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公开(公告)号：US07942803B2
公开(公告)日：2011-05-17
申请号：US12691508
申请日：2010-01-21
IPC分类号： A61N5/00
CPC分类号： A61N5/1027 , A61N5/1007 , A61N2005/1023 , A61N2005/1024 , B29C47/0009 , B29C47/021 , B29C47/028 , G21G4/08
摘要： A prescription method of treating tissue comprises the steps of accepting a prescription tissue treatment plan for the tissue to be treated, positioning seeds relative to each other per the prescription tissue treatment plan such that the positions of seeds relative to each other is only established by the prescription tissue treatment plan, and creating a treatment strand by heating and cooling a material to position the plurality of treatment seeds in the material. The prescription tissue treatment plan specifies a number and a spacing of the seeds to be provided in the treatment strand, the spacing of the treatment seeds being unrestricted by any use of spacers and independently set by and according to the prescription tissue treatment plan.
摘要翻译： 处理组织的处方方法包括以下步骤：接受处理组织的处方组织处理计划，根据处方组织处理计划相对于彼此定位种子，使得种子相对于彼此的位置仅由 处方组织处理计划，以及通过加热和冷却材料以将多种处理种子定位在材料中来形成治疗股。 处方组织处理计划规定了要在治疗链中提供的种子的数量和间距，处理种子的间距通过任何使用间隔物而不受限制，并且根据处方组织处理计划独立设定。
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公开(公告)号：US07874976B1
公开(公告)日：2011-01-25
申请号：US11517649
申请日：2006-09-07
IPC分类号： A61M36/00
CPC分类号： A61N5/1027 , A61B2090/3925 , A61N2005/1023
摘要： Echogenic strands and spacers are provided for use in brachytherapy. Methods of making the strands and spacers are also provided. An echogenic strand for use in brachytherapy includes an encapsulating material, a seed disposed within the encapsulating material, and a spacer disposed within the encapsulating material and arranged adjacent to the seed. The spacer has an external length and a chamber formed along the external length, the chamber being adapted to improve ultrasound visibility relative to the spacer.
摘要翻译： 提供了生长性丝束和间隔物用于近距离放射治疗。 还提供了制造股线和间隔物的方法。 用于近距离放射治疗的回声链包括封装材料，设置在封装材料内的种子以及设置在封装材料内且邻近晶种布置的间隔物。 间隔件具有外部长度和沿着外部长度形成的腔室，腔室适于改善相对于间隔件的超声可见性。
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3.发明授权Delivery system and method for interstitial radiation therapy using custom end spacing 失效使用定制末端间距的间质放射治疗的输送系统和方法公开(公告)号：US07736295B2
公开(公告)日：2010-06-15
申请号：US11274424
申请日：2005-11-15
IPC分类号： A61N5/00
CPC分类号： A61M37/0069 , A61B17/3468 , A61B2017/3407 , A61B2017/3411 , A61N5/1027 , A61N2005/1012 , A61N2005/1023
摘要： A delivery system and method for interstitial radiation therapy comprising a strand made of material, which is bio-absorbable in living tissue and a plurality of radioactive seeds dispersed in a predetermined array within the strand. The strands can have custom end spacings, which allow the optimal placing of seeds within the treatment tissue by implanting a plurality of strands to the same depth. A plurality of these strands can be implanted at the same time by the use of a guiding device. In certain embodiments, a custom end spacing within a needle is not attached to the strand in the needle. In certain embodiments, the custom end spacing, seeds and spacers within a needle are loose, i.e., not part of a strand.
摘要翻译： 用于间质放射治疗的递送系统和方法，包括由活体组织中可生物吸收的材料制成的股线，以及以预定阵列分散在股线内的多个放射性种子。 股线可以具有定制的端部间隔，其允许通过将多个股线植入同一深度来最佳地将种子放置在处理组织内。 可以通过使用引导装置同时植入多个这些线。 在某些实施例中，针内的定制端部间隔未附接到针中的股线。 在某些实施例中，针内的定制端间距，种子和间隔物是松散的，即不是绞线的一部分。
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公开(公告)号：US07497818B2
公开(公告)日：2009-03-03
申请号：US10397940
申请日：2003-03-26
IPC分类号： A61N5/00
CPC分类号： A61N5/1027 , A61N5/1007 , A61N2005/1023 , A61N2005/1024 , B29C47/0009 , B29C47/021 , B29C47/028 , G21G4/08
摘要： A delivery system and method for interstitial radiation therapy comprising a substantially axially stiff and longitudinally flexible elongated member made of material, which is bio-absorbable in living tissue and a plurality of radioactive seeds dispersed in a predetermined array within the member. The delivery system and method further customize the member based on a prescription.
摘要翻译： 一种用于间质放射治疗的递送系统和方法，包括基本上轴向刚性的和纵向柔性的细长构件，其由在生物体组织中可生物吸收的材料制成，并且多个放射性种子以预定阵列分散在该构件内。 递送系统和方法基于处方进一步定制成员。
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公开(公告)号：US07278972B2
公开(公告)日：2007-10-09
申请号：US10347966
申请日：2003-01-21
IPC分类号： A61B10/00
CPC分类号： A61B10/025 , A61B10/0266 , A61B10/0283 , A61B2010/0225
摘要： A combined bone marrow aspiration and core biopsy device. A large bore cannula includes a coaxial stylet which seals both ends of the cannula, allowing fluid to be aspirated through the space between stylet and cannula. Then, a core sample is taken with the cannula after the stylet is retracted.
摘要翻译： 联合骨髓抽吸和核心活检装置。 大口径套管包括密封套管两端的同轴管心针，允许流体通过探针和插管之间的空间被吸入。 然后，在探针收回后，用插管取出核心样品。
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6.发明授权Delivery system and method for interstitial radiation therapy using seed strands with custom end spacing 失效使用具有定制末端间距的种子线进行间质放射治疗的递送系统和方法公开(公告)号：US06997862B2
公开(公告)日：2006-02-14
申请号：US10619928
申请日：2003-07-15
CPC分类号： A61M37/0069 , A61B17/3468 , A61B2017/3407 , A61B2017/3411 , A61N5/1027 , A61N2005/1012 , A61N2005/1023
摘要： A delivery system and method for interstitial radiation therapy comprising a substantially axially stiff and longitudinally flexible elongated strand made of material, which is bio-absorbable in living tissue and a plurality of radioactive seeds dispersed in a predetermined array within the strand. The delivery system and method further customize the strand based on a prescription. The strands can have custom end spacings, which allow the optimal placing of seeds within the treatment tissue by implanting a plurality of strands to the same depth. A plurality of these strands can be implanted at the same time by the use of a guiding device.
摘要翻译： 一种用于间质放射治疗的递送系统和方法，其包括在生物体组织中可生物吸收的基本上轴向刚性且纵向柔性的由细长的材料构成的细长股线，以及分散在股线内预定阵列的多个放射性种子。 递送系统和方法基于处方进一步定制链。 股线可以具有定制的端部间隔，其允许通过将多个股线植入同一深度来最佳地将种子放置在处理组织内。 可以通过使用引导装置同时植入多个这些股线。
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公开(公告)号：US20100121130A1
公开(公告)日：2010-05-13
申请号：US12691508
申请日：2010-01-21
IPC分类号： A61M36/12
CPC分类号： A61N5/1027 , A61N5/1007 , A61N2005/1023 , A61N2005/1024 , B29C47/0009 , B29C47/021 , B29C47/028 , G21G4/08
摘要： A prescription method of treating tissue comprises the steps of accepting a prescription tissue treatment plan for the tissue to be treated, positioning seeds relative to each other per the prescription tissue treatment plan such that the positions of seeds relative to each other is only established by the prescription tissue treatment plan, and creating a treatment strand by heating and cooling a material to position the plurality of treatment seeds in the material. The prescription tissue treatment plan specifies a number and a spacing of the seeds to be provided in the treatment strand, the spacing of the treatment seeds being unrestricted by any use of spacers and independently set by and according to the prescription tissue treatment plan.
摘要翻译： 处理组织的处方方法包括以下步骤：接受处理组织的处方组织处理计划，根据处方组织处理计划相对于彼此定位种子，使得种子相对于彼此的位置仅由 处方组织处理计划，以及通过加热和冷却材料以将多种处理种子定位在材料中来形成治疗股。 处方组织处理计划规定了要在治疗链中提供的种子的数量和间距，处理种子的间距通过任何使用间隔物而不受限制，并且根据处方组织处理计划独立设定。
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8.发明授权公开(公告)号：US07540998B2
公开(公告)日：2009-06-02
申请号：US10987141
申请日：2004-11-12
CPC分类号： A61L2/206 , A61N5/1027 , A61N2005/1011
摘要： A process is provided for sterilizing brachytherapy devices with Ethylene Oxide gas and releasing the devices on a parametric release basis. Devices that can be sterilized with this process include interstitial radiation seed strand implants and the needles used for implantation. In order to be sterilized effectively by EtO gas, the devices are constructed such that surfaces not readily infused with EtO gas are made to be gas permeable, and will not retain the gas after the sterilization process. Performance qualification of the sterilization process is performed through physical and microbiological studies, and set of established physical process parameters. Maintaining the physical process parameters in subsequent sterilization cycles will consistently yield the desired sterility assurance level without having to test the devices for sterility.
摘要翻译： 提供了一种使用环氧乙烷气体灭菌近距离放射治疗装置并以参数释放为基础释放装置的方法。 可以用该方法灭菌的装置包括间质辐射种子线植入物和用于植入的针。 为了通过EtO气体有效灭菌，这些装置被构造成使得不容易注入EtO气体的表面被制成透气性，并且在灭菌过程之后不会保留气体。 灭菌过程的性能鉴定通过物理和微生物学研究以及既定的物理过程参数进行。 在随后的灭菌循环中保持物理过程参数将一直产生所需的无菌保证水平，而无需测试设备的无菌性。
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公开(公告)号：US07060020B2
公开(公告)日：2006-06-13
申请号：US10035083
申请日：2001-12-28
IPC分类号： A61N5/00
CPC分类号： A61N5/1027 , A61N5/1007 , A61N2005/1023 , A61N2005/1024 , B29C47/0009 , B29C47/021 , B29C47/028 , G21G4/08
摘要： A delivery system and method for interstitial radiation therapy comprising a substantially axially stiff and longitudinally flexible elongated member made of material, which is bio-absorbable in living tissue and a plurality of radioactive seeds dispersed in a predetermined array within the member. The delivery system and method further customize the member based on a prescription.
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公开(公告)号：US07008368B2
公开(公告)日：2006-03-07
申请号：US10716328
申请日：2003-11-18
CPC分类号： A61N5/1007 , A61N5/1027 , A61N2005/1023 , B29C47/0016 , B29C47/021 , B29C47/028 , G21G4/08 , Y10T29/49
摘要： A delivery system and method for interstitial radiation therapy uses a seed strand composed of a plurality of tubular shaped, hollow radioactive seeds with a bore. The seed strand as assembled with a material provided in the bore and between the spaced seeds is axially stiff and radially flexible and is bioabsorbable in living tissue.
摘要翻译： 用于间质放射治疗的递送系统和方法使用由具有孔的多个管状中空放射性种子组成的种子线。 与设置在孔中和间隔开的种子之间的材料组装的种子线轴向刚性并且具有径向柔性，并且在生物组织中是生物可吸收的。
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