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公开(公告)号：US07238813B2
公开(公告)日：2007-07-03
申请号：US10433128
申请日：2001-11-28
申请人： Mui Cheung , Philip Anthony Harris , Masaichi Hasegawa , Satoru Ida , Kazuya Kano , Naohiko Nishigaki , Hideyuki Sato , James Marvin Veal , Yoshiaki Washio , Rob I. West
发明人： Mui Cheung , Philip Anthony Harris , Masaichi Hasegawa , Satoru Ida , Kazuya Kano , Naohiko Nishigaki , Hideyuki Sato , James Marvin Veal , Yoshiaki Washio , Rob I. West
IPC分类号： A61K31/4184 , C07D235/30
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D235/30 , C07D235/32 , C07D263/58 , C07D277/82 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/14 , C07D487/04
摘要： Benzimidazole derivatives, which are useful as TIE-2 and/or VEGFR2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要翻译： 本文描述了可用作TIE-2和/或VEGFR2抑制剂的苯并咪唑衍生物。 所述的发明还包括制备这种苯并咪唑衍生物的方法以及使用它们在治疗过度增殖性疾病中的方法。
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公开(公告)号：US20070249600A1
公开(公告)日：2007-10-25
申请号：US11763524
申请日：2007-06-15
申请人： Mui Cheung , Philip Harris , Masaichi Hasegawa , Satoru Ida , Kazuya Kano , Naohiko Nishigaki , Hideyuki Sato , James Veal , Yoshiaki Washio , Rob West
发明人： Mui Cheung , Philip Harris , Masaichi Hasegawa , Satoru Ida , Kazuya Kano , Naohiko Nishigaki , Hideyuki Sato , James Veal , Yoshiaki Washio , Rob West
IPC分类号： A61K31/4184 , A61K31/41 , A61K31/428 , A61K31/437 , A61K31/4439 , A61K31/496 , A61K31/519 , A61K31/5377 , C07D235/30 , C07D277/82 , C07D401/12 , C07D403/06 , C07D413/06 , C07D417/10 , C07D471/04 , C07D487/14
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D235/30 , C07D235/32 , C07D263/58 , C07D277/82 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D471/14 , C07D487/04
摘要： Benzimidazole derivatives, which are useful as TIE-2 and/or VEGFR2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要翻译： 本文描述了可用作TIE-2和/或VEGFR2抑制剂的苯并咪唑衍生物。 所述的发明还包括制备这种苯并咪唑衍生物的方法以及使用它们在治疗过度增殖性疾病中的方法。
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![2-[2--1H-Pyrrolo[2,3-D]Pyrimidin-4-YL)Amino] Benzamide Derivatives As IGF-1R Inhibitors For The Treatment Of Cancer](/abs-image/US/2010/08/12/US20100204196A1/abs.jpg.150x150.jpg)
3.发明申请2-[2--1H-Pyrrolo[2,3-D]Pyrimidin-4-YL)Amino] Benzamide Derivatives As IGF-1R Inhibitors For The Treatment Of Cancer 有权2- [2- [1H-吡咯并[2,3-D]嘧啶-4-基）氨基]苯甲酰胺衍生物作为IGF-1R抑制剂治疗癌症公开(公告)号：US20100204196A1
公开(公告)日：2010-08-12
申请号：US12671960
申请日：2008-08-06
申请人： Stanley Dawes Chamberlain , Felix Deanda, JR. , Roseanne Gerding , Masaichi Hasegawa , Kevin Kuntz , Huangshu Lei , Yasushi Miyazaki , Naohiko Nishigaki , Samarjit Patnaik , Aniko Redman , John Brad Shotwell , Kirk Stevens , Joseph Wilson , Bin Yang
发明人： Stanley Dawes Chamberlain , Felix Deanda, JR. , Roseanne Gerding , Masaichi Hasegawa , Kevin Kuntz , Huangshu Lei , Yasushi Miyazaki , Naohiko Nishigaki , Samarjit Patnaik , Aniko Redman , John Brad Shotwell , Kirk Stevens , Joseph Wilson , Bin Yang
IPC分类号： A61K31/397 , C07D487/04 , A61K31/519 , A61K31/496 , A61K31/5377 , A61K31/551 , A61P35/00
CPC分类号： C07D487/04 , C07D487/14
摘要： Novel pyrrolopyrimidines as shown in formula (I): and pharmaceutically acceptable derivatives thereof. The compounds are useful in the inhibition of IGF-1R.
摘要翻译： 式（I）所示的新型吡咯并嘧啶及其药学上可接受的衍生物。 该化合物可用于抑制IGF-1R。
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![2-[2-{phenylamino}-1H-pyrrolo[2,3-D]pyrimidin-4-yl)amino] benzamide derivatives as IGF-1R inhibitors for the treatment of cancer](/abs-image/US/2011/07/19/US07981903B2/abs.jpg.150x150.jpg)
4.发明授权2-[2-{phenylamino}-1H-pyrrolo[2,3-D]pyrimidin-4-yl)amino] benzamide derivatives as IGF-1R inhibitors for the treatment of cancer 有权2- [2- {苯基氨基} -1H-吡咯并[2,3-D]嘧啶-4-基）氨基]苯甲酰胺衍生物作为治疗癌症的IGF-1R抑制剂公开(公告)号：US07981903B2
公开(公告)日：2011-07-19
申请号：US12671960
申请日：2008-08-06
申请人： Stanley Dawes Chamberlain , Felix Deanda, Jr. , Roseanne Gerding , Masaichi Hasegawa , Kevin Kuntz , Huangshu Lei , Yasushi Miyazaki , Naohiko Nishigaki , Samarjit Patnaik , Aniko Redman , John Brad Shotwell , Kirk Stevens , Joseph Wilson , Bin Yang
发明人： Stanley Dawes Chamberlain , Felix Deanda, Jr. , Roseanne Gerding , Masaichi Hasegawa , Kevin Kuntz , Huangshu Lei , Yasushi Miyazaki , Naohiko Nishigaki , Samarjit Patnaik , Aniko Redman , John Brad Shotwell , Kirk Stevens , Joseph Wilson , Bin Yang
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： C07D487/04 , C07D487/14
摘要： Novel pyrrolopyrimidines as shown in formula (I): and pharmaceutically acceptable derivatives thereof. The compounds are useful in the inhibition of IGF-1R.
摘要翻译： 式（I）所示的新型吡咯并嘧啶及其药学上可接受的衍生物。 该化合物可用于抑制IGF-1R。
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公开(公告)号：US20070117818A1
公开(公告)日：2007-05-24
申请号：US10588527
申请日：2005-02-03
申请人： Masaichi Hasegawa , Mio Takada , Yoshiaki Washio
发明人： Masaichi Hasegawa , Mio Takada , Yoshiaki Washio
IPC分类号： A61K31/513 , C07D405/02 , C07D403/02
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/10 , C07D405/14 , C07D407/04 , C07D407/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： This invention relates to newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with the imbalance or inappropriate activity of hYAK3 proteins.
摘要翻译： 本发明涉及新鉴定的用于抑制hYAK3蛋白的化合物和用于治疗与hYAK3蛋白的不平衡或不适当活性相关的疾病的方法。
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公开(公告)号：US20090270456A1
公开(公告)日：2009-10-29
申请号：US10585676
申请日：2005-01-06
申请人： Masaichi Hasegawa , Kazuya Kano , Masato Nakano , Mariko Yamabe
发明人： Masaichi Hasegawa , Kazuya Kano , Masato Nakano , Mariko Yamabe
IPC分类号： A61K31/427 , C07D277/38 , C07D417/10 , C07D417/04 , C07D417/14 , A61K31/426 , A61K31/4439 , A61K31/444 , A61P7/00 , A61P31/12 , A61P35/00
CPC分类号： C07D277/56 , C07D417/04 , C07D417/14
摘要： This invention relates to newly identified compounds for inhibiting hYAK3 and/or CK2 proteins and methods for treating diseases associated with the imbalance or inappropriate activity of hYAK3 and/or CK2 proteins.
摘要翻译： 本发明涉及新鉴定的用于抑制hYAK3和/或CK2蛋白的化合物和用于治疗与hYAK3和/或CK2蛋白的不平衡或不适当活性相关的疾病的方法。
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公开(公告)号：US20060293338A1
公开(公告)日：2006-12-28
申请号：US10535690
申请日：2003-11-18
申请人： Masaichi Hasegawa , Jun Tang , Hideyuki Sato
发明人： Masaichi Hasegawa , Jun Tang , Hideyuki Sato
IPC分类号： A61K31/496 , A61K31/4709 , A61K31/4439 , A61K31/426 , C07D417/02
CPC分类号： C07D277/20 , C07D417/06 , C07D417/10 , C07D417/14 , C07D471/04
摘要： This invention relates to newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with the imbalance or inappropriate activity of hYAK3 proteins.
摘要翻译： 本发明涉及新鉴定的用于抑制hYAK3蛋白的化合物和用于治疗与hYAK3蛋白的不平衡或不适当活性相关的疾病的方法。
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公开(公告)号：US07767701B2
公开(公告)日：2010-08-03
申请号：US10535690
申请日：2003-11-18
申请人： Masaichi Hasegawa , Jun Tang , Hideyuki Sato
发明人： Masaichi Hasegawa , Jun Tang , Hideyuki Sato
IPC分类号： C07D417/08 , C07D417/10 , C07D417/12 , C07D417/14 , A61K31/47 , A61K31/4427 , A61K31/42 , A61K31/435 , A61P7/04 , A61P7/06
CPC分类号： C07D277/20 , C07D417/06 , C07D417/10 , C07D417/14 , C07D471/04
摘要： This invention relates to newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with the imbalance or inappropriate activity of hYAK3 proteins.
摘要翻译： 本发明涉及新鉴定的用于抑制hYAK3蛋白的化合物和用于治疗与hYAK3蛋白的不平衡或不适当活性相关的疾病的方法。
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公开(公告)号：US20070249599A1
公开(公告)日：2007-10-25
申请号：US10590623
申请日：2005-02-24
申请人： Kevin Duffy , Duke Fitch , Steven Goodman , Masaichi Hasegawa , Neil Johnson , Jiri Kasparec , Antony Shaw
发明人： Kevin Duffy , Duke Fitch , Steven Goodman , Masaichi Hasegawa , Neil Johnson , Jiri Kasparec , Antony Shaw
IPC分类号： A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5355 , C07D277/04 , C07D417/10
CPC分类号： C07D417/06 , C07D417/14
摘要： This invention relates to the newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with the imbalance or inappropriate activity of hYAK3 proteins.
摘要翻译： 本发明涉及新鉴定的用于抑制hYAK3蛋白的化合物和用于治疗与hYAK3蛋白的不平衡或不适当活性相关的疾病的方法。
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公开(公告)号：US5614520A
公开(公告)日：1997-03-25
申请号：US380214
申请日：1995-01-30
申请人： Shiro Kondo , Hisashi Fukushima , Masaichi Hasegawa , Masahiro Tsuchimoto , Ikuo Nagata , Yoshio Osada , Keiji Komoriya , Hisao Yamaguchi
发明人： Shiro Kondo , Hisashi Fukushima , Masaichi Hasegawa , Masahiro Tsuchimoto , Ikuo Nagata , Yoshio Osada , Keiji Komoriya , Hisao Yamaguchi
IPC分类号： A61K31/425 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/535 , C07D277/22 , C07D277/24 , C07D277/26 , C07D277/28 , C07D277/30 , C07D277/56 , C07D417/04 , C07D417/06 , C07D417/10 , C07D417/12
CPC分类号： C07D417/04 , A61K31/425 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/535 , C07D277/56 , C07D417/06 , C07D417/10 , C07D417/12
摘要： Pharmaceutical compositions for treating gout or hyperuricemia and containing a new categorized compound, i.e. 2-arylthiazole derivatives, as an active ingredient, are provided. The 2-arylthiazole derivatives in the present invention are represented by the following formula (I): ##STR1## wherein Ar is an unsubstituted or substituted pyridyl, thienyl, furyl, naphthyl or phenyl group;X is a hydrogen atom, alkyl group or carboxyl group which may be protected, andY is a hydrogen atom, alkyl group, or a hydroxyl or carbonyl group which may be protected.Furthermore, novel compounds included in the 2-arylthiazole derivatives and pharmaceutically acceptable salts thereof are provided.
摘要翻译： 提供用于治疗痛风或高尿酸血症并含有新分类化合物（即2-芳基噻唑衍生物）作为活性成分的药物组合物。 本发明中的2-芳基噻唑衍生物由下式（I）表示：其中Ar是未取代或取代的吡啶基，噻吩基，呋喃基，萘基或苯基; X是可以被保护的氢原子，烷基或羧基，Y是氢原子，烷基或被保护的羟基或羰基。 此外，提供了包括在2-芳基噻唑衍生物中的新化合物及其药学上可接受的盐。
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