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公开(公告)号:US07238813B2
公开(公告)日:2007-07-03
申请号:US10433128
申请日:2001-11-28
申请人: Mui Cheung , Philip Anthony Harris , Masaichi Hasegawa , Satoru Ida , Kazuya Kano , Naohiko Nishigaki , Hideyuki Sato , James Marvin Veal , Yoshiaki Washio , Rob I. West
发明人: Mui Cheung , Philip Anthony Harris , Masaichi Hasegawa , Satoru Ida , Kazuya Kano , Naohiko Nishigaki , Hideyuki Sato , James Marvin Veal , Yoshiaki Washio , Rob I. West
IPC分类号: A61K31/4184 , C07D235/30
CPC分类号: C07D249/08 , C07D231/12 , C07D233/56 , C07D235/30 , C07D235/32 , C07D263/58 , C07D277/82 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/14 , C07D487/04
摘要: Benzimidazole derivatives, which are useful as TIE-2 and/or VEGFR2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要翻译: 本文描述了可用作TIE-2和/或VEGFR2抑制剂的苯并咪唑衍生物。 所述的发明还包括制备这种苯并咪唑衍生物的方法以及使用它们在治疗过度增殖性疾病中的方法。