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公开(公告)号：US08114348B2
公开(公告)日：2012-02-14
申请号：US12480886
申请日：2009-06-09
Applicant: Stephen J. Caracci , Volker H. O. Eckelt , Anthony G. Frutos , Mark F. Krol , Thomas C. Moore , David A. Pastel , Gordon M. Shedd
Inventor： Stephen J. Caracci , Volker H. O. Eckelt , Anthony G. Frutos , Mark F. Krol , Thomas C. Moore , David A. Pastel , Gordon M. Shedd
CPC classification number: G01N35/028 , G01N2035/00158 , G01N2035/00356 , G01N2035/0097
Abstract: A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a chemical compound (drug candidate) with a biomolecule (therapeutic target) can be detected using assay volumes and concentrations that are compatible with the current practices of HTS in the pharmaceutical industry. The screening system also enables the detection of bio-chemical interactions that occur in the wells of a microplate which incorporates biosensors and surface chemistry to immobilize the therapeutic target at the surface of the biosensors. The screening system also includes fluid handling and plate handling devices to help perform automated HTS assays.
Abstract translation: 本文描述了一种筛选系统和方法，其提供用于实现无标记高通量筛选（HTS）以帮助发现新药物的独特且实用的解决方案。 在一个实施方案中，筛选系统使得能够进行直接结合测定，其中化学化合物（药物候选物）与生物分子（治疗靶标）的生物分子相互作用可以使用与当前实践相兼容的测定体积和浓度来检测 HTS在制药行业。 筛选系统还能够检测在微板的孔中发生的生物化学相互作用，其结合生物传感器和表面化学以将治疗靶固定在生物传感器的表面。 筛选系统还包括流体处理和板处理装置，以帮助执行自动HTS测定。
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公开(公告)号：US20110142092A1
公开(公告)日：2011-06-16
申请号：US13034214
申请日：2011-02-24
Applicant: Mark F. Krol , Thomas C. Moore , David A. Pastel , Gordon M. Shedd
Inventor： Mark F. Krol , Thomas C. Moore , David A. Pastel , Gordon M. Shedd
IPC: G01K13/00
CPC classification number: G01N35/028 , G01J3/453 , G01N21/0332 , G01N21/553 , G01N21/7743 , G01N2035/00346 , G01N2035/00366
Abstract: A screening device and a method are described herein which can automatically handle and measure (interrogate) a plurality of sensor carriers (i.e., multiwell plates, microplates) with multi-dimensionally arranged, temperature-compensated or temperature-compensatable optical sensors, while maintaining a substantially constant temperature gradient for a relatively long period of time around the optical sensors where temperature compensation has been performed on the sensor carriers.
Abstract translation: 本文描述了一种筛选装置和方法，其可以自动地处理和询问多个传感器载体（即，多孔板，微孔板），其具有多维布置的，温度补偿的或可温度补偿的光学传感器，同时保持 在对传感器载体进行温度补偿的光学传感器周围相当长的周期内的基本恒定的温度梯度。
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公开(公告)号：US07776609B2
公开(公告)日：2010-08-17
申请号：US12692696
申请日：2010-01-25
Applicant: David A. Pastel , Garrett A. Piech , Gordon M. Shedd , Brett C. Shelton , Mohamed A. Zainul
Inventor： David A. Pastel , Garrett A. Piech , Gordon M. Shedd , Brett C. Shelton , Mohamed A. Zainul
IPC: B01L3/00
CPC classification number: G01N21/253 , B01L3/5085 , B01L2300/0636 , B01L2300/0829 , B01L2300/168 , B01L2300/1827 , G01N21/0332 , G01N21/31 , G01N35/00594 , G01N35/028 , G01N2001/2893 , G01N2021/0325
Abstract: A reference microplate is described herein which can be used to help calibrate and troubleshoot an optical interrogation system. In one embodiment, the reference microplate has a frame with an array of wells each of which contains an optical biosensor and each optical biosensor is at least partially coated with a substance (e.g., elastomer, optical epoxy). In another embodiment, the reference microplate in addition to having its optical biosensors at least partially covered with a substance (e.g., elastomer, optical epoxy) also has a controllable heating device attached thereto which is used to heat the optical biosensors.
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公开(公告)号：US20090219540A1
公开(公告)日：2009-09-03
申请号：US12402901
申请日：2009-03-12
Applicant: Robert A. Modavis , Qi Wu , Stephen J. Caracci , David A. Pastel
Inventor： Robert A. Modavis , Qi Wu , Stephen J. Caracci , David A. Pastel
IPC: G01N21/55
CPC classification number: G01N21/253 , G01N21/39 , G01N21/7743 , G01N2021/4742 , G01N2201/08
Abstract: An optical interrogation system and a method are described herein that enable the interrogation of one or more biosensors which can be located within the wells of a microplate. In one embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N-lenses and N-detectors that are set-up to interrogate N-biosensors. In another embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N+1 lenses and N-detectors that are set-up to interrogate N-biosensors.
Abstract translation: 本文描述了光学询问系统和方法，其能够询问可以位于微板的孔内的一个或多个生物传感器。 在一个实施例中，光学询问系统具有可调谐激光器，N-纤维发射，N型透镜和N个检测器，其被设置成询问N-生物传感器。 在另一个实施例中，光学询问系统具有可调激光器，N-光纤发射，N + 1透镜和N个检测器，其被设置成询问N-生物传感器。
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公开(公告)号：US07576333B2
公开(公告)日：2009-08-18
申请号：US11888495
申请日：2007-08-01
Applicant: Stephen J. Caracci , Robert A. Modavis , David A. Pastel , Qi Wu
Inventor： Stephen J. Caracci , Robert A. Modavis , David A. Pastel , Qi Wu
CPC classification number: G01N21/253 , G01N21/39 , G01N21/7743 , G01N2021/4742 , G01N2201/08
Abstract: An optical interrogation system and a method are described herein that enable the interrogation of one or more biosensors which can be located within the wells of a microplate. In one embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N-lenses and N-detectors that are set-up to interrogate N-biosensors. In another embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N+1 lenses and N-detectors that are set-up to interrogate N-biosensors.
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Patent Agency Ranking
6.发明授权Multi-channel swept wavelength optical interrogation system and method for using same 失效多通道扫波波长光询问系统及其使用方法公开(公告)号：US07999944B2
公开(公告)日：2011-08-16
申请号：US12256852
申请日：2008-10-23
Applicant: Stephen J. Caracci , Michael J. Dailey, Jr. , William J. Miller , Robert A. Modavis , Deepti J. Mudaliar , David A. Pastel , Michael B. Webb , Qi Wu
Inventor： Stephen J. Caracci , Michael J. Dailey, Jr. , William J. Miller , Robert A. Modavis , Deepti J. Mudaliar , David A. Pastel , Michael B. Webb , Qi Wu
IPC: G01N21/55
CPC classification number: G01N21/253 , G01N21/39 , G01N21/45
Abstract: A multi-channel swept wavelength optical interrogation system and a method are described herein that enable the interrogation of one or more biosensors which for example could be located within the wells of a microplate. In one embodiment, the optical interrogation system comprises: (a) a tunable laser that emits an optical beam which has a predetermined sequence of distinct wavelengths over a predetermined time period; (b) a distribution unit that splits the optical beam into a plurality of interrogation beams; (c) an array of optical interrogation units that receive and direct the interrogation beams towards an array of biosensors; (d) the array of optical interrogation units receive a plurality of reflected interrogation beams from the array of biosensors; (e) a data processing device that receives and processes information associated with the reflected interrogation beams to determine for example whether or not there was a biochemical interaction on anyone of the biosensors.
Abstract translation: 本文描述了多通道扫频波长光询问系统和方法，其能够询问一个或多个生物传感器，例如其可位于微板的孔内。 在一个实施例中，光学询问系统包括：（a）可调激光器，其在预定时间段内发射具有预定的不同波长序列的光束; （b）分配单元，其将光束分成多个询问光束; （c）光学询问单元的阵列，其接收并将询问光束定向到生物传感器的阵列; （d）光学询问单元的阵列从生物传感器阵列接收多个反射询问光束; （e）数据处理装置，其接收和处理与所反映的询问光束相关联的信息，以确定例如生物传感器中任何一个生化交互是否存在。
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公开(公告)号：US07741598B2
公开(公告)日：2010-06-22
申请号：US12402901
申请日：2009-03-12
Applicant: Robert A. Modavis , Qi Wu , Stephen J. Caracci , David A. Pastel
Inventor： Robert A. Modavis , Qi Wu , Stephen J. Caracci , David A. Pastel
CPC classification number: G01N21/253 , G01N21/39 , G01N21/7743 , G01N2021/4742 , G01N2201/08
Abstract: An optical interrogation system and a method are described herein that enable the interrogation of one or more biosensors which can be located within the wells of a microplate. In one embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N-lenses and N-detectors that are set-up to interrogate N-biosensors. In another embodiment, the optical interrogation system has a tunable laser, N-fiber launches, N+1 lenses and N-detectors that are set-up to interrogate N-biosensors.
Abstract translation: 本文描述了光学询问系统和方法，其能够询问可以位于微板的孔内的一个或多个生物传感器。 在一个实施例中，光学询问系统具有可调谐激光器，N-纤维发射，N型透镜和N个检测器，其被设置成询问N-生物传感器。 在另一个实施例中，光学询问系统具有可调激光器，N-光纤发射，N + 1透镜和N个检测器，其被设置成询问N-生物传感器。
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8.发明申请Reference microplates and methods for making and using the reference microplates 失效参考微孔板和制作和使用参比微孔板的方法公开(公告)号：US20070211245A1
公开(公告)日：2007-09-13
申请号：US11716417
申请日：2007-03-09
Applicant: David A. Pastel , Garrett A. Piech , Gordon M. Shedd , Brett C. Shelton , Mohamed A. Zainul
Inventor： David A. Pastel , Garrett A. Piech , Gordon M. Shedd , Brett C. Shelton , Mohamed A. Zainul
IPC: G01N1/10
CPC classification number: G01N21/0332 , B01L3/5085 , B01L3/50851 , B01L2200/148 , B01L2300/0636 , B01L2300/0654 , B01L2300/0829 , B01L2300/168 , B01L2300/1827 , G01N21/253 , G01N21/274 , G01N21/278 , G01N21/31 , G01N35/00594 , G01N35/028 , G01N2001/2893 , G01N2021/0325
Abstract: A reference microplate is described herein which can be used to help calibrate and troubleshoot an optical interrogation system. In one embodiment, the reference microplate has a frame with an array of wells each of which contains an optical biosensor and each optical biosensor is at least partially coated with a substance (e.g., elastomer, optical epoxy). In another embodiment, the reference microplate in addition to having its optical biosensors at least partially covered with a substance (e.g., elastomer, optical epoxy) also has a controllable heating device attached thereto which is used to heat the optical biosensors.
Abstract translation: 本文描述了参考微孔板，其可用于帮助校准和诊断光学询问系统。 在一个实施方案中，参考微量培养板具有一个具有孔阵列的框架，每个孔包含光学生物传感器，并且每个光学生物传感器至少部分涂覆有物质（例如弹性体，光学环氧树脂）。 在另一个实施方案中，参考微板除了使其光学生物传感器至少部分被物质（例如弹性体，光学环氧树脂）覆盖之外，还具有连接到其上的可控加热装置，其用于加热光学生物传感器。
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公开(公告)号：US08231268B2
公开(公告)日：2012-07-31
申请号：US13034214
申请日：2011-02-24
Applicant: Mark F. Krol , Thomas C. Moore , David A. Pastel , Gordon M. Shedd
Inventor： Mark F. Krol , Thomas C. Moore , David A. Pastel , Gordon M. Shedd
CPC classification number: G01N35/028 , G01J3/453 , G01N21/0332 , G01N21/553 , G01N21/7743 , G01N2035/00346 , G01N2035/00366
Abstract: A screening device and a method are described herein which can automatically handle and measure (interrogate) a plurality of sensor carriers (i.e., multiwell plates, microplates) with multi-dimensionally arranged, temperature-compensated or temperature-compensatable optical sensors, while maintaining a substantially constant temperature gradient for a relatively long period of time around the optical sensors where temperature compensation has been performed on the sensor carriers.
Abstract translation: 本文描述了一种筛选装置和方法，其可以自动地处理和询问多个传感器载体（即，多孔板，微孔板），其具有多维布置的，温度补偿的或可温度补偿的光学传感器，同时保持 在对传感器载体进行温度补偿的光学传感器周围相当长的周期内的基本恒定的温度梯度。
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公开(公告)号：US07976217B2
公开(公告)日：2011-07-12
申请号：US11521771
申请日：2006-09-15
Applicant: Mark F. Krol , Thomas C. Moore , David A. Pastel , Gordon M. Shedd
Inventor： Mark F. Krol , Thomas C. Moore , David A. Pastel , Gordon M. Shedd
IPC: G01K3/00
CPC classification number: G01N35/028 , G01J3/453 , G01N21/0332 , G01N21/553 , G01N21/7743 , G01N2035/00346 , G01N2035/00366
Abstract: A screening device and a method are described herein which can automatically handle and measure (interrogate) a plurality of sensor carriers (i.e., multiwell plates, microplates) with multi-dimensionally arranged, temperature-compensated or temperature-compensatable optical sensors, while maintaining a substantially constant temperature gradient for a relatively long period of time around the optical sensors where temperature compensation has been performed on the sensor carriers.
Abstract translation: 本文描述了一种筛选装置和方法，其可以自动地处理和询问多个传感器载体（即，多孔板，微孔板），其具有多维布置的，温度补偿的或可温度补偿的光学传感器，同时保持 在对传感器载体进行温度补偿的光学传感器周围相当长的周期内的基本恒定的温度梯度。
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