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公开(公告)号：US20100121130A1
公开(公告)日：2010-05-13
申请号：US12691508
申请日：2010-01-21
IPC分类号： A61M36/12
CPC分类号： A61N5/1027 , A61N5/1007 , A61N2005/1023 , A61N2005/1024 , B29C47/0009 , B29C47/021 , B29C47/028 , G21G4/08
摘要： A prescription method of treating tissue comprises the steps of accepting a prescription tissue treatment plan for the tissue to be treated, positioning seeds relative to each other per the prescription tissue treatment plan such that the positions of seeds relative to each other is only established by the prescription tissue treatment plan, and creating a treatment strand by heating and cooling a material to position the plurality of treatment seeds in the material. The prescription tissue treatment plan specifies a number and a spacing of the seeds to be provided in the treatment strand, the spacing of the treatment seeds being unrestricted by any use of spacers and independently set by and according to the prescription tissue treatment plan.
摘要翻译： 处理组织的处方方法包括以下步骤：接受处理组织的处方组织处理计划，根据处方组织处理计划相对于彼此定位种子，使得种子相对于彼此的位置仅由 处方组织处理计划，以及通过加热和冷却材料以将多种处理种子定位在材料中来形成治疗股。 处方组织处理计划规定了要在治疗链中提供的种子的数量和间距，处理种子的间距通过任何使用间隔物而不受限制，并且根据处方组织处理计划独立设定。
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2.发明授权公开(公告)号：US07540998B2
公开(公告)日：2009-06-02
申请号：US10987141
申请日：2004-11-12
CPC分类号： A61L2/206 , A61N5/1027 , A61N2005/1011
摘要： A process is provided for sterilizing brachytherapy devices with Ethylene Oxide gas and releasing the devices on a parametric release basis. Devices that can be sterilized with this process include interstitial radiation seed strand implants and the needles used for implantation. In order to be sterilized effectively by EtO gas, the devices are constructed such that surfaces not readily infused with EtO gas are made to be gas permeable, and will not retain the gas after the sterilization process. Performance qualification of the sterilization process is performed through physical and microbiological studies, and set of established physical process parameters. Maintaining the physical process parameters in subsequent sterilization cycles will consistently yield the desired sterility assurance level without having to test the devices for sterility.
摘要翻译： 提供了一种使用环氧乙烷气体灭菌近距离放射治疗装置并以参数释放为基础释放装置的方法。 可以用该方法灭菌的装置包括间质辐射种子线植入物和用于植入的针。 为了通过EtO气体有效灭菌，这些装置被构造成使得不容易注入EtO气体的表面被制成透气性，并且在灭菌过程之后不会保留气体。 灭菌过程的性能鉴定通过物理和微生物学研究以及既定的物理过程参数进行。 在随后的灭菌循环中保持物理过程参数将一直产生所需的无菌保证水平，而无需测试设备的无菌性。
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公开(公告)号：US07060020B2
公开(公告)日：2006-06-13
申请号：US10035083
申请日：2001-12-28
IPC分类号： A61N5/00
CPC分类号： A61N5/1027 , A61N5/1007 , A61N2005/1023 , A61N2005/1024 , B29C47/0009 , B29C47/021 , B29C47/028 , G21G4/08
摘要： A delivery system and method for interstitial radiation therapy comprising a substantially axially stiff and longitudinally flexible elongated member made of material, which is bio-absorbable in living tissue and a plurality of radioactive seeds dispersed in a predetermined array within the member. The delivery system and method further customize the member based on a prescription.
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公开(公告)号：US07008368B2
公开(公告)日：2006-03-07
申请号：US10716328
申请日：2003-11-18
CPC分类号： A61N5/1007 , A61N5/1027 , A61N2005/1023 , B29C47/0016 , B29C47/021 , B29C47/028 , G21G4/08 , Y10T29/49
摘要： A delivery system and method for interstitial radiation therapy uses a seed strand composed of a plurality of tubular shaped, hollow radioactive seeds with a bore. The seed strand as assembled with a material provided in the bore and between the spaced seeds is axially stiff and radially flexible and is bioabsorbable in living tissue.
摘要翻译： 用于间质放射治疗的递送系统和方法使用由具有孔的多个管状中空放射性种子组成的种子线。 与设置在孔中和间隔开的种子之间的材料组装的种子线轴向刚性并且具有径向柔性，并且在生物组织中是生物可吸收的。
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5.发明授权Delivery system and method for interstitial radiation therapy using seed strands constructed with preformed strand housing 失效用预先形成的股线构造的种子股进行间质放射治疗的递送系统和方法公开(公告)号：US06761680B2
公开(公告)日：2004-07-13
申请号：US10162548
申请日：2002-06-04
IPC分类号： A61N500
CPC分类号： A61N5/1027 , A61N2005/1023 , A61N2005/1024 , B29C47/0023 , B29C47/021 , B29C47/028 , G21G4/08
摘要： A delivery system and method for interstitial radiation therapy comprising substantially axially stiff and radially flexible elongated members made of material which is bioabsorbable in living tissue and a plurality of radioactive seeds dispersed in a predetermined array within the elongate member. The radioactive seeds can be dispersed within assembled half-shells made of the same material. The housing for the radiation seeds can also be manufactured from extruded material. A system for manufacturing the interstitial radiation therapy seed strands that automatically makes the seed strands is also provided. The delivery system and method further customize the member based on a prescription.
摘要翻译： 一种用于间质放射治疗的递送系统和方法，包括由活体组织中生物可吸收的材料制成的基本上轴向刚性和径向柔性的细长构件，以及以预定阵列分散在细长构件内的多个放射性种子。 放射性种子可以分散在由相同材料制成的组装的半壳内。 用于辐射种子的外壳也可以由挤压材料制成。 还提供了用于制造自动制作种子股的间质放射线种子股的系统。 递送系统和方法基于处方进一步定制成员。
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公开(公告)号：US06554760B2
公开(公告)日：2003-04-29
申请号：US09983463
申请日：2001-10-24
IPC分类号： A61N510
CPC分类号： A61N5/1027 , A61N2005/1011 , A61N2005/1023
摘要： For implanting a therapeutic element, this needle assembly includes a cannula having a sharpened distal end, a line of elements in the cannula extending rearward from the distal end. A yieldable positioner including an absorbable plug positions the element more proximate the distal end a predetermined distance from the distal end. The positioner may be in various forms including an end plug, a tab in the cannula. The needle assembly may also be pre-loaded with the line of elements and be sterile and a distortion of the wall of the cannula. A stylet is reciprocable in the cannula and engages the end of the line of elements more remote from the distal end of the cannula.
摘要翻译： 为了植入治疗元件，该针组件包括具有锐化的远端的插管，插管中的元件线从远端向后延伸。 包括可吸收塞子的可屈服定位器使元件更靠近远端距离远端预定距离。 定位器可以是各种形式，包括端塞，套管中的突片。 针组件还可以预先加载元件线，并且是无菌的并且插管的壁变形。 探针可以在插管中往复运动，并且使得远离套管远端的元件线的端部接合。
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7.发明授权Delivery system and method for interstitial radiation therapy using strands constructed with extruded strand housings 失效使用由挤出线股架构成的股线进行间质放射治疗的输送系统和方法公开(公告)号：US08066627B2
公开(公告)日：2011-11-29
申请号：US11455305
申请日：2006-06-16
CPC分类号： B29C47/028 , A61N5/1027 , A61N2005/1023 , B29C47/0023 , B29C47/021 , G21G4/08
摘要： A delivery system and method for interstitial radiation therapy comprising substantially axially stiff and longitudinally flexible elongated members made of material which is bioabsorbable in living tissue and a plurality of radioactive seeds dispersed in a predetermined array within the elongate member. The radioactive seeds can be dispersed within assembled half-shells made of the same material. The housing for the radiation seeds can also be manufactured from extruded material. A system for manufacturing the interstitial radiation therapy seed strands that automatically makes the seed strands at the patient's bedside. The delivery system and method further customize the member based on a prescription.
摘要翻译： 一种用于间质放射治疗的输送系统和方法，包括由活体组织中生物可吸收的材料制成的基本上轴向刚性和纵向柔性的细长构件，以及以预定阵列分散在细长构件内的多个放射性种子。 放射性种子可以分散在由相同材料制成的组装的半壳内。 用于辐射种子的外壳也可以由挤压材料制成。 用于制造间质放射治疗种子股的系统，其自动使种子股在病人的床边。 递送系统和方法基于处方进一步定制成员。
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公开(公告)号：US07874974B2
公开(公告)日：2011-01-25
申请号：US11260939
申请日：2005-10-28
IPC分类号： A61N5/00
CPC分类号： A61N5/1027 , A61N5/1007 , A61N2005/1023 , A61N2005/1024 , B29C47/0009 , B29C47/021 , B29C47/028 , G21G4/08
摘要： A delivery system and method for interstitial radiation therapy comprising a substantially axially stiff and longitudinally flexible elongated member made of material, which is bio-absorbable in living tissue and a plurality of radioactive seeds dispersed in a predetermined array within the member. The delivery system and method further customize the member based on a prescription.
摘要翻译： 一种用于间质放射治疗的递送系统和方法，包括基本上轴向刚性的和纵向柔性的细长构件，其由在生物体组织中可生物吸收的材料制成，并且多个放射性种子以预定阵列分散在该构件内。 递送系统和方法基于处方进一步定制成员。
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9.发明授权公开(公告)号：US07244226B2
公开(公告)日：2007-07-17
申请号：US10705133
申请日：2003-11-10
IPC分类号： A61N5/00
CPC分类号： A61N5/1027 , A61N2005/1023 , A61N2005/1024 , B29C47/0023 , B29C47/021 , B29C47/028 , G21G4/08
摘要： A delivery system and method for interstitial radiation therapy comprising substantially axially stiff and radially flexible elongated members made of material which is bioabsorbable in living tissue and a plurality of radioactive seeds dispersed in a predetermined array within the elongate member. The radioactive seeds can be dispersed within assembled half-shells made of the same material. The housing for the radiation seeds can also be manufactured from extruded material. A system for manufacturing the interstitial radiation therapy seed strands that automatically makes the seed strands is also provided. The delivery system and method further customize the member based on a prescription.
摘要翻译： 一种用于间质放射治疗的递送系统和方法，包括由活体组织中生物可吸收的材料制成的基本上轴向刚性和径向柔性的细长构件，以及以预定阵列分散在细长构件内的多个放射性种子。 放射性种子可以分散在由相同材料制成的组装的半壳内。 用于辐射种子的外壳也可以由挤压材料制成。 还提供了用于制造自动制作种子股的间质放射线种子股的系统。 递送系统和方法基于处方进一步定制成员。
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公开(公告)号：US07094198B2
公开(公告)日：2006-08-22
申请号：US10162547
申请日：2002-06-04
IPC分类号： A61B5/00
CPC分类号： G21G4/08 , A61N5/1027 , A61N2005/1023 , B29C47/0016 , B29C47/0033 , B29C47/021 , B29C47/028
摘要： A delivery system and method for interstitial radiation therapy uses a seed strand composed of a plurality of radioactive seeds or encapsulated seeds having ends with projections or indentations connected by a polymer. The seed strand is axially stiff and radially flexible and is bioabsorbable in living tissue.
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