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    Methods and devices for diagnosis of appendicitis
    1.
    发明授权
    Methods and devices for diagnosis of appendicitis 有权
    用于诊断阑尾炎的方法和装置

    公开(公告)号：US07501256B2

    公开(公告)日：2009-03-10

    申请号：US11189120

    申请日：2005-07-25

    申请人： Mark A. Colgin ,  John F. Bealer ,  Richard Donnelly ,  Diane Newman

    发明人： Mark A. Colgin ,  John F. Bealer ,  Richard Donnelly ,  Diane Newman

    IPC分类号： G01N33/53 ,  G01N33/567

    CPC分类号： G01N33/6872 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2800/06 ,  Y10S435/81

    摘要： A method is provided for diagnosing appendicitis in a patient that includes identifying at least one symptom of appendicitis in the patient and identifying the presence of at least one molecule differentially associated with appendicitis in a fluid or tissue sample of said patient. MRP-8/14 and haptoglobin are examples of molecules differentially associated with appendicitis. Devices and kits for performing the appendicitis assays of this invention are also provided. In one embodiment, the device is in a flow-through immunoassay format for testing blood samples. Further, methods for screening for molecules differentially associated with appendicitis are provided that include the use of samples from patients being operated on for suspected appendicitis.

    摘要翻译： 提供了一种用于诊断患者阑尾炎的方法，包括鉴定患者阑尾炎的至少一种症状，并鉴定在所述患者的流体或组织样品中与阑尾炎差异相关的至少一种分子的存在。 MRP-8/14和触珠蛋白是与阑尾炎差异相关的分子的实例。 还提供了用于执行本发明的阑尾炎测定的装置和试剂盒。 在一个实施例中，该装置是用于测试血液样本的流通免疫测定格式。 此外，提供了筛选与阑尾炎差异相关的分子的方法，其包括使用来自用于怀疑阑尾炎的患者的样品。

    METHODS AND DEVICES FOR DIAGNOSIS OF APPENDICITIS
    3.
    发明申请
    METHODS AND DEVICES FOR DIAGNOSIS OF APPENDICITIS 失效
    用于诊断附件的方法和设备

    公开(公告)号：US20070249003A1

    公开(公告)日：2007-10-25

    申请号：US11670882

    申请日：2007-02-02

    申请人： Mark Colgin ,  John Bealer ,  Richard Donnelly

    发明人： Mark Colgin ,  John Bealer ,  Richard Donnelly

    IPC分类号： G01N33/53

    CPC分类号： C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2800/06 ,  Y10T436/10

    摘要： A method is provided for determining the severity of appendicitis in a patient that includes testing a blood, serum or plasma sample from the patient for the quantity of MRP8/14 in the sample and comparing it with the quantity of MRP8/14 present in standard samples correlated with an appendicitis severity scoring system. A histologically-based appendicitis severity scoring system is also provided. Immunoassays and kits for performing the appendicitis assays of this invention are also provided, as are standard samples and data correlating MRP8/14 quantities present in patient samples to histologically-based appendicitis severity grades. The methods and immunoassay devices and kits of this invention are useful for managing the treatment of patients presenting with appendicitis symptoms.

    摘要翻译： 提供了一种用于确定患者阑尾炎的严重程度的方法，其包括测试患者的血液，血清或血浆或血浆样品中样品中MRP8 / 14的量，并将其与标准样品中存在的MRP8 / 14的量进行比较 与阑尾炎严重程度评分系统相关。 还提供了一种基于组织学的阑尾炎严重程度评分系统。 还提供了用于进行本发明的阑尾炎测定的免疫测定和试剂盒，以及将患者样品中存在的MRP8 / 14量与基于组织学的阑尾炎严重程度等级相关的标准样品和数据。 本发明的方法和免疫测定装置和试剂盒可用于治疗呈现阑尾炎症状的患者的治疗。

    Low-cost linear positioning device
    4.
    发明授权
    Low-cost linear positioning device 失效
    低成本线性定位装置

    公开(公告)号：US5910192A

    公开(公告)日：1999-06-08

    申请号：US925189

    申请日：1997-09-08

    申请人： Robert Pulford, Jr. ,  Richard Donnelly ,  Brian Peterson

    发明人： Robert Pulford, Jr. ,  Richard Donnelly ,  Brian Peterson

    IPC分类号： G05G11/00

    CPC分类号： G05G11/00 ,  Y10T403/455 ,  Y10T74/18648 ,  Y10T74/20201 ,  Y10T74/20207

    摘要： In a preferred embodiment, a linear positioning device, including: a frame member; an electric motor disposed to selectively move axially back and forth in the frame member; carriage apparatus attached to the electric motor; and apparatus to guide the motor in axial movement and to prevent radial movement thereof. In a further aspect of the invention, there is provided a frame for a linear positioning device, including: a horizontal base plate; vertical end plates for attachment to ends of the base plate; the base plate including a first groove defined in the surface thereof for the mounting therein of a guide rail for a moving member; and the base plate is cut from an extrusion which includes the first groove, without the machining thereof. In another aspect of the invention, there is provided, in a linear positioning device, having the front end plate of an electric motor as an end plate of the device. In an additional aspect of the invention, there is provided, in a positioning device, having an electric motor fixedly mounted to an end plate of the device.

    摘要翻译： 在优选实施例中，一种线性定位装置，包括：框架构件; 设置成选择性地在所述框架构件中来回移动的电动机; 附着在电动机上的运输装置; 以及用于引导电动机轴向移动并防止其径向移动的装置。 在本发明的另一方面，提供了一种用于线性定位装置的框架，包括：水平底板; 用于连接到底板端部的垂直端板; 所述基板包括限定在其表面中的第一槽，用于在其中安装用于移动构件的导轨; 并且从包括第一凹槽的挤出物切割基板，而不进行其加工。 在本发明的另一方面，在线性定位装置中，具有电动机的前端板作为装置的端板。 在本发明的另一方面，在定位装置中，提供一种固定地安装在该装置的端板上的电动马达。

    Electrical connector assembly for mounting on a printed circuit board
    5.
    发明授权
    Electrical connector assembly for mounting on a printed circuit board 失效
    用于安装在印刷电路板上的电连接器组件

    公开(公告)号：US5076804A

    公开(公告)日：1991-12-31

    申请号：US618549

    申请日：1990-11-27

    申请人： Dominique Bertho ,  Richard Donnelly ,  Patrick Kirby

    发明人： Dominique Bertho ,  Richard Donnelly ,  Patrick Kirby

    IPC分类号： H01R12/58 ,  H01R12/83 ,  H01R24/00 ,  H05K3/30

    CPC分类号： H01R12/58 ,  H01R12/83 ,  H05K3/308 ,  H05K2201/10189 ,  H05K2201/10787 ,  H05K2201/10878

    摘要： An electrical connector assembly is provided for mounting on a printed circuit board which includes at least a pair of mounting post-receiving holes and at least one solder tail-receiving aperture. The assembly includes a housing having at least a pair of mounting posts for positioning in the holes in the printed circuit board. At least one contact member is mounted on the housing and includes a solder tail for positioning in the aperture in the printed circuit board. The solder tail has a generally straight side and a projecting hook on an opposite side for retaining the connector assembly on the printed circuit board. The width of the solder tail between the straight side and the outermost point of the hook on the opposite side is no greater than the width of the aperture, and the centerline of the solder tail between its sides is offset, in the direction of the hook, relative to the centerline of the aperture when the mounting posts are aligned with the holes in the printed circuit board.

    Methods and Devices for Diagnosis of Appendicitis
    6.
    发明申请
    Methods and Devices for Diagnosis of Appendicitis 失效
    阑尾炎诊断方法与装置

    公开(公告)号：US20090155813A1

    公开(公告)日：2009-06-18

    申请号：US12369640

    申请日：2009-02-11

    申请人： Mark A. Colgin ,  John F. Bealer ,  Richard Donnelly ,  Diane Newman

    发明人： Mark A. Colgin ,  John F. Bealer ,  Richard Donnelly ,  Diane Newman

    IPC分类号： G01N33/53

    CPC分类号： G01N33/6872 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2800/06 ,  Y10S435/81

    摘要： A method is provided for diagnosing appendicitis in a patient that includes identifying at least one symptom of appendicitis in the patient and identifying the presence of at least one molecule differentially associated with appendicitis in a fluid or tissue sample of said patient. MRP-8/14 and haptoglobin are examples of molecules differentially associated with appendicitis. Devices and kits for performing the appendicitis assays of this invention are also provided. In one embodiment, the device is in a flow-through immunoassay format for testing blood samples. Further, methods for screening for molecules differentially associated with appendicitis are provided that include the use of samples from patients being operated on for suspected appendicitis.

    摘要翻译： 提供了一种用于诊断患者阑尾炎的方法，包括鉴定患者阑尾炎的至少一种症状，并鉴定在所述患者的流体或组织样品中与阑尾炎差异相关的至少一种分子的存在。 MRP-8/14和触珠蛋白是与阑尾炎差异相关的分子的实例。 还提供了用于执行本发明的阑尾炎测定的装置和试剂盒。 在一个实施例中，该装置是用于测试血液样本的流通免疫测定格式。 此外，提供了筛选与阑尾炎差异相关的分子的方法，其包括使用来自用于怀疑阑尾炎的患者的样品。