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公开(公告)号：US5069370A
公开(公告)日：1991-12-03
申请号：US564360
申请日：1990-08-08
申请人： David J. Cady , Kevin R. Hall , Robert W. Lynn
发明人： David J. Cady , Kevin R. Hall , Robert W. Lynn
IPC分类号： B67D7/02
CPC分类号： B67D7/02 , B67D7/0288
摘要： Disclosed is a system for dispensing and supplementing a large volume of liquid for use with cell and tissue cultures. The system disclosed comprises a large volume drum having liquid contained therein. The system disclosed further comprises a first assembly for dispensing the liquid from the large volume drum. The system disclosed further comprises a second assembly for supplementing the first liquid contained in the large volume drum with the second liquid. The system disclosed may also comprise a third mechanical arrangement for mixing the first and second liquids. The materials chosen are compatible with gamma irradiation sterilization process, sterile cell culture media, and standard distribution systems.
摘要翻译： 公开了一种用于分配和补充大量液体以用于细胞和组织培养物的系统。 所公开的系统包括其中容纳有液体的大体积的鼓。 所公开的系统还包括用于从大体积滚筒分配液体的第一组件。 所公开的系统进一步包括第二组件，用于用第二液体补充容纳在大体积滚筒中的第一液体。 所公开的系统还可以包括用于混合第一和第二液体的第三机械装置。 所选择的材料与γ辐射灭菌工艺，无菌细胞培养基和标准分配系统相容。
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公开(公告)号：US4289248A
公开(公告)日：1981-09-15
申请号：US84883
申请日：1979-10-15
申请人： Robert W. Lynn
发明人： Robert W. Lynn
IPC分类号： B65D41/04
CPC分类号： B65D41/0471
摘要： The object of the invention is to provide a container-closure assembly with detent means for positive positioning of the closure with respect to the container at a preselect intermediate position between full closure-container cooperation and non-cooperative relationship.A neck (16) of a container (10) is provided with external threads (22) including a detent positioning assembly (24) comprised of a pair of outwardly extending projections (26a and 26b) formed on a plane perpendicular to the axis of the container. The closure or cap (30) thereof is formed with internal threads (38) for engaging the external threads (22) of the container (10) and a detent positioning assembly comprised of inwardly extending projections (40) below the internal threads (38) thereof. Threading of the closure or cap (30) on the neck (16) of such a container (10) cause the inwardly extending projections (40) of the closure (30) to contact the initial downwardly extending projections (26a and 26b) provided on the neck (16) of the container (10) necessitating a slightly greater rotational force to be torsionally applied to cause the projection (40) on the closure to override the initial projection (26a) on the neck of the container thereby to place the projections (40) of the closure (10) intermediate the pair of outwardly extending projections (26a and 26b) on the container (10).
摘要翻译： 本发明的目的是提供一种具有制动装置的容器 - 封闭组件，用于在完全关闭 - 容器合作和非合作关系之间的预选中间位置处相对于容器正面定位封闭件。 容器（10）的颈部（16）设置有外螺纹（22），其包括定位定位组件（24），该定位组件由一对向外延伸的突起（26a和26b）构成，该突出部形成在垂直于 容器。 其封闭件或盖子（30）形成有用于接合容器（10）的外螺纹（22）的内螺纹（38）和由内螺纹（38）下方的向内延伸的突出部（40）构成的制动定位组件， 其中。 封闭物或盖（30）在这种容器（10）的颈部（16）上的穿线使得封闭件（30）的向内延伸的突起（40）与设置在其上的初始向下延伸的突起（26a和26b）接触 容器（10）的颈部（16）需要稍微更大的旋转力被扭转地施加以使得封闭件上的突起（40）超过容器的颈部上的初始突起（26a），从而将突起 在所述容器（10）上的所述一对向外延伸的突起（26a和26b）之间的所述封闭件（10）的中心（40）。
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3.发明授权System and method for attenuating the effect of ambient light on an optical sensor 有权用于衰减环境光对光学传感器的影响的系统和方法公开(公告)号：US07755022B2
公开(公告)日：2010-07-13
申请号：US12180745
申请日：2008-07-28
申请人： Arthur E. Colvin, Jr. , Paul Samuel Zerwekh , Jeffrey C. Lesho , Robert W. Lynn , Carrie R. Lorenz , Casey J. O'Connor , Steven J. Walters
发明人： Arthur E. Colvin, Jr. , Paul Samuel Zerwekh , Jeffrey C. Lesho , Robert W. Lynn , Carrie R. Lorenz , Casey J. O'Connor , Steven J. Walters
CPC分类号： A61B5/14556 , A61B5/0031 , A61B5/14532 , A61B5/1459 , A61B5/681 , G01N21/6428 , G01N21/645 , G01N2201/1244 , H05K1/0306 , H05K1/165 , H05K3/403 , H05K2201/086 , H05K2201/09972 , H05K2201/10106
摘要： The present invention provides systems and methods for attenuating the effect of ambient light on optical sensors and for measuring and compensating quantitatively for the ambient light.
摘要翻译： 本发明提供了用于衰减环境光对光学传感器的影响并用于量化和补偿环境光的系统和方法。
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公开(公告)号：US06330464B1
公开(公告)日：2001-12-11
申请号：US09383148
申请日：1999-08-26
申请人： Arthur E. Colvin, Jr. , Gregory A. Dale , Paul Samuel Zerwekh , Jeffery C. Lesho , Robert W. Lynn
发明人： Arthur E. Colvin, Jr. , Gregory A. Dale , Paul Samuel Zerwekh , Jeffery C. Lesho , Robert W. Lynn
IPC分类号： A61B500
CPC分类号： A61B5/076 , A61B5/0031 , A61B5/14532 , A61B5/14552 , A61B5/1459 , A61B5/6861 , A61B2560/0219 , A61B2562/12 , G01N21/552 , G01N21/6428 , G01N21/648 , G01N21/77 , G01N21/7703 , G01N33/54373 , G01N2021/7773 , G01N2021/7783 , G01N2021/7786 , Y10S128/903
摘要： An optical-based sensor for detecting the presence or amount of an analyte using both indicator and reference channels. The sensor has a sensor body with a source of radiation embedded therein. Radiation emitted by the source interacts with indicator membrane indicator molecules proximate the surface of the body. At least one optical characteristic of these indicator molecules varies with analyte concentration. For example, the level of fluorescence of fluorescent indicator molecules or the amount of light absorbed by light-absorbing indicator molecules can vary as a function of analyte concentration. In addition, radiation emitted by the source also interacts with reference membrane indicator molecules proximate the surface of the body. Radiation (e.g., light) emitted or reflected by these indicator molecules enters and is internally reflected in the sensor body. Photosensitive elements within the sensor body generate both indicator channel and reference channel signals to provide an accurate indication of the concentration of the analyte. Preferred embodiments are totally self-contained and are sized and shaped for use in vivo in a human being. Such embodiments preferably include a power source, e.g. an inductor, which powers the source of radiation using external means, as well as a transmitter, e.g. an inductor, to transmit to external pickup means the signal representing the level of analyte.
摘要翻译： 一种光学传感器，用于使用指示器和参考通道来检测分析物的存在或量。 该传感器具有一个传感器体，其中嵌有辐射源。 源发射的辐射与靠近身体表面的指示剂膜指示剂分子相互作用。 这些指示剂分子的至少一种光学特性随分析物浓度而变化。 例如，荧光指示剂分子的荧光水平或光吸收指示剂分子吸收的光量可以作为分析物浓度的函数而变化。 此外，源发射的辐射也与靠近身体表面的参考膜指示剂分子相互作用。 由这些指示剂分子发射或反射的辐射（例如，光）进入并在内部反射在传感器主体中。 传感器体内的感光元件产生指示通道和参考通道信号，以提供分析物浓度的准确指示。 优选的实施方案是完全独立的并且其尺寸和形状用于人体内的体内。 这样的实施例优选地包括电源，例如电源。 电感器，其使用外部装置为辐射源供电，以及发射器，例如， 电感器，用于向外部拾取装置传输表示分析物水平的信号。
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公开(公告)号：US5083686A
公开(公告)日：1992-01-28
申请号：US541908
申请日：1990-06-22
申请人： David J. Cady , Kevin R. Hall , Robert W. Lynn
发明人： David J. Cady , Kevin R. Hall , Robert W. Lynn
IPC分类号： B67D7/02
CPC分类号： B67D7/02 , B67D7/0288
摘要： Disclosed is a system for dispensing and supplementing a large volume of liquid for use with cell and tissue cultures. The system disclosed comprises a large volume drum having liquid contained therein. The system disclosed further comprises a first assembly for dispensing the liquid from the large volume drum. The system disclosed further comprises a second assembly for supplementing the first liquid contained in the large volume drum with the second liquid. The system disclosed may also comprise a third mechanical arrangement for mixing the first and second liquids.
摘要翻译： 公开了一种用于分配和补充大量液体以用于细胞和组织培养物的系统。 所公开的系统包括其中容纳有液体的大体积的鼓。 所公开的系统还包括用于从大体积滚筒分配液体的第一组件。 所公开的系统进一步包括第二组件，用于用第二液体补充容纳在大容积滚筒中的第一液体。 所公开的系统还可以包括用于混合第一和第二液体的第三机械装置。
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公开(公告)号：USD303007S
公开(公告)日：1989-08-22
申请号：US10113
申请日：1987-02-02
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公开(公告)号：US4770308A
公开(公告)日：1988-09-13
申请号：US625575
申请日：1984-06-28
申请人： Robert W. Lynn
发明人： Robert W. Lynn
IPC分类号： B65D41/04
CPC分类号： B65D41/0471
摘要： A container having an open neck portion formed with a screw thread and a removable closure having a side wall portion formed with a mating screw thread. The closure has at least one protuberance on the side wall. The neck portion has at least one projection shaped to allow said protuberance to pass thereover in either direction when the closure is threaded on or off of the neck portion using an applied rotational force only. The projection extends downwardly away from the screw thread toward the neck portion/container interface. The protuberance requires an applied rotational force to enable same to pass over the projection wherein the closure can be partially unthreaded from the neck portion before the protuberance passes over the projection.
摘要翻译： 具有形成有螺纹的开口颈部的容器和具有形成有配合螺纹的侧壁部的可拆卸的封闭件。 封闭件在侧壁上具有至少一个凸起。 颈部具有至少一个突起，该突起成形为当使用所施加的旋转力仅在颈部上拧紧颈部时，允许所述突起在任一方向上穿过其上。 突出部从螺纹朝向颈部/容器接口向下延伸。 突起需要施加的旋转力以使其能够穿过突起，其中在突起穿过突起之前，封闭件可以部分地从颈部部分脱开。
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公开(公告)号：USD267818S
公开(公告)日：1983-02-01
申请号：US166820
申请日：1980-07-08
申请人： Robert W. Lynn , Judith B. Lynn
设计人： Robert W. Lynn , Judith B. Lynn
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公开(公告)号：US20110064617A1
公开(公告)日：2011-03-17
申请号：US12953067
申请日：2010-11-23
IPC分类号： G01N21/77
CPC分类号： G01N21/77 , G01N21/6428 , G01N21/783 , G01N2021/6432 , G01N2021/7786 , G01N2021/7793 , G01N2021/7796 , Y10T436/144444
摘要： An electro-optical sensing device for detecting the presence and concentration of an analyte in a liquid or gaseous medium includes a pair of indicator elements positioned to receive radiation from a radiation source and transmit radiation to a pair of photosensitive elements. The indicator elements each contain indicator molecules having an optical characteristic responsive to the presence of an analyte; however, one of the indicator elements is covered by an analyte-impermeable chamber that renders the indicator element insensitive to the presence of the analyte in the medium outside the chamber so that it can be used as a reference to cancel environmental and systemic variables that affect both indicator elements. The chamber preferably holds an analyte-containing fluid in contact with the reference indicator element so that the indicator elements operate under nominally identical conditions. The indicator element used to measure the analyte in the external medium is preferably also covered, but in a manner that provides direct contact between the analyte and the indicator element.
摘要翻译： 用于检测液体或气体介质中分析物的存在和浓度的电光检测装置包括一对指示元件，其被定位成接收来自辐射源的辐射并将辐射传输到一对感光元件。 指示剂元素各自包含具有响应于分析物存在的光学特性的指示剂分子; 然而，其中一个指示元件被分析物不可渗透的腔室覆盖，使得指示元件对室内的介质中分析物的存在不敏感，使得其可以用作参考以消除影响的环境和系统变量 两个指标元素。 该室优选地保持与参考指示元件接触的含分析物的流体，使得指示元件在名义上相同的条件下操作。 用于测量外部介质中的分析物的指示剂元素优选也被覆盖，但是以提供分析物与指示剂元件之间的直接接触的方式。
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公开(公告)号：US4337104A
公开(公告)日：1982-06-29
申请号：US232619
申请日：1981-02-09
申请人： Robert W. Lynn
发明人： Robert W. Lynn
CPC分类号： C12M27/12 , B29C65/0672 , B29C65/08 , B29C66/5432 , C12M23/28 , C12M25/06 , Y10T156/1062 , Y10T428/31
摘要： A method for manufacturing a roller bottle for cell growth production includes tissue culture treating the interior surface of a substantially cylindrical center portion having an open first end, an open second end and interior and exterior surfaces. A first end cap having a serrated circumferential surface is attached to the first end of the center portion. A second end cap also having a serrated circumferential surface is attached to the second end of the center portion. These end caps are attached so that their serrated surfaces protrude from the exterior surface of the center portion.
摘要翻译： 制造用于细胞生长生产的滚瓶的方法包括组织培养，处理具有敞开的第一端，开放的第二端以及内部和外部表面的基本上圆柱形的中心部分的内表面。 具有锯齿形圆周表面的第一端盖附接到中心部分的第一端。 还具有锯齿形周面的第二端盖附接到中心部分的第二端。 这些端盖被附接成使得它们的锯齿形表面从中心部分的外表面突出。
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