。 可以用该方法灭菌的装置包括间质辐射种子线植入物和用于植入的针。 为了通过EtO气体有效灭菌，这些装置被构造成使得不容易注入EtO气体的表面被制成透气性，并且在灭菌过程之后不会保留气体。 灭菌过程的性能鉴定通过物理和微生物学研究以及既定的物理过程参数进行。 在随后的灭菌循环中保持物理过程参数将一直产生所需的无菌保证水平，而无需测试设备的无菌性。
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4.发明申请EXPANDABLE BRACHYTHERAPY DEVICE WITH CONSTANT RADIATION SOURCE SPACING 有权具有恒定辐射源间隔的可扩展的BRACHYTHERAPY器件公开(公告)号：US20080108859A1
公开(公告)日：2008-05-08
申请号：US11737028
申请日：2007-04-18
IPC分类号： A61M36/12
CPC分类号： A61N5/1015 , A61N2005/1018
摘要： A brachytherapy device may include an expandable outer cage, an expandable inner cage positioned within the outer cage and configured to receive radioactive material at its perimeter, and a movable actuator configured to cause the outer and inner cages to expand simultaneously in response to movement of the actuator between certain positions while maintaining a substantially constant separation distance between the outer and inner cages.
摘要翻译： 近距离放射治疗装置可以包括可扩张的外笼，位于外笼内并被配置为在其外周处接收放射性物质的可扩展的内笼，以及可移动的致动器，该致动器构造成使得外壳和内笼同时响应于 致动器在某些位置之间，同时保持外笼和内笼之间的基本恒定的间隔距离。
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公开(公告)号：US07060020B2
公开(公告)日：2006-06-13
申请号：US10035083
申请日：2001-12-28
IPC分类号： A61N5/00
CPC分类号： A61N5/1027 , A61N5/1007 , A61N2005/1023 , A61N2005/1024 , B29C47/0009 , B29C47/021 , B29C47/028 , G21G4/08
摘要： A delivery system and method for interstitial radiation therapy comprising a substantially axially stiff and longitudinally flexible elongated member made of material, which is bio-absorbable in living tissue and a plurality of radioactive seeds dispersed in a predetermined array within the member. The delivery system and method further customize the member based on a prescription.
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公开(公告)号：US07008368B2
公开(公告)日：2006-03-07
申请号：US10716328
申请日：2003-11-18
CPC分类号： A61N5/1007 , A61N5/1027 , A61N2005/1023 , B29C47/0016 , B29C47/021 , B29C47/028 , G21G4/08 , Y10T29/49
摘要： A delivery system and method for interstitial radiation therapy uses a seed strand composed of a plurality of tubular shaped, hollow radioactive seeds with a bore. The seed strand as assembled with a material provided in the bore and between the spaced seeds is axially stiff and radially flexible and is bioabsorbable in living tissue.
摘要翻译： 用于间质放射治疗的递送系统和方法使用由具有孔的多个管状中空放射性种子组成的种子线。 与设置在孔中和间隔开的种子之间的材料组装的种子线轴向刚性并且具有径向柔性，并且在生物组织中是生物可吸收的。
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公开(公告)号：US08226539B2
公开(公告)日：2012-07-24
申请号：US12554732
申请日：2009-09-04
申请人： L. Michael Cutrer , Richard A. Terwilliger , Fredrick W. Winch , John Zhang , Wayne Higgins , Terence Ellard , David Bossi
发明人： L. Michael Cutrer , Richard A. Terwilliger , Fredrick W. Winch , John Zhang , Wayne Higgins , Terence Ellard , David Bossi
IPC分类号： A61N5/00
CPC分类号： A61N5/1015 , A61N2005/1018
摘要： The present disclosure provides a brachytherapy apparatus, system and method that delivers partial breast irradiation treatment for post-lumpectomy patients via introduction of a catheter-like device through a trocar. The apparatus may be introduced post-surgically with local anesthesia under image guidance into the previous excision site and into a cavity by a surgeon. The brachytherapy apparatus includes one or more thin-walled tubes, each of said thin-walled tubes being configured to contain one or more radioactive sources, at least one radiation source configured to deliver a prescribed dose of radiation, a whisk adjuster configured to permit adjustment of each of the one or more thin-walled tubes so that the tubes substantially conform to a size of the body cavity; and an expansion element configured to expand outwardly said one or more thin-walled tubes within the cavity so that the thin-walled tubes substantially conform to a shape and/or size of the body cavity.
摘要翻译： 本公开提供了一种近距离放射治疗装置，系统和方法，其通过经由套管针引入导管状装置来递送部分乳房外照射治疗肿瘤后切除术患者。 该装置可以在图像引导下用手术后的局部麻醉引入先前的切除部位并由外科医生进入腔中。 近距离放射治疗装置包括一个或多个薄壁管，每个所述薄壁管被构造成容纳一个或多个放射源，至少一个辐射源被配置为传送规定剂量的辐射，构造成允许调节的搅拌器 所述一个或多个薄壁管中的每一个使得所述管基本上符合所述体腔的尺寸; 以及膨胀元件，其构造成向外扩张所述空腔内的所述一个或多个薄壁管，使得所述薄壁管基本上符合所述体腔的形状和/或尺寸。
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公开(公告)号：US08137256B2
公开(公告)日：2012-03-20
申请号：US11305437
申请日：2005-12-16
申请人： L. Michael Cutrer , Richard A. Terwilliger , Fredrick Winch , John Zhang , Wayne Higgins , Terence Ellard , David Bossi
发明人： L. Michael Cutrer , Richard A. Terwilliger , Fredrick Winch , John Zhang , Wayne Higgins , Terence Ellard , David Bossi
IPC分类号： A61N5/00
CPC分类号： A61N5/1015 , A61N2005/1018
摘要： The present disclosure provides a brachytherapy apparatus that delivers a low dose, partial breast irradiation treatment for post-lumpectomy patients via introduction of a catheter-like device through a cannula. The apparatus may be introduced post-surgically with local anesthesia under image guidance into the previous excision site and into a cavity by a surgeon. The brachytherapy apparatus includes a seed containment device configured to contain a plurality of low-dose radioactive seeds therein. The seed containment device may be one or more thin-walled tubes. The apparatus is further configured to expand so that at least a portion of the seed containment device is positioned against the remaining tissue and the plurality of radioactive seeds are disposed at the perimeter of the seed containment device. Also described are various clamps for the apparatus, and sleeves for adjusting the size of the device to fit a cavity when the apparatus is in use.
摘要翻译： 本公开提供了一种近距离放射治疗装置，其通过经由插管引入导管状装置来递送针对后肿瘤切除术患者的低剂量部分乳房照射治疗。 该装置可以在图像引导下用手术后的局部麻醉引入先前的切除部位并由外科医生进入腔中。 近程放射治疗装置包括种子容纳装置，其构造成在其中容纳多个低剂量放射性种子。 种子容纳装置可以是一个或多个薄壁管。 该装置进一步构造成扩张，使得种子容纳装置的至少一部分抵靠剩余的组织定位，并且多个放射性种子设置在种子容纳装置的周边。 还描述了用于装置的各种夹具以及用于在装置使用时调节装置的尺寸以配合空腔的套筒。
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9.发明授权Delivery system and method for interstitial radiation therapy using seed strands with custom end spacing 失效使用具有定制末端间距的种子线进行间质放射治疗的递送系统和方法公开(公告)号：US07736294B2
公开(公告)日：2010-06-15
申请号：US11261970
申请日：2005-10-28
IPC分类号： A61N5/00
CPC分类号： A61M37/0069 , A61B17/3468 , A61B2017/3407 , A61B2017/3411 , A61N5/1027 , A61N2005/1012 , A61N2005/1023
摘要： A delivery system and method for interstitial radiation therapy comprising a substantially axially stiff and longitudinally flexible elongated strand made of material, which is bio-absorbable in living tissue and a plurality of radioactive seeds dispersed in a predetermined array within the strand. The delivery system and method further customize the strand based on a prescription. The strands can have custom end spacings, which allow the optimal placing of seeds within the treatment tissue by implanting a plurality of strands to the same depth. A plurality of these strands can be implanted at the same time by the use of a guiding device.
摘要翻译： 一种用于间质放射治疗的递送系统和方法，其包括在生物体组织中可生物吸收的基本上轴向刚性且纵向柔性的由细长的材料构成的细长股线，以及分散在股线内预定阵列中的多个放射性种子。 递送系统和方法基于处方进一步定制链。 股线可以具有定制的端部间隔，其允许通过将多个股线植入同一深度来最佳地将种子放置在处理组织内。 可以通过使用引导装置同时植入多个这些线。
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公开(公告)号：US20070142694A1
公开(公告)日：2007-06-21
申请号：US11305437
申请日：2005-12-16
申请人： L. Michael Cutrer , Richard A. Terwilliger , Fredrick Winch , John Zhang , Wayne Higgins , Terence Ellard , David Bossi
发明人： L. Michael Cutrer , Richard A. Terwilliger , Fredrick Winch , John Zhang , Wayne Higgins , Terence Ellard , David Bossi
CPC分类号： A61N5/1015 , A61N2005/1018
摘要： The present disclosure provides a brachytherapy apparatus that delivers a low dose, partial breast irradiation treatment for post-lumpectomy patients via introduction of a catheter-like device through a cannula. The apparatus may be introduced post-surgically with local anesthesia under image guidance into the previous excision site and into a cavity by a surgeon. The brachytherapy apparatus includes a seed containment device configured to contain a plurality of low-dose radioactive seeds therein. The seed containment device may be one or more thin-walled tubes. The apparatus is further configured to expand so that at least a portion of the seed containment device is positioned against the remaining tissue and the plurality of radioactive seeds are disposed at the perimeter of the seed containment device. Also described are various clamps for the apparatus, and sleeves for adjusting the size of the device to fit a cavity when the apparatus is in use.
摘要翻译： 本公开提供了一种近距离放射治疗装置，其通过经由插管引入导管状装置来递送针对后肿瘤切除术患者的低剂量部分乳房照射治疗。 该装置可以在图像引导下用手术后的局部麻醉引入先前的切除部位并由外科医生进入腔中。 近程放射治疗装置包括种子容纳装置，其构造成在其中容纳多个低剂量放射性种子。 种子容纳装置可以是一个或多个薄壁管。 该装置进一步构造成扩张，使得种子容纳装置的至少一部分抵靠剩余的组织定位，并且多个放射性种子设置在种子容纳装置的周边。 还描述了用于装置的各种夹具以及用于在装置使用时调节装置的尺寸以配合空腔的套筒。
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