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    Acute phase protein modulating endotoxic activity of lipopolysaccharides, assay methods and polypeptides
    2.
    发明授权
    Acute phase protein modulating endotoxic activity of lipopolysaccharides, assay methods and polypeptides 失效
    急性期蛋白调节脂多糖的内毒素活性，测定方法和多肽

    公开(公告)号：US5245013A

    公开(公告)日：1993-09-14

    申请号：US367454

    申请日：1989-06-16

    申请人： Richard Ulevitch ,  Peter Tobias

    发明人： Richard Ulevitch ,  Peter Tobias

    IPC分类号： A61K38/00 ,  C07K14/47 ,  G01N33/569

    CPC分类号： C07K14/47 ,  G01N33/56916 ,  A61K38/00 ,  G01N2400/50

    摘要： A lipopolysaccharide binding protein is disclosed as are an assay method, polypeptides and antibodies related to that binding protein. The binding protein: (a) is present in impure form in acute phase serum, but is substantially absent from normal serum; (b) binds to Gram-negative bacterially secreted lipopolysaccharide in vitro in the serum of the animal treated; (c) retards in vitro binding of the lipopolysaccharide to high density lipoprotein present in the normal serum of the animal host; and (d) immunoreacts with antibodies raised to a polypeptide having the amino acid residue sequence, from left to right and in the direction from amino-terminus to carboxy-terminus, or ##STR1## wherein each of said parenthesized amino acid residues in an alternative to the immediately preceding residue in said sequence.

    摘要翻译： 公开了与该结合蛋白相关的测定方法，多肽和抗体的脂多糖结合蛋白。 结合蛋白：（a）以不纯形式存在于急性期血清中，但在正常血清中基本不存在; （b）在动物处理的血清中体外结合革兰阴性细菌分泌的脂多糖; （c）阻止脂多糖与动物宿主正常血清中存在的高密度脂蛋白的体外结合; 和（d）从产生于具有从左至右和从氨基末端至羧基末端的方向的氨基酸残基序列的多肽产生的抗体的免疫反应，或Thr-Asn-Pro-Gly-Leu-Ile-Thr- Arg-Ile-Thr-Asp-Lys-Gly-Leu-Glu-Tyr-Ala-Ala-Arg-Glu-Gly-Leu-Leu-Ala-Leu-Gln-Arg-Lys-Leu-Asn（Leu） -Val-Thr-Leu-Pro-Asp-Phe（Ser）-Asp-Gly; 其中每个所述括号中的氨基酸残基与所述序列中紧邻的前一个残基相替。