公开(公告)号：US20100105148A1

公开(公告)日：2010-04-29

申请号：US12256852

申请日：2008-10-23

申请人： Stephen J. Caracci ,  Michael J. Dailey, JR. ,  William J. Miller ,  Robert A. Modavis ,  Deepti J. Mudaliar ,  David A. Pastel ,  Michael B. Webb ,  Qi Wu

发明人： Stephen J. Caracci ,  Michael J. Dailey, JR. ,  William J. Miller ,  Robert A. Modavis ,  Deepti J. Mudaliar ,  David A. Pastel ,  Michael B. Webb ,  Qi Wu

IPC分类号： G01N21/00 ,  G01N21/45 ,  G01N21/41

CPC分类号： G01N21/253 ,  G01N21/39 ,  G01N21/45

摘要： A multi-channel swept wavelength optical interrogation system and a method are described herein that enable the interrogation of one or more biosensors which for example could be located within the wells of a microplate. In one embodiment, the optical interrogation system comprises: (a) a tunable laser that emits an optical beam which has a predetermined sequence of distinct wavelengths over a predetermined time period; (b) a distribution unit that splits the optical beam into a plurality of interrogation beams; (c) an array of optical interrogation units that receive and direct the interrogation beams towards an array of biosensors; (d) the array of optical interrogation units receive a plurality of reflected interrogation beams from the array of biosensors; (e) a data processing device that receives and processes information associated with the reflected interrogation beams to determine for example whether or not there was a biochemical interaction on anyone of the biosensors.

摘要翻译： 本文描述了多通道扫频波长光询问系统和方法，其能够询问一个或多个生物传感器，例如其可位于微板的孔内。 在一个实施例中，光学询问系统包括：（a）可调激光器，其在预定时间段内发射具有预定的不同波长序列的光束; （b）分配单元，其将光束分成多个询问光束; （c）光学询问单元的阵列，其接收并将询问光束定向到生物传感器的阵列; （d）光学询问单元的阵列从生物传感器阵列接收多个反射询问光束; （e）数据处理装置，其接收和处理与所反映的询问光束相关联的信息，以确定例如生物传感器中任何一个生化交互是否存在。

公开(公告)号：US07471435B2

公开(公告)日：2008-12-30

申请号：US11054722

申请日：2005-02-10

申请人： Robert A. Modavis

发明人： Robert A. Modavis

IPC分类号： G02B26/02

CPC分类号： G02B27/58

摘要： The present invention provides an apodization mask that narrows the central lobe of an optical image of a point in a focusing system and suppresses the amplitudes of the sidelobes of the image that are within a predetermined radius of the central axis of the sidelobes, thereby improving resolution of point objects that are relatively close together and presenting better images of small objects.

摘要翻译： 本发明提供一种变迹掩模，其使聚焦系统中的点的光学图像的中心波瓣变窄，并且抑制图像的旁瓣的振幅在旁瓣的中心轴的预定半径内，从而提高分辨率 相对靠近在一起的点对象，并呈现更好的小物体图像。

公开(公告)号：US5894537A

公开(公告)日：1999-04-13

申请号：US584868

申请日：1996-01-11

申请人： George E. Berkey ,  Venkata A. Bhagavatula ,  Peter C. Jones ,  Donald B. Keck ,  Yanming Liu ,  Robert A. Modavis ,  Alan J. Morrow ,  Mark A. Newhouse ,  Daniel A. Nolan

发明人： George E. Berkey ,  Venkata A. Bhagavatula ,  Peter C. Jones ,  Donald B. Keck ,  Yanming Liu ,  Robert A. Modavis ,  Alan J. Morrow ,  Mark A. Newhouse ,  Daniel A. Nolan

IPC分类号： C03B37/012 ,  C03B37/014 ,  C03B37/027 ,  G02B6/10

CPC分类号： G02B6/02247 ,  C03B37/01211 ,  C03B37/01228 ,  C03B37/0124 ,  C03B37/01248 ,  C03B37/01257 ,  C03B37/01413 ,  C03B37/01466 ,  C03B37/0148 ,  C03B37/01493 ,  C03B37/027 ,  G02B6/03611 ,  G02B6/03644 ,  C03B2203/18 ,  C03B2203/20 ,  C03B2203/22 ,  C03B2203/24 ,  C03B2203/36

摘要： A single-mode optical waveguide fiber designed to limit power penalty due to four wave mixing and a method of making the waveguide is disclosed. Variations in properties, e.g., radius or refractive index, of the waveguide fiber core provide a total dispersion which varies along the length of the waveguide. The algebraic sum of products of length times total dispersion is controlled to a pre-selected value for each waveguide fiber which makes up a system link. Proper choice of total dispersion variation magnitude and sub-length results in a system link wherein a signal travels only short distances in waveguide portions having total dispersion near zero. However, the variation of the total dispersion provides a system link which has a pre-selected dispersive effect on the signal over a selected wavelength range. The dispersive effect on the signal can be chosen to be essentially zero. A number of techniques for fabricating DM fiber are also disclosed.

摘要翻译： 公开了一种设计用于限制由于四波混频引起的功率损失的单模光纤光纤和制造波导的方法。 波导纤维芯的性质，例如半径或折射率的变化提供沿波导长度变化的总色散。 将长度乘以总色散的乘积的代数和控制为构成系统链路的每个波导光纤的预选值。 总体色散变化幅度和子长度的适当选择导致系统链路，其中信号在具有接近零的总色散的波导部分中仅行进短距离。 然而，总色散的变化提供了对所选波长范围上的信号具有预选色散效应的系统链路。 对信号的色散效应可以选择为基本为零。 还公开了用于制造DM纤维的许多技术。

公开(公告)号：US20110006116A1

公开(公告)日：2011-01-13

申请号：US12887048

申请日：2010-09-21

申请人： Robert A. Modavis ,  Garrett A. Piech

发明人： Robert A. Modavis ,  Garrett A. Piech

IPC分类号： G06K5/00

CPC分类号： G01N21/253 ,  G01N21/7743

摘要： The disclosure relates to a system and a method for light beam interrogation of an optical biosensor and for monitoring a biological event on the biosensor for use, for example, in microplate image analysis. The system and method correct pointing-errors that can be encountered, for example, in scanning label-independent-detection biosensor applications.

摘要翻译： 本公开涉及一种用于光学生物传感器的光束询问的系统和方法，并且用于监测生物传感器上的生物学事件以用于例如微孔板图像分析。 系统和方法可能会遇到正确的指向错误，例如扫描标签无关检测生物传感器应用程序。

公开(公告)号：US20090219540A1

公开(公告)日：2009-09-03

申请号：US12402901

申请日：2009-03-12

申请人： Robert A. Modavis ,  Qi Wu ,  Stephen J. Caracci ,  David A. Pastel

发明人： Robert A. Modavis ,  Qi Wu ,  Stephen J. Caracci ,  David A. Pastel

IPC分类号： G01N21/55

CPC分类号： G01N21/253 ,  G01N21/39 ,  G01N21/7743 ,  G01N2021/4742 ,  G01N2201/08

摘要： An optical interrogation system and a method are described herein that enable the interrogation of one or more biosensors which can be located within the wells of a microplate. In one embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N-lenses and N-detectors that are set-up to interrogate N-biosensors. In another embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N+1 lenses and N-detectors that are set-up to interrogate N-biosensors.

摘要翻译： 本文描述了光学询问系统和方法，其能够询问可以位于微板的孔内的一个或多个生物传感器。 在一个实施例中，光学询问系统具有可调谐激光器，N-纤维发射，N型透镜和N个检测器，其被设置成询问N-生物传感器。 在另一个实施例中，光学询问系统具有可调激光器，N-光纤发射，N + 1透镜和N个检测器，其被设置成询问N-生物传感器。

公开(公告)号：US07576333B2

公开(公告)日：2009-08-18

申请号：US11888495

申请日：2007-08-01

申请人： Stephen J. Caracci ,  Robert A. Modavis ,  David A. Pastel ,  Qi Wu

发明人： Stephen J. Caracci ,  Robert A. Modavis ,  David A. Pastel ,  Qi Wu

IPC分类号： G01J1/58 ,  G01N33/53 ,  G01N21/62 ,  C12Q1/04

CPC分类号： G01N21/253 ,  G01N21/39 ,  G01N21/7743 ,  G01N2021/4742 ,  G01N2201/08

摘要： An optical interrogation system and a method are described herein that enable the interrogation of one or more biosensors which can be located within the wells of a microplate. In one embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N-lenses and N-detectors that are set-up to interrogate N-biosensors. In another embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N+1 lenses and N-detectors that are set-up to interrogate N-biosensors.

公开(公告)号：US06269208B1

公开(公告)日：2001-07-31

申请号：US09417818

申请日：1999-10-14

申请人： Vikram Bhatia ,  Robert A. Modavis

发明人： Vikram Bhatia ,  Robert A. Modavis

IPC分类号： G02B634

CPC分类号： G03F7/70191 ,  G02B6/0208 ,  G02B6/02133 ,  G02B6/02138 ,  G02B6/02142 ,  G03F7/7035 ,  G03F7/70408 ,  Y10S359/90

摘要： Optical gratings having a range of possible Bragg wavelengths can be produced using a single phase mask by exposing the mask to a non-collimated spatially filtered beam of light. A spatial filter removes high spatial frequency components from the beam, and a focusing system directs the filtered beam to a phase mask. A rate at which the beam is focused and a spacing between the phase mask and a photo-sensitive waveguide are varied to produce gratings in the waveguide having a range of possible periods.

摘要翻译： 具有可能的布拉格波长范围的光栅可以使用单相掩模通过将掩模暴露于非准直空间滤光光束而产生。 空间滤波器从波束去除高空间频率分量，并且聚焦系统将滤波的波束引导到相位掩模。 波束聚焦的速率和相位掩模与光敏波导之间的间距是变化的，以在具有可能周期范围的波导中产生光栅。

公开(公告)号：US06178045B1

公开(公告)日：2001-01-23

申请号：US09081912

申请日：1998-05-19

申请人： Thomas A. Cook ,  Robert A. Modavis

发明人： Thomas A. Cook ,  Robert A. Modavis

IPC分类号： G02B2746

CPC分类号： G02B27/46 ,  G02B6/02133 ,  G02B6/02138 ,  H01S3/005

摘要： The invention comprises a spatial filter and a method of spatially filtering a laser beam, particularly a high power laser beam. The inventive spatial filter and method of use is especially suited for use in an optical system for writing index gratings in optical waveguides. The invention provides a method of writing gratings in optical waveguide fiber that results in improved grating performance.

摘要翻译： 本发明包括空间滤波器和空间滤波激光束，特别是大功率激光束的方法。 本发明的空间滤波器和使用方法特别适用于用于在光波导中写索引光栅的光学系统。 本发明提供了一种在光波导光纤中写入光栅的方法，其导致光栅性能的提高。

公开(公告)号：US08408461B2

公开(公告)日：2013-04-02

申请号：US12887048

申请日：2010-09-21

申请人： Robert A. Modavis ,  Garrett A. Piech

发明人： Robert A. Modavis ,  Garrett A. Piech

IPC分类号： G06K5/00

CPC分类号： G01N21/253 ,  G01N21/7743

摘要： The disclosure relates to a system and a method for light beam interrogation of an optical biosensor and for monitoring a biological event on the biosensor for use, for example, in microplate image analysis. The system and method correct pointing-errors that can be encountered, for example, in scanning label-independent-detection biosensor applications.

公开(公告)号：US08062900B2

公开(公告)日：2011-11-22

申请号：US11436923

申请日：2006-05-17

申请人： Robert A. Modavis

发明人： Robert A. Modavis

IPC分类号： G01N21/00

CPC分类号： B01L3/5085 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/0851 ,  G01N21/774 ,  Y10S436/805 ,  Y10S436/809 ,  Y10T436/25

摘要： A microplate for use within an interrogation system and a method of using the microplate are disclosed. The microplate contains within the bottom of each well, an optical waveguide grating based sensor. Approximate to each sensor is a mask having an aperture of predetermined size. The aperture regulates the light that enters and exits the sensor upon successive scans and ensures repeatable readings from the sensor. In an extended embodiment, a method of detection is disclosed that utilizes a launch and receive system while employing the aforementioned microplate.

摘要翻译： 公开了一种在询问系统内使用的微板和使用该微板的方法。 微孔板包含在每个孔的底部，基于光波导光栅的传感器。 近似于每个传感器是具有预定尺寸的孔的掩模。 光圈调节在连续扫描时进入和退出传感器的光，并确保来自传感器的重复读数。 在扩展实施例中，公开了一种检测方法，其在使用上述微孔板的同时利用发射和接收系统。